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Q9NRM6

- I17RB_HUMAN

UniProt

Q9NRM6 - I17RB_HUMAN

Protein

Interleukin-17 receptor B

Gene

IL17RB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (27 May 2002)
      Previous versions | rss
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    Functioni

    Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.1 Publication

    GO - Molecular functioni

    1. cytokine receptor activity Source: UniProtKB

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. defense response Source: ProtInc
    3. regulation of cell growth Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17 receptor B
    Short name:
    IL-17 receptor B
    Short name:
    IL-17RB
    Alternative name(s):
    Cytokine receptor-like 4
    IL-17 receptor homolog 1
    Short name:
    IL-17Rh1
    Short name:
    IL17Rh1
    Interleukin-17B receptor
    Short name:
    IL-17B receptor
    Gene namesi
    Name:IL17RB
    Synonyms:CRL4, EVI27, IL17BR
    ORF Names:UNQ2501/PRO19612
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:18015. IL17RB.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. extracellular region Source: UniProtKB-SubCell
    4. integral component of plasma membrane Source: ProtInc
    5. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29796.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17172 PublicationsAdd
    BLAST
    Chaini18 – 502485Interleukin-17 receptor BPRO_0000011032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9NRM6.
    PaxDbiQ9NRM6.
    PRIDEiQ9NRM6.

    PTM databases

    PhosphoSiteiQ9NRM6.

    Expressioni

    Tissue specificityi

    Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

    Gene expression databases

    ArrayExpressiQ9NRM6.
    BgeeiQ9NRM6.
    CleanExiHS_IL17RB.
    GenevestigatoriQ9NRM6.

    Organism-specific databases

    HPAiHPA005482.

    Interactioni

    Subunit structurei

    Interacts with DAZAP2.1 Publication

    Protein-protein interaction databases

    BioGridi120708. 7 interactions.
    IntActiQ9NRM6. 2 interactions.
    STRINGi9606.ENSP00000288167.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRM6.
    SMRiQ9NRM6. Positions 13-272, 328-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 292275ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 502189CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini331 – 477147SEFIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SEFIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47257.
    HOGENOMiHOG000112985.
    HOVERGENiHBG052063.
    InParanoidiQ9NRM6.
    KOiK05165.
    OMAiMGPVQWL.
    OrthoDBiEOG7P8P7V.
    PhylomeDBiQ9NRM6.
    TreeFamiTF329644.

    Family and domain databases

    InterProiIPR013568. SEFIR.
    [Graphical view]
    PfamiPF08357. SEFIR. 1 hit.
    [Graphical view]
    PROSITEiPS51534. SEFIR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NRM6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV    50
    EPVTTSVATG DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV 100
    RCNYTEAFQT QTRPSGGKWT FSYIGFPVEL NTVYFIGAHN IPNANMNEDG 150
    PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW DPNITACKKN EETVEVNFTT 200
    TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT GDSEGATVQL 250
    TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV 300
    ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY 350
    FTEFLQNHCR SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV 400
    NSVCDGTCGK SEGSPSENSQ DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE 450
    IDTKDDYNAL SVCPKYHLMK DATAFCAELL HVKQQVSAGK RSQACHDGCC 500
    SL 502
    Length:502
    Mass (Da):55,885
    Last modified:May 27, 2002 - v2
    Checksum:iCDB87586FAAE49CC
    GO
    Isoform 2 (identifier: Q9NRM6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         250-288: LTPYFPTCGS...PLDNNKSKPG → VKFSELLWGG...SNALLPADTS
         289-502: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:288
    Mass (Da):31,773
    Checksum:iFCBFB384C674F9AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61L → I in AAF86051. (PubMed:10815801)Curated
    Sequence conflicti6 – 61L → I in AAF86052. (PubMed:10815801)Curated
    Sequence conflicti422 – 4265LFPLA → SSPCL AA sequence (PubMed:10749887)Curated
    Sequence conflicti427 – 50276Missing AA sequence (PubMed:10749887)CuratedAdd
    BLAST
    Sequence conflicti468 – 4681L → F in AAF86051. (PubMed:10815801)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti177 – 1771G → R.
    Corresponds to variant rs2232337 [ dbSNP | Ensembl ].
    VAR_059304
    Natural varianti177 – 1771G → S.
    Corresponds to variant rs2232337 [ dbSNP | Ensembl ].
    VAR_049177
    Natural varianti209 – 2091A → V.
    Corresponds to variant rs2232340 [ dbSNP | Ensembl ].
    VAR_049178
    Natural varianti232 – 2321R → Q.
    Corresponds to variant rs2232343 [ dbSNP | Ensembl ].
    VAR_049179
    Natural varianti278 – 2781F → L.1 Publication
    Corresponds to variant rs2232346 [ dbSNP | Ensembl ].
    VAR_019209
    Natural varianti451 – 4511I → T.1 Publication
    Corresponds to variant rs2232350 [ dbSNP | Ensembl ].
    VAR_019210
    Natural varianti458 – 4581N → S.1 Publication
    Corresponds to variant rs2232351 [ dbSNP | Ensembl ].
    VAR_019211
    Natural varianti499 – 4991C → R.1 Publication
    Corresponds to variant rs28385751 [ dbSNP | Ensembl ].
    VAR_019212

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei250 – 28839LTPYF…KSKPG → VKFSELLWGGKGHRRLFHHS LLLRMSSLLSNALLPADTS in isoform 2. 1 PublicationVSP_001740Add
    BLAST
    Alternative sequencei289 – 502214Missing in isoform 2. 1 PublicationVSP_001741Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208110 mRNA. Translation: AAF86051.1.
    AF208111 mRNA. Translation: AAF86052.1.
    AF212365 mRNA. Translation: AAF78776.1.
    AF250309 mRNA. Translation: AAK37428.1.
    AY359122 mRNA. Translation: AAQ89956.1.
    AY518533 Genomic DNA. Translation: AAR89910.1.
    BC000980 mRNA. Translation: AAH00980.1.
    CCDSiCCDS2874.1. [Q9NRM6-1]
    RefSeqiNP_061195.2. NM_018725.3. [Q9NRM6-1]
    UniGeneiHs.654970.

    Genome annotation databases

    EnsembliENST00000288167; ENSP00000288167; ENSG00000056736. [Q9NRM6-1]
    GeneIDi55540.
    KEGGihsa:55540.
    UCSCiuc003dha.3. human. [Q9NRM6-1]

    Polymorphism databases

    DMDMi21263748.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208110 mRNA. Translation: AAF86051.1 .
    AF208111 mRNA. Translation: AAF86052.1 .
    AF212365 mRNA. Translation: AAF78776.1 .
    AF250309 mRNA. Translation: AAK37428.1 .
    AY359122 mRNA. Translation: AAQ89956.1 .
    AY518533 Genomic DNA. Translation: AAR89910.1 .
    BC000980 mRNA. Translation: AAH00980.1 .
    CCDSi CCDS2874.1. [Q9NRM6-1 ]
    RefSeqi NP_061195.2. NM_018725.3. [Q9NRM6-1 ]
    UniGenei Hs.654970.

    3D structure databases

    ProteinModelPortali Q9NRM6.
    SMRi Q9NRM6. Positions 13-272, 328-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120708. 7 interactions.
    IntActi Q9NRM6. 2 interactions.
    STRINGi 9606.ENSP00000288167.

    PTM databases

    PhosphoSitei Q9NRM6.

    Polymorphism databases

    DMDMi 21263748.

    Proteomic databases

    MaxQBi Q9NRM6.
    PaxDbi Q9NRM6.
    PRIDEi Q9NRM6.

    Protocols and materials databases

    DNASUi 55540.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288167 ; ENSP00000288167 ; ENSG00000056736 . [Q9NRM6-1 ]
    GeneIDi 55540.
    KEGGi hsa:55540.
    UCSCi uc003dha.3. human. [Q9NRM6-1 ]

    Organism-specific databases

    CTDi 55540.
    GeneCardsi GC03P053855.
    H-InvDB HIX0119152.
    HGNCi HGNC:18015. IL17RB.
    HPAi HPA005482.
    MIMi 605458. gene.
    neXtProti NX_Q9NRM6.
    PharmGKBi PA29796.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47257.
    HOGENOMi HOG000112985.
    HOVERGENi HBG052063.
    InParanoidi Q9NRM6.
    KOi K05165.
    OMAi MGPVQWL.
    OrthoDBi EOG7P8P7V.
    PhylomeDBi Q9NRM6.
    TreeFami TF329644.

    Miscellaneous databases

    GeneWikii IL17RB.
    GenomeRNAii 55540.
    NextBioi 59986.
    PROi Q9NRM6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NRM6.
    Bgeei Q9NRM6.
    CleanExi HS_IL17RB.
    Genevestigatori Q9NRM6.

    Family and domain databases

    InterProi IPR013568. SEFIR.
    [Graphical view ]
    Pfami PF08357. SEFIR. 1 hit.
    [Graphical view ]
    PROSITEi PS51534. SEFIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evi27 encodes a novel membrane protein with homology to the IL17 receptor."
      Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G., Shaughnessy J.D. Jr.
      Oncogene 19:2098-2109(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity."
      Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A., Ebner R.
      J. Biol. Chem. 275:19167-19176(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF N-TERMINUS.
      Tissue: Lung.
    3. Zhang W., Cao X.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. SeattleSNPs variation discovery resource
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-278; THR-451; SER-458 AND ARG-499.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 18-32.
    8. Cited for: FUNCTION.
    9. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    10. "Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2."
      Popova A., Kzhyshkowska J., Nurgazieva D., Goerdt S., Gratchev A.
      Immunobiology 217:321-328(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAZAP2.

    Entry informationi

    Entry nameiI17RB_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRM6
    Secondary accession number(s): Q9BPZ0, Q9NRL4, Q9NRM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3