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Protein

Zinc finger protein 277

Gene

ZNF277

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri224 – 248C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri355 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33385-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 277
Alternative name(s):
Nuclear receptor-interacting factor 4
Gene namesi
Name:ZNF277
Synonyms:NRIF4, ZNF277P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13070. ZNF277.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11179.
OpenTargetsiENSG00000198839.
PharmGKBiPA37646.

Polymorphism and mutation databases

BioMutaiZNF277.
DMDMi251757417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000475032 – 450Zinc finger protein 277Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NRM2.
MaxQBiQ9NRM2.
PaxDbiQ9NRM2.
PeptideAtlasiQ9NRM2.
PRIDEiQ9NRM2.

PTM databases

iPTMnetiQ9NRM2.
PhosphoSitePlusiQ9NRM2.

Expressioni

Gene expression databases

BgeeiENSG00000198839.
ExpressionAtlasiQ9NRM2. baseline and differential.
GenevisibleiQ9NRM2. HS.

Organism-specific databases

HPAiHPA027307.
HPA041811.

Interactioni

Protein-protein interaction databases

BioGridi116349. 15 interactors.
IntActiQ9NRM2. 13 interactors.
STRINGi9606.ENSP00000354501.

Structurei

3D structure databases

ProteinModelPortaliQ9NRM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZNF277 family.Curated
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri224 – 248C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri355 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2482. Eukaryota.
ENOG410XQ2B. LUCA.
GeneTreeiENSGT00390000010852.
HOGENOMiHOG000247001.
HOVERGENiHBG054015.
InParanoidiQ9NRM2.
OMAiCEKQAET.
OrthoDBiEOG091G0A09.
PhylomeDBiQ9NRM2.
TreeFamiTF318036.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF12756. zf-C2H2_2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKTQGAV ARMQEDRDGS CSTVGGVGYG DSKDCILEPL SLPESPGGTT
60 70 80 90 100
TLEGSPSVPC IFCEEHFPVA EQDKLLKHMI IEHKIVIADV KLVADFQRYI
110 120 130 140 150
LYWRKRFTEQ PITDFCSVIR INSTAPFEEQ ENYFLLCDVL PEDRILREEL
160 170 180 190 200
QKQRLREILE QQQQERNDTN FHGVCMFCNE EFLGNRSVIL NHMAREHAFN
210 220 230 240 250
IGLPDNIVNC NEFLCTLQKK LDNLQCLYCE KTFRDKNTLK DHMRKKQHRK
260 270 280 290 300
INPKNREYDR FYVINYLELG KSWEEVQLED DRELLDHQED DWSDWEEHPA
310 320 330 340 350
SAVCLFCEKQ AETIEKLYVH MEDAHEFDLL KIKSELGLNF YQQVKLVNFI
360 370 380 390 400
RRQVHQCRCY GCHVKFKSKA DLRTHMEETK HTSLLPDRKT WDQLEYYFPT
410 420 430 440 450
YENDTLLCTL SDSESDLTAQ EQNENVPIIS EDTSKLYALK QSSILNQLLL
Length:450
Mass (Da):52,788
Last modified:July 7, 2009 - v2
Checksum:i07A35E08BB6E9521
GO

Sequence cautioni

The sequence AAF85941 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAS07413 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059908174V → I.Corresponds to variant rs34571830dbSNPEnsembl.1
Natural variantiVAR_035574332I → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_057415364V → M.Corresponds to variant rs11539696dbSNPEnsembl.1
Natural variantiVAR_035575445L → F in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209198 mRNA. Translation: AAF85941.1. Different initiation.
AF308819 mRNA. Translation: AAL55819.1.
AC004112 Genomic DNA. Translation: AAS07407.1.
AC004111 Genomic DNA. Translation: AAS07413.1. Different initiation.
CH471070 Genomic DNA. Translation: EAW83461.1.
CCDSiCCDS5755.2.
RefSeqiNP_068834.2. NM_021994.2.
UniGeneiHs.655904.

Genome annotation databases

EnsembliENST00000361822; ENSP00000354501; ENSG00000198839.
GeneIDi11179.
KEGGihsa:11179.
UCSCiuc003vge.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209198 mRNA. Translation: AAF85941.1. Different initiation.
AF308819 mRNA. Translation: AAL55819.1.
AC004112 Genomic DNA. Translation: AAS07407.1.
AC004111 Genomic DNA. Translation: AAS07413.1. Different initiation.
CH471070 Genomic DNA. Translation: EAW83461.1.
CCDSiCCDS5755.2.
RefSeqiNP_068834.2. NM_021994.2.
UniGeneiHs.655904.

3D structure databases

ProteinModelPortaliQ9NRM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116349. 15 interactors.
IntActiQ9NRM2. 13 interactors.
STRINGi9606.ENSP00000354501.

PTM databases

iPTMnetiQ9NRM2.
PhosphoSitePlusiQ9NRM2.

Polymorphism and mutation databases

BioMutaiZNF277.
DMDMi251757417.

Proteomic databases

EPDiQ9NRM2.
MaxQBiQ9NRM2.
PaxDbiQ9NRM2.
PeptideAtlasiQ9NRM2.
PRIDEiQ9NRM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361822; ENSP00000354501; ENSG00000198839.
GeneIDi11179.
KEGGihsa:11179.
UCSCiuc003vge.3. human.

Organism-specific databases

CTDi11179.
DisGeNETi11179.
GeneCardsiZNF277.
HGNCiHGNC:13070. ZNF277.
HPAiHPA027307.
HPA041811.
MIMi605465. gene.
neXtProtiNX_Q9NRM2.
OpenTargetsiENSG00000198839.
PharmGKBiPA37646.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2482. Eukaryota.
ENOG410XQ2B. LUCA.
GeneTreeiENSGT00390000010852.
HOGENOMiHOG000247001.
HOVERGENiHBG054015.
InParanoidiQ9NRM2.
OMAiCEKQAET.
OrthoDBiEOG091G0A09.
PhylomeDBiQ9NRM2.
TreeFamiTF318036.

Enzyme and pathway databases

BioCyciZFISH:G66-33385-MONOMER.

Miscellaneous databases

GeneWikiiZNF277P.
GenomeRNAii11179.
PROiQ9NRM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198839.
ExpressionAtlasiQ9NRM2. baseline and differential.
GenevisibleiQ9NRM2. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF12756. zf-C2H2_2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN277_HUMAN
AccessioniPrimary (citable) accession number: Q9NRM2
Secondary accession number(s): Q75MZ2, Q75MZ3, Q8WY14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.