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Protein

Single-pass membrane and coiled-coil domain-containing protein 4

Gene

SMCO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Single-pass membrane and coiled-coil domain-containing protein 4
Alternative name(s):
Protein FN5
Gene namesi
Name:SMCO4
Synonyms:C11orf75, FN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166002.6.
HGNCiHGNC:24810. SMCO4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166002.
PharmGKBiPA144596494.

Polymorphism and mutation databases

BioMutaiSMCO4.
DMDMi74734326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873191 – 59Single-pass membrane and coiled-coil domain-containing protein 4Add BLAST59

Proteomic databases

PaxDbiQ9NRQ5.
PeptideAtlasiQ9NRQ5.
PRIDEiQ9NRQ5.
TopDownProteomicsiQ9NRQ5.

Expressioni

Gene expression databases

BgeeiENSG00000166002.
CleanExiHS_C11orf75.
ExpressionAtlasiQ9NRQ5. baseline and differential.
GenevisibleiQ9NRQ5. HS.

Organism-specific databases

HPAiHPA041120.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121260. 6 interactors.
IntActiQ9NRQ5. 16 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9NRQ5.
SMRiQ9NRQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili9 – 31Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the SMCO4 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J51Z. Eukaryota.
ENOG410Z59X. LUCA.
GeneTreeiENSGT00390000015987.
InParanoidiQ9NRQ5.
OMAiKLRGGQT.
OrthoDBiEOG09370GXN.
TreeFamiTF324415.

Family and domain databases

InterProiView protein in InterPro
IPR027960. DUF4519.
PfamiView protein in Pfam
PF15012. DUF4519. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NRQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQLKGKPKK ETSKDKKERK QAMQEARQQI TTVVLPTLAV VVLLIVVFVY

VATRPTITE
Length:59
Mass (Da):6,738
Last modified:October 1, 2000 - v1
Checksum:i00D250C357495E73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197137 mRNA. Translation: AAF86046.1.
AP004242 Genomic DNA. No translation available.
BC031564 mRNA. Translation: AAH31564.1.
CCDSiCCDS8292.1.
RefSeqiNP_064564.1. NM_020179.2.
UniGeneiHs.438064.

Genome annotation databases

EnsembliENST00000298966; ENSP00000298966; ENSG00000166002.
ENST00000525141; ENSP00000431781; ENSG00000166002.
ENST00000527149; ENSP00000433555; ENSG00000166002.
ENST00000596676; ENSP00000479594; ENSG00000166002.
GeneIDi56935.
KEGGihsa:56935.
UCSCiuc001pds.5. human.

Similar proteinsi

Entry informationi

Entry nameiSMCO4_HUMAN
AccessioniPrimary (citable) accession number: Q9NRQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries