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Q9NRK6

- ABCBA_HUMAN

UniProt

Q9NRK6 - ABCBA_HUMAN

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Protein
ATP-binding cassette sub-family B member 10, mitochondrial
Gene
ABCB10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May mediate critical mitochondrial transport functions related to heme biosynthesis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi527 – 5348ATP

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  3. transporter activity Source: UniProtKB

GO - Biological processi

  1. transmembrane transport Source: RefGenome
  2. transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.43. 2681.
ReactomeiREACT_111108. Mitochondrial ABC transporters.

Protein family/group databases

TCDBi3.A.1.201.17. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 10, mitochondrial
Alternative name(s):
ATP-binding cassette transporter 10
Short name:
ABC transporter 10 protein
Mitochondrial ATP-binding cassette 2
Short name:
M-ABC2
Gene namesi
Name:ABCB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:41. ABCB10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 170Mitochondrial intermembrane Reviewed prediction
Transmembranei171 – 19121Helical; Reviewed prediction
Add
BLAST
Topological domaini192 – 21524Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Reviewed prediction
Add
BLAST
Topological domaini237 – 31276Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei313 – 33321Helical; Reviewed prediction
Add
BLAST
Topological domaini334 – 40774Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei408 – 42821Helical; Reviewed prediction
Add
BLAST
Topological domaini429 – 4302Mitochondrial intermembrane Reviewed prediction
Transmembranei431 – 45121Helical; Reviewed prediction
Add
BLAST
Topological domaini452 – 738287Mitochondrial matrix Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of mitochondrial membrane Source: UniProtKB
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 105105Mitochondrion
Add
BLAST
Chaini106 – 738633ATP-binding cassette sub-family B member 10, mitochondrial
PRO_0000000255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NRK6.
PaxDbiQ9NRK6.
PRIDEiQ9NRK6.

PTM databases

PhosphoSiteiQ9NRK6.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.

Gene expression databases

ArrayExpressiQ9NRK6.
BgeeiQ9NRK6.
CleanExiHS_ABCB10.
GenevestigatoriQ9NRK6.

Organism-specific databases

HPAiCAB044063.
CAB044065.

Interactioni

Subunit structurei

Homodimer or homooligomer.2 Publications

Protein-protein interaction databases

BioGridi117020. 9 interactions.
IntActiQ9NRK6. 1 interaction.
STRINGi9606.ENSP00000355637.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi154 – 16411
Helixi165 – 1673
Helixi168 – 18518
Helixi188 – 20114
Helixi208 – 25548
Helixi260 – 2656
Helixi268 – 28518
Helixi288 – 31023
Helixi312 – 35948
Helixi361 – 3666
Helixi370 – 42253
Helixi428 – 46942
Turni485 – 4873
Beta strandi492 – 4998
Beta strandi502 – 5043
Beta strandi509 – 5179
Beta strandi522 – 5265
Helixi530 – 54011
Beta strandi547 – 5537
Helixi558 – 5603
Helixi563 – 5686
Beta strandi569 – 5735
Beta strandi581 – 5833
Helixi584 – 5896
Beta strandi592 – 5943
Turni595 – 5973
Helixi600 – 60910
Helixi613 – 6175
Beta strandi619 – 6213
Helixi622 – 6243
Beta strandi628 – 6314
Helixi636 – 65015
Beta strandi653 – 6586
Helixi666 – 68015
Beta strandi683 – 6886
Helixi692 – 6976
Beta strandi698 – 7047
Beta strandi706 – 7138
Helixi715 – 7195

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZDQX-ray2.85A152-738[»]
4AYTX-ray2.85A152-738[»]
4AYWX-ray3.30A1-738[»]
4AYXX-ray2.90A152-738[»]
ProteinModelPortaliQ9NRK6.
SMRiQ9NRK6. Positions 153-722.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini171 – 457287ABC transmembrane type-1
Add
BLAST
Domaini492 – 731240ABC transporter
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOVERGENiHBG008358.
InParanoidiQ9NRK6.
KOiK05657.
OMAiIEVNRYN.
OrthoDBiEOG7Z3F4H.
PhylomeDBiQ9NRK6.
TreeFamiTF105198.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRK6-1 [UniParc]FASTAAdd to Basket

« Hide

MRGPPAWPLR LLEPPSPAEP GRLLPVACVW AAASRVPGSL SPFTGLRPAR    50
LWGAGPALLW GVGAARRWRS GCRGGGPGAS RGVLGLARLL GLWARGPGSC 100
RCGAFAGPGA PRLPRARFPG GPAAAAWAGD EAWRRGPAAP PGDKGRLRPA 150
AAGLPEARKL LGLAYPERRR LAAAVGFLTM SSVISMSAPF FLGKIIDVIY 200
TNPTVDYSDN LTRLCLGLSA VFLCGAAANA IRVYLMQTSG QRIVNRLRTS 250
LFSSILRQEV AFFDKTRTGE LINRLSSDTA LLGRSVTENL SDGLRAGAQA 300
SVGISMMFFV SPNLATFVLS VVPPVSIIAV IYGRYLRKLT KVTQDSLAQA 350
TQLAEERIGN VRTVRAFGKE MTEIEKYASK VDHVMQLARK EAFARAGFFG 400
ATGLSGNLIV LSVLYKGGLL MGSAHMTVGE LSSFLMYAFW VGISIGGLSS 450
FYSELMKGLG AGGRLWELLE REPKLPFNEG VILNEKSFQG ALEFKNVHFA 500
YPARPEVPIF QDFSLSIPSG SVTALVGPSG SGKSTVLSLL LRLYDPASGT 550
ISLDGHDIRQ LNPVWLRSKI GTVSQEPILF SCSIAENIAY GADDPSSVTA 600
EEIQRVAEVA NAVAFIRNFP QGFNTVVGEK GVLLSGGQKQ RIAIARALLK 650
NPKILLLDEA TSALDAENEY LVQEALDRLM DGRTVLVIAH RLSTIKNANM 700
VAVLDQGKIT EYGKHEELLS KPNGIYRKLM NKQSFISA 738
Length:738
Mass (Da):79,148
Last modified:April 3, 2007 - v2
Checksum:iC68B4FAC0F8B7E43
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501A → S.1 Publication
Corresponds to variant rs4148756 [ dbSNP | Ensembl ].
VAR_013702
Natural varianti242 – 2421R → G.
Corresponds to variant rs17584642 [ dbSNP | Ensembl ].
VAR_048133
Natural varianti471 – 4711R → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_035735
Natural varianti545 – 5451D → N.1 Publication
Corresponds to variant rs35698797 [ dbSNP | Ensembl ].
VAR_031435

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti393 – 3931F → V in AAF78198. 1 Publication
Sequence conflicti511 – 5111Q → K in AAA84438. 1 Publication
Sequence conflicti558 – 5636IRQLNP → NPSAKPS in AAA84438. 1 Publication
Sequence conflicti606 – 6116VAEVAN → GLKGQ in BAB20265. 1 Publication
Sequence conflicti615 – 6228FIRNFPQG → SPEFPPR in AAA84438. 1 Publication
Sequence conflicti691 – 6911R → S in AAA84438. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF216833 mRNA. Translation: AAF78198.1.
AB013380 mRNA. Translation: BAB20265.1.
AL121990 Genomic DNA. Translation: CAI22012.1.
CH471098 Genomic DNA. Translation: EAW69901.1.
BC064930 mRNA. Translation: AAH64930.1.
U18237 mRNA. Translation: AAA84438.1.
CCDSiCCDS1580.1.
RefSeqiNP_036221.2. NM_012089.2.
UniGeneiHs.17614.

Genome annotation databases

EnsembliENST00000344517; ENSP00000355637; ENSG00000135776.
GeneIDi23456.
KEGGihsa:23456.
UCSCiuc001htp.4. human.

Polymorphism databases

DMDMi143811359.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF216833 mRNA. Translation: AAF78198.1 .
AB013380 mRNA. Translation: BAB20265.1 .
AL121990 Genomic DNA. Translation: CAI22012.1 .
CH471098 Genomic DNA. Translation: EAW69901.1 .
BC064930 mRNA. Translation: AAH64930.1 .
U18237 mRNA. Translation: AAA84438.1 .
CCDSi CCDS1580.1.
RefSeqi NP_036221.2. NM_012089.2.
UniGenei Hs.17614.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZDQ X-ray 2.85 A 152-738 [» ]
4AYT X-ray 2.85 A 152-738 [» ]
4AYW X-ray 3.30 A 1-738 [» ]
4AYX X-ray 2.90 A 152-738 [» ]
ProteinModelPortali Q9NRK6.
SMRi Q9NRK6. Positions 153-722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117020. 9 interactions.
IntActi Q9NRK6. 1 interaction.
STRINGi 9606.ENSP00000355637.

Protein family/group databases

TCDBi 3.A.1.201.17. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei Q9NRK6.

Polymorphism databases

DMDMi 143811359.

Proteomic databases

MaxQBi Q9NRK6.
PaxDbi Q9NRK6.
PRIDEi Q9NRK6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344517 ; ENSP00000355637 ; ENSG00000135776 .
GeneIDi 23456.
KEGGi hsa:23456.
UCSCi uc001htp.4. human.

Organism-specific databases

CTDi 23456.
GeneCardsi GC01M229652.
H-InvDB HIX0028493.
HGNCi HGNC:41. ABCB10.
HPAi CAB044063.
CAB044065.
MIMi 605454. gene.
neXtProti NX_Q9NRK6.
PharmGKBi PA24385.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
HOVERGENi HBG008358.
InParanoidi Q9NRK6.
KOi K05657.
OMAi IEVNRYN.
OrthoDBi EOG7Z3F4H.
PhylomeDBi Q9NRK6.
TreeFami TF105198.

Enzyme and pathway databases

BRENDAi 3.6.3.43. 2681.
Reactomei REACT_111108. Mitochondrial ABC transporters.

Miscellaneous databases

GenomeRNAii 23456.
NextBioi 45747.
PROi Q9NRK6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NRK6.
Bgeei Q9NRK6.
CleanExi HS_ABCB10.
Genevestigatori Q9NRK6.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein."
    Zhang F., Hogue D.L., Liu L., Fisher C.L., Hui D., Childs S., Ling V.
    FEBS Lett. 478:89-94(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-545.
    Tissue: Lymphoblast.
  2. "Human mono ATP-binding cassette protein."
    Ito K., Suzuki H., Sugiyama Y.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "Characterization and mapping of three new mammalian ATP-binding transporter genes from an EST database."
    Allikmets R., Gerrard B., Glavac D., Ravnik-Glavac M., Jenkins N.A., Gilbert D.J., Copeland N.G., Modi W., Dean M.
    Mamm. Genome 6:114-117(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 510-738.
  7. "Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me)."
    Graf S.A., Haigh S.E., Corson E.D., Shirihai O.S.
    J. Biol. Chem. 279:42954-42963(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSIT PEPTIDE CLEAVAGE SITE, SUBUNIT.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 152-738 ALONE AND IN COMPLEX WITH ATP ANALOGS, ATP-BINDING REGION, SUBUNIT.
  11. "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
    Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
    J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-150.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-471.

Entry informationi

Entry nameiABCBA_HUMAN
AccessioniPrimary (citable) accession number: Q9NRK6
Secondary accession number(s): Q13040, Q6P1Q8, Q9H3V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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