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Q9NRM2 (ZN277_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 277
Alternative name(s):
Nuclear receptor-interacting factor 4
Gene names
Name:ZNF277
Synonyms:NRIF4, ZNF277P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the ZNF277 family.

Contains 2 C2H2-type zinc fingers.

Sequence caution

The sequence AAF85941.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAS07413.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Non-traceable author statement. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Non-traceable author statement. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Zinc finger protein 277
PRO_0000047503

Regions

Zinc finger224 – 24825C2H2-type 1
Zinc finger355 – 38127C2H2-type 2

Natural variations

Natural variant1741V → I.
Corresponds to variant rs34571830 [ dbSNP | Ensembl ].
VAR_059908
Natural variant3321I → L in a breast cancer sample; somatic mutation. Ref.5
VAR_035574
Natural variant3641V → M.
Corresponds to variant rs11539696 [ dbSNP | Ensembl ].
VAR_057415
Natural variant4451L → F in a breast cancer sample; somatic mutation. Ref.5
VAR_035575

Sequences

Sequence LengthMass (Da)Tools
Q9NRM2 [UniParc].

Last modified July 7, 2009. Version 2.
Checksum: 07A35E08BB6E9521

FASTA45052,788
        10         20         30         40         50         60 
MAASKTQGAV ARMQEDRDGS CSTVGGVGYG DSKDCILEPL SLPESPGGTT TLEGSPSVPC 

        70         80         90        100        110        120 
IFCEEHFPVA EQDKLLKHMI IEHKIVIADV KLVADFQRYI LYWRKRFTEQ PITDFCSVIR 

       130        140        150        160        170        180 
INSTAPFEEQ ENYFLLCDVL PEDRILREEL QKQRLREILE QQQQERNDTN FHGVCMFCNE 

       190        200        210        220        230        240 
EFLGNRSVIL NHMAREHAFN IGLPDNIVNC NEFLCTLQKK LDNLQCLYCE KTFRDKNTLK 

       250        260        270        280        290        300 
DHMRKKQHRK INPKNREYDR FYVINYLELG KSWEEVQLED DRELLDHQED DWSDWEEHPA 

       310        320        330        340        350        360 
SAVCLFCEKQ AETIEKLYVH MEDAHEFDLL KIKSELGLNF YQQVKLVNFI RRQVHQCRCY 

       370        380        390        400        410        420 
GCHVKFKSKA DLRTHMEETK HTSLLPDRKT WDQLEYYFPT YENDTLLCTL SDSESDLTAQ 

       430        440        450 
EQNENVPIIS EDTSKLYALK QSSILNQLLL 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277."
Liang H., Guo W., Nagarajan L.
Genomics 66:226-228(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The putative nuclear receptor coregulator NRIF4."
Li D., Desai-Yajnik V., Samuels H.H.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-332 AND PHE-445.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF209198 mRNA. Translation: AAF85941.1. Different initiation.
AF308819 mRNA. Translation: AAL55819.1.
AC004112 Genomic DNA. Translation: AAS07407.1.
AC004111 Genomic DNA. Translation: AAS07413.1. Different initiation.
CH471070 Genomic DNA. Translation: EAW83461.1.
IPIIPI00465033.
RefSeqNP_068834.2. NM_021994.2.
UniGeneHs.655904.

3D structure databases

ProteinModelPortalQ9NRM2.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9NRM2. 11 interactions.
STRING9606.ENSP00000354501.

Polymorphism databases

DMDM251757417.

Proteomic databases

PaxDbQ9NRM2.
PRIDEQ9NRM2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361822; ENSP00000354501; ENSG00000198839.
GeneID11179.
KEGGhsa:11179.
UCSCuc003vge.2. human.

Organism-specific databases

CTD11179.
GeneCardsGC07P111846.
HGNCHGNC:13070. ZNF277.
HPAHPA027307.
MIM605465. gene.
neXtProtNX_Q9NRM2.
PharmGKBPA37646.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG275991.
HOGENOMHOG000247001.
HOVERGENHBG054015.
InParanoidQ9NRM2.
OMARCYGCHV.
OrthoDBEOG47H5PW.
PhylomeDBQ9NRM2.

Gene expression databases

ArrayExpressQ9NRM2.
BgeeQ9NRM2.
GenevestigatorQ9NRM2.
GermOnlineENSG00000198839. Homo sapiens.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi11179.
NextBio42539.
SOURCESearch...

Entry information

Entry nameZN277_HUMAN
AccessionPrimary (citable) accession number: Q9NRM2
Secondary accession number(s): Q75MZ2, Q75MZ3, Q8WY14
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 7, 2009
Last modified: May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families