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Q9NRP7

- STK36_HUMAN

UniProt

Q9NRP7 - STK36_HUMAN

Protein

Serine/threonine-protein kinase 36

Gene

STK36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.By similarity

    Cofactori

    Magnesium.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATP
    Active sitei125 – 1251Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. protein serine/threonine kinase activity Source: UniProtKB
    5. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cilium assembly Source: UniProtKB
    3. epithelial cilium movement Source: Ensembl
    4. positive regulation of hh target transcription factor activity Source: UniProtKB
    5. positive regulation of smoothened signaling pathway Source: UniProtKB
    6. post-embryonic development Source: UniProtKB
    7. protein phosphorylation Source: UniProtKB
    8. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9NRP7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase 36 (EC:2.7.11.1)
    Alternative name(s):
    Fused homolog
    Gene namesi
    Name:STK36Imported
    Synonyms:KIAA1278Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:17209. STK36.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Low levels also present in the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi33 – 331K → R: No effect on nuclear localization of GLI1 or GLI2 or on GLI-mediated transcription. 1 Publication

    Organism-specific databases

    PharmGKBiPA38212.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13151315Serine/threonine-protein kinase 36PRO_0000229020Add
    BLAST

    Proteomic databases

    MaxQBiQ9NRP7.
    PaxDbiQ9NRP7.
    PRIDEiQ9NRP7.

    PTM databases

    PhosphoSiteiQ9NRP7.

    Expressioni

    Tissue specificityi

    Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9NRP7.
    BgeeiQ9NRP7.
    CleanExiHS_STK36.
    GenevestigatoriQ9NRP7.

    Organism-specific databases

    HPAiHPA027409.
    HPA027453.
    HPA030058.

    Interactioni

    Subunit structurei

    Interacts with SPAG16 and KIF27.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GLI1P081512EBI-863797,EBI-308084
    GLI3P100712EBI-863797,EBI-308055
    SUFUQ9UMX13EBI-863797,EBI-740595

    Protein-protein interaction databases

    BioGridi118032. 10 interactions.
    IntActiQ9NRP7. 7 interactions.
    STRINGi9606.ENSP00000295709.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRP7.
    SMRiQ9NRP7. Positions 1-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 254251Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000015284.
    HOVERGENiHBG094005.
    InParanoidiQ9NRP7.
    KOiK06228.
    OMAiMACGDPQ.
    OrthoDBiEOG7PK8Z2.
    PhylomeDBiQ9NRP7.
    TreeFamiTF105340.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 6 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 13 Publications (identifier: Q9NRP7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR     50
    EIEIMRGLRH PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED 100
    QVQAIAAQLV SALYYLHSHR ILHRDMKPQN ILLAKGGGIK LCDFGFARAM 150
    STNTMVLTSI KGTPLYMSPE LVEERPYDHT ADLWSVGCIL YELAVGTPPF 200
    YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR QRLSWPDLLY 250
    HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 300
    ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE 350
    SSLLAGILAS ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG 400
    QRSTDVVDLE NEEPDSDNEW QHLLETTEPV PIQLKAPLTL LCNPDFCQRI 450
    QSQLHEAGGQ ILKGILEGAS HILPAFRVLS SLLSSCSDSV ALYSFCREAG 500
    LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA CTFNLERSQT 550
    SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 600
    SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ 650
    SEDIPGAISS ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS 700
    LISGLQHPIL CLHLLKVLYS CCLVSEGLCR LLGQEPLALE SLFMLIQGKV 750
    KVVDWEESTE VTLYFLSLLV FRLQNLPCGM EKLGSDVATL FTHSHVVSLV 800
    SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL TPPGSCGFYD 850
    GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG 900
    ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI 950
    LMSILKHLLC PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL 1000
    LIGVLADLRD SEVAAHLLQV CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ 1050
    FVNTVSASPR TIVSFLSVAL LSDQPLLTSD LLSLLAHTAR VLSPSHLSFI 1100
    QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS MALRGALQSQ 1150
    SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL 1200
    LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK 1250
    EAALIALRSL QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK 1300
    HCRKLIHLLR PAHSM 1315
    Length:1,315
    Mass (Da):143,995
    Last modified:March 21, 2006 - v2
    Checksum:i793F4638F1871C01
    GO
    Isoform 21 Publication (identifier: Q9NRP7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         838-858: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:1,294
    Mass (Da):141,737
    Checksum:i42376671A0F272AF
    GO

    Sequence cautioni

    The sequence BAB14184.1 differs from that shown. Reason: Frameshift at position 987.
    The sequence BAA86592.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti229 – 2291N → D in AAH26158. (PubMed:15489334)Curated
    Sequence conflicti971 – 98616Missing(PubMed:14702039)CuratedAdd
    BLAST
    Sequence conflicti1003 – 10031G → V in AAF97028. (PubMed:10806483)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901I → M.1 Publication
    Corresponds to variant rs55706732 [ dbSNP | Ensembl ].
    VAR_041177
    Natural varianti240 – 2401R → W.1 Publication
    Corresponds to variant rs35038757 [ dbSNP | Ensembl ].
    VAR_041178
    Natural varianti295 – 2951K → R.1 Publication
    Corresponds to variant rs1863703 [ dbSNP | Ensembl ].
    VAR_041179
    Natural varianti329 – 3291D → N.1 Publication
    Corresponds to variant rs34027859 [ dbSNP | Ensembl ].
    VAR_041180
    Natural varianti462 – 4621L → V.1 Publication
    Corresponds to variant rs45586733 [ dbSNP | Ensembl ].
    VAR_041181
    Natural varianti463 – 4631K → N.1 Publication
    Corresponds to variant rs17856747 [ dbSNP | Ensembl ].
    VAR_025727
    Natural varianti476 – 4761F → S.1 Publication
    Corresponds to variant rs34128793 [ dbSNP | Ensembl ].
    VAR_041182
    Natural varianti477 – 4771R → W.1 Publication
    Corresponds to variant rs16859180 [ dbSNP | Ensembl ].
    VAR_041183
    Natural varianti583 – 5831R → Q.1 Publication
    Corresponds to variant rs1344642 [ dbSNP | Ensembl ].
    VAR_041184
    Natural varianti638 – 6381Q → P.
    Corresponds to variant rs6709303 [ dbSNP | Ensembl ].
    VAR_057112
    Natural varianti660 – 6601S → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication
    VAR_041185
    Natural varianti672 – 6721L → P.1 Publication
    Corresponds to variant rs35448374 [ dbSNP | Ensembl ].
    VAR_041186
    Natural varianti767 – 7671S → T.1 Publication
    Corresponds to variant rs17856748 [ dbSNP | Ensembl ].
    VAR_025728
    Natural varianti767 – 7671S → Y in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041187
    Natural varianti816 – 8161T → A.1 Publication
    Corresponds to variant rs34271431 [ dbSNP | Ensembl ].
    VAR_041188
    Natural varianti839 – 8391R → Q.1 Publication
    Corresponds to variant rs13023540 [ dbSNP | Ensembl ].
    VAR_041189
    Natural varianti840 – 8401L → V.1 Publication
    Corresponds to variant rs36099639 [ dbSNP | Ensembl ].
    VAR_041190
    Natural varianti1003 – 10031G → D.2 Publications
    Corresponds to variant rs1863704 [ dbSNP | Ensembl ].
    VAR_025729
    Natural varianti1004 – 10041V → I.
    Corresponds to variant rs55633575 [ dbSNP | Ensembl ].
    VAR_061747
    Natural varianti1111 – 11111Y → C.1 Publication
    Corresponds to variant rs56278660 [ dbSNP | Ensembl ].
    VAR_041191
    Natural varianti1112 – 11121R → Q.1 Publication
    Corresponds to variant rs12993599 [ dbSNP | Ensembl ].
    VAR_041192
    Natural varianti1138 – 11381Q → K in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
    VAR_041193
    Natural varianti1185 – 11851P → S in an ovarian endometrioid sample; somatic mutation. 1 Publication
    VAR_041194
    Natural varianti1313 – 13131H → P.1 Publication
    VAR_041195

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei838 – 85821Missing in isoform 2. 1 PublicationVSP_051983Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF200815 mRNA. Translation: AAF97028.1.
    AB033104 mRNA. Translation: BAA86592.1. Different initiation.
    AC009974 Genomic DNA. No translation available.
    BC026158 mRNA. Translation: AAH26158.1.
    AL133630 mRNA. Translation: CAB63754.1.
    AK022692 mRNA. Translation: BAB14184.1. Frameshift.
    CCDSiCCDS2421.1. [Q9NRP7-1]
    CCDS58750.1. [Q9NRP7-2]
    PIRiT43465.
    RefSeqiNP_001230242.1. NM_001243313.1. [Q9NRP7-2]
    NP_056505.2. NM_015690.4. [Q9NRP7-1]
    XP_005246521.1. XM_005246464.1. [Q9NRP7-1]
    UniGeneiHs.471404.
    Hs.712986.

    Genome annotation databases

    EnsembliENST00000295709; ENSP00000295709; ENSG00000163482. [Q9NRP7-1]
    ENST00000392105; ENSP00000375954; ENSG00000163482. [Q9NRP7-2]
    ENST00000440309; ENSP00000394095; ENSG00000163482. [Q9NRP7-1]
    GeneIDi27148.
    KEGGihsa:27148.
    UCSCiuc002viu.3. human. [Q9NRP7-1]
    uc002viv.3. human. [Q9NRP7-2]

    Polymorphism databases

    DMDMi90101761.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF200815 mRNA. Translation: AAF97028.1 .
    AB033104 mRNA. Translation: BAA86592.1 . Different initiation.
    AC009974 Genomic DNA. No translation available.
    BC026158 mRNA. Translation: AAH26158.1 .
    AL133630 mRNA. Translation: CAB63754.1 .
    AK022692 mRNA. Translation: BAB14184.1 . Frameshift.
    CCDSi CCDS2421.1. [Q9NRP7-1 ]
    CCDS58750.1. [Q9NRP7-2 ]
    PIRi T43465.
    RefSeqi NP_001230242.1. NM_001243313.1. [Q9NRP7-2 ]
    NP_056505.2. NM_015690.4. [Q9NRP7-1 ]
    XP_005246521.1. XM_005246464.1. [Q9NRP7-1 ]
    UniGenei Hs.471404.
    Hs.712986.

    3D structure databases

    ProteinModelPortali Q9NRP7.
    SMRi Q9NRP7. Positions 1-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118032. 10 interactions.
    IntActi Q9NRP7. 7 interactions.
    STRINGi 9606.ENSP00000295709.

    Chemistry

    BindingDBi Q9NRP7.
    ChEMBLi CHEMBL4312.
    GuidetoPHARMACOLOGYi 2223.

    PTM databases

    PhosphoSitei Q9NRP7.

    Polymorphism databases

    DMDMi 90101761.

    Proteomic databases

    MaxQBi Q9NRP7.
    PaxDbi Q9NRP7.
    PRIDEi Q9NRP7.

    Protocols and materials databases

    DNASUi 27148.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295709 ; ENSP00000295709 ; ENSG00000163482 . [Q9NRP7-1 ]
    ENST00000392105 ; ENSP00000375954 ; ENSG00000163482 . [Q9NRP7-2 ]
    ENST00000440309 ; ENSP00000394095 ; ENSG00000163482 . [Q9NRP7-1 ]
    GeneIDi 27148.
    KEGGi hsa:27148.
    UCSCi uc002viu.3. human. [Q9NRP7-1 ]
    uc002viv.3. human. [Q9NRP7-2 ]

    Organism-specific databases

    CTDi 27148.
    GeneCardsi GC02P219536.
    H-InvDB HIX0002836.
    HGNCi HGNC:17209. STK36.
    HPAi HPA027409.
    HPA027453.
    HPA030058.
    MIMi 607652. gene.
    neXtProti NX_Q9NRP7.
    PharmGKBi PA38212.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000015284.
    HOVERGENi HBG094005.
    InParanoidi Q9NRP7.
    KOi K06228.
    OMAi MACGDPQ.
    OrthoDBi EOG7PK8Z2.
    PhylomeDBi Q9NRP7.
    TreeFami TF105340.

    Enzyme and pathway databases

    SignaLinki Q9NRP7.

    Miscellaneous databases

    GeneWikii STK36.
    GenomeRNAii 27148.
    NextBioi 49907.
    PROi Q9NRP7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NRP7.
    Bgeei Q9NRP7.
    CleanExi HS_STK36.
    Genevestigatori Q9NRP7.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 6 hits.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gli regulation by the opposing activities of fused and suppressor of fused."
      Murone M., Luoh S.-L., Stone D., Li W., Gurney A., Armanini M., Grey C., Rosenthal A., de Sauvage F.J.
      Nat. Cell Biol. 2:310-312(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH GLI1; GLI2; GLI3 AND SUFU, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-33.
    2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: BrainImported.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-463 AND THR-767.
      Tissue: TestisImported.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 823-1315 (ISOFORM 1).
      Tissue: Testis.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 839-1315 (ISOFORM 1), VARIANT ASP-1003.
      Tissue: TeratocarcinomaImported.
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-90; TRP-240; ARG-295; ASN-329; VAL-462; SER-476; TRP-477; GLN-583; CYS-660; PRO-672; TYR-767; ALA-816; GLN-839; VAL-840; ASP-1003; CYS-1111; GLN-1112; LYS-1138; SER-1185 AND PRO-1313.

    Entry informationi

    Entry nameiSTK36_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRP7
    Secondary accession number(s): B7WPM3
    , Q8TC32, Q9H9N9, Q9UF35, Q9ULE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3