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Q9NRJ1

- MOST1_HUMAN

UniProt

Q9NRJ1 - MOST1_HUMAN

Protein

Protein MOST-1

Gene

C8orf17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May be involved in cell survival, proliferation and progression of cancer cells.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein MOST-1
    Gene namesi
    Name:C8orf17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:17737. C8orf17.

    Subcellular locationi

    Cytoplasm 1 Publication. Microsome membrane 1 Publication. Endoplasmic reticulum membrane 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9999Protein MOST-1PRO_0000331456Add
    BLAST

    Proteomic databases

    PRIDEiQ9NRJ1.

    Expressioni

    Tissue specificityi

    Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate and thymus. Expressed in all of the cancer cell lines tested.1 Publication

    Gene expression databases

    BgeeiQ9NRJ1.
    CleanExiHS_C8orf17.
    GenevestigatoriQ9NRJ1.

    Interactioni

    Subunit structurei

    Interacts with TSPO, IGHM and IGHD.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRJ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000208500.
    InParanoidiQ9NRJ1.
    OMAiGSEARWT.
    OrthoDBiEOG7P02M5.
    PhylomeDBiQ9NRJ1.
    TreeFamiTF351561.

    Sequencei

    Sequence statusi: Complete.

    Q9NRJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGECPHLVDV RLGHRSLATG PEQSDICHTG SEARWTTTWY GSLSFSRHKY   50
    KMLADLTPGV EMSCRHWARW LTPVIPALWK AEAGGLPELR SSRPAWTTW 99
    Length:99
    Mass (Da):11,219
    Last modified:October 1, 2000 - v1
    Checksum:i29768671630A8D65
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191T → M.
    Corresponds to variant rs2233233 [ dbSNP | Ensembl ].
    VAR_042878
    Natural varianti49 – 491K → R.
    Corresponds to variant rs2233235 [ dbSNP | Ensembl ].
    VAR_042879
    Natural varianti57 – 571T → I.
    Corresponds to variant rs2233236 [ dbSNP | Ensembl ].
    VAR_042880

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220264 mRNA. Translation: AAF87328.1.
    CH471060 Genomic DNA. Translation: EAW92204.1.
    UniGeneiHs.283098.

    Genome annotation databases

    EnsembliENST00000507535; ENSP00000428230; ENSG00000250733.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220264 mRNA. Translation: AAF87328.1 .
    CH471060 Genomic DNA. Translation: EAW92204.1 .
    UniGenei Hs.283098.

    3D structure databases

    ProteinModelPortali Q9NRJ1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9NRJ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000507535 ; ENSP00000428230 ; ENSG00000250733 .

    Organism-specific databases

    GeneCardsi GC08P141012.
    H-InvDB HIX0034271.
    HGNCi HGNC:17737. C8orf17.
    neXtProti NX_Q9NRJ1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000208500.
    InParanoidi Q9NRJ1.
    OMAi GSEARWT.
    OrthoDBi EOG7P02M5.
    PhylomeDBi Q9NRJ1.
    TreeFami TF351561.

    Miscellaneous databases

    NextBioi 13652124.

    Gene expression databases

    Bgeei Q9NRJ1.
    CleanExi HS_C8orf17.
    Genevestigatori Q9NRJ1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate."
      Tan J.M.M., Tock E.P.C., Chow V.T.K.
      Mol. Pathol. 56:109-115(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers."
      Tan J.M.M., Chow V.T.K.
      Int. J. Oncol. 30:81-89(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TSPO; IGHM AND IGHD.

    Entry informationi

    Entry nameiMOST1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Encoded in an intron of the TRAPPC9 gene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3