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Q9NRP7 (STK36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase 36

EC=2.7.11.1
Alternative name(s):
Fused homolog
Gene names
Name:STK36
Synonyms:KIAA1278
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1315 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. Ref.1

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB P23647

Cofactor

Magnesium.

Subunit structure

Interacts with SPAG16 and KIF27 By similarity. Ref.1

Subcellular location

Cytoplasm. Nucleus. Note: Low levels also present in the nucleus. Ref.1

Tissue specificity

Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells. Ref.1

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAA86592.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB14184.1 differs from that shown. Reason: Frameshift at position 987.

Ontologies

Keywords
   Biological processCilium biogenesis/degradation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionDevelopmental protein
Kinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from electronic annotation. Source: Ensembl

cilium assembly

Inferred from sequence or structural similarity. Source: UniProtKB

epithelial cilium movement

Inferred from electronic annotation. Source: Ensembl

positive regulation of hh target transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of smoothened signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

post-embryonic development

Inferred from sequence or structural similarity. Source: UniProtKB

protein phosphorylation

Traceable author statement Ref.1. Source: UniProtKB

regulation of sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.1. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

nucleus

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionATP binding

Traceable author statement Ref.1. Source: UniProtKB

magnesium ion binding

Inferred by curator Ref.1. Source: UniProtKB

protein serine/threonine kinase activity

Traceable author statement Ref.1. Source: UniProtKB

transcription factor binding

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SUFUQ9UMX12EBI-863797,EBI-740595

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 Ref.4 Ref.6 (identifier: Q9NRP7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.2 (identifier: Q9NRP7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     838-858: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13151315Serine/threonine-protein kinase 36
PRO_0000229020

Regions

Domain4 – 254251Protein kinase
Nucleotide binding10 – 189ATP By similarity UniProtKB P23647

Sites

Active site1251Proton acceptor By similarity UniProtKB P23647
Binding site331ATP UniProtKB P23647

Natural variations

Alternative sequence838 – 85821Missing in isoform 2. Ref.2
VSP_051983
Natural variant901I → M. Ref.7
Corresponds to variant rs55706732 [ dbSNP | Ensembl ].
VAR_041177
Natural variant2401R → W. Ref.7
Corresponds to variant rs35038757 [ dbSNP | Ensembl ].
VAR_041178
Natural variant2951K → R. Ref.7
Corresponds to variant rs1863703 [ dbSNP | Ensembl ].
VAR_041179
Natural variant3291D → N. Ref.7
Corresponds to variant rs34027859 [ dbSNP | Ensembl ].
VAR_041180
Natural variant4621L → V. Ref.7
Corresponds to variant rs45586733 [ dbSNP | Ensembl ].
VAR_041181
Natural variant4631K → N. Ref.4
Corresponds to variant rs17856747 [ dbSNP | Ensembl ].
VAR_025727
Natural variant4761F → S. Ref.7
Corresponds to variant rs34128793 [ dbSNP | Ensembl ].
VAR_041182
Natural variant4771R → W. Ref.7
Corresponds to variant rs16859180 [ dbSNP | Ensembl ].
VAR_041183
Natural variant5831R → Q. Ref.7
Corresponds to variant rs1344642 [ dbSNP | Ensembl ].
VAR_041184
Natural variant6381Q → P.
Corresponds to variant rs6709303 [ dbSNP | Ensembl ].
VAR_057112
Natural variant6601S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. Ref.7
VAR_041185
Natural variant6721L → P. Ref.7
Corresponds to variant rs35448374 [ dbSNP | Ensembl ].
VAR_041186
Natural variant7671S → T. Ref.4
Corresponds to variant rs17856748 [ dbSNP | Ensembl ].
VAR_025728
Natural variant7671S → Y in an ovarian papillary serous adenocarcinoma sample; somatic mutation. Ref.7
VAR_041187
Natural variant8161T → A. Ref.7
Corresponds to variant rs34271431 [ dbSNP | Ensembl ].
VAR_041188
Natural variant8391R → Q. Ref.7
Corresponds to variant rs13023540 [ dbSNP | Ensembl ].
VAR_041189
Natural variant8401L → V. Ref.7
Corresponds to variant rs36099639 [ dbSNP | Ensembl ].
VAR_041190
Natural variant10031G → D. Ref.6 Ref.7
Corresponds to variant rs1863704 [ dbSNP | Ensembl ].
VAR_025729
Natural variant10041V → I.
Corresponds to variant rs55633575 [ dbSNP | Ensembl ].
VAR_061747
Natural variant11111Y → C. Ref.7
Corresponds to variant rs56278660 [ dbSNP | Ensembl ].
VAR_041191
Natural variant11121R → Q. Ref.7
Corresponds to variant rs12993599 [ dbSNP | Ensembl ].
VAR_041192
Natural variant11381Q → K in an ovarian serous carcinoma sample; somatic mutation. Ref.7
VAR_041193
Natural variant11851P → S in an ovarian endometrioid sample; somatic mutation. Ref.7
VAR_041194
Natural variant13131H → P. Ref.7
VAR_041195

Experimental info

Mutagenesis331K → R: No effect on nuclear localization of GLI1 or GLI2 or on GLI-mediated transcription. Ref.1
Sequence conflict2291N → D in AAH26158. Ref.4
Sequence conflict971 – 98616Missing Ref.6
Sequence conflict10031G → V in AAF97028. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: 793F4638F1871C01

FASTA1,315143,995
        10         20         30         40         50         60 
MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 

        70         80         90        100        110        120 
PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 

       130        140        150        160        170        180 
ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 

       190        200        210        220        230        240 
ADLWSVGCIL YELAVGTPPF YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR 

       250        260        270        280        290        300 
QRLSWPDLLY HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 

       310        320        330        340        350        360 
ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE SSLLAGILAS 

       370        380        390        400        410        420 
ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG QRSTDVVDLE NEEPDSDNEW 

       430        440        450        460        470        480 
QHLLETTEPV PIQLKAPLTL LCNPDFCQRI QSQLHEAGGQ ILKGILEGAS HILPAFRVLS 

       490        500        510        520        530        540 
SLLSSCSDSV ALYSFCREAG LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA 

       550        560        570        580        590        600 
CTFNLERSQT SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 

       610        620        630        640        650        660 
SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ SEDIPGAISS 

       670        680        690        700        710        720 
ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS LISGLQHPIL CLHLLKVLYS 

       730        740        750        760        770        780 
CCLVSEGLCR LLGQEPLALE SLFMLIQGKV KVVDWEESTE VTLYFLSLLV FRLQNLPCGM 

       790        800        810        820        830        840 
EKLGSDVATL FTHSHVVSLV SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL 

       850        860        870        880        890        900 
TPPGSCGFYD GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG 

       910        920        930        940        950        960 
ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI LMSILKHLLC 

       970        980        990       1000       1010       1020 
PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL LIGVLADLRD SEVAAHLLQV 

      1030       1040       1050       1060       1070       1080 
CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ FVNTVSASPR TIVSFLSVAL LSDQPLLTSD 

      1090       1100       1110       1120       1130       1140 
LLSLLAHTAR VLSPSHLSFI QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS 

      1150       1160       1170       1180       1190       1200 
MALRGALQSQ SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL 

      1210       1220       1230       1240       1250       1260 
LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK EAALIALRSL 

      1270       1280       1290       1300       1310 
QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK HCRKLIHLLR PAHSM 

« Hide

Isoform 2 [UniParc].

Checksum: 42376671A0F272AF
Show »

FASTA1,294141,737

References

« Hide 'large scale' references
[1]"Gli regulation by the opposing activities of fused and suppressor of fused."
Murone M., Luoh S.-L., Stone D., Li W., Gurney A., Armanini M., Grey C., Rosenthal A., de Sauvage F.J.
Nat. Cell Biol. 2:310-312(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH GLI1; GLI2; GLI3 AND SUFU, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-33.
[2]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-463 AND THR-767.
Tissue: Testis.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 823-1315 (ISOFORM 1).
Tissue: Testis.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 839-1315 (ISOFORM 1), VARIANT ASP-1003.
Tissue: Teratocarcinoma.
[7]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-90; TRP-240; ARG-295; ASN-329; VAL-462; SER-476; TRP-477; GLN-583; CYS-660; PRO-672; TYR-767; ALA-816; GLN-839; VAL-840; ASP-1003; CYS-1111; GLN-1112; LYS-1138; SER-1185 AND PRO-1313.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF200815 mRNA. Translation: AAF97028.1.
AB033104 mRNA. Translation: BAA86592.1. Different initiation.
AC009974 Genomic DNA. No translation available.
BC026158 mRNA. Translation: AAH26158.1.
AL133630 mRNA. Translation: CAB63754.1.
AK022692 mRNA. Translation: BAB14184.1. Frameshift.
PIRT43465.
RefSeqNP_001230242.1. NM_001243313.1.
NP_056505.2. NM_015690.4.
XP_005246521.1. XM_005246464.1.
UniGeneHs.471404.
Hs.712986.

3D structure databases

ProteinModelPortalQ9NRP7.
SMRQ9NRP7. Positions 1-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118032. 10 interactions.
IntActQ9NRP7. 7 interactions.
STRING9606.ENSP00000295709.

Chemistry

BindingDBQ9NRP7.
ChEMBLCHEMBL4312.
GuidetoPHARMACOLOGY2223.

PTM databases

PhosphoSiteQ9NRP7.

Polymorphism databases

DMDM90101761.

Proteomic databases

PaxDbQ9NRP7.
PRIDEQ9NRP7.

Protocols and materials databases

DNASU27148.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295709; ENSP00000295709; ENSG00000163482. [Q9NRP7-1]
ENST00000392105; ENSP00000375954; ENSG00000163482. [Q9NRP7-2]
ENST00000440309; ENSP00000394095; ENSG00000163482. [Q9NRP7-1]
GeneID27148.
KEGGhsa:27148.
UCSCuc002viu.3. human. [Q9NRP7-1]
uc002viv.3. human. [Q9NRP7-2]

Organism-specific databases

CTD27148.
GeneCardsGC02P219536.
H-InvDBHIX0002836.
HGNCHGNC:17209. STK36.
HPAHPA027409.
HPA027453.
HPA030058.
MIM607652. gene.
neXtProtNX_Q9NRP7.
PharmGKBPA38212.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000015284.
HOVERGENHBG094005.
InParanoidQ9NRP7.
KOK06228.
OMAMACGDPQ.
OrthoDBEOG7PK8Z2.
PhylomeDBQ9NRP7.
TreeFamTF105340.

Enzyme and pathway databases

SignaLinkQ9NRP7.

Gene expression databases

ArrayExpressQ9NRP7.
BgeeQ9NRP7.
CleanExHS_STK36.
GenevestigatorQ9NRP7.

Family and domain databases

Gene3D1.25.10.10. 2 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSTK36.
GenomeRNAi27148.
NextBio49907.
PROQ9NRP7.
SOURCESearch...

Entry information

Entry nameSTK36_HUMAN
AccessionPrimary (citable) accession number: Q9NRP7
Secondary accession number(s): B7WPM3 expand/collapse secondary AC list , Q8TC32, Q9H9N9, Q9UF35, Q9ULE2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM