Q9NRJ3 (CCL28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 28

Alternative name(s):
Mucosae-associated epithelial chemokine
Short name=MEC
Protein CCK1
Small-inducible cytokine A28

Gene names

Name:	CCL28
Synonyms:	SCYA28

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Subcellular location	Secreted.
Tissue specificity	Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Traceable author statement Ref.1. Source: UniProtKB elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Traceable author statement. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chemokine activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 127	108	C-C motif chemokine 28		PRO_0000005242
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Disulfide bond	30 ↔ 58		By similarity
	Disulfide bond	31 ↔ 73		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9NRJ3 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3E8551A63A2C8D62	FASTA	127	14,280
	10 20 30 40 50 60 MQQRGLAIVA LAVCAALHAS EAILPIASSC CTEVSHHISR RLLERVNMCR IQRADGDCDL 70 80 90 100 110 120 AAVILHVKRR RICVSPHNHT VKQWMKVQAA KKNGKGNVCH RKKHHGKRNS NRAHQGKHET YGHKTPY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)." Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D., Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J., Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A. J. Biol. Chem. 275:22313-22323(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], RECEPTOR INTERACTION. Tissue: Fetal heart and Osteoblast.
[2]	"A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues." Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D. J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], RECEPTOR INTERACTION.
[3]	"A novel CC chemokine homology with TECK." Zhang W., He L., Yuan Z., Wan T., Cao X. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

CCL28 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF220210 mRNA. Translation: AAF87205.1. AF266504 mRNA. Translation: AAG16691.1. AF110384 mRNA. Translation: AAG43193.1. BC062668 mRNA. Translation: AAH62668.1. BC069532 mRNA. Translation: AAH69532.1.
IPI	IPI00016593.
RefSeq	NP_683513.1. NM_148672.2.
UniGene	Hs.656904.
3D structure databases
ProteinModelPortal	Q9NRJ3.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6629016.
STRING	9606.ENSP00000354416.
PTM databases
PhosphoSite	Q9NRJ3.
Polymorphism databases
DMDM	12230650.
Proteomic databases
PaxDb	Q9NRJ3.
PRIDE	Q9NRJ3.
Protocols and materials databases
DNASU	56477.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361115; ENSP00000354416; ENSG00000151882. ENST00000489442; ENSP00000426424; ENSG00000151882.
GeneID	56477.
KEGG	hsa:56477.
UCSC	uc003jnu.3. human.
Organism-specific databases
CTD	56477.
GeneCards	GC05M043376.
HGNC	HGNC:17700. CCL28.
MIM	605240. gene.
neXtProt	NX_Q9NRJ3.
PharmGKB	PA38463.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41057.
HOGENOM	HOG000036970.
HOVERGEN	HBG101413.
InParanoid	Q9NRJ3.
KO	K05513.
OMA	GNICHKK.
OrthoDB	EOG4G4GRT.
PhylomeDB	Q9NRJ3.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9NRJ3.
Bgee	Q9NRJ3.
CleanEx	HS_CCL28.
Genevestigator	Q9NRJ3.
GermOnline	ENSG00000151882. Homo sapiens.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56477.
NextBio	62013.
SOURCE	Search...

Entry information

Entry name

CCL28_HUMAN

Accession

Primary (citable) accession number: Q9NRJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.