Q9NRJ1 (MOST1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MOST-1

Gene names

Name:

C8orf17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in cell survival, proliferation and progression of cancer cells. Ref.1
Subunit structure	Interacts with TSPO, IGHM and IGHD. Ref.3
Subcellular location	Cytoplasm. Microsome membrane. Endoplasmic reticulum membrane Ref.3.
Tissue specificity	Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate and thymus. Expressed in all of the cancer cell lines tested. Ref.1

Ontologies

Keywords
Cellular component	Cytoplasm Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 99	99	Protein MOST-1		PRO_0000331456
Natural variations
	Natural variant	19	1	T → M. Corresponds to variant rs2233233 [ dbSNP | Ensembl ].		VAR_042878
	Natural variant	49	1	K → R. Corresponds to variant rs2233235 [ dbSNP | Ensembl ].		VAR_042879
	Natural variant	57	1	T → I. Corresponds to variant rs2233236 [ dbSNP | Ensembl ].		VAR_042880

Sequences

	Sequence		Length	Mass (Da)
	Q9NRJ1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 29768671630A8D65	FASTA	99	11,219
	10 20 30 40 50 60 MGECPHLVDV RLGHRSLATG PEQSDICHTG SEARWTTTWY GSLSFSRHKY KMLADLTPGV 70 80 90 EMSCRHWARW LTPVIPALWK AEAGGLPELR SSRPAWTTW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate." Tan J.M.M., Tock E.P.C., Chow V.T.K. Mol. Pathol. 56:109-115(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers." Tan J.M.M., Chow V.T.K. Int. J. Oncol. 30:81-89(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TSPO; IGHM AND IGHD.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF220264 mRNA. Translation: AAF87328.1. CH471060 Genomic DNA. Translation: EAW92204.1.
IPI	IPI00024969.
UniGene	Hs.283098.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9NRJ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000507535; ENSP00000428230; ENSG00000250733.
Organism-specific databases
GeneCards	GC08P141012.
H-InvDB	HIX0034271.
HGNC	HGNC:17737. C8orf17.
neXtProt	NX_Q9NRJ1.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000208500.
InParanoid	Q9NRJ1.
OMA	GSEARWT.
Gene expression databases
Bgee	Q9NRJ1.
CleanEx	HS_C8orf17.
Genevestigator	Q9NRJ1.
Family and domain databases
ProtoNet	Search...
Other
NextBio	13652124.

Entry information

Entry name

MOST1_HUMAN

Accession

Primary (citable) accession number: Q9NRJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.