Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Single-pass membrane and coiled-coil domain-containing protein 4

Gene

SMCO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Single-pass membrane and coiled-coil domain-containing protein 4
Alternative name(s):
Protein FN5
Gene namesi
Name:SMCO4
Synonyms:C11orf75, FN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24810. SMCO4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596494.

Polymorphism and mutation databases

BioMutaiSMCO4.
DMDMi74734326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5959Single-pass membrane and coiled-coil domain-containing protein 4PRO_0000087319Add
BLAST

Proteomic databases

PaxDbiQ9NRQ5.
PeptideAtlasiQ9NRQ5.
PRIDEiQ9NRQ5.
TopDownProteomicsiQ9NRQ5.

Expressioni

Gene expression databases

BgeeiENSG00000166002.
CleanExiHS_C11orf75.
ExpressionAtlasiQ9NRQ5. baseline and differential.
GenevisibleiQ9NRQ5. HS.

Organism-specific databases

HPAiHPA041120.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BNIP3LO602384EBI-8640191,EBI-849893
CCDC155Q8N6L03EBI-8640191,EBI-749265
KRT40Q6A1623EBI-8640191,EBI-10171697
KRTAP10-7P604093EBI-8640191,EBI-10172290
SYNE4Q8N2053EBI-8640191,EBI-7131783

Protein-protein interaction databases

BioGridi121260. 6 interactions.
IntActiQ9NRQ5. 5 interactions.
STRINGi9606.ENSP00000298966.

Structurei

3D structure databases

ProteinModelPortaliQ9NRQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili9 – 3123Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SMCO4 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J51Z. Eukaryota.
ENOG410Z59X. LUCA.
GeneTreeiENSGT00390000015987.
InParanoidiQ9NRQ5.
OMAiLENAQMQ.
TreeFamiTF324415.

Family and domain databases

InterProiIPR027960. DUF4519.
[Graphical view]
PfamiPF15012. DUF4519. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NRQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQLKGKPKK ETSKDKKERK QAMQEARQQI TTVVLPTLAV VVLLIVVFVY

VATRPTITE
Length:59
Mass (Da):6,738
Last modified:October 1, 2000 - v1
Checksum:i00D250C357495E73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197137 mRNA. Translation: AAF86046.1.
AP004242 Genomic DNA. No translation available.
BC031564 mRNA. Translation: AAH31564.1.
CCDSiCCDS8292.1.
RefSeqiNP_064564.1. NM_020179.2.
UniGeneiHs.438064.

Genome annotation databases

EnsembliENST00000298966; ENSP00000298966; ENSG00000166002.
ENST00000525141; ENSP00000431781; ENSG00000166002.
ENST00000527149; ENSP00000433555; ENSG00000166002.
ENST00000596676; ENSP00000479594; ENSG00000166002.
GeneIDi56935.
KEGGihsa:56935.
UCSCiuc001pds.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197137 mRNA. Translation: AAF86046.1.
AP004242 Genomic DNA. No translation available.
BC031564 mRNA. Translation: AAH31564.1.
CCDSiCCDS8292.1.
RefSeqiNP_064564.1. NM_020179.2.
UniGeneiHs.438064.

3D structure databases

ProteinModelPortaliQ9NRQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121260. 6 interactions.
IntActiQ9NRQ5. 5 interactions.
STRINGi9606.ENSP00000298966.

Polymorphism and mutation databases

BioMutaiSMCO4.
DMDMi74734326.

Proteomic databases

PaxDbiQ9NRQ5.
PeptideAtlasiQ9NRQ5.
PRIDEiQ9NRQ5.
TopDownProteomicsiQ9NRQ5.

Protocols and materials databases

DNASUi56935.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298966; ENSP00000298966; ENSG00000166002.
ENST00000525141; ENSP00000431781; ENSG00000166002.
ENST00000527149; ENSP00000433555; ENSG00000166002.
ENST00000596676; ENSP00000479594; ENSG00000166002.
GeneIDi56935.
KEGGihsa:56935.
UCSCiuc001pds.5. human.

Organism-specific databases

CTDi56935.
GeneCardsiSMCO4.
H-InvDBHIX0010022.
HGNCiHGNC:24810. SMCO4.
HPAiHPA041120.
MIMi609477. gene.
neXtProtiNX_Q9NRQ5.
PharmGKBiPA144596494.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J51Z. Eukaryota.
ENOG410Z59X. LUCA.
GeneTreeiENSGT00390000015987.
InParanoidiQ9NRQ5.
OMAiLENAQMQ.
TreeFamiTF324415.

Miscellaneous databases

GenomeRNAii56935.
PROiQ9NRQ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166002.
CleanExiHS_C11orf75.
ExpressionAtlasiQ9NRQ5. baseline and differential.
GenevisibleiQ9NRQ5. HS.

Family and domain databases

InterProiIPR027960. DUF4519.
[Graphical view]
PfamiPF15012. DUF4519. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMCO4_HUMAN
AccessioniPrimary (citable) accession number: Q9NRQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.