Q9NRM6 (I17RB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17 receptor B
Short name=IL-17 receptor B
Short name=IL-17RB

Alternative name(s):
Cytokine receptor-like 4
IL-17 receptor homolog 1
Short name=IL-17Rh1
Short name=IL17Rh1
Interleukin-17B receptor
Short name=IL-17B receptor

Gene names

Name:	IL17RB
Synonyms:	CRL4, EVI27, IL17BR
ORF Names:	UNQ2501/PRO19612

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. Ref.8
Subunit structure	Interacts with DAZAP2. Ref.10
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Tissue specificity	Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.
Sequence similarities	Contains 1 SEFIR domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	defense response Traceable author statement Ref.2. Source: ProtInc regulation of cell growth Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	cytokine receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NRM6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NRM6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     250-288: LTPYFPTCGS...PLDNNKSKPG → VKFSELLWGG...SNALLPADTS
     289-502: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Ref.2 Ref.7
	Chain	18 – 502	485	Interleukin-17 receptor B		PRO_0000011032
Regions
	Topological domain	18 – 292	275	Extracellular Potential
	Transmembrane	293 – 313	21	Helical; Potential
	Topological domain	314 – 502	189	Cytoplasmic Potential
	Domain	331 – 477	147	SEFIR
Amino acid modifications
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	156	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
	Glycosylation	197	1	N-linked (GlcNAc...) Potential
	Glycosylation	283	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	250 – 288	39	LTPYF…KSKPG → VKFSELLWGGKGHRRLFHHS LLLRMSSLLSNALLPADTS in isoform 2.		VSP_001740
	Alternative sequence	289 – 502	214	Missing in isoform 2.		VSP_001741
	Natural variant	177	1	G → R. Corresponds to variant rs2232337 [ dbSNP | Ensembl ].		VAR_059304
	Natural variant	177	1	G → S. Corresponds to variant rs2232337 [ dbSNP | Ensembl ].		VAR_049177
	Natural variant	209	1	A → V. Corresponds to variant rs2232340 [ dbSNP | Ensembl ].		VAR_049178
	Natural variant	232	1	R → Q. Corresponds to variant rs2232343 [ dbSNP | Ensembl ].		VAR_049179
	Natural variant	278	1	F → L. Ref.5 Corresponds to variant rs2232346 [ dbSNP | Ensembl ].		VAR_019209
	Natural variant	451	1	I → T. Ref.5 Corresponds to variant rs2232350 [ dbSNP | Ensembl ].		VAR_019210
	Natural variant	458	1	N → S. Ref.5 Corresponds to variant rs2232351 [ dbSNP | Ensembl ].		VAR_019211
	Natural variant	499	1	C → R. Ref.5 Corresponds to variant rs28385751 [ dbSNP | Ensembl ].		VAR_019212
Experimental info
	Sequence conflict	6	1	L → I in AAF86051. Ref.1
	Sequence conflict	6	1	L → I in AAF86052. Ref.1
	Sequence conflict	422 – 426	5	LFPLA → SSPCL AA sequence Ref.2
	Sequence conflict	427 – 502	76	Missing AA sequence Ref.2
	Sequence conflict	468	1	L → F in AAF86051. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: CDB87586FAAE49CC	FASTA	502	55,885
	10 20 30 40 50 60 MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV EPVTTSVATG 70 80 90 100 110 120 DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV RCNYTEAFQT QTRPSGGKWT 130 140 150 160 170 180 FSYIGFPVEL NTVYFIGAHN IPNANMNEDG PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW 190 200 210 220 230 240 DPNITACKKN EETVEVNFTT TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT 250 260 270 280 290 300 GDSEGATVQL TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV 310 320 330 340 350 360 ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY FTEFLQNHCR 370 380 390 400 410 420 SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV NSVCDGTCGK SEGSPSENSQ 430 440 450 460 470 480 DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE IDTKDDYNAL SVCPKYHLMK DATAFCAELL 490 500 HVKQQVSAGK RSQACHDGCC SL
	Isoform 2 [UniParc]. Checksum: FCBFB384C674F9AC	FASTA	288	31,773
	10 20 30 40 50 60 MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV EPVTTSVATG 70 80 90 100 110 120 DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV RCNYTEAFQT QTRPSGGKWT 130 140 150 160 170 180 FSYIGFPVEL NTVYFIGAHN IPNANMNEDG PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW 190 200 210 220 230 240 DPNITACKKN EETVEVNFTT TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT 250 260 270 280 GDSEGATVQV KFSELLWGGK GHRRLFHHSL LLRMSSLLSN ALLPADTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evi27 encodes a novel membrane protein with homology to the IL17 receptor." Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G., Shaughnessy J.D. Jr. Oncogene 19:2098-2109(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity." Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A., Ebner R. J. Biol. Chem. 275:19167-19176(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF N-TERMINUS. Tissue: Lung.
[3]	Zhang W., Cao X. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	SeattleSNPs variation discovery resource Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-278; THR-451; SER-458 AND ARG-499.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 18-32.
[8]	"IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1." Lee J., Ho W.-H., Maruoka M., Corpuz R.T., Baldwin D.T., Foster J.S., Goddard A.D., Yansura D.G., Vandlen R.L., Wood W.I., Gurney A.L. J. Biol. Chem. 276:1660-1664(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[10]	"Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2." Popova A., Kzhyshkowska J., Nurgazieva D., Goerdt S., Gratchev A. Immunobiology 217:321-328(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DAZAP2.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF208110 mRNA. Translation: AAF86051.1. AF208111 mRNA. Translation: AAF86052.1. AF212365 mRNA. Translation: AAF78776.1. AF250309 mRNA. Translation: AAK37428.1. AY359122 mRNA. Translation: AAQ89956.1. AY518533 Genomic DNA. Translation: AAR89910.1. BC000980 mRNA. Translation: AAH00980.1.
IPI	IPI00148059. IPI00220930.
RefSeq	NP_061195.2. NM_018725.3.
UniGene	Hs.654970.
3D structure databases
ProteinModelPortal	Q9NRM6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NRM6. 2 interactions.
STRING	9606.ENSP00000288167.
PTM databases
PhosphoSite	Q9NRM6.
Polymorphism databases
DMDM	21263748.
Proteomic databases
PaxDb	Q9NRM6.
PRIDE	Q9NRM6.
Protocols and materials databases
DNASU	55540.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288167; ENSP00000288167; ENSG00000056736.
GeneID	55540.
KEGG	hsa:55540.
UCSC	uc003dha.3. human.
Organism-specific databases
CTD	55540.
GeneCards	GC03P053855.
H-InvDB	HIX0119152.
HGNC	HGNC:18015. IL17RB.
HPA	HPA005482.
MIM	605458. gene.
neXtProt	NX_Q9NRM6.
PharmGKB	PA29796.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47257.
HOGENOM	HOG000112985.
HOVERGEN	HBG052063.
InParanoid	Q9NRM6.
KO	K05165.
OMA	MGPVQWL.
OrthoDB	EOG4J9MZP.
PhylomeDB	Q9NRM6.
Gene expression databases
ArrayExpress	Q9NRM6.
Bgee	Q9NRM6.
CleanEx	HS_IL17RB.
Genevestigator	Q9NRM6.
GermOnline	ENSG00000056736. Homo sapiens.
Family and domain databases
InterPro	IPR013568. SEFIR. [Graphical view]
Pfam	PF08357. SEFIR. 1 hit. [Graphical view]
PROSITE	PS51534. SEFIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55540.
NextBio	59986.
SOURCE	Search...

Entry information

Entry name

I17RB_HUMAN

Accession

Primary (citable) accession number: Q9NRM6
Secondary accession number(s): Q9BPZ0, Q9NRL4, Q9NRM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	May 27, 2002
Last modified:	April 3, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.