Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oligosaccharyltransferase complex subunit OSTC

Gene

OSTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. protein N-linked glycosylation via asparagine Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Oligosaccharyltransferase complex subunit OSTC
Alternative name(s):
Hydrophobic protein HSF-28
Gene namesi
Name:OSTC
ORF Names:DC2, HDCMD45P, HSPC307
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24448. OSTC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Topological domaini54 – 8330ExtracellularSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Topological domaini105 – 11713CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Topological domaini139 – 14911ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. oligosaccharyltransferase complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Oligosaccharyltransferase complex subunit OSTCPRO_0000320602Add
BLAST

Proteomic databases

MaxQBiQ9NRP0.
PaxDbiQ9NRP0.
PeptideAtlasiQ9NRP0.
PRIDEiQ9NRP0.

PTM databases

PhosphoSiteiQ9NRP0.

Expressioni

Gene expression databases

BgeeiQ9NRP0.
ExpressionAtlasiQ9NRP0. baseline and differential.
GenevestigatoriQ9NRP0.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity).By similarity

Protein-protein interaction databases

BioGridi121833. 5 interactions.
IntActiQ9NRP0. 2 interactions.
STRINGi9606.ENSP00000354676.

Structurei

3D structure databases

ProteinModelPortaliQ9NRP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OSTC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235395.
GeneTreeiENSGT00390000001376.
HOGENOMiHOG000006225.
HOVERGENiHBG056614.
InParanoidiQ9NRP0.
OMAiVSFFTTW.
OrthoDBiEOG70S77D.
PhylomeDBiQ9NRP0.
TreeFamiTF323315.

Family and domain databases

InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METLYRVPFL VLECPNLKLK KPPWLHMPSA MTVYALVVVS YFLITGGIIY
60 70 80 90 100
DVIVEPPSVG SMTDEHGHQR PVAFLAYRVN GQYIMEGLAS SFLFTMGGLG
110 120 130 140
FIILDRSNAP NIPKLNRFLL LFIGFVCVLL SFFMARVFMR MKLPGYLMG
Length:149
Mass (Da):16,829
Last modified:September 30, 2000 - v1
Checksum:iE59289BB927442B4
GO
Isoform 2 (identifier: Q9NRP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-149: GYLMG → RSLALLPRLECSGVISAHYKLCLPGAI

Note: No experimental confirmation available.

Show »
Length:171
Mass (Da):19,171
Checksum:iFB730593ACD33B44
GO

Sequence cautioni

The sequence AAF28985.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAF65186.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CN430159 differs from that shown. Reason: Frameshift at position 134. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191L → P in AAF65186 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91F → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_039231

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei145 – 1495GYLMG → RSLALLPRLECSGVISAHYK LCLPGAI in isoform 2. 1 PublicationVSP_047376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343342 mRNA. Translation: AAK69656.1.
AF068297 mRNA. Translation: AAF65186.1. Different initiation.
AF161425 mRNA. Translation: AAF28985.1. Different initiation.
AF201937 mRNA. Translation: AAF86873.1.
CN430159 mRNA. No translation available.
AK312185 mRNA. Translation: BAG35118.1.
AC107071 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06233.1.
BC016321 mRNA. Translation: AAH16321.1.
BC054857 mRNA. Translation: AAH54857.1.
CCDSiCCDS3681.1. [Q9NRP0-1]
CCDS58921.1. [Q9NRP0-2]
RefSeqiNP_001254746.1. NM_001267817.1.
NP_001254747.1. NM_001267818.1. [Q9NRP0-2]
NP_067050.1. NM_021227.3. [Q9NRP0-1]
UniGeneiHs.445803.

Genome annotation databases

EnsembliENST00000361564; ENSP00000354676; ENSG00000198856. [Q9NRP0-1]
ENST00000512478; ENSP00000426167; ENSG00000198856. [Q9NRP0-2]
GeneIDi58505.
KEGGihsa:58505.
UCSCiuc003hzb.2. human. [Q9NRP0-1]

Polymorphism databases

DMDMi74734324.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF343342 mRNA. Translation: AAK69656.1.
AF068297 mRNA. Translation: AAF65186.1. Different initiation.
AF161425 mRNA. Translation: AAF28985.1. Different initiation.
AF201937 mRNA. Translation: AAF86873.1.
CN430159 mRNA. No translation available.
AK312185 mRNA. Translation: BAG35118.1.
AC107071 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06233.1.
BC016321 mRNA. Translation: AAH16321.1.
BC054857 mRNA. Translation: AAH54857.1.
CCDSiCCDS3681.1. [Q9NRP0-1]
CCDS58921.1. [Q9NRP0-2]
RefSeqiNP_001254746.1. NM_001267817.1.
NP_001254747.1. NM_001267818.1. [Q9NRP0-2]
NP_067050.1. NM_021227.3. [Q9NRP0-1]
UniGeneiHs.445803.

3D structure databases

ProteinModelPortaliQ9NRP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121833. 5 interactions.
IntActiQ9NRP0. 2 interactions.
STRINGi9606.ENSP00000354676.

PTM databases

PhosphoSiteiQ9NRP0.

Polymorphism databases

DMDMi74734324.

Proteomic databases

MaxQBiQ9NRP0.
PaxDbiQ9NRP0.
PeptideAtlasiQ9NRP0.
PRIDEiQ9NRP0.

Protocols and materials databases

DNASUi58505.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361564; ENSP00000354676; ENSG00000198856. [Q9NRP0-1]
ENST00000512478; ENSP00000426167; ENSG00000198856. [Q9NRP0-2]
GeneIDi58505.
KEGGihsa:58505.
UCSCiuc003hzb.2. human. [Q9NRP0-1]

Organism-specific databases

CTDi58505.
GeneCardsiGC04P109572.
HGNCiHGNC:24448. OSTC.
neXtProtiNX_Q9NRP0.
PharmGKBiPA164724280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG235395.
GeneTreeiENSGT00390000001376.
HOGENOMiHOG000006225.
HOVERGENiHBG056614.
InParanoidiQ9NRP0.
OMAiVSFFTTW.
OrthoDBiEOG70S77D.
PhylomeDBiQ9NRP0.
TreeFamiTF323315.

Miscellaneous databases

ChiTaRSiOSTC. human.
GenomeRNAii58505.
NextBioi65016.
PROiQ9NRP0.

Gene expression databases

BgeeiQ9NRP0.
ExpressionAtlasiQ9NRP0. baseline and differential.
GenevestigatoriQ9NRP0.

Family and domain databases

InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Favier A.-L., Harsi C., Chrobozcek J.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "A novel gene from human dendritic cell."
    Zhao Z., Huang X., Li N., Zhu X., Cao X.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  3. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  4. "Novel genes expressed in human dendritic cell."
    Peng Y., Li Y., Li N., Gu W., Han Z., Fu G., Chen Z.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  5. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
    Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y., Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J., Stanton L.W.
    Nat. Biotechnol. 22:707-716(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mesangial cell.
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Urinary bladder.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-9.

Entry informationi

Entry nameiOSTC_HUMAN
AccessioniPrimary (citable) accession number: Q9NRP0
Secondary accession number(s): A8MYS2
, B2R5H1, D6RH22, Q9P075, Q9P1R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 25, 2008
Last sequence update: September 30, 2000
Last modified: March 3, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.