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Q9NRM6 (I17RB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17 receptor B

Short name=IL-17 receptor B
Short name=IL-17RB
Alternative name(s):
Cytokine receptor-like 4
IL-17 receptor homolog 1
Short name=IL-17Rh1
Short name=IL17Rh1
Interleukin-17B receptor
Short name=IL-17B receptor
Gene names
Name:IL17RB
Synonyms:CRL4, EVI27, IL17BR
ORF Names:UNQ2501/PRO19612
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. Ref.8

Subunit structure

Interacts with DAZAP2. Ref.10

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Isoform 2: Secreted.

Tissue specificity

Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

Sequence similarities

Contains 1 SEFIR domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NRM6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NRM6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     250-288: LTPYFPTCGS...PLDNNKSKPG → VKFSELLWGG...SNALLPADTS
     289-502: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Ref.2 Ref.7
Chain18 – 502485Interleukin-17 receptor B
PRO_0000011032

Regions

Topological domain18 – 292275Extracellular Potential
Transmembrane293 – 31321Helical; Potential
Topological domain314 – 502189Cytoplasmic Potential
Domain331 – 477147SEFIR

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation1971N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence250 – 28839LTPYF…KSKPG → VKFSELLWGGKGHRRLFHHS LLLRMSSLLSNALLPADTS in isoform 2.
VSP_001740
Alternative sequence289 – 502214Missing in isoform 2.
VSP_001741
Natural variant1771G → R.
Corresponds to variant rs2232337 [ dbSNP | Ensembl ].
VAR_059304
Natural variant1771G → S.
Corresponds to variant rs2232337 [ dbSNP | Ensembl ].
VAR_049177
Natural variant2091A → V.
Corresponds to variant rs2232340 [ dbSNP | Ensembl ].
VAR_049178
Natural variant2321R → Q.
Corresponds to variant rs2232343 [ dbSNP | Ensembl ].
VAR_049179
Natural variant2781F → L. Ref.5
Corresponds to variant rs2232346 [ dbSNP | Ensembl ].
VAR_019209
Natural variant4511I → T. Ref.5
Corresponds to variant rs2232350 [ dbSNP | Ensembl ].
VAR_019210
Natural variant4581N → S. Ref.5
Corresponds to variant rs2232351 [ dbSNP | Ensembl ].
VAR_019211
Natural variant4991C → R. Ref.5
Corresponds to variant rs28385751 [ dbSNP | Ensembl ].
VAR_019212

Experimental info

Sequence conflict61L → I in AAF86051. Ref.1
Sequence conflict61L → I in AAF86052. Ref.1
Sequence conflict422 – 4265LFPLA → SSPCL AA sequence Ref.2
Sequence conflict427 – 50276Missing AA sequence Ref.2
Sequence conflict4681L → F in AAF86051. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: CDB87586FAAE49CC

FASTA50255,885
        10         20         30         40         50         60 
MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV EPVTTSVATG 

        70         80         90        100        110        120 
DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV RCNYTEAFQT QTRPSGGKWT 

       130        140        150        160        170        180 
FSYIGFPVEL NTVYFIGAHN IPNANMNEDG PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW 

       190        200        210        220        230        240 
DPNITACKKN EETVEVNFTT TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT 

       250        260        270        280        290        300 
GDSEGATVQL TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV 

       310        320        330        340        350        360 
ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY FTEFLQNHCR 

       370        380        390        400        410        420 
SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV NSVCDGTCGK SEGSPSENSQ 

       430        440        450        460        470        480 
DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE IDTKDDYNAL SVCPKYHLMK DATAFCAELL 

       490        500 
HVKQQVSAGK RSQACHDGCC SL 

« Hide

Isoform 2 [UniParc].

Checksum: FCBFB384C674F9AC
Show »

FASTA28831,773

References

« Hide 'large scale' references
[1]"Evi27 encodes a novel membrane protein with homology to the IL17 receptor."
Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G., Shaughnessy J.D. Jr.
Oncogene 19:2098-2109(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity."
Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A., Ebner R.
J. Biol. Chem. 275:19167-19176(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF N-TERMINUS.
Tissue: Lung.
[3]Zhang W., Cao X.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]SeattleSNPs variation discovery resource
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-278; THR-451; SER-458 AND ARG-499.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cervix.
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 18-32.
[8]"IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1."
Lee J., Ho W.-H., Maruoka M., Corpuz R.T., Baldwin D.T., Foster J.S., Goddard A.D., Yansura D.G., Vandlen R.L., Wood W.I., Gurney A.L.
J. Biol. Chem. 276:1660-1664(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[10]"Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2."
Popova A., Kzhyshkowska J., Nurgazieva D., Goerdt S., Gratchev A.
Immunobiology 217:321-328(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DAZAP2.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF208110 mRNA. Translation: AAF86051.1.
AF208111 mRNA. Translation: AAF86052.1.
AF212365 mRNA. Translation: AAF78776.1.
AF250309 mRNA. Translation: AAK37428.1.
AY359122 mRNA. Translation: AAQ89956.1.
AY518533 Genomic DNA. Translation: AAR89910.1.
BC000980 mRNA. Translation: AAH00980.1.
CCDSCCDS2874.1. [Q9NRM6-1]
RefSeqNP_061195.2. NM_018725.3. [Q9NRM6-1]
UniGeneHs.654970.

3D structure databases

ProteinModelPortalQ9NRM6.
SMRQ9NRM6. Positions 13-272, 328-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120708. 7 interactions.
IntActQ9NRM6. 2 interactions.
STRING9606.ENSP00000288167.

PTM databases

PhosphoSiteQ9NRM6.

Polymorphism databases

DMDM21263748.

Proteomic databases

MaxQBQ9NRM6.
PaxDbQ9NRM6.
PRIDEQ9NRM6.

Protocols and materials databases

DNASU55540.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288167; ENSP00000288167; ENSG00000056736. [Q9NRM6-1]
GeneID55540.
KEGGhsa:55540.
UCSCuc003dha.3. human. [Q9NRM6-1]

Organism-specific databases

CTD55540.
GeneCardsGC03P053855.
H-InvDBHIX0119152.
HGNCHGNC:18015. IL17RB.
HPAHPA005482.
MIM605458. gene.
neXtProtNX_Q9NRM6.
PharmGKBPA29796.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47257.
HOGENOMHOG000112985.
HOVERGENHBG052063.
InParanoidQ9NRM6.
KOK05165.
OMAMGPVQWL.
OrthoDBEOG7P8P7V.
PhylomeDBQ9NRM6.
TreeFamTF329644.

Gene expression databases

ArrayExpressQ9NRM6.
BgeeQ9NRM6.
CleanExHS_IL17RB.
GenevestigatorQ9NRM6.

Family and domain databases

InterProIPR013568. SEFIR.
[Graphical view]
PfamPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIL17RB.
GenomeRNAi55540.
NextBio59986.
PROQ9NRM6.
SOURCESearch...

Entry information

Entry nameI17RB_HUMAN
AccessionPrimary (citable) accession number: Q9NRM6
Secondary accession number(s): Q9BPZ0, Q9NRL4, Q9NRM5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM