Q9NRP7 (STK36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase 36
EC=2.7.11.1

Alternative name(s):
Fused homolog

Gene names

Name:	STK36
Synonyms:	KIAA1278

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1315 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. Ref.1
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB P23647
Cofactor	Magnesium.
Subunit structure	Interacts with SPAG16 and KIF27 By similarity. Ref.1
Subcellular location	Cytoplasm. Nucleus. Note: Low levels also present in the nucleus. Ref.1
Tissue specificity	Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells. Ref.1
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.
Sequence caution	The sequence BAA86592.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14184.1 differs from that shown. Reason: Frameshift at position 987.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from electronic annotation. Source: Compara cilium assembly Inferred from sequence or structural similarity. Source: UniProtKB epithelial cilium movement Inferred from electronic annotation. Source: Compara positive regulation of hh target transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB post-embryonic development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	ATP binding Non-traceable author statement. Source: UniProtKB magnesium ion binding Inferred by curator Ref.1. Source: UniProtKB protein serine/threonine kinase activity Non-traceable author statement. Source: UniProtKB transcription factor binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SUFU	Q9UMX1	2	EBI-863797,EBI-740595

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.4 Ref.6 (identifier: Q9NRP7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.2 (identifier: Q9NRP7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     838-858: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1315	1315	Serine/threonine-protein kinase 36		PRO_0000229020
Regions
	Domain	4 – 254	251	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity UniProtKB P23647
Sites
	Active site	125	1	Proton acceptor By similarity UniProtKB P23647
	Binding site	33	1	ATP UniProtKB P23647
Natural variations
	Alternative sequence	838 – 858	21	Missing in isoform 2. Ref.2		VSP_051983
	Natural variant	90	1	I → M. Ref.7 Corresponds to variant rs55706732 [ dbSNP | Ensembl ].		VAR_041177
	Natural variant	240	1	R → W. Ref.7 Corresponds to variant rs35038757 [ dbSNP | Ensembl ].		VAR_041178
	Natural variant	295	1	K → R. Ref.7 Corresponds to variant rs1863703 [ dbSNP | Ensembl ].		VAR_041179
	Natural variant	329	1	D → N. Ref.7 Corresponds to variant rs34027859 [ dbSNP | Ensembl ].		VAR_041180
	Natural variant	462	1	L → V. Ref.7 Corresponds to variant rs45586733 [ dbSNP | Ensembl ].		VAR_041181
	Natural variant	463	1	K → N. Ref.4 Corresponds to variant rs17856747 [ dbSNP | Ensembl ].		VAR_025727
	Natural variant	476	1	F → S. Ref.7 Corresponds to variant rs34128793 [ dbSNP | Ensembl ].		VAR_041182
	Natural variant	477	1	R → W. Ref.7 Corresponds to variant rs16859180 [ dbSNP | Ensembl ].		VAR_041183
	Natural variant	583	1	R → Q. Ref.7 Corresponds to variant rs1344642 [ dbSNP | Ensembl ].		VAR_041184
	Natural variant	638	1	Q → P. Corresponds to variant rs6709303 [ dbSNP | Ensembl ].		VAR_057112
	Natural variant	660	1	S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. Ref.7		VAR_041185
	Natural variant	672	1	L → P. Ref.7 Corresponds to variant rs35448374 [ dbSNP | Ensembl ].		VAR_041186
	Natural variant	767	1	S → T. Ref.4 Corresponds to variant rs17856748 [ dbSNP | Ensembl ].		VAR_025728
	Natural variant	767	1	S → Y in an ovarian papillary serous adenocarcinoma sample; somatic mutation. Ref.7		VAR_041187
	Natural variant	816	1	T → A. Ref.7 Corresponds to variant rs34271431 [ dbSNP | Ensembl ].		VAR_041188
	Natural variant	839	1	R → Q. Ref.7 Corresponds to variant rs13023540 [ dbSNP | Ensembl ].		VAR_041189
	Natural variant	840	1	L → V. Ref.7 Corresponds to variant rs36099639 [ dbSNP | Ensembl ].		VAR_041190
	Natural variant	1003	1	G → D. Ref.6 Ref.7 Corresponds to variant rs1863704 [ dbSNP | Ensembl ].		VAR_025729
	Natural variant	1004	1	V → I. Corresponds to variant rs55633575 [ dbSNP | Ensembl ].		VAR_061747
	Natural variant	1111	1	Y → C. Ref.7 Corresponds to variant rs56278660 [ dbSNP | Ensembl ].		VAR_041191
	Natural variant	1112	1	R → Q. Ref.7 Corresponds to variant rs12993599 [ dbSNP | Ensembl ].		VAR_041192
	Natural variant	1138	1	Q → K in an ovarian serous carcinoma sample; somatic mutation. Ref.7		VAR_041193
	Natural variant	1185	1	P → S in an ovarian endometrioid sample; somatic mutation. Ref.7		VAR_041194
	Natural variant	1313	1	H → P. Ref.7		VAR_041195
Experimental info
	Mutagenesis	33	1	K → R: No effect on nuclear localization of GLI1 or GLI2 or on GLI-mediated transcription. Ref.1
	Sequence conflict	229	1	N → D in AAH26158. Ref.4
	Sequence conflict	971 – 986	16	Missing Ref.6
	Sequence conflict	1003	1	G → V in AAF97028. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 21, 2006. Version 2. Checksum: 793F4638F1871C01	FASTA	1,315	143,995
	10 20 30 40 50 60 MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 70 80 90 100 110 120 PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 130 140 150 160 170 180 ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 190 200 210 220 230 240 ADLWSVGCIL YELAVGTPPF YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR 250 260 270 280 290 300 QRLSWPDLLY HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 310 320 330 340 350 360 ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE SSLLAGILAS 370 380 390 400 410 420 ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG QRSTDVVDLE NEEPDSDNEW 430 440 450 460 470 480 QHLLETTEPV PIQLKAPLTL LCNPDFCQRI QSQLHEAGGQ ILKGILEGAS HILPAFRVLS 490 500 510 520 530 540 SLLSSCSDSV ALYSFCREAG LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA 550 560 570 580 590 600 CTFNLERSQT SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 610 620 630 640 650 660 SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ SEDIPGAISS 670 680 690 700 710 720 ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS LISGLQHPIL CLHLLKVLYS 730 740 750 760 770 780 CCLVSEGLCR LLGQEPLALE SLFMLIQGKV KVVDWEESTE VTLYFLSLLV FRLQNLPCGM 790 800 810 820 830 840 EKLGSDVATL FTHSHVVSLV SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL 850 860 870 880 890 900 TPPGSCGFYD GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG 910 920 930 940 950 960 ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI LMSILKHLLC 970 980 990 1000 1010 1020 PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL LIGVLADLRD SEVAAHLLQV 1030 1040 1050 1060 1070 1080 CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ FVNTVSASPR TIVSFLSVAL LSDQPLLTSD 1090 1100 1110 1120 1130 1140 LLSLLAHTAR VLSPSHLSFI QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS 1150 1160 1170 1180 1190 1200 MALRGALQSQ SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL 1210 1220 1230 1240 1250 1260 LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK EAALIALRSL 1270 1280 1290 1300 1310 QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK HCRKLIHLLR PAHSM
	Isoform 2 [UniParc]. Checksum: 42376671A0F272AF	FASTA	1,294	141,737
	10 20 30 40 50 60 MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 70 80 90 100 110 120 PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 130 140 150 160 170 180 ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 190 200 210 220 230 240 ADLWSVGCIL YELAVGTPPF YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR 250 260 270 280 290 300 QRLSWPDLLY HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 310 320 330 340 350 360 ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE SSLLAGILAS 370 380 390 400 410 420 ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG QRSTDVVDLE NEEPDSDNEW 430 440 450 460 470 480 QHLLETTEPV PIQLKAPLTL LCNPDFCQRI QSQLHEAGGQ ILKGILEGAS HILPAFRVLS 490 500 510 520 530 540 SLLSSCSDSV ALYSFCREAG LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA 550 560 570 580 590 600 CTFNLERSQT SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 610 620 630 640 650 660 SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ SEDIPGAISS 670 680 690 700 710 720 ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS LISGLQHPIL CLHLLKVLYS 730 740 750 760 770 780 CCLVSEGLCR LLGQEPLALE SLFMLIQGKV KVVDWEESTE VTLYFLSLLV FRLQNLPCGM 790 800 810 820 830 840 EKLGSDVATL FTHSHVVSLV SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAELLT 850 860 870 880 890 900 EQGKASLIRD MSSSEMWTVL WHRFSMVLRL PEEASAQEGE LSLSSPPSPE PDWTLISPQG 910 920 930 940 950 960 MAALLSLAMA TFTQEPQLCL SCLSQHGSIL MSILKHLLCP SFLNQLRQAP HGSEFLPVVV 970 980 990 1000 1010 1020 LSVCQLLCFP FALDMDADLL IGVLADLRDS EVAAHLLQVC CYHLPLMQVE LPISLLTRLA 1030 1040 1050 1060 1070 1080 LMDPTSLNQF VNTVSASPRT IVSFLSVALL SDQPLLTSDL LSLLAHTARV LSPSHLSFIQ 1090 1100 1110 1120 1130 1140 ELLAGSDESY RPLRSLLGHP ENSVRAHTYR LLGHLLQHSM ALRGALQSQS GLLSLLLLGL 1150 1160 1170 1180 1190 1200 GDKDPVVRCS ASFAVGNAAY QAGPLGPALA AAVPSMTQLL GDPQAGIRRN VASALGNLGP 1210 1220 1230 1240 1250 1260 EGLGEELLQC EVPQRLLEMA CGDPQPNVKE AALIALRSLQ QEPGIHQVLV SLGASEKLSL 1270 1280 1290 LSLGNQSLPH SSPRPASAKH CRKLIHLLRP AHSM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gli regulation by the opposing activities of fused and suppressor of fused." Murone M., Luoh S.-L., Stone D., Li W., Gurney A., Armanini M., Grey C., Rosenthal A., de Sauvage F.J. Nat. Cell Biol. 2:310-312(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH GLI1; GLI2; GLI3 AND SUFU, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-33.
[2]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-463 AND THR-767. Tissue: Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 823-1315 (ISOFORM 1). Tissue: Testis.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 839-1315 (ISOFORM 1), VARIANT ASP-1003. Tissue: Teratocarcinoma.
[7]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-90; TRP-240; ARG-295; ASN-329; VAL-462; SER-476; TRP-477; GLN-583; CYS-660; PRO-672; TYR-767; ALA-816; GLN-839; VAL-840; ASP-1003; CYS-1111; GLN-1112; LYS-1138; SER-1185 AND PRO-1313.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF200815 mRNA. Translation: AAF97028.1. AB033104 mRNA. Translation: BAA86592.1. Different initiation. AC009974 Genomic DNA. No translation available. BC026158 mRNA. Translation: AAH26158.1. AL133630 mRNA. Translation: CAB63754.1. AK022692 mRNA. Translation: BAB14184.1. Frameshift.
IPI	IPI00235407. IPI00735634.
PIR	T43465.
RefSeq	NP_001230242.1. NM_001243313.1. NP_056505.2. NM_015690.4.
UniGene	Hs.471404. Hs.712986.
3D structure databases
ProteinModelPortal	Q9NRP7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NRP7. 7 interactions.
STRING	9606.ENSP00000295709.
PTM databases
PhosphoSite	Q9NRP7.
Polymorphism databases
DMDM	90101761.
Proteomic databases
PaxDb	Q9NRP7.
PRIDE	Q9NRP7.
Protocols and materials databases
DNASU	27148.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295709; ENSP00000295709; ENSG00000163482. ENST00000392105; ENSP00000375954; ENSG00000163482. ENST00000440309; ENSP00000394095; ENSG00000163482.
GeneID	27148.
KEGG	hsa:27148.
UCSC	uc002viu.3. human. uc002viv.3. human.
Organism-specific databases
CTD	27148.
GeneCards	GC02P219536.
H-InvDB	HIX0002836.
HGNC	HGNC:17209. STK36.
HPA	HPA027409. HPA027453. HPA030058.
MIM	607652. gene.
neXtProt	NX_Q9NRP7.
PharmGKB	PA38212.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000015284.
HOVERGEN	HBG094005.
InParanoid	Q9NRP7.
KO	K06228.
OMA	MACGDPQ.
OrthoDB	EOG405S07.
PhylomeDB	Q9NRP7.
Enzyme and pathway databases
Pathway_Interaction_DB	hedgehog_glipathway. Hedgehog signaling events mediated by Gli proteins.
Gene expression databases
ArrayExpress	Q9NRP7.
Bgee	Q9NRP7.
CleanEx	HS_STK36.
Genevestigator	Q9NRP7.
GermOnline	ENSG00000163482. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 2 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9NRP7.
ChEMBL	CHEMBL4312.
GenomeRNAi	27148.
NextBio	49907.
SOURCE	Search...

Entry information

Entry name

STK36_HUMAN

Accession

Primary (citable) accession number: Q9NRP7
Secondary accession number(s): B7WPM3 , Q8TC32, Q9H9N9, Q9UF35, Q9ULE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.