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Q9NRM2

- ZN277_HUMAN

UniProt

Q9NRM2 - ZN277_HUMAN

Protein

Zinc finger protein 277

Gene

ZNF277

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri224 – 24825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri355 – 38127C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 277
    Alternative name(s):
    Nuclear receptor-interacting factor 4
    Gene namesi
    Name:ZNF277
    Synonyms:NRIF4, ZNF277P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:13070. ZNF277.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37646.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 450449Zinc finger protein 277PRO_0000047503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9NRM2.
    PaxDbiQ9NRM2.
    PRIDEiQ9NRM2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NRM2.
    BgeeiQ9NRM2.
    GenevestigatoriQ9NRM2.

    Organism-specific databases

    HPAiHPA027307.

    Interactioni

    Protein-protein interaction databases

    BioGridi116349. 6 interactions.
    IntActiQ9NRM2. 11 interactions.
    STRINGi9606.ENSP00000354501.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRM2.
    SMRiQ9NRM2. Positions 173-245, 302-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ZNF277 family.Curated
    Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri224 – 24825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri355 – 38127C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG275991.
    HOGENOMiHOG000247001.
    HOVERGENiHBG054015.
    InParanoidiQ9NRM2.
    OMAiCEKQAET.
    OrthoDBiEOG77HDDS.
    PhylomeDBiQ9NRM2.
    TreeFamiTF318036.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NRM2-1 [UniParc]FASTAAdd to Basket

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    MAASKTQGAV ARMQEDRDGS CSTVGGVGYG DSKDCILEPL SLPESPGGTT    50
    TLEGSPSVPC IFCEEHFPVA EQDKLLKHMI IEHKIVIADV KLVADFQRYI 100
    LYWRKRFTEQ PITDFCSVIR INSTAPFEEQ ENYFLLCDVL PEDRILREEL 150
    QKQRLREILE QQQQERNDTN FHGVCMFCNE EFLGNRSVIL NHMAREHAFN 200
    IGLPDNIVNC NEFLCTLQKK LDNLQCLYCE KTFRDKNTLK DHMRKKQHRK 250
    INPKNREYDR FYVINYLELG KSWEEVQLED DRELLDHQED DWSDWEEHPA 300
    SAVCLFCEKQ AETIEKLYVH MEDAHEFDLL KIKSELGLNF YQQVKLVNFI 350
    RRQVHQCRCY GCHVKFKSKA DLRTHMEETK HTSLLPDRKT WDQLEYYFPT 400
    YENDTLLCTL SDSESDLTAQ EQNENVPIIS EDTSKLYALK QSSILNQLLL 450
    Length:450
    Mass (Da):52,788
    Last modified:July 7, 2009 - v2
    Checksum:i07A35E08BB6E9521
    GO

    Sequence cautioni

    The sequence AAF85941.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAS07413.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti174 – 1741V → I.
    Corresponds to variant rs34571830 [ dbSNP | Ensembl ].
    VAR_059908
    Natural varianti332 – 3321I → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035574
    Natural varianti364 – 3641V → M.
    Corresponds to variant rs11539696 [ dbSNP | Ensembl ].
    VAR_057415
    Natural varianti445 – 4451L → F in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035575

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF209198 mRNA. Translation: AAF85941.1. Different initiation.
    AF308819 mRNA. Translation: AAL55819.1.
    AC004112 Genomic DNA. Translation: AAS07407.1.
    AC004111 Genomic DNA. Translation: AAS07413.1. Different initiation.
    CH471070 Genomic DNA. Translation: EAW83461.1.
    CCDSiCCDS5755.2.
    RefSeqiNP_068834.2. NM_021994.2.
    UniGeneiHs.655904.

    Genome annotation databases

    EnsembliENST00000361822; ENSP00000354501; ENSG00000198839.
    GeneIDi11179.
    KEGGihsa:11179.
    UCSCiuc003vge.2. human.

    Polymorphism databases

    DMDMi251757417.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF209198 mRNA. Translation: AAF85941.1 . Different initiation.
    AF308819 mRNA. Translation: AAL55819.1 .
    AC004112 Genomic DNA. Translation: AAS07407.1 .
    AC004111 Genomic DNA. Translation: AAS07413.1 . Different initiation.
    CH471070 Genomic DNA. Translation: EAW83461.1 .
    CCDSi CCDS5755.2.
    RefSeqi NP_068834.2. NM_021994.2.
    UniGenei Hs.655904.

    3D structure databases

    ProteinModelPortali Q9NRM2.
    SMRi Q9NRM2. Positions 173-245, 302-377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116349. 6 interactions.
    IntActi Q9NRM2. 11 interactions.
    STRINGi 9606.ENSP00000354501.

    Polymorphism databases

    DMDMi 251757417.

    Proteomic databases

    MaxQBi Q9NRM2.
    PaxDbi Q9NRM2.
    PRIDEi Q9NRM2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361822 ; ENSP00000354501 ; ENSG00000198839 .
    GeneIDi 11179.
    KEGGi hsa:11179.
    UCSCi uc003vge.2. human.

    Organism-specific databases

    CTDi 11179.
    GeneCardsi GC07P111846.
    HGNCi HGNC:13070. ZNF277.
    HPAi HPA027307.
    MIMi 605465. gene.
    neXtProti NX_Q9NRM2.
    PharmGKBi PA37646.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275991.
    HOGENOMi HOG000247001.
    HOVERGENi HBG054015.
    InParanoidi Q9NRM2.
    OMAi CEKQAET.
    OrthoDBi EOG77HDDS.
    PhylomeDBi Q9NRM2.
    TreeFami TF318036.

    Miscellaneous databases

    GeneWikii ZNF277P.
    GenomeRNAii 11179.
    NextBioi 42539.
    PROi Q9NRM2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NRM2.
    Bgeei Q9NRM2.
    Genevestigatori Q9NRM2.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277."
      Liang H., Guo W., Nagarajan L.
      Genomics 66:226-228(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The putative nuclear receptor coregulator NRIF4."
      Li D., Desai-Yajnik V., Samuels H.H.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-332 AND PHE-445.

    Entry informationi

    Entry nameiZN277_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRM2
    Secondary accession number(s): Q75MZ2, Q75MZ3, Q8WY14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3