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Protein

C-C motif chemokine 28

Gene

CCL28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cell chemotaxis Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • cytolysis in other organism Source: UniProtKB
  • immune response Source: InterPro
  • killing of cells of other organism Source: UniProtKB
  • negative regulation of leukocyte tethering or rolling Source: UniProtKB
  • positive regulation of cell-matrix adhesion Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • response to nutrient Source: Ensembl

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 28
Alternative name(s):
Mucosae-associated epithelial chemokine
Short name:
MEC
Protein CCK1
Small-inducible cytokine A28
Gene namesi
Name:CCL28
Synonyms:SCYA28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000151882.11.
HGNCiHGNC:17700. CCL28.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56477.
OpenTargetsiENSG00000151882.
PharmGKBiPA38463.

Polymorphism and mutation databases

BioMutaiCCL28.
DMDMi12230650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000524220 – 127C-C motif chemokine 28Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 73By similarity
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NRJ3.
PeptideAtlasiQ9NRJ3.
PRIDEiQ9NRJ3.

PTM databases

iPTMnetiQ9NRJ3.
PhosphoSitePlusiQ9NRJ3.

Expressioni

Tissue specificityi

Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

Gene expression databases

BgeeiENSG00000151882.
CleanExiHS_CCL28.
ExpressionAtlasiQ9NRJ3. baseline and differential.
GenevisibleiQ9NRJ3. HS.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi121147. 3 interactors.
DIPiDIP-57392N.
IntActiQ9NRJ3. 6 interactors.
MINTiMINT-6629016.
STRINGi9606.ENSP00000354416.

Structurei

3D structure databases

ProteinModelPortaliQ9NRJ3.
SMRiQ9NRJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBTP. Eukaryota.
ENOG411138S. LUCA.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000036970.
HOVERGENiHBG101413.
InParanoidiQ9NRJ3.
KOiK05513.
OMAiGNICHKK.
OrthoDBiEOG091G0U3F.
PhylomeDBiQ9NRJ3.
TreeFamiTF337014.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQRGLAIVA LAVCAALHAS EAILPIASSC CTEVSHHISR RLLERVNMCR
60 70 80 90 100
IQRADGDCDL AAVILHVKRR RICVSPHNHT VKQWMKVQAA KKNGKGNVCH
110 120
RKKHHGKRNS NRAHQGKHET YGHKTPY
Length:127
Mass (Da):14,280
Last modified:October 1, 2000 - v1
Checksum:i3E8551A63A2C8D62
GO
Isoform 2 (identifier: Q9NRJ3-2) [UniParc]FASTAAdd to basket
Also known as: CCL28chi

The sequence of this isoform differs from the canonical sequence as follows:
     64-127: ILHVKRRRIC...HETYGHKTPY → MLECSDMISA...ARTTILLSSG

Show »
Length:117
Mass (Da):12,375
Checksum:i2E0390498F47B135
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04773564 – 127ILHVK…HKTPY → MLECSDMISAHYNLHLPGSN DSPTSAFQVAGITAFMSSAE ESVSARTTILLSSG in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220210 mRNA. Translation: AAF87205.1.
AF266504 mRNA. Translation: AAG16691.1.
AF110384 mRNA. Translation: AAG43193.1.
HM067700 mRNA. Translation: ADH95184.1.
AC025457 Genomic DNA. No translation available.
BC062668 mRNA. Translation: AAH62668.1.
BC069532 mRNA. Translation: AAH69532.1.
CCDSiCCDS3944.1. [Q9NRJ3-1]
RefSeqiNP_001288802.1. NM_001301873.1. [Q9NRJ3-1]
NP_001288803.1. NM_001301874.1. [Q9NRJ3-1]
NP_683513.1. NM_148672.3. [Q9NRJ3-1]
UniGeneiHs.656904.

Genome annotation databases

EnsembliENST00000361115; ENSP00000354416; ENSG00000151882. [Q9NRJ3-1]
ENST00000489442; ENSP00000426424; ENSG00000151882. [Q9NRJ3-1]
GeneIDi56477.
KEGGihsa:56477.
UCSCiuc003jnu.4. human. [Q9NRJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCL28_HUMAN
AccessioniPrimary (citable) accession number: Q9NRJ3
Secondary accession number(s): D7RIE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families