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Protein

CDC42 small effector protein 2

Gene

CDC42SE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.2 Publications

Miscellaneous

CDC42SE2 is mapped in the genomic region associated with schizophrenia.

GO - Molecular functioni

  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • phagocytosis Source: UniProtKB-KW
  • regulation of cell shape Source: UniProtKB-KW
  • regulation of signal transduction Source: UniProtKB

Keywordsi

Biological processCell shape, Phagocytosis

Enzyme and pathway databases

SignaLinkiQ9NRR3

Names & Taxonomyi

Protein namesi
Recommended name:
CDC42 small effector protein 2
Alternative name(s):
Small effector of CDC42 protein 2
Gene namesi
Name:CDC42SE2
Synonyms:SPEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000158985.13
HGNCiHGNC:18547 CDC42SE2
neXtProtiNX_Q9NRR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56990
OpenTargetsiENSG00000158985
PharmGKBiPA133787056

Polymorphism and mutation databases

BioMutaiCDC42SE2
DMDMi74719133

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003346391 – 84CDC42 small effector protein 2Add BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi10S-palmitoyl cysteine1 Publication1
Lipidationi11S-palmitoyl cysteine1 Publication1
Modified residuei43PhosphoserineBy similarity1
Modified residuei52PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9NRR3
MaxQBiQ9NRR3
PaxDbiQ9NRR3
PeptideAtlasiQ9NRR3
PRIDEiQ9NRR3
TopDownProteomicsiQ9NRR3

PTM databases

iPTMnetiQ9NRR3
PhosphoSitePlusiQ9NRR3
SwissPalmiQ9NRR3

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000158985
CleanExiHS_CDC42SE2
ExpressionAtlasiQ9NRR3 baseline and differential
GenevisibleiQ9NRR3 HS

Organism-specific databases

HPAiHPA038624

Interactioni

Subunit structurei

Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.1 Publication

Protein-protein interaction databases

BioGridi121306, 11 interactors
IntActiQ9NRR3, 2 interactors
STRINGi9606.ENSP00000353706

Structurei

3D structure databases

ProteinModelPortaliQ9NRR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 42CRIBPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 23Poly-Arg4

Domaini

The CRIB domain mediates interaction with CDC42.

Sequence similaritiesi

Belongs to the CDC42SE/SPEC family.Curated

Phylogenomic databases

eggNOGiENOG410J410 Eukaryota
ENOG4112ATR LUCA
GeneTreeiENSGT00390000010375
HOGENOMiHOG000006512
HOVERGENiHBG107546
InParanoidiQ9NRR3
OMAiELWVQCF
OrthoDBiEOG091G114R
PhylomeDBiQ9NRR3
TreeFamiTF323815

Family and domain databases

CDDicd00132 CRIB, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NRR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEFWLCFNC CIAEQPQPKR RRRIDRSMIG EPTNFVHTAH VGSGDLFSGM
60 70 80
NSVSSIQNQM QSKGGYGGGM PANVQMQLVD TKAG
Length:84
Mass (Da):9,223
Last modified:October 1, 2000 - v1
Checksum:i98C5E82176DA990A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189692 mRNA Translation: AAF87598.1
AK312406 mRNA Translation: BAG35319.1
CH471062 Genomic DNA Translation: EAW62373.1
BC096703 mRNA Translation: AAH96703.1
BC096738 mRNA Translation: AAH96738.1
BC098349 mRNA Translation: AAH98349.1
CCDSiCCDS34224.1
RefSeqiNP_001033791.1, NM_001038702.1
NP_064625.1, NM_020240.2
XP_016865137.1, XM_017009648.1
XP_016865138.1, XM_017009649.1
UniGeneiHs.508829
Hs.713870

Genome annotation databases

EnsembliENST00000360515; ENSP00000353706; ENSG00000158985
ENST00000395246; ENSP00000378667; ENSG00000158985
ENST00000505065; ENSP00000427421; ENSG00000158985
GeneIDi56990
KEGGihsa:56990
UCSCiuc003kvh.4 human

Similar proteinsi

Entry informationi

Entry nameiC42S2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRR3
Secondary accession number(s): B2R622, Q4KMT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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