Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptase gamma

Gene

TPSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78Charge relay systemBy similarity1
Active sitei125Charge relay systemBy similarity1
Active sitei222Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116176-MONOMER.

Protein family/group databases

MEROPSiS01.028.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptase gamma (EC:3.4.21.-)
Alternative name(s):
Serine protease 31
Transmembrane tryptase
Cleaved into the following 2 chains:
Gene namesi
Name:TPSG1
Synonyms:PRSS31, TMT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14134. TPSG1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25823.
PharmGKBiPA37849.

Chemistry databases

ChEMBLiCHEMBL4955.

Polymorphism and mutation databases

BioMutaiTPSG1.
DMDMi296453005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002749820 – 321Tryptase gammaAdd BLAST302
ChainiPRO_000002749920 – 36Tryptase gamma light chainAdd BLAST17
ChainiPRO_000002750038 – 321Tryptase gamma heavy chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 145Interchain (between light and heavy chains)PROSITE-ProRule annotation
Disulfide bondi63 ↔ 79PROSITE-ProRule annotation
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi159 ↔ 228PROSITE-ProRule annotation
Disulfide bondi192 ↔ 210PROSITE-ProRule annotation
Disulfide bondi218 ↔ 246PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9NRR2.
PeptideAtlasiQ9NRR2.
PRIDEiQ9NRR2.

Expressioni

Tissue specificityi

Expressed in many tissues.

Gene expression databases

BgeeiENSG00000116176.
CleanExiHS_TPSG1.
GenevisibleiQ9NRR2. HS.

Organism-specific databases

HPAiHPA060458.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000234798.

Chemistry databases

BindingDBiQ9NRR2.

Structurei

3D structure databases

ProteinModelPortaliQ9NRR2.
SMRiQ9NRR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 270Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family. Tryptase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9NRR2.
KOiK09615.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ9NRR2.
TreeFamiTF351676.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGACGLLL LLAVPGVSLR TLQPGCGRPQ VSDAGGRIVG GHAAPAGAWP
60 70 80 90 100
WQASLRLRRM HVCGGSLLSP QWVLTAAHCF SGSLNSSDYQ VHLGELEITL
110 120 130 140 150
SPHFSTVRQI ILHSSPSGQP GTSGDIALVE LSVPVTLSSR ILPVCLPEAS
160 170 180 190 200
DDFCPGIRCW VTGWGYTREG EPLPPPYSLR EVKVSVVDTE TCRRDYPGPG
210 220 230 240 250
GSILQPDMLC ARGPGDACQD DSGGPLVCQV NGAWVQAGTV SWGEGCGRPN
260 270 280 290 300
RPGVYTRVPA YVNWIRRHIT ASGGSESGYP RLPLLAGLFL PGLFLLLVSC
310 320
VLLAKCLLHP SADGTPFPAP D
Length:321
Mass (Da):33,815
Last modified:May 18, 2010 - v3
Checksum:iD2F7A5A1D66F59C7
GO

Polymorphismi

There are two alleles; gamma-I and gamma-II which differ by 5 residues.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01209760M → V in allele gamma-II. 2 PublicationsCorresponds to variant rs760357dbSNPEnsembl.1
Natural variantiVAR_012098126I → M in allele gamma-II. 1 Publication1
Natural variantiVAR_012099132S → T in allele gamma-II. 1 Publication1
Natural variantiVAR_025012160W → S.1 PublicationCorresponds to variant rs4984638dbSNPEnsembl.1
Natural variantiVAR_012100204L → I in allele gamma-II. 1 Publication1
Natural variantiVAR_061773239T → I.4 PublicationsCorresponds to variant rs11248860dbSNPEnsembl.1
Natural variantiVAR_012101288L → F in allele gamma-II. 2 PublicationsCorresponds to variant rs1004041dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175522 mRNA. Translation: AAF03695.1.
AF175759 Genomic DNA. Translation: AAF03697.1.
AF191031 Genomic DNA. Translation: AAF76457.1.
AF195508 Genomic DNA. Translation: AAF76458.1.
AE006466 Genomic DNA. Translation: AAK61269.1.
AC120498 Genomic DNA. No translation available.
AF223563 Genomic DNA. Translation: AAG48852.2.
CCDSiCCDS10430.1.
RefSeqiNP_036599.3. NM_012467.3.
UniGeneiHs.592076.

Genome annotation databases

EnsembliENST00000234798; ENSP00000234798; ENSG00000116176.
GeneIDi25823.
KEGGihsa:25823.
UCSCiuc002ckw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175522 mRNA. Translation: AAF03695.1.
AF175759 Genomic DNA. Translation: AAF03697.1.
AF191031 Genomic DNA. Translation: AAF76457.1.
AF195508 Genomic DNA. Translation: AAF76458.1.
AE006466 Genomic DNA. Translation: AAK61269.1.
AC120498 Genomic DNA. No translation available.
AF223563 Genomic DNA. Translation: AAG48852.2.
CCDSiCCDS10430.1.
RefSeqiNP_036599.3. NM_012467.3.
UniGeneiHs.592076.

3D structure databases

ProteinModelPortaliQ9NRR2.
SMRiQ9NRR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000234798.

Chemistry databases

BindingDBiQ9NRR2.
ChEMBLiCHEMBL4955.

Protein family/group databases

MEROPSiS01.028.

Polymorphism and mutation databases

BioMutaiTPSG1.
DMDMi296453005.

Proteomic databases

PaxDbiQ9NRR2.
PeptideAtlasiQ9NRR2.
PRIDEiQ9NRR2.

Protocols and materials databases

DNASUi25823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234798; ENSP00000234798; ENSG00000116176.
GeneIDi25823.
KEGGihsa:25823.
UCSCiuc002ckw.3. human.

Organism-specific databases

CTDi25823.
DisGeNETi25823.
GeneCardsiTPSG1.
H-InvDBHIX0038548.
HGNCiHGNC:14134. TPSG1.
HPAiHPA060458.
MIMi609341. gene.
neXtProtiNX_Q9NRR2.
PharmGKBiPA37849.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9NRR2.
KOiK09615.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ9NRR2.
TreeFamiTF351676.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116176-MONOMER.

Miscellaneous databases

GeneWikiiTPSG1.
GenomeRNAii25823.
PROiQ9NRR2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116176.
CleanExiHS_TPSG1.
GenevisibleiQ9NRR2. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRYG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRR2
Secondary accession number(s): Q96RZ8
, Q9C015, Q9NRQ8, Q9UBB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.