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Protein

Interleukin-17 receptor B

Gene

IL17RB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.1 Publication

GO - Molecular functioni

  • cytokine receptor activity Source: UniProtKB
  • interleukin-17 receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000056736-MONOMER.
ReactomeiR-HSA-448424. Interleukin-17 signaling.
SIGNORiQ9NRM6.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor B
Short name:
IL-17 receptor B
Short name:
IL-17RB
Alternative name(s):
Cytokine receptor-like 4
IL-17 receptor homolog 1
Short name:
IL-17Rh1
Short name:
IL17Rh1
Interleukin-17B receptor
Short name:
IL-17B receptor
Gene namesi
Name:IL17RB
Synonyms:CRL4, EVI27, IL17BR
ORF Names:UNQ2501/PRO19612
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18015. IL17RB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 292ExtracellularSequence analysisAdd BLAST275
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 502CytoplasmicSequence analysisAdd BLAST189

GO - Cellular componenti

  • cell surface Source: Ensembl
  • cytoplasm Source: Ensembl
  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55540.
OpenTargetsiENSG00000056736.
PharmGKBiPA29796.

Polymorphism and mutation databases

BioMutaiIL17RB.
DMDMi21263748.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 172 PublicationsAdd BLAST17
ChainiPRO_000001103218 – 502Interleukin-17 receptor BAdd BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NRM6.
PaxDbiQ9NRM6.
PRIDEiQ9NRM6.

PTM databases

iPTMnetiQ9NRM6.
PhosphoSitePlusiQ9NRM6.

Expressioni

Tissue specificityi

Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

Gene expression databases

BgeeiENSG00000056736.
CleanExiHS_IL17RB.
ExpressionAtlasiQ9NRM6. baseline and differential.
GenevisibleiQ9NRM6. HS.

Organism-specific databases

HPAiHPA005482.

Interactioni

Subunit structurei

Interacts with DAZAP2.1 Publication

Protein-protein interaction databases

BioGridi120708. 27 interactors.
IntActiQ9NRM6. 2 interactors.
STRINGi9606.ENSP00000288167.

Structurei

3D structure databases

ProteinModelPortaliQ9NRM6.
SMRiQ9NRM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini331 – 477SEFIRPROSITE-ProRule annotationAdd BLAST147

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK7X. Eukaryota.
ENOG410YA4Q. LUCA.
GeneTreeiENSGT00860000133810.
HOGENOMiHOG000112985.
HOVERGENiHBG052063.
InParanoidiQ9NRM6.
KOiK05165.
OMAiEFLQNHC.
OrthoDBiEOG091G01XZ.
PhylomeDBiQ9NRM6.
TreeFamiTF329644.

Family and domain databases

InterProiIPR032356. IL17R_fnIII_D1.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF16556. IL17R_fnIII_D1. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV
60 70 80 90 100
EPVTTSVATG DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV
110 120 130 140 150
RCNYTEAFQT QTRPSGGKWT FSYIGFPVEL NTVYFIGAHN IPNANMNEDG
160 170 180 190 200
PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW DPNITACKKN EETVEVNFTT
210 220 230 240 250
TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT GDSEGATVQL
260 270 280 290 300
TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV
310 320 330 340 350
ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY
360 370 380 390 400
FTEFLQNHCR SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV
410 420 430 440 450
NSVCDGTCGK SEGSPSENSQ DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE
460 470 480 490 500
IDTKDDYNAL SVCPKYHLMK DATAFCAELL HVKQQVSAGK RSQACHDGCC

SL
Length:502
Mass (Da):55,885
Last modified:May 27, 2002 - v2
Checksum:iCDB87586FAAE49CC
GO
Isoform 2 (identifier: Q9NRM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-288: LTPYFPTCGS...PLDNNKSKPG → VKFSELLWGG...SNALLPADTS
     289-502: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:288
Mass (Da):31,773
Checksum:iFCBFB384C674F9AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6L → I in AAF86051 (PubMed:10815801).Curated1
Sequence conflicti6L → I in AAF86052 (PubMed:10815801).Curated1
Sequence conflicti422 – 426LFPLA → SSPCL AA sequence (PubMed:10749887).Curated5
Sequence conflicti427 – 502Missing AA sequence (PubMed:10749887).CuratedAdd BLAST76
Sequence conflicti468L → F in AAF86051 (PubMed:10815801).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059304177G → R.Corresponds to variant rs2232337dbSNPEnsembl.1
Natural variantiVAR_049177177G → S.Corresponds to variant rs2232337dbSNPEnsembl.1
Natural variantiVAR_049178209A → V.Corresponds to variant rs2232340dbSNPEnsembl.1
Natural variantiVAR_049179232R → Q.Corresponds to variant rs2232343dbSNPEnsembl.1
Natural variantiVAR_019209278F → L.1 PublicationCorresponds to variant rs2232346dbSNPEnsembl.1
Natural variantiVAR_019210451I → T.1 PublicationCorresponds to variant rs2232350dbSNPEnsembl.1
Natural variantiVAR_019211458N → S.1 PublicationCorresponds to variant rs2232351dbSNPEnsembl.1
Natural variantiVAR_019212499C → R.1 PublicationCorresponds to variant rs28385751dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001740250 – 288LTPYF…KSKPG → VKFSELLWGGKGHRRLFHHS LLLRMSSLLSNALLPADTS in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_001741289 – 502Missing in isoform 2. 1 PublicationAdd BLAST214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208110 mRNA. Translation: AAF86051.1.
AF208111 mRNA. Translation: AAF86052.1.
AF212365 mRNA. Translation: AAF78776.1.
AF250309 mRNA. Translation: AAK37428.1.
AY359122 mRNA. Translation: AAQ89956.1.
AY518533 Genomic DNA. Translation: AAR89910.1.
BC000980 mRNA. Translation: AAH00980.1.
CCDSiCCDS2874.1. [Q9NRM6-1]
RefSeqiNP_061195.2. NM_018725.3. [Q9NRM6-1]
UniGeneiHs.654970.

Genome annotation databases

EnsembliENST00000288167; ENSP00000288167; ENSG00000056736. [Q9NRM6-1]
GeneIDi55540.
KEGGihsa:55540.
UCSCiuc003dha.4. human. [Q9NRM6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208110 mRNA. Translation: AAF86051.1.
AF208111 mRNA. Translation: AAF86052.1.
AF212365 mRNA. Translation: AAF78776.1.
AF250309 mRNA. Translation: AAK37428.1.
AY359122 mRNA. Translation: AAQ89956.1.
AY518533 Genomic DNA. Translation: AAR89910.1.
BC000980 mRNA. Translation: AAH00980.1.
CCDSiCCDS2874.1. [Q9NRM6-1]
RefSeqiNP_061195.2. NM_018725.3. [Q9NRM6-1]
UniGeneiHs.654970.

3D structure databases

ProteinModelPortaliQ9NRM6.
SMRiQ9NRM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120708. 27 interactors.
IntActiQ9NRM6. 2 interactors.
STRINGi9606.ENSP00000288167.

PTM databases

iPTMnetiQ9NRM6.
PhosphoSitePlusiQ9NRM6.

Polymorphism and mutation databases

BioMutaiIL17RB.
DMDMi21263748.

Proteomic databases

MaxQBiQ9NRM6.
PaxDbiQ9NRM6.
PRIDEiQ9NRM6.

Protocols and materials databases

DNASUi55540.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288167; ENSP00000288167; ENSG00000056736. [Q9NRM6-1]
GeneIDi55540.
KEGGihsa:55540.
UCSCiuc003dha.4. human. [Q9NRM6-1]

Organism-specific databases

CTDi55540.
DisGeNETi55540.
GeneCardsiIL17RB.
H-InvDBHIX0119152.
HGNCiHGNC:18015. IL17RB.
HPAiHPA005482.
MIMi605458. gene.
neXtProtiNX_Q9NRM6.
OpenTargetsiENSG00000056736.
PharmGKBiPA29796.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK7X. Eukaryota.
ENOG410YA4Q. LUCA.
GeneTreeiENSGT00860000133810.
HOGENOMiHOG000112985.
HOVERGENiHBG052063.
InParanoidiQ9NRM6.
KOiK05165.
OMAiEFLQNHC.
OrthoDBiEOG091G01XZ.
PhylomeDBiQ9NRM6.
TreeFamiTF329644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000056736-MONOMER.
ReactomeiR-HSA-448424. Interleukin-17 signaling.
SIGNORiQ9NRM6.

Miscellaneous databases

GeneWikiiIL17RB.
GenomeRNAii55540.
PROiQ9NRM6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000056736.
CleanExiHS_IL17RB.
ExpressionAtlasiQ9NRM6. baseline and differential.
GenevisibleiQ9NRM6. HS.

Family and domain databases

InterProiIPR032356. IL17R_fnIII_D1.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF16556. IL17R_fnIII_D1. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI17RB_HUMAN
AccessioniPrimary (citable) accession number: Q9NRM6
Secondary accession number(s): Q9BPZ0, Q9NRL4, Q9NRM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.