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Protein

Protocadherin beta-16

Gene

PCDHB16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:G66-33237-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin beta-16
Short name:
PCDH-beta-16
Alternative name(s):
Protocadherin-3X
Gene namesi
Name:PCDHB16
Synonyms:KIAA1621, PCDH3X
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14546. PCDHB16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 690ExtracellularSequence analysisAdd BLAST662
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 776CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33032.

Polymorphism and mutation databases

BioMutaiPCDHB16.
DMDMi308153560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000394429 – 776Protocadherin beta-16Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi436N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NRJ7.
PaxDbiQ9NRJ7.
PeptideAtlasiQ9NRJ7.
PRIDEiQ9NRJ7.

PTM databases

iPTMnetiQ9NRJ7.
PhosphoSitePlusiQ9NRJ7.

Expressioni

Gene expression databases

BgeeiENSG00000196963.
CleanExiHS_PCDHB16.
ExpressionAtlasiQ9NRJ7. baseline and differential.
GenevisibleiQ9NRJ7. HS.

Organism-specific databases

HPAiHPA014668.

Interactioni

Protein-protein interaction databases

BioGridi121740. 35 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9NRJ7.
SMRiQ9NRJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini138 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini247 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST101
Domaini352 – 451Cadherin 4PROSITE-ProRule annotationAdd BLAST100
Domaini456 – 561Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini568 – 671Cadherin 6PROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9NRJ7.
KOiK16494.
OrthoDBiEOG091G024L.
PhylomeDBiQ9NRJ7.
TreeFamiTF332299.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIGWMHNRR QRQVLVFFVL LSLSGAGAEL GSYSVVEETE RGSFVANLGK
60 70 80 90 100
DLGLGLTEMS TRKARIISQG NKQHLQLKAQ TGDLLINEKL DREELCGPTE
110 120 130 140 150
PCILHFQVLM ENPLEIFQAE LRVIDINDHS PMFTEKEMIL KIPENSPLGT
160 170 180 190 200
EFPLNHALDL DVGSNNVQNY KISPSSHFRV LIHEFRDGRK YPELVLDKEL
210 220 230 240 250
DREEEPQLRL TLTALDGGSP PRSGTAQVRI EVVDINDNAP EFEQPIYKVQ
260 270 280 290 300
IPENSPLGSL VATVSARDLD GGANGKISYT LFQPSEDISK TLEVNPMTGE
310 320 330 340 350
VRLRKQVDFE MVTSYEVRIK ATDGGGLSGK CTLLLQVVDV NDNPPQVTMS
360 370 380 390 400
ALTSPIPENS PEIVVAVFSV SDPDSGNNGK TISSIQEDLP FLLKPSVKNF
410 420 430 440 450
YTLVTERALD REARAEYNIT LTVTDMGTPR LKTEHNITVQ ISDVNDNAPT
460 470 480 490 500
FTQTSYTLFV RENNSPALHI GSVSATDRDS GTNAQVTYSL LPPQDPHLPL
510 520 530 540 550
ASLVSINADN GHLFALRSLD YEALREFEFR VSATDRGSPA LSSEALVRVL
560 570 580 590 600
VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA
610 620 630 640 650
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP
660 670 680 690 700
PRSATATLHV LLVDGFSQPF LPLPEAAPGQ TQANSLTVYL VVALASVSSL
710 720 730 740 750
FLFSVLLFVA VRLCRRSRAA SVGRCSMPEG PFPGRLVDVS GTGTLSQSYQ
760 770
YEVCLTGGSE TSEFKFLKPI IPNFSP
Length:776
Mass (Da):84,983
Last modified:October 5, 2010 - v3
Checksum:i03F420D3098D6032
GO

Sequence cautioni

The sequence BAB13447 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357P → A in AAH36062 (PubMed:15489334).Curated1
Sequence conflicti482T → I in BAB13447 (PubMed:10997877).Curated1
Sequence conflicti526E → A in AAF81914 (PubMed:11322959).Curated1
Sequence conflicti526E → A in AAG10030 (PubMed:11322959).Curated1
Sequence conflicti526E → A in AAH36062 (PubMed:15489334).Curated1
Sequence conflicti543S → R in AAF81914 (PubMed:11322959).Curated1
Sequence conflicti543S → R in AAG10030 (PubMed:11322959).Curated1
Sequence conflicti543S → R in AAH36062 (PubMed:15489334).Curated1
Sequence conflicti560F → L in AAH36062 (PubMed:15489334).Curated1
Sequence conflicti638Q → H in BAB13447 (PubMed:10997877).Curated1
Sequence conflicti652R → C in BAB13447 (PubMed:10997877).Curated1
Sequence conflicti710A → V in BAB13447 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05558791D → E.Corresponds to variant rs17096969dbSNPEnsembl.1
Natural variantiVAR_061068347V → L.Corresponds to variant rs28664170dbSNPEnsembl.1
Natural variantiVAR_061069508A → T.Corresponds to variant rs56327450dbSNPEnsembl.1
Natural variantiVAR_026478525R → Q.2 PublicationsCorresponds to variant rs17844651dbSNPEnsembl.1
Natural variantiVAR_026479532S → G.2 PublicationsCorresponds to variant rs2697532dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217757 mRNA. Translation: AAF81914.1.
AF282973 Genomic DNA. Translation: AAG10030.1.
AY013878 mRNA. Translation: AAK21988.1.
AB046841 mRNA. Translation: BAB13447.1. Different initiation.
AK056460 mRNA. Translation: BAG51717.1.
AC074130 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61975.1.
BC036062 mRNA. Translation: AAH36062.1.
CCDSiCCDS4251.1.
RefSeqiNP_066008.2. NM_020957.3.
UniGeneiHs.147674.
Hs.582172.

Genome annotation databases

EnsembliENST00000609684; ENSP00000477314; ENSG00000272674.
GeneIDi57717.
KEGGihsa:57717.
UCSCiuc032vnl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217757 mRNA. Translation: AAF81914.1.
AF282973 Genomic DNA. Translation: AAG10030.1.
AY013878 mRNA. Translation: AAK21988.1.
AB046841 mRNA. Translation: BAB13447.1. Different initiation.
AK056460 mRNA. Translation: BAG51717.1.
AC074130 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61975.1.
BC036062 mRNA. Translation: AAH36062.1.
CCDSiCCDS4251.1.
RefSeqiNP_066008.2. NM_020957.3.
UniGeneiHs.147674.
Hs.582172.

3D structure databases

ProteinModelPortaliQ9NRJ7.
SMRiQ9NRJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121740. 35 interactors.

PTM databases

iPTMnetiQ9NRJ7.
PhosphoSitePlusiQ9NRJ7.

Polymorphism and mutation databases

BioMutaiPCDHB16.
DMDMi308153560.

Proteomic databases

EPDiQ9NRJ7.
PaxDbiQ9NRJ7.
PeptideAtlasiQ9NRJ7.
PRIDEiQ9NRJ7.

Protocols and materials databases

DNASUi57717.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000609684; ENSP00000477314; ENSG00000272674.
GeneIDi57717.
KEGGihsa:57717.
UCSCiuc032vnl.2. human.

Organism-specific databases

CTDi57717.
GeneCardsiPCDHB16.
HGNCiHGNC:14546. PCDHB16.
HPAiHPA014668.
MIMi604967. gene.
606345. gene.
neXtProtiNX_Q9NRJ7.
PharmGKBiPA33032.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ9NRJ7.
KOiK16494.
OrthoDBiEOG091G024L.
PhylomeDBiQ9NRJ7.
TreeFamiTF332299.

Enzyme and pathway databases

BioCyciZFISH:G66-33237-MONOMER.

Miscellaneous databases

GeneWikiiPCDHB16.
GenomeRNAii57717.
PROiQ9NRJ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196963.
CleanExiHS_PCDHB16.
ExpressionAtlasiQ9NRJ7. baseline and differential.
GenevisibleiQ9NRJ7. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBG_HUMAN
AccessioniPrimary (citable) accession number: Q9NRJ7
Secondary accession number(s): B3KPK5
, Q8IYD5, Q96SE9, Q9HCF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.