Reviewed, UniProtKB/Swiss-Prot Q9NRJ1 (MOST1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein MOST-1

Gene names

Name:

C8orf17

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in cell survival, proliferation and progression of cancer cells. Ref.1
Subunit structure	Interacts with TSPO, IGHM and IGHD. Ref.3
Subcellular location	Cytoplasm. Microsome membrane. Endoplasmic reticulum membrane.
Tissue specificity	Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate and thymus. Expressed in all of the cancer cell lines tested. Ref.1

Ontologies

Keywords
Cellular component	Cytoplasm Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 99	99	Protein MOST-1		PRO_0000331456
Natural variations
	Natural variant	19	1	T → M: dbSNP rs2233233.		VAR_042878
	Natural variant	49	1	K → R: dbSNP rs2233235.		VAR_042879
	Natural variant	57	1	T → I: dbSNP rs2233236.		VAR_042880

Sequences

	Sequence		Length	Mass (Da)
	Q9NRJ1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 29768671630A8D65	FASTA	99	11,219
	10 20 30 40 50 60 MGECPHLVDV RLGHRSLATG PEQSDICHTG SEARWTTTWY GSLSFSRHKY KMLADLTPGV 70 80 90 EMSCRHWARW LTPVIPALWK AEAGGLPELR SSRPAWTTW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate." Tan J.M.M., Tock E.P.C., Chow V.T.K. Mol. Pathol. 56:109-115(2003) [PubMed: 12665628] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers." Tan J.M.M., Chow V.T.K. Int. J. Oncol. 30:81-89(2007) [PubMed: 17143515] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TSPO; IGHM AND IGHD.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF220264 mRNA. Translation: AAF87328.1. CH471060 Genomic DNA. Translation: EAW92204.1.
IPI	IPI00024969.
RefSeq	XP_002346169.1.
UniGene	Hs.283098
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NRJ1.
Proteomic databases
PRIDE	Q9NRJ1.
Genome annotation databases
GeneID	100293561.
KEGG	hsa:100293561.
Organism-specific databases
GeneCards	GC08P141013. GC08U901089.
HGNC	HGNC:17737. C8orf17.
PharmGKB	PA25960.
GenAtlas	Search...
Gene expression databases
CleanEx	HS_C8orf17.
Genevestigator	Q9NRJ1.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

MOST1_HUMAN

Accession

Primary (citable) accession number: Q9NRJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 1, 2000
Last modified:	November 24, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.