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Q9NRJ1 (MOST1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein MOST-1
Gene names
Name:C8orf17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in cell survival, proliferation and progression of cancer cells. Ref.1

Subunit structure

Interacts with TSPO, IGHM and IGHD. Ref.3

Subcellular location

Cytoplasm. Microsome membrane. Endoplasmic reticulum membrane Ref.3.

Tissue specificity

Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate and thymus. Expressed in all of the cancer cell lines tested. Ref.1

Ontologies

Keywords
   Cellular componentCytoplasm
Endoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9999Protein MOST-1
PRO_0000331456

Natural variations

Natural variant191T → M.
Corresponds to variant rs2233233 [ dbSNP | Ensembl ].
VAR_042878
Natural variant491K → R.
Corresponds to variant rs2233235 [ dbSNP | Ensembl ].
VAR_042879
Natural variant571T → I.
Corresponds to variant rs2233236 [ dbSNP | Ensembl ].
VAR_042880

Sequences

Sequence LengthMass (Da)Tools
Q9NRJ1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 29768671630A8D65

FASTA9911,219
        10         20         30         40         50         60 
MGECPHLVDV RLGHRSLATG PEQSDICHTG SEARWTTTWY GSLSFSRHKY KMLADLTPGV 

        70         80         90 
EMSCRHWARW LTPVIPALWK AEAGGLPELR SSRPAWTTW 

« Hide

References

« Hide 'large scale' references
[1]"The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate."
Tan J.M.M., Tock E.P.C., Chow V.T.K.
Mol. Pathol. 56:109-115(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers."
Tan J.M.M., Chow V.T.K.
Int. J. Oncol. 30:81-89(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TSPO; IGHM AND IGHD.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF220264 mRNA. Translation: AAF87328.1.
CH471060 Genomic DNA. Translation: EAW92204.1.
UniGeneHs.283098.

3D structure databases

ProteinModelPortalQ9NRJ1.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9NRJ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000507535; ENSP00000428230; ENSG00000250733.

Organism-specific databases

GeneCardsGC08P141012.
H-InvDBHIX0034271.
HGNCHGNC:17737. C8orf17.
neXtProtNX_Q9NRJ1.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000208500.
InParanoidQ9NRJ1.
OMAGSEARWT.
OrthoDBEOG7P02M5.
PhylomeDBQ9NRJ1.
TreeFamTF351561.

Gene expression databases

BgeeQ9NRJ1.
CleanExHS_C8orf17.
GenevestigatorQ9NRJ1.

Family and domain databases

ProtoNetSearch...

Other

NextBio13652124.

Entry information

Entry nameMOST1_HUMAN
AccessionPrimary (citable) accession number: Q9NRJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM