Reviewed, UniProtKB/Swiss-Prot Q9NRR1 (CYTL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytokine-like protein 1
Alternative name(s):
    Protein C17

Gene names

Name:	CYTL1
Synonyms:	C4orf4
ORF Names:	UNQ1942/PRO4425

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Ref.1.
Tissue specificity	Specifically expressed in CD34+ hematopoietic cells. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Ref.1 Traceable author statement. Source: ProtInc soluble fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	receptor binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.4
	Chain	23 – 136	114	Cytokine-like protein 1		PRO_0000020838
Natural variations
	Natural variant	51	1	S → L: dbSNP rs35755546.		VAR_050940
	Natural variant	136	1	R → C: dbSNP rs11722554.		VAR_050941

Sequences

	Sequence		Length	Mass (Da)
	Q9NRR1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 1CAEE1BFC31A3AE3	FASTA	136	15,577
	10 20 30 40 50 60 MRTPGPLPVL LLLLAGAPAA RPTPPTCYSR MRALSQEITR DFNLLQVSEP SEPCVRYLPR 70 80 90 100 110 120 LYLDIHNYCV LDKLRDFVAS PPCWKVAQVD SLKDKARKLY TIMNSFCRRD LVFLLDDCNA 130 LEYPIPVTTV LPDRQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells." Liu X., Rapp N., Deans R., Cheng L. Genomics 65:283-292(2000) [PubMed: 10857752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Blood.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF193766 mRNA. Translation: AAF73372.1. AY359101 mRNA. Translation: AAQ89459.1. BC031391 mRNA. Translation: AAH31391.1.
IPI	IPI00032876.
RefSeq	NP_061129.1.
UniGene	Hs.13872
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NRR1.
Proteomic databases
PeptideAtlas	Q9NRR1.
PRIDE	Q9NRR1.
Genome annotation databases
Ensembl	ENST00000307746; ENSP00000303550; ENSG00000170891; Homo sapiens. [Genome view]
GeneID	54360.
KEGG	hsa:54360.
UCSC	uc003gig.1. human.
Organism-specific databases
CTD	54360.
GeneCards	GC04M005135.
H-InvDB	HIX0004054.
HGNC	HGNC:24435. CYTL1.
MIM	607930. gene.
PharmGKB	PA134978681.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20340.
HOGENOM	HBG283160.
HOVERGEN	Q9NRR1.
InParanoid	Q9NRR1.
OMA	SEPCVRY.
OrthoDB	EOG9QRKPK.
PhylomeDB	Q9NRR1.
Gene expression databases
ArrayExpress	Q9NRR1.
Bgee	Q9NRR1.
CleanEx	HS_CYTL1.
Genevestigator	Q9NRR1.
GermOnline	ENSG00000170891. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	56595.
SOURCE	Search...

Entry information

Entry name

CYTL1_HUMAN

Accession

Primary (citable) accession number: Q9NRR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	October 1, 2000
Last modified:	January 19, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.