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Q9NRP7

- STK36_HUMAN

UniProt

Q9NRP7 - STK36_HUMAN

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Protein

Serine/threonine-protein kinase 36

Gene

STK36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP
Active sitei125 – 1251Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. protein serine/threonine kinase activity Source: UniProtKB
  4. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. brain development Source: Ensembl
  2. cilium assembly Source: UniProtKB
  3. epithelial cilium movement Source: Ensembl
  4. positive regulation of hh target transcription factor activity Source: UniProtKB
  5. positive regulation of smoothened signaling pathway Source: UniProtKB
  6. post-embryonic development Source: UniProtKB
  7. protein phosphorylation Source: UniProtKB
  8. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9NRP7.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 36 (EC:2.7.11.1)
Alternative name(s):
Fused homolog
Gene namesi
Name:STK36Imported
Synonyms:KIAA1278Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17209. STK36.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Low levels also present in the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi33 – 331K → R: No effect on nuclear localization of GLI1 or GLI2 or on GLI-mediated transcription. 1 Publication

Organism-specific databases

PharmGKBiPA38212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13151315Serine/threonine-protein kinase 36PRO_0000229020Add
BLAST

Proteomic databases

MaxQBiQ9NRP7.
PaxDbiQ9NRP7.
PRIDEiQ9NRP7.

PTM databases

PhosphoSiteiQ9NRP7.

Expressioni

Tissue specificityi

Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.1 Publication

Gene expression databases

BgeeiQ9NRP7.
CleanExiHS_STK36.
ExpressionAtlasiQ9NRP7. baseline and differential.
GenevestigatoriQ9NRP7.

Organism-specific databases

HPAiHPA027409.
HPA027453.
HPA030058.

Interactioni

Subunit structurei

Interacts with SPAG16 and KIF27.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GLI1P081512EBI-863797,EBI-308084
GLI3P100712EBI-863797,EBI-308055
SUFUQ9UMX13EBI-863797,EBI-740595

Protein-protein interaction databases

BioGridi118032. 10 interactions.
IntActiQ9NRP7. 7 interactions.
STRINGi9606.ENSP00000295709.

Structurei

3D structure databases

ProteinModelPortaliQ9NRP7.
SMRiQ9NRP7. Positions 1-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 254251Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119118.
HOGENOMiHOG000015284.
HOVERGENiHBG094005.
InParanoidiQ9NRP7.
KOiK06228.
OMAiMACGDPQ.
OrthoDBiEOG7PK8Z2.
PhylomeDBiQ9NRP7.
TreeFamiTF105340.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 13 Publications (identifier: Q9NRP7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR
60 70 80 90 100
EIEIMRGLRH PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED
110 120 130 140 150
QVQAIAAQLV SALYYLHSHR ILHRDMKPQN ILLAKGGGIK LCDFGFARAM
160 170 180 190 200
STNTMVLTSI KGTPLYMSPE LVEERPYDHT ADLWSVGCIL YELAVGTPPF
210 220 230 240 250
YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR QRLSWPDLLY
260 270 280 290 300
HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR
310 320 330 340 350
ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE
360 370 380 390 400
SSLLAGILAS ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG
410 420 430 440 450
QRSTDVVDLE NEEPDSDNEW QHLLETTEPV PIQLKAPLTL LCNPDFCQRI
460 470 480 490 500
QSQLHEAGGQ ILKGILEGAS HILPAFRVLS SLLSSCSDSV ALYSFCREAG
510 520 530 540 550
LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA CTFNLERSQT
560 570 580 590 600
SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN
610 620 630 640 650
SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ
660 670 680 690 700
SEDIPGAISS ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS
710 720 730 740 750
LISGLQHPIL CLHLLKVLYS CCLVSEGLCR LLGQEPLALE SLFMLIQGKV
760 770 780 790 800
KVVDWEESTE VTLYFLSLLV FRLQNLPCGM EKLGSDVATL FTHSHVVSLV
810 820 830 840 850
SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL TPPGSCGFYD
860 870 880 890 900
GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG
910 920 930 940 950
ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI
960 970 980 990 1000
LMSILKHLLC PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL
1010 1020 1030 1040 1050
LIGVLADLRD SEVAAHLLQV CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ
1060 1070 1080 1090 1100
FVNTVSASPR TIVSFLSVAL LSDQPLLTSD LLSLLAHTAR VLSPSHLSFI
1110 1120 1130 1140 1150
QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS MALRGALQSQ
1160 1170 1180 1190 1200
SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL
1210 1220 1230 1240 1250
LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK
1260 1270 1280 1290 1300
EAALIALRSL QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK
1310
HCRKLIHLLR PAHSM
Length:1,315
Mass (Da):143,995
Last modified:March 21, 2006 - v2
Checksum:i793F4638F1871C01
GO
Isoform 21 Publication (identifier: Q9NRP7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-858: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:1,294
Mass (Da):141,737
Checksum:i42376671A0F272AF
GO

Sequence cautioni

The sequence BAB14184.1 differs from that shown. Reason: Frameshift at position 987.
The sequence BAA86592.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291N → D in AAH26158. (PubMed:15489334)Curated
Sequence conflicti971 – 98616Missing(PubMed:14702039)CuratedAdd
BLAST
Sequence conflicti1003 – 10031G → V in AAF97028. (PubMed:10806483)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901I → M.1 Publication
Corresponds to variant rs55706732 [ dbSNP | Ensembl ].
VAR_041177
Natural varianti240 – 2401R → W.1 Publication
Corresponds to variant rs35038757 [ dbSNP | Ensembl ].
VAR_041178
Natural varianti295 – 2951K → R.1 Publication
Corresponds to variant rs1863703 [ dbSNP | Ensembl ].
VAR_041179
Natural varianti329 – 3291D → N.1 Publication
Corresponds to variant rs34027859 [ dbSNP | Ensembl ].
VAR_041180
Natural varianti462 – 4621L → V.1 Publication
Corresponds to variant rs45586733 [ dbSNP | Ensembl ].
VAR_041181
Natural varianti463 – 4631K → N.1 Publication
Corresponds to variant rs17856747 [ dbSNP | Ensembl ].
VAR_025727
Natural varianti476 – 4761F → S.1 Publication
Corresponds to variant rs34128793 [ dbSNP | Ensembl ].
VAR_041182
Natural varianti477 – 4771R → W.1 Publication
Corresponds to variant rs16859180 [ dbSNP | Ensembl ].
VAR_041183
Natural varianti583 – 5831R → Q.1 Publication
Corresponds to variant rs1344642 [ dbSNP | Ensembl ].
VAR_041184
Natural varianti638 – 6381Q → P.
Corresponds to variant rs6709303 [ dbSNP | Ensembl ].
VAR_057112
Natural varianti660 – 6601S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication
VAR_041185
Natural varianti672 – 6721L → P.1 Publication
Corresponds to variant rs35448374 [ dbSNP | Ensembl ].
VAR_041186
Natural varianti767 – 7671S → T.1 Publication
Corresponds to variant rs17856748 [ dbSNP | Ensembl ].
VAR_025728
Natural varianti767 – 7671S → Y in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041187
Natural varianti816 – 8161T → A.1 Publication
Corresponds to variant rs34271431 [ dbSNP | Ensembl ].
VAR_041188
Natural varianti839 – 8391R → Q.1 Publication
Corresponds to variant rs13023540 [ dbSNP | Ensembl ].
VAR_041189
Natural varianti840 – 8401L → V.1 Publication
Corresponds to variant rs36099639 [ dbSNP | Ensembl ].
VAR_041190
Natural varianti1003 – 10031G → D.2 Publications
Corresponds to variant rs1863704 [ dbSNP | Ensembl ].
VAR_025729
Natural varianti1004 – 10041V → I.
Corresponds to variant rs55633575 [ dbSNP | Ensembl ].
VAR_061747
Natural varianti1111 – 11111Y → C.1 Publication
Corresponds to variant rs56278660 [ dbSNP | Ensembl ].
VAR_041191
Natural varianti1112 – 11121R → Q.1 Publication
Corresponds to variant rs12993599 [ dbSNP | Ensembl ].
VAR_041192
Natural varianti1138 – 11381Q → K in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
VAR_041193
Natural varianti1185 – 11851P → S in an ovarian endometrioid sample; somatic mutation. 1 Publication
VAR_041194
Natural varianti1313 – 13131H → P.1 Publication
VAR_041195

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei838 – 85821Missing in isoform 2. 1 PublicationVSP_051983Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF200815 mRNA. Translation: AAF97028.1.
AB033104 mRNA. Translation: BAA86592.1. Different initiation.
AC009974 Genomic DNA. No translation available.
BC026158 mRNA. Translation: AAH26158.1.
AL133630 mRNA. Translation: CAB63754.1.
AK022692 mRNA. Translation: BAB14184.1. Frameshift.
CCDSiCCDS2421.1. [Q9NRP7-1]
CCDS58750.1. [Q9NRP7-2]
PIRiT43465.
RefSeqiNP_001230242.1. NM_001243313.1. [Q9NRP7-2]
NP_056505.2. NM_015690.4. [Q9NRP7-1]
XP_005246521.1. XM_005246464.1. [Q9NRP7-1]
UniGeneiHs.471404.
Hs.712986.

Genome annotation databases

EnsembliENST00000295709; ENSP00000295709; ENSG00000163482. [Q9NRP7-1]
ENST00000392105; ENSP00000375954; ENSG00000163482. [Q9NRP7-2]
ENST00000440309; ENSP00000394095; ENSG00000163482. [Q9NRP7-1]
GeneIDi27148.
KEGGihsa:27148.
UCSCiuc002viu.3. human. [Q9NRP7-1]
uc002viv.3. human. [Q9NRP7-2]

Polymorphism databases

DMDMi90101761.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF200815 mRNA. Translation: AAF97028.1 .
AB033104 mRNA. Translation: BAA86592.1 . Different initiation.
AC009974 Genomic DNA. No translation available.
BC026158 mRNA. Translation: AAH26158.1 .
AL133630 mRNA. Translation: CAB63754.1 .
AK022692 mRNA. Translation: BAB14184.1 . Frameshift.
CCDSi CCDS2421.1. [Q9NRP7-1 ]
CCDS58750.1. [Q9NRP7-2 ]
PIRi T43465.
RefSeqi NP_001230242.1. NM_001243313.1. [Q9NRP7-2 ]
NP_056505.2. NM_015690.4. [Q9NRP7-1 ]
XP_005246521.1. XM_005246464.1. [Q9NRP7-1 ]
UniGenei Hs.471404.
Hs.712986.

3D structure databases

ProteinModelPortali Q9NRP7.
SMRi Q9NRP7. Positions 1-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118032. 10 interactions.
IntActi Q9NRP7. 7 interactions.
STRINGi 9606.ENSP00000295709.

Chemistry

BindingDBi Q9NRP7.
ChEMBLi CHEMBL4312.
GuidetoPHARMACOLOGYi 2223.

PTM databases

PhosphoSitei Q9NRP7.

Polymorphism databases

DMDMi 90101761.

Proteomic databases

MaxQBi Q9NRP7.
PaxDbi Q9NRP7.
PRIDEi Q9NRP7.

Protocols and materials databases

DNASUi 27148.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295709 ; ENSP00000295709 ; ENSG00000163482 . [Q9NRP7-1 ]
ENST00000392105 ; ENSP00000375954 ; ENSG00000163482 . [Q9NRP7-2 ]
ENST00000440309 ; ENSP00000394095 ; ENSG00000163482 . [Q9NRP7-1 ]
GeneIDi 27148.
KEGGi hsa:27148.
UCSCi uc002viu.3. human. [Q9NRP7-1 ]
uc002viv.3. human. [Q9NRP7-2 ]

Organism-specific databases

CTDi 27148.
GeneCardsi GC02P219536.
H-InvDB HIX0002836.
HGNCi HGNC:17209. STK36.
HPAi HPA027409.
HPA027453.
HPA030058.
MIMi 607652. gene.
neXtProti NX_Q9NRP7.
PharmGKBi PA38212.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119118.
HOGENOMi HOG000015284.
HOVERGENi HBG094005.
InParanoidi Q9NRP7.
KOi K06228.
OMAi MACGDPQ.
OrthoDBi EOG7PK8Z2.
PhylomeDBi Q9NRP7.
TreeFami TF105340.

Enzyme and pathway databases

SignaLinki Q9NRP7.

Miscellaneous databases

GeneWikii STK36.
GenomeRNAii 27148.
NextBioi 49907.
PROi Q9NRP7.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRP7.
CleanExi HS_STK36.
ExpressionAtlasi Q9NRP7. baseline and differential.
Genevestigatori Q9NRP7.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gli regulation by the opposing activities of fused and suppressor of fused."
    Murone M., Luoh S.-L., Stone D., Li W., Gurney A., Armanini M., Grey C., Rosenthal A., de Sauvage F.J.
    Nat. Cell Biol. 2:310-312(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH GLI1; GLI2; GLI3 AND SUFU, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-33.
  2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: BrainImported.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-463 AND THR-767.
    Tissue: TestisImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 823-1315 (ISOFORM 1).
    Tissue: Testis.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 839-1315 (ISOFORM 1), VARIANT ASP-1003.
    Tissue: TeratocarcinomaImported.
  7. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-90; TRP-240; ARG-295; ASN-329; VAL-462; SER-476; TRP-477; GLN-583; CYS-660; PRO-672; TYR-767; ALA-816; GLN-839; VAL-840; ASP-1003; CYS-1111; GLN-1112; LYS-1138; SER-1185 AND PRO-1313.

Entry informationi

Entry nameiSTK36_HUMAN
AccessioniPrimary (citable) accession number: Q9NRP7
Secondary accession number(s): B7WPM3
, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3