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Q9NRJ7 (PCDBG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin beta-16

Short name=PCDH-beta-16
Alternative name(s):
Protocadherin-3X
Gene names
Name:PCDHB16
Synonyms:KIAA1621, PCDH3X
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length776 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Sequence caution

The sequence BAB13447.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 776748Protocadherin beta-16
PRO_0000003944

Regions

Topological domain29 – 690662Extracellular Potential
Transmembrane691 – 71121Helical; Potential
Topological domain712 – 77665Cytoplasmic Potential
Domain35 – 13399Cadherin 1
Domain138 – 242105Cadherin 2
Domain247 – 347101Cadherin 3
Domain352 – 451100Cadherin 4
Domain456 – 561106Cadherin 5
Domain568 – 671104Cadherin 6

Amino acid modifications

Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential
Glycosylation5671N-linked (GlcNAc...) Potential

Natural variations

Natural variant911D → E.
Corresponds to variant rs17096969 [ dbSNP | Ensembl ].
VAR_055587
Natural variant3471V → L.
Corresponds to variant rs28664170 [ dbSNP | Ensembl ].
VAR_061068
Natural variant5081A → T.
Corresponds to variant rs56327450 [ dbSNP | Ensembl ].
VAR_061069
Natural variant5251R → Q. Ref.1 Ref.7
Corresponds to variant rs17844651 [ dbSNP | Ensembl ].
VAR_026478
Natural variant5321S → G. Ref.1 Ref.7
Corresponds to variant rs2697532 [ dbSNP | Ensembl ].
VAR_026479

Experimental info

Sequence conflict3571P → A in AAH36062. Ref.7
Sequence conflict4821T → I in BAB13447. Ref.3
Sequence conflict5261E → A in AAF81914. Ref.1
Sequence conflict5261E → A in AAG10030. Ref.1
Sequence conflict5261E → A in AAH36062. Ref.7
Sequence conflict5431S → R in AAF81914. Ref.1
Sequence conflict5431S → R in AAG10030. Ref.1
Sequence conflict5431S → R in AAH36062. Ref.7
Sequence conflict5601F → L in AAH36062. Ref.7
Sequence conflict6381Q → H in BAB13447. Ref.3
Sequence conflict6521R → C in BAB13447. Ref.3
Sequence conflict7101A → V in BAB13447. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9NRJ7 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 03F420D3098D6032

FASTA77684,983
        10         20         30         40         50         60 
MEIGWMHNRR QRQVLVFFVL LSLSGAGAEL GSYSVVEETE RGSFVANLGK DLGLGLTEMS 

        70         80         90        100        110        120 
TRKARIISQG NKQHLQLKAQ TGDLLINEKL DREELCGPTE PCILHFQVLM ENPLEIFQAE 

       130        140        150        160        170        180 
LRVIDINDHS PMFTEKEMIL KIPENSPLGT EFPLNHALDL DVGSNNVQNY KISPSSHFRV 

       190        200        210        220        230        240 
LIHEFRDGRK YPELVLDKEL DREEEPQLRL TLTALDGGSP PRSGTAQVRI EVVDINDNAP 

       250        260        270        280        290        300 
EFEQPIYKVQ IPENSPLGSL VATVSARDLD GGANGKISYT LFQPSEDISK TLEVNPMTGE 

       310        320        330        340        350        360 
VRLRKQVDFE MVTSYEVRIK ATDGGGLSGK CTLLLQVVDV NDNPPQVTMS ALTSPIPENS 

       370        380        390        400        410        420 
PEIVVAVFSV SDPDSGNNGK TISSIQEDLP FLLKPSVKNF YTLVTERALD REARAEYNIT 

       430        440        450        460        470        480 
LTVTDMGTPR LKTEHNITVQ ISDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS 

       490        500        510        520        530        540 
GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALREFEFR VSATDRGSPA 

       550        560        570        580        590        600 
LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 

       610        620        630        640        650        660 
WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP PRSATATLHV 

       670        680        690        700        710        720 
LLVDGFSQPF LPLPEAAPGQ TQANSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA 

       730        740        750        760        770 
SVGRCSMPEG PFPGRLVDVS GTGTLSQSYQ YEVCLTGGSE TSEFKFLKPI IPNFSP 

« Hide

References

« Hide 'large scale' references
[1]"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number."
Vanhalst K., Kools P., Vanden Eynde E., van Roy F.
FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS GLN-525 AND GLY-532.
[2]"Comparative DNA sequence analysis of mouse and human protocadherin gene clusters."
Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.
Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-525 AND GLY-532.
Tissue: Brain.
[8]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 518-525.
Tissue: Platelet.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF217757 mRNA. Translation: AAF81914.1.
AF282973 Genomic DNA. Translation: AAG10030.1.
AY013878 mRNA. Translation: AAK21988.1.
AB046841 mRNA. Translation: BAB13447.1. Different initiation.
AK056460 mRNA. Translation: BAG51717.1.
AC074130 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61975.1.
BC036062 mRNA. Translation: AAH36062.1.
RefSeqNP_066008.2. NM_020957.3.
UniGeneHs.147674.
Hs.582172.

3D structure databases

ProteinModelPortalQ9NRJ7.
SMRQ9NRJ7. Positions 32-677.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9NRJ7.

Polymorphism databases

DMDM308153560.

Proteomic databases

PaxDbQ9NRJ7.
PRIDEQ9NRJ7.

Protocols and materials databases

DNASU57717.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361016; ENSP00000354293; ENSG00000196963.
GeneID57717.
KEGGhsa:57717.
UCSCuc003liv.3. human.

Organism-specific databases

CTD57717.
GeneCardsGC05P140561.
HGNCHGNC:14546. PCDHB16.
HPAHPA014668.
HPA016475.
MIM604967. gene.
606345. gene.
neXtProtNX_Q9NRJ7.
PharmGKBPA33032.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251260.
HOGENOMHOG000220892.
HOVERGENHBG054878.
InParanoidQ9NRJ7.
KOK16494.
OMAEHNITVQ.
OrthoDBEOG7KSX80.
PhylomeDBQ9NRJ7.
TreeFamTF332299.

Gene expression databases

BgeeQ9NRJ7.
CleanExHS_PCDHB16.
GenevestigatorQ9NRJ7.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPCDHB16.
GenomeRNAi57717.
NextBio64644.
PROQ9NRJ7.
SOURCESearch...

Entry information

Entry namePCDBG_HUMAN
AccessionPrimary (citable) accession number: Q9NRJ7
Secondary accession number(s): B3KPK5 expand/collapse secondary AC list , Q8IYD5, Q96SE9, Q9HCF1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: June 11, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM