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Q9NRJ3 (CCL28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 28
Alternative name(s):
Mucosae-associated epithelial chemokine
Short name=MEC
Protein CCK1
Small-inducible cytokine A28
Gene names
Name:CCL28
Synonyms:SCYA28
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Subcellular location

Secreted.

Tissue specificity

Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NRJ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NRJ3-2)

Also known as: CCL28chi;

The sequence of this isoform differs from the canonical sequence as follows:
     64-127: ILHVKRRRIC...HETYGHKTPY → MLECSDMISA...ARTTILLSSG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 127108C-C motif chemokine 28
PRO_0000005242

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 58 By similarity
Disulfide bond31 ↔ 73 By similarity

Natural variations

Alternative sequence64 – 12764ILHVK…HKTPY → MLECSDMISAHYNLHLPGSN DSPTSAFQVAGITAFMSSAE ESVSARTTILLSSG in isoform 2.
VSP_047735

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3E8551A63A2C8D62

FASTA12714,280
        10         20         30         40         50         60 
MQQRGLAIVA LAVCAALHAS EAILPIASSC CTEVSHHISR RLLERVNMCR IQRADGDCDL 

        70         80         90        100        110        120 
AAVILHVKRR RICVSPHNHT VKQWMKVQAA KKNGKGNVCH RKKHHGKRNS NRAHQGKHET 


YGHKTPY 

« Hide

Isoform 2 (CCL28chi) [UniParc].

Checksum: 2E0390498F47B135
Show »

FASTA11712,375

References

« Hide 'large scale' references
[1]"Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)."
Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D., Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J., Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A.
J. Biol. Chem. 275:22313-22323(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RECEPTOR INTERACTION.
Tissue: Fetal heart and Osteoblast.
[2]"A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."
Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D.
J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RECEPTOR INTERACTION.
[3]"A novel CC chemokine homology with TECK."
Zhang W., He L., Yuan Z., Wan T., Cao X.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"Prediction and identification of a novel CCL28 splice variant CCL28chi."
Scanlon K.M., Mahon B.P.
Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[5]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Web resources

Wikipedia

CCL28 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF220210 mRNA. Translation: AAF87205.1.
AF266504 mRNA. Translation: AAG16691.1.
AF110384 mRNA. Translation: AAG43193.1.
HM067700 mRNA. Translation: ADH95184.1.
AC025457 Genomic DNA. No translation available.
BC062668 mRNA. Translation: AAH62668.1.
BC069532 mRNA. Translation: AAH69532.1.
CCDSCCDS3944.1. [Q9NRJ3-1]
RefSeqNP_683513.1. NM_148672.2. [Q9NRJ3-1]
XP_005248382.1. XM_005248325.1. [Q9NRJ3-2]
UniGeneHs.656904.

3D structure databases

ProteinModelPortalQ9NRJ3.
SMRQ9NRJ3. Positions 23-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9NRJ3. 2 interactions.
MINTMINT-6629016.
STRING9606.ENSP00000354416.

PTM databases

PhosphoSiteQ9NRJ3.

Polymorphism databases

DMDM12230650.

Proteomic databases

PaxDbQ9NRJ3.
PRIDEQ9NRJ3.

Protocols and materials databases

DNASU56477.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361115; ENSP00000354416; ENSG00000151882. [Q9NRJ3-1]
ENST00000489442; ENSP00000426424; ENSG00000151882. [Q9NRJ3-1]
ENST00000537013; ENSP00000443823; ENSG00000151882. [Q9NRJ3-2]
GeneID56477.
KEGGhsa:56477.
UCSCuc003jnu.3. human. [Q9NRJ3-1]

Organism-specific databases

CTD56477.
GeneCardsGC05M043376.
HGNCHGNC:17700. CCL28.
MIM605240. gene.
neXtProtNX_Q9NRJ3.
PharmGKBPA38463.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41057.
HOGENOMHOG000036970.
HOVERGENHBG101413.
InParanoidQ9NRJ3.
KOK05513.
OMAHVIKQWM.
OrthoDBEOG70W3G4.
PhylomeDBQ9NRJ3.
TreeFamTF337014.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9NRJ3.
BgeeQ9NRJ3.
CleanExHS_CCL28.
GenevestigatorQ9NRJ3.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56477.
NextBio35495724.
PROQ9NRJ3.
SOURCESearch...

Entry information

Entry nameCCL28_HUMAN
AccessionPrimary (citable) accession number: Q9NRJ3
Secondary accession number(s): D7RIE7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM