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Reviewed, UniProtKB/Swiss-Prot Q9NRJ1 (MOST1_HUMAN)

Last modified November 24, 2009. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein MOST-1
Gene names
Name: C8orf17
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be involved in cell survival, proliferation and progression of cancer cells. Ref.1

Subunit structure

Interacts with TSPO, IGHM and IGHD. Ref.3

Subcellular location

Cytoplasm. Microsome membrane. Endoplasmic reticulum membrane.

Tissue specificity

Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate and thymus. Expressed in all of the cancer cell lines tested. Ref.1

Ontologies

Keywords
   Cellular componentCytoplasm
Endoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

microsome

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9999Protein MOST-1
PRO_0000331456

Natural variations

Natural variant191T → M: dbSNP rs2233233.
VAR_042878
Natural variant491K → R: dbSNP rs2233235.
VAR_042879
Natural variant571T → I: dbSNP rs2233236.
VAR_042880

Sequences

Sequence LengthMass (Da)Tools
Q9NRJ1-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 29768671630A8D65

FASTA9911,219
        10         20         30         40         50         60 
MGECPHLVDV RLGHRSLATG PEQSDICHTG SEARWTTTWY GSLSFSRHKY KMLADLTPGV 

        70         80         90 
EMSCRHWARW LTPVIPALWK AEAGGLPELR SSRPAWTTW 

« Hide

References

« Hide 'large scale' references
[1]"The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate."
Tan J.M.M., Tock E.P.C., Chow V.T.K.
Mol. Pathol. 56:109-115(2003) [PubMed: 12665628] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers."
Tan J.M.M., Chow V.T.K.
Int. J. Oncol. 30:81-89(2007) [PubMed: 17143515] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TSPO; IGHM AND IGHD.

Cross-references

Sequence databases

AF220264 mRNA. Translation: AAF87328.1.
CH471060 Genomic DNA. Translation: EAW92204.1.
IPIIPI00024969.
RefSeqXP_002346169.1.
UniGeneHs.283098

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9NRJ1.

Proteomic databases

PRIDEQ9NRJ1.

Genome annotation databases

GeneID100293561.
KEGGhsa:100293561.

Organism-specific databases

GeneCardsGC08P141013.
GC08U901089.
HGNCHGNC:17737. C8orf17.
PharmGKBPA25960.
GenAtlasSearch...

Gene expression databases

CleanExHS_C8orf17.
GenevestigatorQ9NRJ1.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameMOST1_HUMAN
AccessionPrimary (citable) accession number: Q9NRJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: November 24, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents