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Q9NRR2

- TRYG1_HUMAN

UniProt

Q9NRR2 - TRYG1_HUMAN

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Protein

Tryptase gamma

Gene
TPSG1, PRSS31, TMT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781Charge relay system By similarity
Active sitei125 – 1251Charge relay system By similarity
Active sitei222 – 2221Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.028.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptase gamma (EC:3.4.21.-)
Alternative name(s):
Serine protease 31
Transmembrane tryptase
Cleaved into the following 2 chains:
Gene namesi
Name:TPSG1
Synonyms:PRSS31, TMT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:14134. TPSG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei284 – 30421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 321302Tryptase gammaPRO_0000027498Add
BLAST
Chaini20 – 3617Tryptase gamma light chainPRO_0000027499Add
BLAST
Chaini38 – 321284Tryptase gamma heavy chainPRO_0000027500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 145Interchain (between light and heavy chains) Reviewed prediction
Disulfide bondi63 ↔ 79 By similarity
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi159 ↔ 228 By similarity
Disulfide bondi192 ↔ 210 By similarity
Disulfide bondi218 ↔ 246 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9NRR2.
PRIDEiQ9NRR2.

Expressioni

Tissue specificityi

Expressed in many tissues.

Gene expression databases

BgeeiQ9NRR2.
CleanExiHS_TPSG1.
GenevestigatoriQ9NRR2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000234798.

Structurei

3D structure databases

ProteinModelPortaliQ9NRR2.
SMRiQ9NRR2. Positions 38-269.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 270233Peptidase S1Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9NRR2.
KOiK09615.
OrthoDBiEOG75B84T.
PhylomeDBiQ9NRR2.
TreeFamiTF351676.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRR2-1 [UniParc]FASTAAdd to Basket

« Hide

MALGACGLLL LLAVPGVSLR TLQPGCGRPQ VSDAGGRIVG GHAAPAGAWP    50
WQASLRLRRM HVCGGSLLSP QWVLTAAHCF SGSLNSSDYQ VHLGELEITL 100
SPHFSTVRQI ILHSSPSGQP GTSGDIALVE LSVPVTLSSR ILPVCLPEAS 150
DDFCPGIRCW VTGWGYTREG EPLPPPYSLR EVKVSVVDTE TCRRDYPGPG 200
GSILQPDMLC ARGPGDACQD DSGGPLVCQV NGAWVQAGTV SWGEGCGRPN 250
RPGVYTRVPA YVNWIRRHIT ASGGSESGYP RLPLLAGLFL PGLFLLLVSC 300
VLLAKCLLHP SADGTPFPAP D 321
Length:321
Mass (Da):33,815
Last modified:May 18, 2010 - v3
Checksum:iD2F7A5A1D66F59C7
GO

Polymorphismi

There are two alleles; gamma-I and gamma-II which differ by 5 residues.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601M → V in allele gamma-II. 2 Publications
Corresponds to variant rs760357 [ dbSNP | Ensembl ].
VAR_012097
Natural varianti126 – 1261I → M in allele gamma-II. 1 Publication
VAR_012098
Natural varianti132 – 1321S → T in allele gamma-II. 1 Publication
VAR_012099
Natural varianti160 – 1601W → S.1 Publication
Corresponds to variant rs4984638 [ dbSNP | Ensembl ].
VAR_025012
Natural varianti204 – 2041L → I in allele gamma-II. 1 Publication
VAR_012100
Natural varianti239 – 2391T → I.4 Publications
Corresponds to variant rs11248860 [ dbSNP | Ensembl ].
VAR_061773
Natural varianti288 – 2881L → F in allele gamma-II. 2 Publications
Corresponds to variant rs1004041 [ dbSNP | Ensembl ].
VAR_012101

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF175522 mRNA. Translation: AAF03695.1.
AF175759 Genomic DNA. Translation: AAF03697.1.
AF191031 Genomic DNA. Translation: AAF76457.1.
AF195508 Genomic DNA. Translation: AAF76458.1.
AE006466 Genomic DNA. Translation: AAK61269.1.
AC120498 Genomic DNA. No translation available.
AF223563 Genomic DNA. Translation: AAG48852.2.
CCDSiCCDS10430.1.
RefSeqiNP_036599.3. NM_012467.3.
UniGeneiHs.592076.

Genome annotation databases

EnsembliENST00000234798; ENSP00000234798; ENSG00000116176.
GeneIDi25823.
KEGGihsa:25823.
UCSCiuc002ckw.2. human.

Polymorphism databases

DMDMi296453005.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF175522 mRNA. Translation: AAF03695.1 .
AF175759 Genomic DNA. Translation: AAF03697.1 .
AF191031 Genomic DNA. Translation: AAF76457.1 .
AF195508 Genomic DNA. Translation: AAF76458.1 .
AE006466 Genomic DNA. Translation: AAK61269.1 .
AC120498 Genomic DNA. No translation available.
AF223563 Genomic DNA. Translation: AAG48852.2 .
CCDSi CCDS10430.1.
RefSeqi NP_036599.3. NM_012467.3.
UniGenei Hs.592076.

3D structure databases

ProteinModelPortali Q9NRR2.
SMRi Q9NRR2. Positions 38-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000234798.

Chemistry

ChEMBLi CHEMBL4955.

Protein family/group databases

MEROPSi S01.028.

Polymorphism databases

DMDMi 296453005.

Proteomic databases

PaxDbi Q9NRR2.
PRIDEi Q9NRR2.

Protocols and materials databases

DNASUi 25823.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000234798 ; ENSP00000234798 ; ENSG00000116176 .
GeneIDi 25823.
KEGGi hsa:25823.
UCSCi uc002ckw.2. human.

Organism-specific databases

CTDi 25823.
GeneCardsi GC16M001271.
H-InvDB HIX0038548.
HGNCi HGNC:14134. TPSG1.
MIMi 609341. gene.
neXtProti NX_Q9NRR2.
PharmGKBi PA37849.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi Q9NRR2.
KOi K09615.
OrthoDBi EOG75B84T.
PhylomeDBi Q9NRR2.
TreeFami TF351676.

Miscellaneous databases

GeneWikii TPSG1.
GenomeRNAii 25823.
NextBioi 47087.
PROi Q9NRR2.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRR2.
CleanExi HS_TPSG1.
Genevestigatori Q9NRR2.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension."
    Wong G.W., Tang Y., Feyfant E., Sali A., Li L., Li Y., Huang C., Friend D.S., Krilis S.A., Stevens R.L.
    J. Biol. Chem. 274:30784-30793(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ILE-239.
  2. "Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families."
    Caughey G.H., Raymond W.W., Blount J.L., Hau L.W., Pallaoro M., Wolters P.J., Verghese G.M.
    J. Immunol. 164:6566-6575(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-60; MET-126; THR-132; SER-160; ILE-204; ILE-239 AND PHE-288.
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-60; ILE-239 AND PHE-288.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Organization and alternative splicing of CACNA1H."
    Mittman S., Agnew W.S.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 220-321, VARIANT ILE-239.

Entry informationi

Entry nameiTRYG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRR2
Secondary accession number(s): Q96RZ8
, Q9C015, Q9NRQ8, Q9UBB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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