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Q9NRR2 (TRYG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptase gamma

EC=3.4.21.-
Alternative name(s):
Serine protease 31
Transmembrane tryptase

Cleaved into the following 2 chains:

  1. Tryptase gamma light chain
  2. Tryptase gamma heavy chain
Gene names
Name:TPSG1
Synonyms:PRSS31, TMT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in many tissues.

Polymorphism

There are two alleles; gamma-I and gamma-II which differ by 5 residues.

Sequence similarities

Belongs to the peptidase S1 family. Tryptase subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 321302Tryptase gamma
PRO_0000027498
Chain20 – 3617Tryptase gamma light chain
PRO_0000027499
Chain38 – 321284Tryptase gamma heavy chain
PRO_0000027500

Regions

Transmembrane284 – 30421Helical; Potential
Domain38 – 270233Peptidase S1

Sites

Active site781Charge relay system By similarity
Active site1251Charge relay system By similarity
Active site2221Charge relay system By similarity

Amino acid modifications

Glycosylation851N-linked (GlcNAc...) Potential
Disulfide bond26 ↔ 145Interchain (between light and heavy chains) Potential
Disulfide bond63 ↔ 79 By similarity
Disulfide bond159 ↔ 228 By similarity
Disulfide bond192 ↔ 210 By similarity
Disulfide bond218 ↔ 246 By similarity

Natural variations

Natural variant601M → V in allele gamma-II. Ref.2 Ref.3
Corresponds to variant rs760357 [ dbSNP | Ensembl ].
VAR_012097
Natural variant1261I → M in allele gamma-II. Ref.2
VAR_012098
Natural variant1321S → T in allele gamma-II. Ref.2
VAR_012099
Natural variant1601W → S. Ref.2
Corresponds to variant rs4984638 [ dbSNP | Ensembl ].
VAR_025012
Natural variant2041L → I in allele gamma-II. Ref.2
VAR_012100
Natural variant2391T → I. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs11248860 [ dbSNP | Ensembl ].
VAR_061773
Natural variant2881L → F in allele gamma-II. Ref.2 Ref.3
Corresponds to variant rs1004041 [ dbSNP | Ensembl ].
VAR_012101

Sequences

Sequence LengthMass (Da)Tools
Q9NRR2 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: D2F7A5A1D66F59C7

FASTA32133,815
        10         20         30         40         50         60 
MALGACGLLL LLAVPGVSLR TLQPGCGRPQ VSDAGGRIVG GHAAPAGAWP WQASLRLRRM 

        70         80         90        100        110        120 
HVCGGSLLSP QWVLTAAHCF SGSLNSSDYQ VHLGELEITL SPHFSTVRQI ILHSSPSGQP 

       130        140        150        160        170        180 
GTSGDIALVE LSVPVTLSSR ILPVCLPEAS DDFCPGIRCW VTGWGYTREG EPLPPPYSLR 

       190        200        210        220        230        240 
EVKVSVVDTE TCRRDYPGPG GSILQPDMLC ARGPGDACQD DSGGPLVCQV NGAWVQAGTV 

       250        260        270        280        290        300 
SWGEGCGRPN RPGVYTRVPA YVNWIRRHIT ASGGSESGYP RLPLLAGLFL PGLFLLLVSC 

       310        320 
VLLAKCLLHP SADGTPFPAP D 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension."
Wong G.W., Tang Y., Feyfant E., Sali A., Li L., Li Y., Huang C., Friend D.S., Krilis S.A., Stevens R.L.
J. Biol. Chem. 274:30784-30793(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ILE-239.
[2]"Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families."
Caughey G.H., Raymond W.W., Blount J.L., Hau L.W., Pallaoro M., Wolters P.J., Verghese G.M.
J. Immunol. 164:6566-6575(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-60; MET-126; THR-132; SER-160; ILE-204; ILE-239 AND PHE-288.
[3]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-60; ILE-239 AND PHE-288.
[4]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Organization and alternative splicing of CACNA1H."
Mittman S., Agnew W.S.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 220-321, VARIANT ILE-239.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF175522 mRNA. Translation: AAF03695.1.
AF175759 Genomic DNA. Translation: AAF03697.1.
AF191031 Genomic DNA. Translation: AAF76457.1.
AF195508 Genomic DNA. Translation: AAF76458.1.
AE006466 Genomic DNA. Translation: AAK61269.1.
AC120498 Genomic DNA. No translation available.
AF223563 Genomic DNA. Translation: AAG48852.2.
CCDSCCDS10430.1.
RefSeqNP_036599.3. NM_012467.3.
UniGeneHs.592076.

3D structure databases

ProteinModelPortalQ9NRR2.
SMRQ9NRR2. Positions 38-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000234798.

Chemistry

ChEMBLCHEMBL4955.

Protein family/group databases

MEROPSS01.028.

Polymorphism databases

DMDM296453005.

Proteomic databases

PaxDbQ9NRR2.
PRIDEQ9NRR2.

Protocols and materials databases

DNASU25823.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000234798; ENSP00000234798; ENSG00000116176.
GeneID25823.
KEGGhsa:25823.
UCSCuc002ckw.2. human.

Organism-specific databases

CTD25823.
GeneCardsGC16M001271.
H-InvDBHIX0038548.
HGNCHGNC:14134. TPSG1.
MIM609341. gene.
neXtProtNX_Q9NRR2.
PharmGKBPA37849.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidQ9NRR2.
KOK09615.
OrthoDBEOG75B84T.
PhylomeDBQ9NRR2.
TreeFamTF351676.

Gene expression databases

BgeeQ9NRR2.
CleanExHS_TPSG1.
GenevestigatorQ9NRR2.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTPSG1.
GenomeRNAi25823.
NextBio47087.
PROQ9NRR2.
SOURCESearch...

Entry information

Entry nameTRYG1_HUMAN
AccessionPrimary (citable) accession number: Q9NRR2
Secondary accession number(s): Q96RZ8 expand/collapse secondary AC list , Q9C015, Q9NRQ8, Q9UBB2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM