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Protein

Cytokine-like protein 1

Gene

CYTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine-like protein 1
Alternative name(s):
Protein C17
Gene namesi
Name:CYTL1
Synonyms:C4orf4
ORF Names:UNQ1942/PRO4425
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24435. CYTL1.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978681.

Polymorphism and mutation databases

BioMutaiCYTL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 136114Cytokine-like protein 1PRO_0000020838Add
BLAST

Proteomic databases

EPDiQ9NRR1.
PaxDbiQ9NRR1.
PeptideAtlasiQ9NRR1.
PRIDEiQ9NRR1.

PTM databases

iPTMnetiQ9NRR1.
PhosphoSiteiQ9NRR1.

Expressioni

Tissue specificityi

Specifically expressed in CD34+ hematopoietic cells.1 Publication

Gene expression databases

BgeeiENSG00000170891.
CleanExiHS_CYTL1.
ExpressionAtlasiQ9NRR1. baseline and differential.
GenevisibleiQ9NRR1. HS.

Interactioni

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

STRINGi9606.ENSP00000303550.

Structurei

3D structure databases

ProteinModelPortaliQ9NRR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXZC. Eukaryota.
ENOG4112045. LUCA.
GeneTreeiENSGT00390000016221.
HOGENOMiHOG000217919.
HOVERGENiHBG079724.
InParanoidiQ9NRR1.
OMAiPSEPCVR.
OrthoDBiEOG091G0UNA.
PhylomeDBiQ9NRR1.
TreeFamiTF333406.

Family and domain databases

InterProiIPR029253. CYTL1.
[Graphical view]
PfamiPF15153. CYTL1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPGPLPVL LLLLAGAPAA RPTPPTCYSR MRALSQEITR DFNLLQVSEP
60 70 80 90 100
SEPCVRYLPR LYLDIHNYCV LDKLRDFVAS PPCWKVAQVD SLKDKARKLY
110 120 130
TIMNSFCRRD LVFLLDDCNA LEYPIPVTTV LPDRQR
Length:136
Mass (Da):15,577
Last modified:October 1, 2000 - v1
Checksum:i1CAEE1BFC31A3AE3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511S → L.
Corresponds to variant rs35755546 [ dbSNP | Ensembl ].
VAR_050940
Natural varianti136 – 1361R → C.
Corresponds to variant rs11722554 [ dbSNP | Ensembl ].
VAR_050941

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193766 mRNA. Translation: AAF73372.1.
AY359101 mRNA. Translation: AAQ89459.1.
BC031391 mRNA. Translation: AAH31391.1.
CCDSiCCDS3379.1.
RefSeqiNP_061129.1. NM_018659.2.
UniGeneiHs.13872.

Genome annotation databases

EnsembliENST00000307746; ENSP00000303550; ENSG00000170891.
GeneIDi54360.
KEGGihsa:54360.
UCSCiuc003gig.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193766 mRNA. Translation: AAF73372.1.
AY359101 mRNA. Translation: AAQ89459.1.
BC031391 mRNA. Translation: AAH31391.1.
CCDSiCCDS3379.1.
RefSeqiNP_061129.1. NM_018659.2.
UniGeneiHs.13872.

3D structure databases

ProteinModelPortaliQ9NRR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303550.

PTM databases

iPTMnetiQ9NRR1.
PhosphoSiteiQ9NRR1.

Polymorphism and mutation databases

BioMutaiCYTL1.

Proteomic databases

EPDiQ9NRR1.
PaxDbiQ9NRR1.
PeptideAtlasiQ9NRR1.
PRIDEiQ9NRR1.

Protocols and materials databases

DNASUi54360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307746; ENSP00000303550; ENSG00000170891.
GeneIDi54360.
KEGGihsa:54360.
UCSCiuc003gig.5. human.

Organism-specific databases

CTDi54360.
GeneCardsiCYTL1.
HGNCiHGNC:24435. CYTL1.
MIMi607930. gene.
neXtProtiNX_Q9NRR1.
PharmGKBiPA134978681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXZC. Eukaryota.
ENOG4112045. LUCA.
GeneTreeiENSGT00390000016221.
HOGENOMiHOG000217919.
HOVERGENiHBG079724.
InParanoidiQ9NRR1.
OMAiPSEPCVR.
OrthoDBiEOG091G0UNA.
PhylomeDBiQ9NRR1.
TreeFamiTF333406.

Miscellaneous databases

GenomeRNAii54360.
PROiQ9NRR1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170891.
CleanExiHS_CYTL1.
ExpressionAtlasiQ9NRR1. baseline and differential.
GenevisibleiQ9NRR1. HS.

Family and domain databases

InterProiIPR029253. CYTL1.
[Graphical view]
PfamiPF15153. CYTL1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.