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Q9NRN9

- METL5_HUMAN

UniProt

Q9NRN9 - METL5_HUMAN

Protein

Methyltransferase-like protein 5

Gene

METTL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Probable methyltransferase.By similarity

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Protein family/group databases

    REBASEi12076. M.UbaDC3ORFAP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyltransferase-like protein 5 (EC:2.1.1.-)
    Gene namesi
    Name:METTL5
    ORF Names:DC3, HSPC133
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25006. METTL5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671461.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Methyltransferase-like protein 5PRO_0000251919Add
    BLAST

    Proteomic databases

    MaxQBiQ9NRN9.
    PaxDbiQ9NRN9.
    PRIDEiQ9NRN9.

    PTM databases

    PhosphoSiteiQ9NRN9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NRN9.
    BgeeiQ9NRN9.
    CleanExiHS_METTL5.
    GenevestigatoriQ9NRN9.

    Organism-specific databases

    HPAiHPA038223.

    Interactioni

    Protein-protein interaction databases

    BioGridi118851. 1 interaction.
    STRINGi9606.ENSP00000260953.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRN9.
    SMRiQ9NRN9. Positions 5-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2263.
    HOGENOMiHOG000222792.
    HOVERGENiHBG054508.
    PhylomeDBiQ9NRN9.
    TreeFamiTF314953.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR029063. SAM-dependent_MTases-like.
    IPR007848. Small_mtfrase_dom.
    [Graphical view]
    PfamiPF05175. MTS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NRN9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKVRLKELE SRLQQVDGFE KPKLLLEQYP TRPHIAACML YTIHNTYDDI    50
    ENKVVADLGC GCGVLSIGTA MLGAGLCVGF DIDEDALEIF NRNAEEFELT 100
    NIDMVQCDVC LLSNRMSKSF DTVIMNPPFG TKNNKGTDMA FLKTALEMAR 150
    TAVYSLHKSS TREHVQKKAA EWKIKIDIIA ELRYDLPASY KFHKKKSVDI 200
    EVDLIRFSF 209
    Length:209
    Mass (Da):23,719
    Last modified:October 1, 2000 - v1
    Checksum:i060B1C2C0D2BA169
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271E → G in BAA91622. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti202 – 2021V → G.
    Corresponds to variant rs1051387 [ dbSNP | Ensembl ].
    VAR_051507

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201938 mRNA. Translation: AAF86874.1.
    AK001321 mRNA. Translation: BAA91622.1.
    AC009967 Genomic DNA. Translation: AAY14869.1.
    CH471058 Genomic DNA. Translation: EAX11254.1.
    CH471058 Genomic DNA. Translation: EAX11255.1.
    BC093014 mRNA. Translation: AAH93014.1.
    BC000921 mRNA. Translation: AAH00921.1.
    CCDSiCCDS33320.1.
    RefSeqiNP_054887.2. NM_014168.3.
    UniGeneiHs.470553.

    Genome annotation databases

    EnsembliENST00000260953; ENSP00000260953; ENSG00000138382.
    ENST00000392640; ENSP00000376415; ENSG00000138382.
    ENST00000409965; ENSP00000386582; ENSG00000138382.
    GeneIDi29081.
    KEGGihsa:29081.
    UCSCiuc002ufn.3. human.

    Polymorphism databases

    DMDMi74761664.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201938 mRNA. Translation: AAF86874.1 .
    AK001321 mRNA. Translation: BAA91622.1 .
    AC009967 Genomic DNA. Translation: AAY14869.1 .
    CH471058 Genomic DNA. Translation: EAX11254.1 .
    CH471058 Genomic DNA. Translation: EAX11255.1 .
    BC093014 mRNA. Translation: AAH93014.1 .
    BC000921 mRNA. Translation: AAH00921.1 .
    CCDSi CCDS33320.1.
    RefSeqi NP_054887.2. NM_014168.3.
    UniGenei Hs.470553.

    3D structure databases

    ProteinModelPortali Q9NRN9.
    SMRi Q9NRN9. Positions 5-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118851. 1 interaction.
    STRINGi 9606.ENSP00000260953.

    Protein family/group databases

    REBASEi 12076. M.UbaDC3ORFAP.

    PTM databases

    PhosphoSitei Q9NRN9.

    Polymorphism databases

    DMDMi 74761664.

    Proteomic databases

    MaxQBi Q9NRN9.
    PaxDbi Q9NRN9.
    PRIDEi Q9NRN9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260953 ; ENSP00000260953 ; ENSG00000138382 .
    ENST00000392640 ; ENSP00000376415 ; ENSG00000138382 .
    ENST00000409965 ; ENSP00000386582 ; ENSG00000138382 .
    GeneIDi 29081.
    KEGGi hsa:29081.
    UCSCi uc002ufn.3. human.

    Organism-specific databases

    CTDi 29081.
    GeneCardsi GC02M170666.
    H-InvDB HIX0002577.
    HGNCi HGNC:25006. METTL5.
    HPAi HPA038223.
    neXtProti NX_Q9NRN9.
    PharmGKBi PA142671461.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2263.
    HOGENOMi HOG000222792.
    HOVERGENi HBG054508.
    PhylomeDBi Q9NRN9.
    TreeFami TF314953.

    Miscellaneous databases

    GenomeRNAii 29081.
    NextBioi 52054.
    PROi Q9NRN9.

    Gene expression databases

    ArrayExpressi Q9NRN9.
    Bgeei Q9NRN9.
    CleanExi HS_METTL5.
    Genevestigatori Q9NRN9.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR029063. SAM-dependent_MTases-like.
    IPR007848. Small_mtfrase_dom.
    [Graphical view ]
    Pfami PF05175. MTS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene from human dendritic cells."
      Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dendritic cell.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Placenta.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMETL5_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRN9
    Secondary accession number(s): D3DPC9, Q9NVX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3