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Protein

Tryptase gamma

Gene

TPSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781Charge relay systemBy similarity
Active sitei125 – 1251Charge relay systemBy similarity
Active sitei222 – 2221Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.028.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptase gamma (EC:3.4.21.-)
Alternative name(s):
Serine protease 31
Transmembrane tryptase
Cleaved into the following 2 chains:
Gene namesi
Name:TPSG1
Synonyms:PRSS31, TMT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14134. TPSG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37849.

Polymorphism and mutation databases

BioMutaiTPSG1.
DMDMi296453005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 321302Tryptase gammaPRO_0000027498Add
BLAST
Chaini20 – 3617Tryptase gamma light chainPRO_0000027499Add
BLAST
Chaini38 – 321284Tryptase gamma heavy chainPRO_0000027500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 145Interchain (between light and heavy chains)PROSITE-ProRule annotation
Disulfide bondi63 ↔ 79PROSITE-ProRule annotation
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi159 ↔ 228PROSITE-ProRule annotation
Disulfide bondi192 ↔ 210PROSITE-ProRule annotation
Disulfide bondi218 ↔ 246PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9NRR2.
PRIDEiQ9NRR2.

Expressioni

Tissue specificityi

Expressed in many tissues.

Gene expression databases

BgeeiQ9NRR2.
CleanExiHS_TPSG1.
GenevestigatoriQ9NRR2.

Organism-specific databases

HPAiHPA060458.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000234798.

Structurei

3D structure databases

ProteinModelPortaliQ9NRR2.
SMRiQ9NRR2. Positions 38-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 270233Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Tryptase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9NRR2.
KOiK09615.
OrthoDBiEOG75B84T.
PhylomeDBiQ9NRR2.
TreeFamiTF351676.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGACGLLL LLAVPGVSLR TLQPGCGRPQ VSDAGGRIVG GHAAPAGAWP
60 70 80 90 100
WQASLRLRRM HVCGGSLLSP QWVLTAAHCF SGSLNSSDYQ VHLGELEITL
110 120 130 140 150
SPHFSTVRQI ILHSSPSGQP GTSGDIALVE LSVPVTLSSR ILPVCLPEAS
160 170 180 190 200
DDFCPGIRCW VTGWGYTREG EPLPPPYSLR EVKVSVVDTE TCRRDYPGPG
210 220 230 240 250
GSILQPDMLC ARGPGDACQD DSGGPLVCQV NGAWVQAGTV SWGEGCGRPN
260 270 280 290 300
RPGVYTRVPA YVNWIRRHIT ASGGSESGYP RLPLLAGLFL PGLFLLLVSC
310 320
VLLAKCLLHP SADGTPFPAP D
Length:321
Mass (Da):33,815
Last modified:May 18, 2010 - v3
Checksum:iD2F7A5A1D66F59C7
GO

Polymorphismi

There are two alleles; gamma-I and gamma-II which differ by 5 residues.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601M → V in allele gamma-II. 2 Publications
Corresponds to variant rs760357 [ dbSNP | Ensembl ].
VAR_012097
Natural varianti126 – 1261I → M in allele gamma-II. 1 Publication
VAR_012098
Natural varianti132 – 1321S → T in allele gamma-II. 1 Publication
VAR_012099
Natural varianti160 – 1601W → S.1 Publication
Corresponds to variant rs4984638 [ dbSNP | Ensembl ].
VAR_025012
Natural varianti204 – 2041L → I in allele gamma-II. 1 Publication
VAR_012100
Natural varianti239 – 2391T → I.4 Publications
Corresponds to variant rs11248860 [ dbSNP | Ensembl ].
VAR_061773
Natural varianti288 – 2881L → F in allele gamma-II. 2 Publications
Corresponds to variant rs1004041 [ dbSNP | Ensembl ].
VAR_012101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175522 mRNA. Translation: AAF03695.1.
AF175759 Genomic DNA. Translation: AAF03697.1.
AF191031 Genomic DNA. Translation: AAF76457.1.
AF195508 Genomic DNA. Translation: AAF76458.1.
AE006466 Genomic DNA. Translation: AAK61269.1.
AC120498 Genomic DNA. No translation available.
AF223563 Genomic DNA. Translation: AAG48852.2.
CCDSiCCDS10430.1.
RefSeqiNP_036599.3. NM_012467.3.
UniGeneiHs.592076.

Genome annotation databases

EnsembliENST00000234798; ENSP00000234798; ENSG00000116176.
GeneIDi25823.
KEGGihsa:25823.
UCSCiuc002ckw.2. human.

Polymorphism and mutation databases

BioMutaiTPSG1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF175522 mRNA. Translation: AAF03695.1.
AF175759 Genomic DNA. Translation: AAF03697.1.
AF191031 Genomic DNA. Translation: AAF76457.1.
AF195508 Genomic DNA. Translation: AAF76458.1.
AE006466 Genomic DNA. Translation: AAK61269.1.
AC120498 Genomic DNA. No translation available.
AF223563 Genomic DNA. Translation: AAG48852.2.
CCDSiCCDS10430.1.
RefSeqiNP_036599.3. NM_012467.3.
UniGeneiHs.592076.

3D structure databases

ProteinModelPortaliQ9NRR2.
SMRiQ9NRR2. Positions 38-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000234798.

Chemistry

BindingDBiQ9NRR2.
ChEMBLiCHEMBL4955.

Protein family/group databases

MEROPSiS01.028.

Polymorphism and mutation databases

BioMutaiTPSG1.
DMDMi296453005.

Proteomic databases

PaxDbiQ9NRR2.
PRIDEiQ9NRR2.

Protocols and materials databases

DNASUi25823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234798; ENSP00000234798; ENSG00000116176.
GeneIDi25823.
KEGGihsa:25823.
UCSCiuc002ckw.2. human.

Organism-specific databases

CTDi25823.
GeneCardsiGC16M001271.
H-InvDBHIX0038548.
HGNCiHGNC:14134. TPSG1.
HPAiHPA060458.
MIMi609341. gene.
neXtProtiNX_Q9NRR2.
PharmGKBiPA37849.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9NRR2.
KOiK09615.
OrthoDBiEOG75B84T.
PhylomeDBiQ9NRR2.
TreeFamiTF351676.

Miscellaneous databases

GeneWikiiTPSG1.
GenomeRNAii25823.
NextBioi47087.
PROiQ9NRR2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NRR2.
CleanExiHS_TPSG1.
GenevestigatoriQ9NRR2.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension."
    Wong G.W., Tang Y., Feyfant E., Sali A., Li L., Li Y., Huang C., Friend D.S., Krilis S.A., Stevens R.L.
    J. Biol. Chem. 274:30784-30793(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ILE-239.
  2. "Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families."
    Caughey G.H., Raymond W.W., Blount J.L., Hau L.W., Pallaoro M., Wolters P.J., Verghese G.M.
    J. Immunol. 164:6566-6575(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-60; MET-126; THR-132; SER-160; ILE-204; ILE-239 AND PHE-288.
  3. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS VAL-60; ILE-239 AND PHE-288.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Organization and alternative splicing of CACNA1H."
    Mittman S., Agnew W.S.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 220-321, VARIANT ILE-239.

Entry informationi

Entry nameiTRYG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRR2
Secondary accession number(s): Q96RZ8
, Q9C015, Q9NRQ8, Q9UBB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.