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Q9NRJ3

- CCL28_HUMAN

UniProt

Q9NRJ3 - CCL28_HUMAN

Protein

C-C motif chemokine 28

Gene

CCL28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

    GO - Molecular functioni

    1. chemokine activity Source: UniProtKB

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. chemotaxis Source: UniProtKB
    3. immune response Source: InterPro
    4. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    5. response to nutrient Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 28
    Alternative name(s):
    Mucosae-associated epithelial chemokine
    Short name:
    MEC
    Protein CCK1
    Small-inducible cytokine A28
    Gene namesi
    Name:CCL28
    Synonyms:SCYA28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:17700. CCL28.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW
    3. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38463.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 127108C-C motif chemokine 28PRO_0000005242Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 58By similarity
    Disulfide bondi31 ↔ 73By similarity
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NRJ3.
    PRIDEiQ9NRJ3.

    PTM databases

    PhosphoSiteiQ9NRJ3.

    Expressioni

    Tissue specificityi

    Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

    Gene expression databases

    ArrayExpressiQ9NRJ3.
    BgeeiQ9NRJ3.
    CleanExiHS_CCL28.
    GenevestigatoriQ9NRJ3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9NRJ3. 2 interactions.
    MINTiMINT-6629016.
    STRINGi9606.ENSP00000354416.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRJ3.
    SMRiQ9NRJ3. Positions 23-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41057.
    HOGENOMiHOG000036970.
    HOVERGENiHBG101413.
    InParanoidiQ9NRJ3.
    KOiK05513.
    OMAiHVIKQWM.
    OrthoDBiEOG70W3G4.
    PhylomeDBiQ9NRJ3.
    TreeFamiTF337014.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NRJ3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQQRGLAIVA LAVCAALHAS EAILPIASSC CTEVSHHISR RLLERVNMCR    50
    IQRADGDCDL AAVILHVKRR RICVSPHNHT VKQWMKVQAA KKNGKGNVCH 100
    RKKHHGKRNS NRAHQGKHET YGHKTPY 127
    Length:127
    Mass (Da):14,280
    Last modified:October 1, 2000 - v1
    Checksum:i3E8551A63A2C8D62
    GO
    Isoform 2 (identifier: Q9NRJ3-2) [UniParc]FASTAAdd to Basket

    Also known as: CCL28chi

    The sequence of this isoform differs from the canonical sequence as follows:
         64-127: ILHVKRRRIC...HETYGHKTPY → MLECSDMISA...ARTTILLSSG

    Show »
    Length:117
    Mass (Da):12,375
    Checksum:i2E0390498F47B135
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei64 – 12764ILHVK…HKTPY → MLECSDMISAHYNLHLPGSN DSPTSAFQVAGITAFMSSAE ESVSARTTILLSSG in isoform 2. 1 PublicationVSP_047735Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220210 mRNA. Translation: AAF87205.1.
    AF266504 mRNA. Translation: AAG16691.1.
    AF110384 mRNA. Translation: AAG43193.1.
    HM067700 mRNA. Translation: ADH95184.1.
    AC025457 Genomic DNA. No translation available.
    BC062668 mRNA. Translation: AAH62668.1.
    BC069532 mRNA. Translation: AAH69532.1.
    CCDSiCCDS3944.1. [Q9NRJ3-1]
    RefSeqiNP_683513.1. NM_148672.2. [Q9NRJ3-1]
    XP_005248382.1. XM_005248325.1. [Q9NRJ3-2]
    UniGeneiHs.656904.

    Genome annotation databases

    EnsembliENST00000361115; ENSP00000354416; ENSG00000151882. [Q9NRJ3-1]
    ENST00000489442; ENSP00000426424; ENSG00000151882. [Q9NRJ3-1]
    GeneIDi56477.
    KEGGihsa:56477.
    UCSCiuc003jnu.3. human. [Q9NRJ3-1]

    Polymorphism databases

    DMDMi12230650.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CCL28 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220210 mRNA. Translation: AAF87205.1 .
    AF266504 mRNA. Translation: AAG16691.1 .
    AF110384 mRNA. Translation: AAG43193.1 .
    HM067700 mRNA. Translation: ADH95184.1 .
    AC025457 Genomic DNA. No translation available.
    BC062668 mRNA. Translation: AAH62668.1 .
    BC069532 mRNA. Translation: AAH69532.1 .
    CCDSi CCDS3944.1. [Q9NRJ3-1 ]
    RefSeqi NP_683513.1. NM_148672.2. [Q9NRJ3-1 ]
    XP_005248382.1. XM_005248325.1. [Q9NRJ3-2 ]
    UniGenei Hs.656904.

    3D structure databases

    ProteinModelPortali Q9NRJ3.
    SMRi Q9NRJ3. Positions 23-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9NRJ3. 2 interactions.
    MINTi MINT-6629016.
    STRINGi 9606.ENSP00000354416.

    PTM databases

    PhosphoSitei Q9NRJ3.

    Polymorphism databases

    DMDMi 12230650.

    Proteomic databases

    PaxDbi Q9NRJ3.
    PRIDEi Q9NRJ3.

    Protocols and materials databases

    DNASUi 56477.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361115 ; ENSP00000354416 ; ENSG00000151882 . [Q9NRJ3-1 ]
    ENST00000489442 ; ENSP00000426424 ; ENSG00000151882 . [Q9NRJ3-1 ]
    GeneIDi 56477.
    KEGGi hsa:56477.
    UCSCi uc003jnu.3. human. [Q9NRJ3-1 ]

    Organism-specific databases

    CTDi 56477.
    GeneCardsi GC05M043376.
    HGNCi HGNC:17700. CCL28.
    MIMi 605240. gene.
    neXtProti NX_Q9NRJ3.
    PharmGKBi PA38463.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41057.
    HOGENOMi HOG000036970.
    HOVERGENi HBG101413.
    InParanoidi Q9NRJ3.
    KOi K05513.
    OMAi HVIKQWM.
    OrthoDBi EOG70W3G4.
    PhylomeDBi Q9NRJ3.
    TreeFami TF337014.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 56477.
    NextBioi 35495724.
    PROi Q9NRJ3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NRJ3.
    Bgeei Q9NRJ3.
    CleanExi HS_CCL28.
    Genevestigatori Q9NRJ3.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RECEPTOR INTERACTION.
      Tissue: Fetal heart and Osteoblast.
    2. "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."
      Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D.
      J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RECEPTOR INTERACTION.
    3. "A novel CC chemokine homology with TECK."
      Zhang W., He L., Yuan Z., Wan T., Cao X.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Prediction and identification of a novel CCL28 splice variant CCL28chi."
      Scanlon K.M., Mahon B.P.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiCCL28_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRJ3
    Secondary accession number(s): D7RIE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3