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Protein

Methyltransferase-like protein 5

Gene

METTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Protein family/group databases

REBASEi12076. M.UbaDC3ORFAP.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 5 (EC:2.1.1.-)
Gene namesi
Name:METTL5
ORF Names:DC3, HSPC133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25006. METTL5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Methyltransferase-like protein 5PRO_0000251919Add
BLAST

Proteomic databases

MaxQBiQ9NRN9.
PaxDbiQ9NRN9.
PRIDEiQ9NRN9.

PTM databases

PhosphoSiteiQ9NRN9.

Expressioni

Gene expression databases

BgeeiQ9NRN9.
CleanExiHS_METTL5.
ExpressionAtlasiQ9NRN9. baseline and differential.
GenevestigatoriQ9NRN9.

Organism-specific databases

HPAiHPA038223.

Interactioni

Protein-protein interaction databases

BioGridi118851. 1 interaction.
STRINGi9606.ENSP00000260953.

Structurei

3D structure databases

ProteinModelPortaliQ9NRN9.
SMRiQ9NRN9. Positions 5-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2263.
GeneTreeiENSGT00390000000227.
HOGENOMiHOG000222792.
HOVERGENiHBG054508.
InParanoidiQ9NRN9.
PhylomeDBiQ9NRN9.
TreeFamiTF314953.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NRN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVRLKELE SRLQQVDGFE KPKLLLEQYP TRPHIAACML YTIHNTYDDI
60 70 80 90 100
ENKVVADLGC GCGVLSIGTA MLGAGLCVGF DIDEDALEIF NRNAEEFELT
110 120 130 140 150
NIDMVQCDVC LLSNRMSKSF DTVIMNPPFG TKNNKGTDMA FLKTALEMAR
160 170 180 190 200
TAVYSLHKSS TREHVQKKAA EWKIKIDIIA ELRYDLPASY KFHKKKSVDI

EVDLIRFSF
Length:209
Mass (Da):23,719
Last modified:September 30, 2000 - v1
Checksum:i060B1C2C0D2BA169
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271E → G in BAA91622 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021V → G.
Corresponds to variant rs1051387 [ dbSNP | Ensembl ].
VAR_051507

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201938 mRNA. Translation: AAF86874.1.
AK001321 mRNA. Translation: BAA91622.1.
AC009967 Genomic DNA. Translation: AAY14869.1.
CH471058 Genomic DNA. Translation: EAX11254.1.
CH471058 Genomic DNA. Translation: EAX11255.1.
BC093014 mRNA. Translation: AAH93014.1.
BC000921 mRNA. Translation: AAH00921.1.
CCDSiCCDS33320.1.
RefSeqiNP_001280115.1. NM_001293186.1.
NP_001280116.1. NM_001293187.1.
NP_054887.2. NM_014168.3.
UniGeneiHs.470553.

Genome annotation databases

EnsembliENST00000260953; ENSP00000260953; ENSG00000138382.
ENST00000392640; ENSP00000376415; ENSG00000138382.
ENST00000409965; ENSP00000386582; ENSG00000138382.
GeneIDi29081.
KEGGihsa:29081.
UCSCiuc002ufn.3. human.

Polymorphism databases

DMDMi74761664.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201938 mRNA. Translation: AAF86874.1.
AK001321 mRNA. Translation: BAA91622.1.
AC009967 Genomic DNA. Translation: AAY14869.1.
CH471058 Genomic DNA. Translation: EAX11254.1.
CH471058 Genomic DNA. Translation: EAX11255.1.
BC093014 mRNA. Translation: AAH93014.1.
BC000921 mRNA. Translation: AAH00921.1.
CCDSiCCDS33320.1.
RefSeqiNP_001280115.1. NM_001293186.1.
NP_001280116.1. NM_001293187.1.
NP_054887.2. NM_014168.3.
UniGeneiHs.470553.

3D structure databases

ProteinModelPortaliQ9NRN9.
SMRiQ9NRN9. Positions 5-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118851. 1 interaction.
STRINGi9606.ENSP00000260953.

Protein family/group databases

REBASEi12076. M.UbaDC3ORFAP.

PTM databases

PhosphoSiteiQ9NRN9.

Polymorphism databases

DMDMi74761664.

Proteomic databases

MaxQBiQ9NRN9.
PaxDbiQ9NRN9.
PRIDEiQ9NRN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260953; ENSP00000260953; ENSG00000138382.
ENST00000392640; ENSP00000376415; ENSG00000138382.
ENST00000409965; ENSP00000386582; ENSG00000138382.
GeneIDi29081.
KEGGihsa:29081.
UCSCiuc002ufn.3. human.

Organism-specific databases

CTDi29081.
GeneCardsiGC02M170666.
H-InvDBHIX0002577.
HGNCiHGNC:25006. METTL5.
HPAiHPA038223.
neXtProtiNX_Q9NRN9.
PharmGKBiPA142671461.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2263.
GeneTreeiENSGT00390000000227.
HOGENOMiHOG000222792.
HOVERGENiHBG054508.
InParanoidiQ9NRN9.
PhylomeDBiQ9NRN9.
TreeFamiTF314953.

Miscellaneous databases

GenomeRNAii29081.
NextBioi52054.
PROiQ9NRN9.

Gene expression databases

BgeeiQ9NRN9.
CleanExiHS_METTL5.
ExpressionAtlasiQ9NRN9. baseline and differential.
GenevestigatoriQ9NRN9.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel gene from human dendritic cells."
    Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dendritic cell.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Placenta.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMETL5_HUMAN
AccessioniPrimary (citable) accession number: Q9NRN9
Secondary accession number(s): D3DPC9, Q9NVX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2006
Last sequence update: September 30, 2000
Last modified: January 6, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.