Q9NRM2 (ZN277_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 277

Alternative name(s):
Nuclear receptor-interacting factor 4

Gene names

Name:	ZNF277
Synonyms:	NRIF4, ZNF277P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the ZNF277 family. Contains 2 C2H2-type zinc fingers.
Sequence caution	The sequence AAF85941.1 differs from that shown. Reason: Erroneous initiation. The sequence AAS07413.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Zinc finger protein 277		PRO_0000047503
Regions
	Zinc finger	224 – 248	25	C2H2-type 1
	Zinc finger	355 – 381	27	C2H2-type 2
Natural variations
	Natural variant	174	1	V → I. Corresponds to variant rs34571830 [ dbSNP | Ensembl ].		VAR_059908
	Natural variant	332	1	I → L in a breast cancer sample; somatic mutation. Ref.5		VAR_035574
	Natural variant	364	1	V → M. Corresponds to variant rs11539696 [ dbSNP | Ensembl ].		VAR_057415
	Natural variant	445	1	L → F in a breast cancer sample; somatic mutation. Ref.5		VAR_035575

Sequences

	Sequence		Length	Mass (Da)
	Q9NRM2 [UniParc]. Last modified July 7, 2009. Version 2. Checksum: 07A35E08BB6E9521	FASTA	450	52,788
	10 20 30 40 50 60 MAASKTQGAV ARMQEDRDGS CSTVGGVGYG DSKDCILEPL SLPESPGGTT TLEGSPSVPC 70 80 90 100 110 120 IFCEEHFPVA EQDKLLKHMI IEHKIVIADV KLVADFQRYI LYWRKRFTEQ PITDFCSVIR 130 140 150 160 170 180 INSTAPFEEQ ENYFLLCDVL PEDRILREEL QKQRLREILE QQQQERNDTN FHGVCMFCNE 190 200 210 220 230 240 EFLGNRSVIL NHMAREHAFN IGLPDNIVNC NEFLCTLQKK LDNLQCLYCE KTFRDKNTLK 250 260 270 280 290 300 DHMRKKQHRK INPKNREYDR FYVINYLELG KSWEEVQLED DRELLDHQED DWSDWEEHPA 310 320 330 340 350 360 SAVCLFCEKQ AETIEKLYVH MEDAHEFDLL KIKSELGLNF YQQVKLVNFI RRQVHQCRCY 370 380 390 400 410 420 GCHVKFKSKA DLRTHMEETK HTSLLPDRKT WDQLEYYFPT YENDTLLCTL SDSESDLTAQ 430 440 450 EQNENVPIIS EDTSKLYALK QSSILNQLLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277." Liang H., Guo W., Nagarajan L. Genomics 66:226-228(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The putative nuclear receptor coregulator NRIF4." Li D., Desai-Yajnik V., Samuels H.H. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-332 AND PHE-445.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF209198 mRNA. Translation: AAF85941.1. Different initiation. AF308819 mRNA. Translation: AAL55819.1. AC004112 Genomic DNA. Translation: AAS07407.1. AC004111 Genomic DNA. Translation: AAS07413.1. Different initiation. CH471070 Genomic DNA. Translation: EAW83461.1.
IPI	IPI00465033.
RefSeq	NP_068834.2. NM_021994.2.
UniGene	Hs.655904.
3D structure databases
ProteinModelPortal	Q9NRM2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NRM2. 11 interactions.
STRING	9606.ENSP00000354501.
Polymorphism databases
DMDM	251757417.
Proteomic databases
PaxDb	Q9NRM2.
PRIDE	Q9NRM2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361822; ENSP00000354501; ENSG00000198839.
GeneID	11179.
KEGG	hsa:11179.
UCSC	uc003vge.2. human.
Organism-specific databases
CTD	11179.
GeneCards	GC07P111846.
HGNC	HGNC:13070. ZNF277.
HPA	HPA027307.
MIM	605465. gene.
neXtProt	NX_Q9NRM2.
PharmGKB	PA37646.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG275991.
HOGENOM	HOG000247001.
HOVERGEN	HBG054015.
InParanoid	Q9NRM2.
OMA	RCYGCHV.
OrthoDB	EOG47H5PW.
PhylomeDB	Q9NRM2.
Gene expression databases
ArrayExpress	Q9NRM2.
Bgee	Q9NRM2.
Genevestigator	Q9NRM2.
GermOnline	ENSG00000198839. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11179.
NextBio	42539.
SOURCE	Search...

Entry information

Entry name

ZN277_HUMAN

Accession

Primary (citable) accession number: Q9NRM2
Secondary accession number(s): Q75MZ2, Q75MZ3, Q8WY14

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.