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Q9NRP0

- OSTC_HUMAN

UniProt

Q9NRP0 - OSTC_HUMAN

Protein

Oligosaccharyltransferase complex subunit OSTC

Gene

OSTC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. protein N-linked glycosylation via asparagine Source: HGNC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oligosaccharyltransferase complex subunit OSTC
    Alternative name(s):
    Hydrophobic protein HSF-28
    Gene namesi
    Name:OSTC
    ORF Names:DC2, HDCMD45P, HSPC307
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:24448. OSTC.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. oligosaccharyltransferase complex Source: HGNC

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164724280.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 149149Oligosaccharyltransferase complex subunit OSTCPRO_0000320602Add
    BLAST

    Proteomic databases

    MaxQBiQ9NRP0.
    PaxDbiQ9NRP0.
    PeptideAtlasiQ9NRP0.
    PRIDEiQ9NRP0.

    PTM databases

    PhosphoSiteiQ9NRP0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NRP0.
    BgeeiQ9NRP0.
    GenevestigatoriQ9NRP0.

    Interactioni

    Subunit structurei

    Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121833. 4 interactions.
    IntActiQ9NRP0. 1 interaction.
    STRINGi9606.ENSP00000354676.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini54 – 8330ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini105 – 11713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 14911ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OSTC family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235395.
    HOGENOMiHOG000006225.
    HOVERGENiHBG056614.
    OMAiTTWIFMR.
    OrthoDBiEOG70S77D.
    PhylomeDBiQ9NRP0.
    TreeFamiTF323315.

    Family and domain databases

    InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
    [Graphical view]
    PfamiPF04756. OST3_OST6. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NRP0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METLYRVPFL VLECPNLKLK KPPWLHMPSA MTVYALVVVS YFLITGGIIY    50
    DVIVEPPSVG SMTDEHGHQR PVAFLAYRVN GQYIMEGLAS SFLFTMGGLG 100
    FIILDRSNAP NIPKLNRFLL LFIGFVCVLL SFFMARVFMR MKLPGYLMG 149
    Length:149
    Mass (Da):16,829
    Last modified:October 1, 2000 - v1
    Checksum:iE59289BB927442B4
    GO
    Isoform 2 (identifier: Q9NRP0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         145-149: GYLMG → RSLALLPRLECSGVISAHYKLCLPGAI

    Note: No experimental confirmation available.

    Show »
    Length:171
    Mass (Da):19,171
    Checksum:iFB730593ACD33B44
    GO

    Sequence cautioni

    The sequence CN430159 differs from that shown. Reason: Frameshift at position 134.
    The sequence AAF28985.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAF65186.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191L → P in AAF65186. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91F → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_039231

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei145 – 1495GYLMG → RSLALLPRLECSGVISAHYK LCLPGAI in isoform 2. 1 PublicationVSP_047376

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF343342 mRNA. Translation: AAK69656.1.
    AF068297 mRNA. Translation: AAF65186.1. Different initiation.
    AF161425 mRNA. Translation: AAF28985.1. Different initiation.
    AF201937 mRNA. Translation: AAF86873.1.
    CN430159 mRNA. No translation available.
    AK312185 mRNA. Translation: BAG35118.1.
    AC107071 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX06233.1.
    BC016321 mRNA. Translation: AAH16321.1.
    BC054857 mRNA. Translation: AAH54857.1.
    CCDSiCCDS3681.1. [Q9NRP0-1]
    CCDS58921.1. [Q9NRP0-2]
    RefSeqiNP_001254746.1. NM_001267817.1.
    NP_001254747.1. NM_001267818.1. [Q9NRP0-2]
    NP_067050.1. NM_021227.3. [Q9NRP0-1]
    UniGeneiHs.445803.

    Genome annotation databases

    EnsembliENST00000361564; ENSP00000354676; ENSG00000198856. [Q9NRP0-1]
    ENST00000512478; ENSP00000426167; ENSG00000198856. [Q9NRP0-2]
    GeneIDi58505.
    KEGGihsa:58505.
    UCSCiuc003hzb.2. human. [Q9NRP0-1]

    Polymorphism databases

    DMDMi74734324.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF343342 mRNA. Translation: AAK69656.1 .
    AF068297 mRNA. Translation: AAF65186.1 . Different initiation.
    AF161425 mRNA. Translation: AAF28985.1 . Different initiation.
    AF201937 mRNA. Translation: AAF86873.1 .
    CN430159 mRNA. No translation available.
    AK312185 mRNA. Translation: BAG35118.1 .
    AC107071 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX06233.1 .
    BC016321 mRNA. Translation: AAH16321.1 .
    BC054857 mRNA. Translation: AAH54857.1 .
    CCDSi CCDS3681.1. [Q9NRP0-1 ]
    CCDS58921.1. [Q9NRP0-2 ]
    RefSeqi NP_001254746.1. NM_001267817.1.
    NP_001254747.1. NM_001267818.1. [Q9NRP0-2 ]
    NP_067050.1. NM_021227.3. [Q9NRP0-1 ]
    UniGenei Hs.445803.

    3D structure databases

    ProteinModelPortali Q9NRP0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121833. 4 interactions.
    IntActi Q9NRP0. 1 interaction.
    STRINGi 9606.ENSP00000354676.

    PTM databases

    PhosphoSitei Q9NRP0.

    Polymorphism databases

    DMDMi 74734324.

    Proteomic databases

    MaxQBi Q9NRP0.
    PaxDbi Q9NRP0.
    PeptideAtlasi Q9NRP0.
    PRIDEi Q9NRP0.

    Protocols and materials databases

    DNASUi 58505.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361564 ; ENSP00000354676 ; ENSG00000198856 . [Q9NRP0-1 ]
    ENST00000512478 ; ENSP00000426167 ; ENSG00000198856 . [Q9NRP0-2 ]
    GeneIDi 58505.
    KEGGi hsa:58505.
    UCSCi uc003hzb.2. human. [Q9NRP0-1 ]

    Organism-specific databases

    CTDi 58505.
    GeneCardsi GC04P109572.
    HGNCi HGNC:24448. OSTC.
    neXtProti NX_Q9NRP0.
    PharmGKBi PA164724280.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235395.
    HOGENOMi HOG000006225.
    HOVERGENi HBG056614.
    OMAi TTWIFMR.
    OrthoDBi EOG70S77D.
    PhylomeDBi Q9NRP0.
    TreeFami TF323315.

    Miscellaneous databases

    GenomeRNAii 58505.
    NextBioi 65016.
    PROi Q9NRP0.

    Gene expression databases

    ArrayExpressi Q9NRP0.
    Bgeei Q9NRP0.
    Genevestigatori Q9NRP0.

    Family and domain databases

    InterProi IPR021149. OligosaccharylTrfase_OST3/OST6.
    [Graphical view ]
    Pfami PF04756. OST3_OST6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Favier A.-L., Harsi C., Chrobozcek J.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    2. "A novel gene from human dendritic cell."
      Zhao Z., Huang X., Li N., Zhu X., Cao X.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Dendritic cell.
    3. "Human partial CDS from CD34+ stem cells."
      Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    4. "Novel genes expressed in human dendritic cell."
      Peng Y., Li Y., Li N., Gu W., Han Z., Fu G., Chen Z.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Dendritic cell.
    5. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
      Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y., Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J., Stanton L.W.
      Nat. Biotechnol. 22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mesangial cell.
    7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Urinary bladder.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-9.

    Entry informationi

    Entry nameiOSTC_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRP0
    Secondary accession number(s): A8MYS2
    , B2R5H1, D6RH22, Q9P075, Q9P1R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3