Q9NRJ7 (PCDBG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin beta-16
Short name=PCDH-beta-16

Alternative name(s):
Protocadherin-3X

Gene names

Name:	PCDHB16
Synonyms:	KIAA1621, PCDH3X

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	776 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Contains 6 cadherin domains.
Sequence caution	The sequence BAB13447.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	calcium-dependent cell-cell adhesion Non-traceable author statement Ref.1. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro synapse assembly Traceable author statement PubMed 12231349. Source: UniProtKB synaptic transmission Traceable author statement PubMed 12231349. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 776	748	Protocadherin beta-16		PRO_0000003944
Regions
	Topological domain	29 – 690	662	Extracellular Potential
	Transmembrane	691 – 711	21	Helical; Potential
	Topological domain	712 – 776	65	Cytoplasmic Potential
	Domain	35 – 133	99	Cadherin 1
	Domain	138 – 242	105	Cadherin 2
	Domain	247 – 347	101	Cadherin 3
	Domain	352 – 451	100	Cadherin 4
	Domain	456 – 561	106	Cadherin 5
	Domain	568 – 671	104	Cadherin 6
Amino acid modifications
	Glycosylation	418	1	N-linked (GlcNAc...) Potential
	Glycosylation	436	1	N-linked (GlcNAc...) Potential
	Glycosylation	567	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	91	1	D → E. Corresponds to variant rs17096969 [ dbSNP | Ensembl ].		VAR_055587
	Natural variant	347	1	V → L. Corresponds to variant rs28664170 [ dbSNP | Ensembl ].		VAR_061068
	Natural variant	508	1	A → T. Corresponds to variant rs56327450 [ dbSNP | Ensembl ].		VAR_061069
	Natural variant	525	1	R → Q. Ref.1 Ref.7 Corresponds to variant rs17844651 [ dbSNP | Ensembl ].		VAR_026478
	Natural variant	532	1	S → G. Ref.1 Ref.7 Corresponds to variant rs2697532 [ dbSNP | Ensembl ].		VAR_026479
Experimental info
	Sequence conflict	357	1	P → A in AAH36062. Ref.7
	Sequence conflict	482	1	T → I in BAB13447. Ref.3
	Sequence conflict	526	1	E → A in AAF81914. Ref.1
	Sequence conflict	526	1	E → A in AAG10030. Ref.1
	Sequence conflict	526	1	E → A in AAH36062. Ref.7
	Sequence conflict	543	1	S → R in AAF81914. Ref.1
	Sequence conflict	543	1	S → R in AAG10030. Ref.1
	Sequence conflict	543	1	S → R in AAH36062. Ref.7
	Sequence conflict	560	1	F → L in AAH36062. Ref.7
	Sequence conflict	638	1	Q → H in BAB13447. Ref.3
	Sequence conflict	652	1	R → C in BAB13447. Ref.3
	Sequence conflict	710	1	A → V in BAB13447. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9NRJ7 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 03F420D3098D6032	FASTA	776	84,983
	10 20 30 40 50 60 MEIGWMHNRR QRQVLVFFVL LSLSGAGAEL GSYSVVEETE RGSFVANLGK DLGLGLTEMS 70 80 90 100 110 120 TRKARIISQG NKQHLQLKAQ TGDLLINEKL DREELCGPTE PCILHFQVLM ENPLEIFQAE 130 140 150 160 170 180 LRVIDINDHS PMFTEKEMIL KIPENSPLGT EFPLNHALDL DVGSNNVQNY KISPSSHFRV 190 200 210 220 230 240 LIHEFRDGRK YPELVLDKEL DREEEPQLRL TLTALDGGSP PRSGTAQVRI EVVDINDNAP 250 260 270 280 290 300 EFEQPIYKVQ IPENSPLGSL VATVSARDLD GGANGKISYT LFQPSEDISK TLEVNPMTGE 310 320 330 340 350 360 VRLRKQVDFE MVTSYEVRIK ATDGGGLSGK CTLLLQVVDV NDNPPQVTMS ALTSPIPENS 370 380 390 400 410 420 PEIVVAVFSV SDPDSGNNGK TISSIQEDLP FLLKPSVKNF YTLVTERALD REARAEYNIT 430 440 450 460 470 480 LTVTDMGTPR LKTEHNITVQ ISDVNDNAPT FTQTSYTLFV RENNSPALHI GSVSATDRDS 490 500 510 520 530 540 GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALREFEFR VSATDRGSPA 550 560 570 580 590 600 LSSEALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EPGYLVTKVV AVDGDSGQNA 610 620 630 640 650 660 WLSYQLLKAT EPGLFGVWAH NGEVRTARLL SERDAAKQRL VVLVKDNGEP PRSATATLHV 670 680 690 700 710 720 LLVDGFSQPF LPLPEAAPGQ TQANSLTVYL VVALASVSSL FLFSVLLFVA VRLCRRSRAA 730 740 750 760 770 SVGRCSMPEG PFPGRLVDVS GTGTLSQSYQ YEVCLTGGSE TSEFKFLKPI IPNFSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number." Vanhalst K., Kools P., Vanden Eynde E., van Roy F. FEBS Lett. 495:120-125(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS GLN-525 AND GLY-532.
[2]	"Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T. Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-525 AND GLY-532. Tissue: Brain.
[8]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 518-525. Tissue: Platelet.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF217757 mRNA. Translation: AAF81914.1. AF282973 Genomic DNA. Translation: AAG10030.1. AY013878 mRNA. Translation: AAK21988.1. AB046841 mRNA. Translation: BAB13447.1. Different initiation. AK056460 mRNA. Translation: BAG51717.1. AC074130 Genomic DNA. No translation available. CH471062 Genomic DNA. Translation: EAW61975.1. BC036062 mRNA. Translation: AAH36062.1.
IPI	IPI00299853.
RefSeq	NP_066008.1. NM_020957.1.
UniGene	Hs.147674.
3D structure databases
ProteinModelPortal	Q9NRJ7.
SMR	Q9NRJ7. Positions 32-677.
ModBase	Search...
PTM databases
PhosphoSite	Q9NRJ7.
Polymorphism databases
DMDM	308153560.
Proteomic databases
PaxDb	Q9NRJ7.
PRIDE	Q9NRJ7.
Protocols and materials databases
DNASU	57717.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361016; ENSP00000354293; ENSG00000196963.
GeneID	57717.
KEGG	hsa:57717.
UCSC	uc003liv.3. human.
Organism-specific databases
CTD	57717.
GeneCards	GC05P140561.
HGNC	HGNC:14546. PCDHB16.
HPA	HPA014668. HPA016475.
MIM	604967. gene. 606345. gene.
neXtProt	NX_Q9NRJ7.
PharmGKB	PA33032.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG251260.
HOGENOM	HOG000220892.
HOVERGEN	HBG054878.
InParanoid	Q9NRJ7.
KO	K16494.
OMA	RKQVDFE.
OrthoDB	EOG405S19.
PhylomeDB	Q9NRJ7.
Gene expression databases
Bgee	Q9NRJ7.
CleanEx	HS_PCDHB16.
Genevestigator	Q9NRJ7.
GermOnline	ENSG00000196963. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57717.
NextBio	64644.
SOURCE	Search...

Entry information

Entry name

PCDBG_HUMAN

Accession

Primary (citable) accession number: Q9NRJ7
Secondary accession number(s): B3KPK5 , Q8IYD5, Q96SE9, Q9HCF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 111 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.