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Q9NRR3

- C42S2_HUMAN

UniProt

Q9NRR3 - C42S2_HUMAN

Protein

CDC42 small effector protein 2

Gene

CDC42SE2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. phagocytosis Source: UniProtKB-KW
    2. regulation of cell shape Source: UniProtKB-KW
    3. regulation of signal transduction Source: UniProtKB

    Keywords - Biological processi

    Cell shape, Phagocytosis

    Enzyme and pathway databases

    SignaLinkiQ9NRR3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDC42 small effector protein 2
    Alternative name(s):
    Small effector of CDC42 protein 2
    Gene namesi
    Name:CDC42SE2
    Synonyms:SPEC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:18547. CDC42SE2.

    Subcellular locationi

    Cytoplasmcytoskeleton. Cell membrane; Lipid-anchor. Cell projectionphagocytic cup
    Note: Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.

    GO - Cellular componenti

    1. cell projection Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-KW
    3. cytoskeleton Source: UniProtKB-SubCell
    4. extracellular vesicular exosome Source: UniProt
    5. phagocytic cup Source: UniProtKB-SubCell
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA133787056.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8484CDC42 small effector protein 2PRO_0000334639Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi10 – 101S-palmitoyl cysteine1 Publication
    Lipidationi11 – 111S-palmitoyl cysteine1 Publication

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ9NRR3.
    PaxDbiQ9NRR3.
    PRIDEiQ9NRR3.

    PTM databases

    PhosphoSiteiQ9NRR3.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ9NRR3.
    BgeeiQ9NRR3.
    CleanExiHS_CDC42SE2.
    GenevestigatoriQ9NRR3.

    Organism-specific databases

    HPAiHPA038624.

    Interactioni

    Subunit structurei

    Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.1 Publication

    Protein-protein interaction databases

    BioGridi121306. 5 interactions.
    STRINGi9606.ENSP00000353706.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 4214CRIBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 234Poly-Arg

    Domaini

    The CRIB domain mediates interaction with CDC42.

    Sequence similaritiesi

    Belongs to the CDC42SE/SPEC family.Curated
    Contains 1 CRIB domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG78697.
    HOGENOMiHOG000006512.
    HOVERGENiHBG107546.
    InParanoidiQ9NRR3.
    OMAiISANVQM.
    PhylomeDBiQ9NRR3.
    TreeFamiTF323815.

    Family and domain databases

    Gene3Di3.90.810.10. 1 hit.
    InterProiIPR000095. CRIB_dom.
    [Graphical view]
    PfamiPF00786. PBD. 1 hit.
    [Graphical view]
    PROSITEiPS50108. CRIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NRR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEFWLCFNC CIAEQPQPKR RRRIDRSMIG EPTNFVHTAH VGSGDLFSGM   50
    NSVSSIQNQM QSKGGYGGGM PANVQMQLVD TKAG 84
    Length:84
    Mass (Da):9,223
    Last modified:October 1, 2000 - v1
    Checksum:i98C5E82176DA990A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF189692 mRNA. Translation: AAF87598.1.
    AK312406 mRNA. Translation: BAG35319.1.
    CH471062 Genomic DNA. Translation: EAW62373.1.
    BC096703 mRNA. Translation: AAH96703.1.
    BC096738 mRNA. Translation: AAH96738.1.
    BC098349 mRNA. Translation: AAH98349.1.
    CCDSiCCDS34224.1.
    RefSeqiNP_001033791.1. NM_001038702.1.
    NP_064625.1. NM_020240.2.
    UniGeneiHs.508829.
    Hs.713870.

    Genome annotation databases

    EnsembliENST00000360515; ENSP00000353706; ENSG00000158985.
    ENST00000395246; ENSP00000378667; ENSG00000158985.
    ENST00000505065; ENSP00000427421; ENSG00000158985.
    GeneIDi56990.
    KEGGihsa:56990.
    UCSCiuc003kvh.3. human.

    Polymorphism databases

    DMDMi74719133.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF189692 mRNA. Translation: AAF87598.1 .
    AK312406 mRNA. Translation: BAG35319.1 .
    CH471062 Genomic DNA. Translation: EAW62373.1 .
    BC096703 mRNA. Translation: AAH96703.1 .
    BC096738 mRNA. Translation: AAH96738.1 .
    BC098349 mRNA. Translation: AAH98349.1 .
    CCDSi CCDS34224.1.
    RefSeqi NP_001033791.1. NM_001038702.1.
    NP_064625.1. NM_020240.2.
    UniGenei Hs.508829.
    Hs.713870.

    3D structure databases

    ProteinModelPortali Q9NRR3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121306. 5 interactions.
    STRINGi 9606.ENSP00000353706.

    PTM databases

    PhosphoSitei Q9NRR3.

    Polymorphism databases

    DMDMi 74719133.

    Proteomic databases

    MaxQBi Q9NRR3.
    PaxDbi Q9NRR3.
    PRIDEi Q9NRR3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360515 ; ENSP00000353706 ; ENSG00000158985 .
    ENST00000395246 ; ENSP00000378667 ; ENSG00000158985 .
    ENST00000505065 ; ENSP00000427421 ; ENSG00000158985 .
    GeneIDi 56990.
    KEGGi hsa:56990.
    UCSCi uc003kvh.3. human.

    Organism-specific databases

    CTDi 56990.
    GeneCardsi GC05P130581.
    H-InvDB HIX0005148.
    HGNCi HGNC:18547. CDC42SE2.
    HPAi HPA038624.
    neXtProti NX_Q9NRR3.
    PharmGKBi PA133787056.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78697.
    HOGENOMi HOG000006512.
    HOVERGENi HBG107546.
    InParanoidi Q9NRR3.
    OMAi ISANVQM.
    PhylomeDBi Q9NRR3.
    TreeFami TF323815.

    Enzyme and pathway databases

    SignaLinki Q9NRR3.

    Miscellaneous databases

    GenomeRNAii 56990.
    NextBioi 62683.
    PROi Q9NRR3.

    Gene expression databases

    ArrayExpressi Q9NRR3.
    Bgeei Q9NRR3.
    CleanExi HS_CDC42SE2.
    Genevestigatori Q9NRR3.

    Family and domain databases

    Gene3Di 3.90.810.10. 1 hit.
    InterProi IPR000095. CRIB_dom.
    [Graphical view ]
    Pfami PF00786. PBD. 1 hit.
    [Graphical view ]
    PROSITEi PS50108. CRIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDC42.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse."
      Ching K.H., Kisailus A.E., Burbelo P.D.
      J. Biol. Chem. 280:23660-23667(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PALMITOYLATION AT CYS-10 AND CYS-11.
    6. "Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis."
      Ching K.H., Kisailus A.E., Burbelo P.D.
      Exp. Cell Res. 313:10-21(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. Cited for: POSSIBLE SUSCEPTIBILITY TO SCHIZOPHRENIA.

    Entry informationi

    Entry nameiC42S2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRR3
    Secondary accession number(s): B2R622, Q4KMT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    CDC42SE2 is mapped in the genomic region associated with schizophrenia.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3