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Q9NRM2

- ZN277_HUMAN

UniProt

Q9NRM2 - ZN277_HUMAN

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Protein

Zinc finger protein 277

Gene

ZNF277

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri224 – 24825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 38127C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: Ensembl
  2. regulation of cellular senescence Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 277
Alternative name(s):
Nuclear receptor-interacting factor 4
Gene namesi
Name:ZNF277
Synonyms:NRIF4, ZNF277P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13070. ZNF277.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37646.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 450449Zinc finger protein 277PRO_0000047503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NRM2.
PaxDbiQ9NRM2.
PRIDEiQ9NRM2.

Expressioni

Gene expression databases

BgeeiQ9NRM2.
ExpressionAtlasiQ9NRM2. baseline and differential.
GenevestigatoriQ9NRM2.

Organism-specific databases

HPAiHPA027307.

Interactioni

Protein-protein interaction databases

BioGridi116349. 10 interactions.
IntActiQ9NRM2. 11 interactions.
STRINGi9606.ENSP00000354501.

Structurei

3D structure databases

ProteinModelPortaliQ9NRM2.
SMRiQ9NRM2. Positions 223-255, 300-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZNF277 family.Curated
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri224 – 24825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 38127C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG275991.
GeneTreeiENSGT00390000010852.
HOGENOMiHOG000247001.
HOVERGENiHBG054015.
InParanoidiQ9NRM2.
OMAiCEKQAET.
OrthoDBiEOG77HDDS.
PhylomeDBiQ9NRM2.
TreeFamiTF318036.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRM2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASKTQGAV ARMQEDRDGS CSTVGGVGYG DSKDCILEPL SLPESPGGTT
60 70 80 90 100
TLEGSPSVPC IFCEEHFPVA EQDKLLKHMI IEHKIVIADV KLVADFQRYI
110 120 130 140 150
LYWRKRFTEQ PITDFCSVIR INSTAPFEEQ ENYFLLCDVL PEDRILREEL
160 170 180 190 200
QKQRLREILE QQQQERNDTN FHGVCMFCNE EFLGNRSVIL NHMAREHAFN
210 220 230 240 250
IGLPDNIVNC NEFLCTLQKK LDNLQCLYCE KTFRDKNTLK DHMRKKQHRK
260 270 280 290 300
INPKNREYDR FYVINYLELG KSWEEVQLED DRELLDHQED DWSDWEEHPA
310 320 330 340 350
SAVCLFCEKQ AETIEKLYVH MEDAHEFDLL KIKSELGLNF YQQVKLVNFI
360 370 380 390 400
RRQVHQCRCY GCHVKFKSKA DLRTHMEETK HTSLLPDRKT WDQLEYYFPT
410 420 430 440 450
YENDTLLCTL SDSESDLTAQ EQNENVPIIS EDTSKLYALK QSSILNQLLL
Length:450
Mass (Da):52,788
Last modified:July 7, 2009 - v2
Checksum:i07A35E08BB6E9521
GO

Sequence cautioni

The sequence AAF85941.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAS07413.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741V → I.
Corresponds to variant rs34571830 [ dbSNP | Ensembl ].
VAR_059908
Natural varianti332 – 3321I → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_035574
Natural varianti364 – 3641V → M.
Corresponds to variant rs11539696 [ dbSNP | Ensembl ].
VAR_057415
Natural varianti445 – 4451L → F in a breast cancer sample; somatic mutation. 1 Publication
VAR_035575

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF209198 mRNA. Translation: AAF85941.1. Different initiation.
AF308819 mRNA. Translation: AAL55819.1.
AC004112 Genomic DNA. Translation: AAS07407.1.
AC004111 Genomic DNA. Translation: AAS07413.1. Different initiation.
CH471070 Genomic DNA. Translation: EAW83461.1.
CCDSiCCDS5755.2.
RefSeqiNP_068834.2. NM_021994.2.
UniGeneiHs.655904.

Genome annotation databases

EnsembliENST00000361822; ENSP00000354501; ENSG00000198839.
GeneIDi11179.
KEGGihsa:11179.
UCSCiuc003vge.2. human.

Polymorphism databases

DMDMi251757417.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF209198 mRNA. Translation: AAF85941.1 . Different initiation.
AF308819 mRNA. Translation: AAL55819.1 .
AC004112 Genomic DNA. Translation: AAS07407.1 .
AC004111 Genomic DNA. Translation: AAS07413.1 . Different initiation.
CH471070 Genomic DNA. Translation: EAW83461.1 .
CCDSi CCDS5755.2.
RefSeqi NP_068834.2. NM_021994.2.
UniGenei Hs.655904.

3D structure databases

ProteinModelPortali Q9NRM2.
SMRi Q9NRM2. Positions 223-255, 300-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116349. 10 interactions.
IntActi Q9NRM2. 11 interactions.
STRINGi 9606.ENSP00000354501.

Polymorphism databases

DMDMi 251757417.

Proteomic databases

MaxQBi Q9NRM2.
PaxDbi Q9NRM2.
PRIDEi Q9NRM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361822 ; ENSP00000354501 ; ENSG00000198839 .
GeneIDi 11179.
KEGGi hsa:11179.
UCSCi uc003vge.2. human.

Organism-specific databases

CTDi 11179.
GeneCardsi GC07P111846.
HGNCi HGNC:13070. ZNF277.
HPAi HPA027307.
MIMi 605465. gene.
neXtProti NX_Q9NRM2.
PharmGKBi PA37646.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275991.
GeneTreei ENSGT00390000010852.
HOGENOMi HOG000247001.
HOVERGENi HBG054015.
InParanoidi Q9NRM2.
OMAi CEKQAET.
OrthoDBi EOG77HDDS.
PhylomeDBi Q9NRM2.
TreeFami TF318036.

Miscellaneous databases

GeneWikii ZNF277P.
GenomeRNAii 11179.
NextBioi 42539.
PROi Q9NRM2.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRM2.
ExpressionAtlasi Q9NRM2. baseline and differential.
Genevestigatori Q9NRM2.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277."
    Liang H., Guo W., Nagarajan L.
    Genomics 66:226-228(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The putative nuclear receptor coregulator NRIF4."
    Li D., Desai-Yajnik V., Samuels H.H.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-332 AND PHE-445.

Entry informationi

Entry nameiZN277_HUMAN
AccessioniPrimary (citable) accession number: Q9NRM2
Secondary accession number(s): Q75MZ2, Q75MZ3, Q8WY14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3