ID   DIS1_HUMAN     STANDARD;      PRT;   854 AA.
AC   Q9NRI5; Q9NRI3; Q9NRI4; O75045; Q9BX19;
DT   15-JUN-2002 (Rel. 41, Created)
DT   15-JUN-2002 (Rel. 41, Last sequence update)
DT   15-JUN-2002 (Rel. 41, Last annotation update)
DE   Disrupted in schizophrenia 1 protein.
GN   DISC1 OR KIAA0457.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RX   MEDLINE=20275630; PubMed=10814723;
RA   Millar J.K., Wilson-Annan J.C., Anderson S., Christie S., Taylor M.S.,
RA   Semple C.A.M., Devon R.S., St Clair D.M., Muir W.J., Blackwood D.H.R.,
RA   Porteous D.J.;
RT   "Disruption of two novel genes by a schizophrenia-linked
RT   translocation.";
RL   Hum. Mol. Genet. 9:1415-1423(2000).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORM 2).
RC   TISSUE=Brain;
RX   MEDLINE=98116662; PubMed=9455484;
RA   Seki N., Ohira M., Nagase T., Ishikawa K.-I., Miyajima N.,
RA   Nakajima D., Nomura N., Ohara O.;
RT   "Characterization of cDNA clones in size-fractionated cDNA libraries
RT   from human brain.";
RL   DNA Res. 4:345-349(1997).
RN   [3]
RP   SEQUENCE OF 662-808 FROM N.A. (ISOFORM 1).
RA   Coville G.;
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALTERNATIVE PRODUCTS: 2 isoforms; 1 (shown here) and 2; may be
CC       produced by alternative splicing.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- DISEASE: Involved in a t(1;11)(q42.1;q14.3) translocation which
CC       segregates with schizophrenia and related psychiatric disorders in
CC       a large Scottish family.
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DR   EMBL; AF222980; AAF73889.1; -.
DR   EMBL; AF222983; AAF73874.1; -.
DR   EMBL; AF222987; AAF73877.1; -.
DR   EMBL; AB007926; BAA32302.1; -.
DR   EMBL; AL161743; CAC36349.1; -.
DR   MIM; 605210; -.
KW   Coiled coil; Chromosomal translocation; Alternative splicing.
FT   DOMAIN      349    394       COILED COIL (POTENTIAL).
FT   DOMAIN      448    504       COILED COIL (POTENTIAL).
FT   DOMAIN      541    564       COILED COIL (POTENTIAL).
FT   DOMAIN      602    668       COILED COIL (POTENTIAL).
FT   DOMAIN      802    835       COILED COIL (POTENTIAL).
FT   VARSPLIC    748    769       MISSING (IN ISOFORM 2).
FT   CONFLICT    704    704       S -> C (IN REF. 1).
SQ   SEQUENCE   854 AA;  93582 MW;  C74903867F83A06A CRC64;
     MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA
     VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS KSAAAPTVTS VRGTSAHFGI
     QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM DSSETLDASW EAACSDGARR VRAAGSLPSA
     ELSSNSCSPG CGPEVPPTPP GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ
     SPQEMGAKAA SLDGPHEDPR CLSQPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG
     SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV ISLRLKLQKL
     QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA LSSFLGHLAA QVQAALRRGA
     TQQASGDDTH TPLRMEPRLL EPTAQDSLHV SITRRDWLLQ EKQQLQKEIE ALQARMFVLE
     AKDQQLRREI EEQEQQLQWQ GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP
     ETIRSLQERI KSLNLSLKEI TTKVCMSEKF CSTLRKKVND IETQLPALLE AKMHAISGNH
     FWTAKDLTEE IRSLTSEREG LEGLLSKLLV LSSRNVKKLG SVKEDYNRLR REVEHQETAY
     ETSVKENTMK YMETLKNKLC SCKCPLLGKV WEADLEACRL LIQSLQLQEA RGSLSVEDER
     QMDDLEGAAP PIPPRLHSED KRKTPLKVLE EWKTHLIPSL HCAGGEQKEE SYILSAELGE
     KCEDIGKKLL YLEDQLHTAI HSHDEDLIQS LRRELQMVKE TLQAMILQLQ PAKEAGEREA
     AASCMTAGVH EAQA
//