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Q9NRM6

- I17RB_HUMAN

UniProt

Q9NRM6 - I17RB_HUMAN

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Protein

Interleukin-17 receptor B

Gene
IL17RB, CRL4, EVI27, IL17BR, UNQ2501/PRO19612
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.1 Publication

GO - Molecular functioni

  1. cytokine receptor activity Source: UniProtKB

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. defense response Source: ProtInc
  3. regulation of cell growth Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor B
Short name:
IL-17 receptor B
Short name:
IL-17RB
Alternative name(s):
Cytokine receptor-like 4
IL-17 receptor homolog 1
Short name:
IL-17Rh1
Short name:
IL17Rh1
Interleukin-17B receptor
Short name:
IL-17B receptor
Gene namesi
Name:IL17RB
Synonyms:CRL4, EVI27, IL17BR
ORF Names:UNQ2501/PRO19612
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18015. IL17RB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 292275Extracellular Reviewed predictionAdd
BLAST
Transmembranei293 – 31321Helical; Reviewed predictionAdd
BLAST
Topological domaini314 – 502189Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. extracellular region Source: UniProtKB-SubCell
  4. integral component of plasma membrane Source: ProtInc
  5. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29796.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17172 PublicationsAdd
BLAST
Chaini18 – 502485Interleukin-17 receptor BPRO_0000011032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi197 – 1971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NRM6.
PaxDbiQ9NRM6.
PRIDEiQ9NRM6.

PTM databases

PhosphoSiteiQ9NRM6.

Expressioni

Tissue specificityi

Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

Gene expression databases

ArrayExpressiQ9NRM6.
BgeeiQ9NRM6.
CleanExiHS_IL17RB.
GenevestigatoriQ9NRM6.

Organism-specific databases

HPAiHPA005482.

Interactioni

Subunit structurei

Interacts with DAZAP2.1 Publication

Protein-protein interaction databases

BioGridi120708. 7 interactions.
IntActiQ9NRM6. 2 interactions.
STRINGi9606.ENSP00000288167.

Structurei

3D structure databases

ProteinModelPortaliQ9NRM6.
SMRiQ9NRM6. Positions 13-272, 328-484.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini331 – 477147SEFIRAdd
BLAST

Sequence similaritiesi

Contains 1 SEFIR domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47257.
HOGENOMiHOG000112985.
HOVERGENiHBG052063.
InParanoidiQ9NRM6.
KOiK05165.
OMAiMGPVQWL.
OrthoDBiEOG7P8P7V.
PhylomeDBiQ9NRM6.
TreeFamiTF329644.

Family and domain databases

InterProiIPR013568. SEFIR.
[Graphical view]
PfamiPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NRM6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLVLLSLAA LCRSAVPREP TVQCGSETGP SPEWMLQHDL IPGDLRDLRV    50
EPVTTSVATG DYSILMNVSW VLRADASIRL LKATKICVTG KSNFQSYSCV 100
RCNYTEAFQT QTRPSGGKWT FSYIGFPVEL NTVYFIGAHN IPNANMNEDG 150
PSMSVNFTSP GCLDHIMKYK KKCVKAGSLW DPNITACKKN EETVEVNFTT 200
TPLGNRYMAL IQHSTIIGFS QVFEPHQKKQ TRASVVIPVT GDSEGATVQL 250
TPYFPTCGSD CIRHKGTVVL CPQTGVPFPL DNNKSKPGGW LPLLLLSLLV 300
ATWVLVAGIY LMWRHERIKK TSFSTTTLLP PIKVLVVYPS EICFHHTICY 350
FTEFLQNHCR SEVILEKWQK KKIAEMGPVQ WLATQKKAAD KVVFLLSNDV 400
NSVCDGTCGK SEGSPSENSQ DLFPLAFNLF CSDLRSQIHL HKYVVVYFRE 450
IDTKDDYNAL SVCPKYHLMK DATAFCAELL HVKQQVSAGK RSQACHDGCC 500
SL 502
Length:502
Mass (Da):55,885
Last modified:May 27, 2002 - v2
Checksum:iCDB87586FAAE49CC
GO
Isoform 2 (identifier: Q9NRM6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-288: LTPYFPTCGS...PLDNNKSKPG → VKFSELLWGG...SNALLPADTS
     289-502: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:288
Mass (Da):31,773
Checksum:iFCBFB384C674F9AC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti177 – 1771G → R.
Corresponds to variant rs2232337 [ dbSNP | Ensembl ].
VAR_059304
Natural varianti177 – 1771G → S.
Corresponds to variant rs2232337 [ dbSNP | Ensembl ].
VAR_049177
Natural varianti209 – 2091A → V.
Corresponds to variant rs2232340 [ dbSNP | Ensembl ].
VAR_049178
Natural varianti232 – 2321R → Q.
Corresponds to variant rs2232343 [ dbSNP | Ensembl ].
VAR_049179
Natural varianti278 – 2781F → L.1 Publication
Corresponds to variant rs2232346 [ dbSNP | Ensembl ].
VAR_019209
Natural varianti451 – 4511I → T.1 Publication
Corresponds to variant rs2232350 [ dbSNP | Ensembl ].
VAR_019210
Natural varianti458 – 4581N → S.1 Publication
Corresponds to variant rs2232351 [ dbSNP | Ensembl ].
VAR_019211
Natural varianti499 – 4991C → R.1 Publication
Corresponds to variant rs28385751 [ dbSNP | Ensembl ].
VAR_019212

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei250 – 28839LTPYF…KSKPG → VKFSELLWGGKGHRRLFHHS LLLRMSSLLSNALLPADTS in isoform 2. VSP_001740Add
BLAST
Alternative sequencei289 – 502214Missing in isoform 2. VSP_001741Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61L → I in AAF86051. 1 Publication
Sequence conflicti6 – 61L → I in AAF86052. 1 Publication
Sequence conflicti422 – 4265LFPLA → SSPCL AA sequence 1 Publication
Sequence conflicti427 – 50276Missing AA sequence 1 PublicationAdd
BLAST
Sequence conflicti468 – 4681L → F in AAF86051. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208110 mRNA. Translation: AAF86051.1.
AF208111 mRNA. Translation: AAF86052.1.
AF212365 mRNA. Translation: AAF78776.1.
AF250309 mRNA. Translation: AAK37428.1.
AY359122 mRNA. Translation: AAQ89956.1.
AY518533 Genomic DNA. Translation: AAR89910.1.
BC000980 mRNA. Translation: AAH00980.1.
CCDSiCCDS2874.1. [Q9NRM6-1]
RefSeqiNP_061195.2. NM_018725.3. [Q9NRM6-1]
UniGeneiHs.654970.

Genome annotation databases

EnsembliENST00000288167; ENSP00000288167; ENSG00000056736. [Q9NRM6-1]
GeneIDi55540.
KEGGihsa:55540.
UCSCiuc003dha.3. human. [Q9NRM6-1]

Polymorphism databases

DMDMi21263748.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF208110 mRNA. Translation: AAF86051.1 .
AF208111 mRNA. Translation: AAF86052.1 .
AF212365 mRNA. Translation: AAF78776.1 .
AF250309 mRNA. Translation: AAK37428.1 .
AY359122 mRNA. Translation: AAQ89956.1 .
AY518533 Genomic DNA. Translation: AAR89910.1 .
BC000980 mRNA. Translation: AAH00980.1 .
CCDSi CCDS2874.1. [Q9NRM6-1 ]
RefSeqi NP_061195.2. NM_018725.3. [Q9NRM6-1 ]
UniGenei Hs.654970.

3D structure databases

ProteinModelPortali Q9NRM6.
SMRi Q9NRM6. Positions 13-272, 328-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120708. 7 interactions.
IntActi Q9NRM6. 2 interactions.
STRINGi 9606.ENSP00000288167.

PTM databases

PhosphoSitei Q9NRM6.

Polymorphism databases

DMDMi 21263748.

Proteomic databases

MaxQBi Q9NRM6.
PaxDbi Q9NRM6.
PRIDEi Q9NRM6.

Protocols and materials databases

DNASUi 55540.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000288167 ; ENSP00000288167 ; ENSG00000056736 . [Q9NRM6-1 ]
GeneIDi 55540.
KEGGi hsa:55540.
UCSCi uc003dha.3. human. [Q9NRM6-1 ]

Organism-specific databases

CTDi 55540.
GeneCardsi GC03P053855.
H-InvDB HIX0119152.
HGNCi HGNC:18015. IL17RB.
HPAi HPA005482.
MIMi 605458. gene.
neXtProti NX_Q9NRM6.
PharmGKBi PA29796.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47257.
HOGENOMi HOG000112985.
HOVERGENi HBG052063.
InParanoidi Q9NRM6.
KOi K05165.
OMAi MGPVQWL.
OrthoDBi EOG7P8P7V.
PhylomeDBi Q9NRM6.
TreeFami TF329644.

Miscellaneous databases

GeneWikii IL17RB.
GenomeRNAii 55540.
NextBioi 59986.
PROi Q9NRM6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NRM6.
Bgeei Q9NRM6.
CleanExi HS_IL17RB.
Genevestigatori Q9NRM6.

Family and domain databases

InterProi IPR013568. SEFIR.
[Graphical view ]
Pfami PF08357. SEFIR. 1 hit.
[Graphical view ]
PROSITEi PS51534. SEFIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evi27 encodes a novel membrane protein with homology to the IL17 receptor."
    Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G., Shaughnessy J.D. Jr.
    Oncogene 19:2098-2109(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity."
    Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A., Ebner R.
    J. Biol. Chem. 275:19167-19176(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Lung.
  3. Zhang W., Cao X.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. SeattleSNPs variation discovery resource
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-278; THR-451; SER-458 AND ARG-499.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-32.
  8. Cited for: FUNCTION.
  9. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  10. "Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2."
    Popova A., Kzhyshkowska J., Nurgazieva D., Goerdt S., Gratchev A.
    Immunobiology 217:321-328(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAZAP2.

Entry informationi

Entry nameiI17RB_HUMAN
AccessioniPrimary (citable) accession number: Q9NRM6
Secondary accession number(s): Q9BPZ0, Q9NRL4, Q9NRM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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