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Protein

Oligosaccharyltransferase complex subunit OSTC

Gene

OSTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • protein N-linked glycosylation via asparagine Source: HGNC
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160783-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Oligosaccharyltransferase complex subunit OSTC
Alternative name(s):
Hydrophobic protein HSF-28
Gene namesi
Name:OSTC
ORF Names:DC2, HDCMD45P, HSPC307
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24448. OSTC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 83ExtracellularSequence analysisAdd BLAST30
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 117CytoplasmicSequence analysisAdd BLAST13
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 149ExtracellularSequence analysisAdd BLAST11

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • oligosaccharyltransferase complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi58505.
OpenTargetsiENSG00000198856.
PharmGKBiPA164724280.

Polymorphism and mutation databases

BioMutaiOSTC.
DMDMi74734324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206021 – 149Oligosaccharyltransferase complex subunit OSTCAdd BLAST149

Proteomic databases

EPDiQ9NRP0.
MaxQBiQ9NRP0.
PaxDbiQ9NRP0.
PeptideAtlasiQ9NRP0.
PRIDEiQ9NRP0.
TopDownProteomicsiQ9NRP0-1. [Q9NRP0-1]

PTM databases

iPTMnetiQ9NRP0.
PhosphoSitePlusiQ9NRP0.
SwissPalmiQ9NRP0.

Expressioni

Gene expression databases

BgeeiENSG00000198856.
ExpressionAtlasiQ9NRP0. baseline and differential.
GenevisibleiQ9NRP0. HS.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EDAQ928383EBI-1044658,EBI-529425

Protein-protein interaction databases

BioGridi121833. 9 interactors.
IntActiQ9NRP0. 8 interactors.
STRINGi9606.ENSP00000354676.

Structurei

3D structure databases

ProteinModelPortaliQ9NRP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OSTC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3356. Eukaryota.
ENOG4111G0G. LUCA.
GeneTreeiENSGT00390000001376.
HOGENOMiHOG000006225.
HOVERGENiHBG056614.
InParanoidiQ9NRP0.
OMAiWIFMRMK.
OrthoDBiEOG091G0RRT.
PhylomeDBiQ9NRP0.
TreeFamiTF323315.

Family and domain databases

InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METLYRVPFL VLECPNLKLK KPPWLHMPSA MTVYALVVVS YFLITGGIIY
60 70 80 90 100
DVIVEPPSVG SMTDEHGHQR PVAFLAYRVN GQYIMEGLAS SFLFTMGGLG
110 120 130 140
FIILDRSNAP NIPKLNRFLL LFIGFVCVLL SFFMARVFMR MKLPGYLMG
Length:149
Mass (Da):16,829
Last modified:October 1, 2000 - v1
Checksum:iE59289BB927442B4
GO
Isoform 2 (identifier: Q9NRP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-149: GYLMG → RSLALLPRLECSGVISAHYKLCLPGAI

Note: No experimental confirmation available.
Show »
Length:171
Mass (Da):19,171
Checksum:iFB730593ACD33B44
GO

Sequence cautioni

The sequence AAF28985 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF65186 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CN430159 differs from that shown. Reason: Frameshift at position 134.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119L → P in AAF65186 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0392319F → L in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047376145 – 149GYLMG → RSLALLPRLECSGVISAHYK LCLPGAI in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343342 mRNA. Translation: AAK69656.1.
AF068297 mRNA. Translation: AAF65186.1. Different initiation.
AF161425 mRNA. Translation: AAF28985.1. Different initiation.
AF201937 mRNA. Translation: AAF86873.1.
CN430159 mRNA. No translation available.
AK312185 mRNA. Translation: BAG35118.1.
AC107071 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06233.1.
BC016321 mRNA. Translation: AAH16321.1.
BC054857 mRNA. Translation: AAH54857.1.
CCDSiCCDS3681.1. [Q9NRP0-1]
CCDS58921.1. [Q9NRP0-2]
RefSeqiNP_001254746.1. NM_001267817.1.
NP_001254747.1. NM_001267818.1. [Q9NRP0-2]
NP_067050.1. NM_021227.3. [Q9NRP0-1]
UniGeneiHs.445803.

Genome annotation databases

EnsembliENST00000361564; ENSP00000354676; ENSG00000198856. [Q9NRP0-1]
ENST00000512478; ENSP00000426167; ENSG00000198856. [Q9NRP0-2]
GeneIDi58505.
KEGGihsa:58505.
UCSCiuc003hzb.3. human. [Q9NRP0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343342 mRNA. Translation: AAK69656.1.
AF068297 mRNA. Translation: AAF65186.1. Different initiation.
AF161425 mRNA. Translation: AAF28985.1. Different initiation.
AF201937 mRNA. Translation: AAF86873.1.
CN430159 mRNA. No translation available.
AK312185 mRNA. Translation: BAG35118.1.
AC107071 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06233.1.
BC016321 mRNA. Translation: AAH16321.1.
BC054857 mRNA. Translation: AAH54857.1.
CCDSiCCDS3681.1. [Q9NRP0-1]
CCDS58921.1. [Q9NRP0-2]
RefSeqiNP_001254746.1. NM_001267817.1.
NP_001254747.1. NM_001267818.1. [Q9NRP0-2]
NP_067050.1. NM_021227.3. [Q9NRP0-1]
UniGeneiHs.445803.

3D structure databases

ProteinModelPortaliQ9NRP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121833. 9 interactors.
IntActiQ9NRP0. 8 interactors.
STRINGi9606.ENSP00000354676.

PTM databases

iPTMnetiQ9NRP0.
PhosphoSitePlusiQ9NRP0.
SwissPalmiQ9NRP0.

Polymorphism and mutation databases

BioMutaiOSTC.
DMDMi74734324.

Proteomic databases

EPDiQ9NRP0.
MaxQBiQ9NRP0.
PaxDbiQ9NRP0.
PeptideAtlasiQ9NRP0.
PRIDEiQ9NRP0.
TopDownProteomicsiQ9NRP0-1. [Q9NRP0-1]

Protocols and materials databases

DNASUi58505.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361564; ENSP00000354676; ENSG00000198856. [Q9NRP0-1]
ENST00000512478; ENSP00000426167; ENSG00000198856. [Q9NRP0-2]
GeneIDi58505.
KEGGihsa:58505.
UCSCiuc003hzb.3. human. [Q9NRP0-1]

Organism-specific databases

CTDi58505.
DisGeNETi58505.
GeneCardsiOSTC.
HGNCiHGNC:24448. OSTC.
neXtProtiNX_Q9NRP0.
OpenTargetsiENSG00000198856.
PharmGKBiPA164724280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3356. Eukaryota.
ENOG4111G0G. LUCA.
GeneTreeiENSGT00390000001376.
HOGENOMiHOG000006225.
HOVERGENiHBG056614.
InParanoidiQ9NRP0.
OMAiWIFMRMK.
OrthoDBiEOG091G0RRT.
PhylomeDBiQ9NRP0.
TreeFamiTF323315.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160783-MONOMER.

Miscellaneous databases

ChiTaRSiOSTC. human.
GenomeRNAii58505.
PROiQ9NRP0.

Gene expression databases

BgeeiENSG00000198856.
ExpressionAtlasiQ9NRP0. baseline and differential.
GenevisibleiQ9NRP0. HS.

Family and domain databases

InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTC_HUMAN
AccessioniPrimary (citable) accession number: Q9NRP0
Secondary accession number(s): A8MYS2
, B2R5H1, D6RH22, Q9P075, Q9P1R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.