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Q9NRJ1

- MOST1_HUMAN

UniProt

Q9NRJ1 - MOST1_HUMAN

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Protein

Protein MOST-1

Gene

C8orf17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in cell survival, proliferation and progression of cancer cells.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MOST-1
Gene namesi
Name:C8orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:17737. C8orf17.

Subcellular locationi

Cytoplasm 1 Publication. Microsome membrane 1 Publication. Endoplasmic reticulum membrane 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Protein MOST-1PRO_0000331456Add
BLAST

Proteomic databases

PRIDEiQ9NRJ1.

Expressioni

Tissue specificityi

Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate and thymus. Expressed in all of the cancer cell lines tested.1 Publication

Gene expression databases

BgeeiQ9NRJ1.
CleanExiHS_C8orf17.
GenevestigatoriQ9NRJ1.

Interactioni

Subunit structurei

Interacts with TSPO, IGHM and IGHD.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9NRJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000065171.
HOGENOMiHOG000208500.
InParanoidiQ9NRJ1.
OMAiGSEARWT.
OrthoDBiEOG7P02M5.
PhylomeDBiQ9NRJ1.
TreeFamiTF351561.

Sequencei

Sequence statusi: Complete.

Q9NRJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGECPHLVDV RLGHRSLATG PEQSDICHTG SEARWTTTWY GSLSFSRHKY
60 70 80 90
KMLADLTPGV EMSCRHWARW LTPVIPALWK AEAGGLPELR SSRPAWTTW
Length:99
Mass (Da):11,219
Last modified:October 1, 2000 - v1
Checksum:i29768671630A8D65
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191T → M.
Corresponds to variant rs2233233 [ dbSNP | Ensembl ].
VAR_042878
Natural varianti49 – 491K → R.
Corresponds to variant rs2233235 [ dbSNP | Ensembl ].
VAR_042879
Natural varianti57 – 571T → I.
Corresponds to variant rs2233236 [ dbSNP | Ensembl ].
VAR_042880

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220264 mRNA. Translation: AAF87328.1.
CH471060 Genomic DNA. Translation: EAW92204.1.
UniGeneiHs.283098.

Genome annotation databases

EnsembliENST00000507535; ENSP00000428230; ENSG00000250733.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220264 mRNA. Translation: AAF87328.1 .
CH471060 Genomic DNA. Translation: EAW92204.1 .
UniGenei Hs.283098.

3D structure databases

ProteinModelPortali Q9NRJ1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9NRJ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000507535 ; ENSP00000428230 ; ENSG00000250733 .

Organism-specific databases

GeneCardsi GC08P141012.
H-InvDB HIX0034271.
HGNCi HGNC:17737. C8orf17.
neXtProti NX_Q9NRJ1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000065171.
HOGENOMi HOG000208500.
InParanoidi Q9NRJ1.
OMAi GSEARWT.
OrthoDBi EOG7P02M5.
PhylomeDBi Q9NRJ1.
TreeFami TF351561.

Miscellaneous databases

NextBioi 13652124.

Gene expression databases

Bgeei Q9NRJ1.
CleanExi HS_C8orf17.
Genevestigatori Q9NRJ1.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate."
    Tan J.M.M., Tock E.P.C., Chow V.T.K.
    Mol. Pathol. 56:109-115(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers."
    Tan J.M.M., Chow V.T.K.
    Int. J. Oncol. 30:81-89(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TSPO; IGHM AND IGHD.

Entry informationi

Entry nameiMOST1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Encoded in an intron of the TRAPPC9 gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3