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Protein

COX assembly mitochondrial protein 2 homolog

Gene

CMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cytochrome c oxidase biogenesis.By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103121-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
COX assembly mitochondrial protein 2 homolog
Gene namesi
Name:CMC2
Synonyms:C16orf61
ORF Names:DC13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24447. CMC2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi56942.
OpenTargetsiENSG00000103121.
PharmGKBiPA143485398.

Polymorphism and mutation databases

BioMutaiCMC2.
DMDMi37999796.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929431 – 79COX assembly mitochondrial protein 2 homologAdd BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14 ↔ 47PROSITE-ProRule annotation
Disulfide bondi24 ↔ 37PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9NRP2.
MaxQBiQ9NRP2.
PaxDbiQ9NRP2.
PeptideAtlasiQ9NRP2.
PRIDEiQ9NRP2.
TopDownProteomicsiQ9NRP2.

PTM databases

iPTMnetiQ9NRP2.
PhosphoSitePlusiQ9NRP2.

Expressioni

Gene expression databases

BgeeiENSG00000103121.
CleanExiHS_C16orf61.
ExpressionAtlasiQ9NRP2. baseline and differential.
GenevisibleiQ9NRP2. HS.

Organism-specific databases

HPAiCAB026396.
HPA006871.

Interactioni

Protein-protein interaction databases

BioGridi121266. 2 interactors.
STRINGi9606.ENSP00000219400.

Structurei

3D structure databases

ProteinModelPortaliQ9NRP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 55CHCHPROSITE-ProRule annotationAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 24Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi37 – 47Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the CMC family.Curated
Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4148. Eukaryota.
ENOG41123JB. LUCA.
GeneTreeiENSGT00390000016908.
HOGENOMiHOG000212591.
HOVERGENiHBG045487.
InParanoidiQ9NRP2.
KOiK18172.
OMAiHTEECNT.
PhylomeDBiQ9NRP2.
TreeFamiTF314049.

Family and domain databases

InterProiIPR013892. Cyt_c_biogenesis_Cmc1-like.
[Graphical view]
PfamiPF08583. Cmc1. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NRP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPDLSPHLH TEECNVLINL LKECHKNHNI LKFFGYCNDV DRELRKCLKN
60 70
EYVENRTKSR EHGIAMRKKL FNPPEESEK
Length:79
Mass (Da):9,460
Last modified:October 1, 2000 - v1
Checksum:i783381BD6DAFB7AA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03381611T → S.Corresponds to variant rs2303217dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201935 mRNA. Translation: AAF86871.1.
AC009079 Genomic DNA. No translation available.
AC092718 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95557.1.
CH471114 Genomic DNA. Translation: EAW95559.1.
CH471114 Genomic DNA. Translation: EAW95560.1.
BC032631 mRNA. Translation: AAH32631.1.
CCDSiCCDS10930.1.
RefSeqiNP_064573.1. NM_020188.3.
XP_016878956.1. XM_017023467.1.
XP_016878957.1. XM_017023468.1.
XP_016878958.1. XM_017023469.1.
XP_016878959.1. XM_017023470.1.
UniGeneiHs.55028.

Genome annotation databases

EnsembliENST00000219400; ENSP00000219400; ENSG00000103121.
ENST00000564249; ENSP00000456841; ENSG00000103121.
ENST00000565650; ENSP00000455457; ENSG00000103121.
ENST00000565914; ENSP00000455723; ENSG00000103121.
GeneIDi56942.
KEGGihsa:56942.
UCSCiuc002ffu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201935 mRNA. Translation: AAF86871.1.
AC009079 Genomic DNA. No translation available.
AC092718 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95557.1.
CH471114 Genomic DNA. Translation: EAW95559.1.
CH471114 Genomic DNA. Translation: EAW95560.1.
BC032631 mRNA. Translation: AAH32631.1.
CCDSiCCDS10930.1.
RefSeqiNP_064573.1. NM_020188.3.
XP_016878956.1. XM_017023467.1.
XP_016878957.1. XM_017023468.1.
XP_016878958.1. XM_017023469.1.
XP_016878959.1. XM_017023470.1.
UniGeneiHs.55028.

3D structure databases

ProteinModelPortaliQ9NRP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121266. 2 interactors.
STRINGi9606.ENSP00000219400.

PTM databases

iPTMnetiQ9NRP2.
PhosphoSitePlusiQ9NRP2.

Polymorphism and mutation databases

BioMutaiCMC2.
DMDMi37999796.

Proteomic databases

EPDiQ9NRP2.
MaxQBiQ9NRP2.
PaxDbiQ9NRP2.
PeptideAtlasiQ9NRP2.
PRIDEiQ9NRP2.
TopDownProteomicsiQ9NRP2.

Protocols and materials databases

DNASUi56942.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219400; ENSP00000219400; ENSG00000103121.
ENST00000564249; ENSP00000456841; ENSG00000103121.
ENST00000565650; ENSP00000455457; ENSG00000103121.
ENST00000565914; ENSP00000455723; ENSG00000103121.
GeneIDi56942.
KEGGihsa:56942.
UCSCiuc002ffu.4. human.

Organism-specific databases

CTDi56942.
DisGeNETi56942.
GeneCardsiCMC2.
HGNCiHGNC:24447. CMC2.
HPAiCAB026396.
HPA006871.
neXtProtiNX_Q9NRP2.
OpenTargetsiENSG00000103121.
PharmGKBiPA143485398.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4148. Eukaryota.
ENOG41123JB. LUCA.
GeneTreeiENSGT00390000016908.
HOGENOMiHOG000212591.
HOVERGENiHBG045487.
InParanoidiQ9NRP2.
KOiK18172.
OMAiHTEECNT.
PhylomeDBiQ9NRP2.
TreeFamiTF314049.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103121-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSiCMC2. human.
GenomeRNAii56942.
PROiQ9NRP2.

Gene expression databases

BgeeiENSG00000103121.
CleanExiHS_C16orf61.
ExpressionAtlasiQ9NRP2. baseline and differential.
GenevisibleiQ9NRP2. HS.

Family and domain databases

InterProiIPR013892. Cyt_c_biogenesis_Cmc1-like.
[Graphical view]
PfamiPF08583. Cmc1. 1 hit.
[Graphical view]
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOXM2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRP2
Secondary accession number(s): D3DUK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.