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Q9NRJ3

- CCL28_HUMAN

UniProt

Q9NRJ3 - CCL28_HUMAN

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Protein

C-C motif chemokine 28

Gene

CCL28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

GO - Molecular functioni

  1. chemokine activity Source: UniProtKB

GO - Biological processi

  1. cell chemotaxis Source: UniProtKB
  2. chemotaxis Source: UniProtKB
  3. immune response Source: InterPro
  4. negative regulation of leukocyte tethering or rolling Source: UniProtKB
  5. positive regulation of cell-matrix adhesion Source: UniProtKB
  6. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  7. response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 28
Alternative name(s):
Mucosae-associated epithelial chemokine
Short name:
MEC
Protein CCK1
Small-inducible cytokine A28
Gene namesi
Name:CCL28
Synonyms:SCYA28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:17700. CCL28.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 127108C-C motif chemokine 28PRO_0000005242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 73By similarity
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NRJ3.
PRIDEiQ9NRJ3.

PTM databases

PhosphoSiteiQ9NRJ3.

Expressioni

Tissue specificityi

Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

Gene expression databases

BgeeiQ9NRJ3.
CleanExiHS_CCL28.
ExpressionAtlasiQ9NRJ3. baseline and differential.
GenevestigatoriQ9NRJ3.

Interactioni

Protein-protein interaction databases

IntActiQ9NRJ3. 2 interactions.
MINTiMINT-6629016.
STRINGi9606.ENSP00000354416.

Structurei

3D structure databases

ProteinModelPortaliQ9NRJ3.
SMRiQ9NRJ3. Positions 23-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41057.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000036970.
HOVERGENiHBG101413.
InParanoidiQ9NRJ3.
KOiK05513.
OMAiHVIKQWM.
OrthoDBiEOG70W3G4.
PhylomeDBiQ9NRJ3.
TreeFamiTF337014.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NRJ3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQRGLAIVA LAVCAALHAS EAILPIASSC CTEVSHHISR RLLERVNMCR
60 70 80 90 100
IQRADGDCDL AAVILHVKRR RICVSPHNHT VKQWMKVQAA KKNGKGNVCH
110 120
RKKHHGKRNS NRAHQGKHET YGHKTPY
Length:127
Mass (Da):14,280
Last modified:October 1, 2000 - v1
Checksum:i3E8551A63A2C8D62
GO
Isoform 2 (identifier: Q9NRJ3-2) [UniParc]FASTAAdd to Basket

Also known as: CCL28chi

The sequence of this isoform differs from the canonical sequence as follows:
     64-127: ILHVKRRRIC...HETYGHKTPY → MLECSDMISA...ARTTILLSSG

Show »
Length:117
Mass (Da):12,375
Checksum:i2E0390498F47B135
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei64 – 12764ILHVK…HKTPY → MLECSDMISAHYNLHLPGSN DSPTSAFQVAGITAFMSSAE ESVSARTTILLSSG in isoform 2. 1 PublicationVSP_047735Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220210 mRNA. Translation: AAF87205.1.
AF266504 mRNA. Translation: AAG16691.1.
AF110384 mRNA. Translation: AAG43193.1.
HM067700 mRNA. Translation: ADH95184.1.
AC025457 Genomic DNA. No translation available.
BC062668 mRNA. Translation: AAH62668.1.
BC069532 mRNA. Translation: AAH69532.1.
CCDSiCCDS3944.1. [Q9NRJ3-1]
RefSeqiNP_683513.1. NM_148672.2. [Q9NRJ3-1]
XP_005248382.1. XM_005248325.1. [Q9NRJ3-2]
UniGeneiHs.656904.

Genome annotation databases

EnsembliENST00000361115; ENSP00000354416; ENSG00000151882. [Q9NRJ3-1]
ENST00000489442; ENSP00000426424; ENSG00000151882. [Q9NRJ3-1]
GeneIDi56477.
KEGGihsa:56477.
UCSCiuc003jnu.3. human. [Q9NRJ3-1]

Polymorphism databases

DMDMi12230650.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

CCL28 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220210 mRNA. Translation: AAF87205.1 .
AF266504 mRNA. Translation: AAG16691.1 .
AF110384 mRNA. Translation: AAG43193.1 .
HM067700 mRNA. Translation: ADH95184.1 .
AC025457 Genomic DNA. No translation available.
BC062668 mRNA. Translation: AAH62668.1 .
BC069532 mRNA. Translation: AAH69532.1 .
CCDSi CCDS3944.1. [Q9NRJ3-1 ]
RefSeqi NP_683513.1. NM_148672.2. [Q9NRJ3-1 ]
XP_005248382.1. XM_005248325.1. [Q9NRJ3-2 ]
UniGenei Hs.656904.

3D structure databases

ProteinModelPortali Q9NRJ3.
SMRi Q9NRJ3. Positions 23-94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9NRJ3. 2 interactions.
MINTi MINT-6629016.
STRINGi 9606.ENSP00000354416.

PTM databases

PhosphoSitei Q9NRJ3.

Polymorphism databases

DMDMi 12230650.

Proteomic databases

PaxDbi Q9NRJ3.
PRIDEi Q9NRJ3.

Protocols and materials databases

DNASUi 56477.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361115 ; ENSP00000354416 ; ENSG00000151882 . [Q9NRJ3-1 ]
ENST00000489442 ; ENSP00000426424 ; ENSG00000151882 . [Q9NRJ3-1 ]
GeneIDi 56477.
KEGGi hsa:56477.
UCSCi uc003jnu.3. human. [Q9NRJ3-1 ]

Organism-specific databases

CTDi 56477.
GeneCardsi GC05M043376.
HGNCi HGNC:17700. CCL28.
MIMi 605240. gene.
neXtProti NX_Q9NRJ3.
PharmGKBi PA38463.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41057.
GeneTreei ENSGT00530000063923.
HOGENOMi HOG000036970.
HOVERGENi HBG101413.
InParanoidi Q9NRJ3.
KOi K05513.
OMAi HVIKQWM.
OrthoDBi EOG70W3G4.
PhylomeDBi Q9NRJ3.
TreeFami TF337014.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii 56477.
NextBioi 35495724.
PROi Q9NRJ3.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRJ3.
CleanExi HS_CCL28.
ExpressionAtlasi Q9NRJ3. baseline and differential.
Genevestigatori Q9NRJ3.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RECEPTOR INTERACTION.
    Tissue: Fetal heart and Osteoblast.
  2. "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."
    Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D.
    J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RECEPTOR INTERACTION.
  3. "A novel CC chemokine homology with TECK."
    Zhang W., He L., Yuan Z., Wan T., Cao X.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Prediction and identification of a novel CCL28 splice variant CCL28chi."
    Scanlon K.M., Mahon B.P.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiCCL28_HUMAN
AccessioniPrimary (citable) accession number: Q9NRJ3
Secondary accession number(s): D7RIE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3