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Q9NRP0

- OSTC_HUMAN

UniProt

Q9NRP0 - OSTC_HUMAN

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Protein
Oligosaccharyltransferase complex subunit OSTC
Gene
OSTC, DC2, HDCMD45P, HSPC307
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. protein N-linked glycosylation via asparagine Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Oligosaccharyltransferase complex subunit OSTC
Alternative name(s):
Hydrophobic protein HSF-28
Gene namesi
Name:OSTC
ORF Names:DC2, HDCMD45P, HSPC307
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:24448. OSTC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei33 – 5321Helical; Reviewed prediction
Add
BLAST
Topological domaini54 – 8330Extracellular Reviewed prediction
Add
BLAST
Transmembranei84 – 10421Helical; Reviewed prediction
Add
BLAST
Topological domaini105 – 11713Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei118 – 13821Helical; Reviewed prediction
Add
BLAST
Topological domaini139 – 14911Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. oligosaccharyltransferase complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Oligosaccharyltransferase complex subunit OSTC
PRO_0000320602Add
BLAST

Proteomic databases

MaxQBiQ9NRP0.
PaxDbiQ9NRP0.
PeptideAtlasiQ9NRP0.
PRIDEiQ9NRP0.

PTM databases

PhosphoSiteiQ9NRP0.

Expressioni

Gene expression databases

ArrayExpressiQ9NRP0.
BgeeiQ9NRP0.
GenevestigatoriQ9NRP0.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes By similarity.

Protein-protein interaction databases

BioGridi121833. 4 interactions.
IntActiQ9NRP0. 1 interaction.
STRINGi9606.ENSP00000354676.

Structurei

3D structure databases

ProteinModelPortaliQ9NRP0.

Family & Domainsi

Sequence similaritiesi

Belongs to the OSTC family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235395.
HOGENOMiHOG000006225.
HOVERGENiHBG056614.
OMAiTTWIFMR.
OrthoDBiEOG70S77D.
PhylomeDBiQ9NRP0.
TreeFamiTF323315.

Family and domain databases

InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NRP0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

METLYRVPFL VLECPNLKLK KPPWLHMPSA MTVYALVVVS YFLITGGIIY    50
DVIVEPPSVG SMTDEHGHQR PVAFLAYRVN GQYIMEGLAS SFLFTMGGLG 100
FIILDRSNAP NIPKLNRFLL LFIGFVCVLL SFFMARVFMR MKLPGYLMG 149
Length:149
Mass (Da):16,829
Last modified:October 1, 2000 - v1
Checksum:iE59289BB927442B4
GO
Isoform 2 (identifier: Q9NRP0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-149: GYLMG → RSLALLPRLECSGVISAHYKLCLPGAI

Note: No experimental confirmation available.

Show »
Length:171
Mass (Da):19,171
Checksum:iFB730593ACD33B44
GO

Sequence cautioni

The sequence CN430159 differs from that shown. Reason: Frameshift at position 134.
The sequence AAF28985.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAF65186.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91F → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_039231

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei145 – 1495GYLMG → RSLALLPRLECSGVISAHYK LCLPGAI in isoform 2.
VSP_047376

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191L → P in AAF65186. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF343342 mRNA. Translation: AAK69656.1.
AF068297 mRNA. Translation: AAF65186.1. Different initiation.
AF161425 mRNA. Translation: AAF28985.1. Different initiation.
AF201937 mRNA. Translation: AAF86873.1.
CN430159 mRNA. No translation available.
AK312185 mRNA. Translation: BAG35118.1.
AC107071 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06233.1.
BC016321 mRNA. Translation: AAH16321.1.
BC054857 mRNA. Translation: AAH54857.1.
CCDSiCCDS3681.1. [Q9NRP0-1]
CCDS58921.1. [Q9NRP0-2]
RefSeqiNP_001254746.1. NM_001267817.1.
NP_001254747.1. NM_001267818.1. [Q9NRP0-2]
NP_067050.1. NM_021227.3. [Q9NRP0-1]
UniGeneiHs.445803.

Genome annotation databases

EnsembliENST00000361564; ENSP00000354676; ENSG00000198856. [Q9NRP0-1]
ENST00000512478; ENSP00000426167; ENSG00000198856. [Q9NRP0-2]
GeneIDi58505.
KEGGihsa:58505.
UCSCiuc003hzb.2. human. [Q9NRP0-1]

Polymorphism databases

DMDMi74734324.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF343342 mRNA. Translation: AAK69656.1 .
AF068297 mRNA. Translation: AAF65186.1 . Different initiation.
AF161425 mRNA. Translation: AAF28985.1 . Different initiation.
AF201937 mRNA. Translation: AAF86873.1 .
CN430159 mRNA. No translation available.
AK312185 mRNA. Translation: BAG35118.1 .
AC107071 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06233.1 .
BC016321 mRNA. Translation: AAH16321.1 .
BC054857 mRNA. Translation: AAH54857.1 .
CCDSi CCDS3681.1. [Q9NRP0-1 ]
CCDS58921.1. [Q9NRP0-2 ]
RefSeqi NP_001254746.1. NM_001267817.1.
NP_001254747.1. NM_001267818.1. [Q9NRP0-2 ]
NP_067050.1. NM_021227.3. [Q9NRP0-1 ]
UniGenei Hs.445803.

3D structure databases

ProteinModelPortali Q9NRP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121833. 4 interactions.
IntActi Q9NRP0. 1 interaction.
STRINGi 9606.ENSP00000354676.

PTM databases

PhosphoSitei Q9NRP0.

Polymorphism databases

DMDMi 74734324.

Proteomic databases

MaxQBi Q9NRP0.
PaxDbi Q9NRP0.
PeptideAtlasi Q9NRP0.
PRIDEi Q9NRP0.

Protocols and materials databases

DNASUi 58505.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361564 ; ENSP00000354676 ; ENSG00000198856 . [Q9NRP0-1 ]
ENST00000512478 ; ENSP00000426167 ; ENSG00000198856 . [Q9NRP0-2 ]
GeneIDi 58505.
KEGGi hsa:58505.
UCSCi uc003hzb.2. human. [Q9NRP0-1 ]

Organism-specific databases

CTDi 58505.
GeneCardsi GC04P109572.
HGNCi HGNC:24448. OSTC.
neXtProti NX_Q9NRP0.
PharmGKBi PA164724280.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235395.
HOGENOMi HOG000006225.
HOVERGENi HBG056614.
OMAi TTWIFMR.
OrthoDBi EOG70S77D.
PhylomeDBi Q9NRP0.
TreeFami TF323315.

Miscellaneous databases

GenomeRNAii 58505.
NextBioi 65016.
PROi Q9NRP0.

Gene expression databases

ArrayExpressi Q9NRP0.
Bgeei Q9NRP0.
Genevestigatori Q9NRP0.

Family and domain databases

InterProi IPR021149. OligosaccharylTrfase_OST3/OST6.
[Graphical view ]
Pfami PF04756. OST3_OST6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Favier A.-L., Harsi C., Chrobozcek J.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "A novel gene from human dendritic cell."
    Zhao Z., Huang X., Li N., Zhu X., Cao X.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  3. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  4. "Novel genes expressed in human dendritic cell."
    Peng Y., Li Y., Li N., Gu W., Han Z., Fu G., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  5. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
    Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y., Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J., Stanton L.W.
    Nat. Biotechnol. 22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mesangial cell.
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Urinary bladder.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-9.

Entry informationi

Entry nameiOSTC_HUMAN
AccessioniPrimary (citable) accession number: Q9NRP0
Secondary accession number(s): A8MYS2
, B2R5H1, D6RH22, Q9P075, Q9P1R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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