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Protein

Tubulin gamma-2 chain

Gene

TUBG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1487GTPSequence Analysis

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • structural molecule activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15510. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-2 chain
Alternative name(s):
Gamma-2-tubulin
Gene namesi
Name:TUBG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:12419. TUBG2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic microtubule Source: Ensembl
  • cytosol Source: Reactome
  • gamma-tubulin complex Source: InterPro
  • microtubule Source: UniProtKB
  • microtubule cytoskeleton Source: ProtInc
  • pericentriolar material Source: Ensembl
  • spindle microtubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37081.

Polymorphism and mutation databases

BioMutaiTUBG2.
DMDMi12585375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Tubulin gamma-2 chainPRO_0000048468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei131 – 1311Phosphoserine; by BRSK1By similarity

Post-translational modificationi

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NRH3.
PaxDbiQ9NRH3.
PRIDEiQ9NRH3.

PTM databases

PhosphoSiteiQ9NRH3.

Expressioni

Gene expression databases

BgeeiQ9NRH3.
CleanExiHS_TUBG2.
GenevisibleiQ9NRH3. HS.

Organism-specific databases

HPAiCAB011495.

Interactioni

Protein-protein interaction databases

BioGridi118052. 5 interactions.
IntActiQ9NRH3. 3 interactions.
MINTiMINT-134564.
STRINGi9606.ENSP00000251412.

Structurei

3D structure databases

ProteinModelPortaliQ9NRH3.
SMRiQ9NRH3. Positions 2-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiCOG5023.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000165714.
HOVERGENiHBG098558.
InParanoidiQ9NRH3.
KOiK10389.
OMAiDIFFYQA.
OrthoDBiEOG70S755.
PhylomeDBiQ9NRH3.
TreeFamiTF300477.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NRH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV
60 70 80 90 100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA
110 120 130 140 150
GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG
160 170 180 190 200
SYLLERLNDR YPKKLVQTYS VFPYQDEMSD VVVQPYNSLL TLKRLTQNAD
210 220 230 240 250
CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN
260 270 280 290 300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
310 320 330 340 350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP
360 370 380 390 400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFES SCQQFDKLRK
410 420 430 440 450
RDAFLEQFRK EDMFKDNFDE MDRSREVVQE LIDEYHAATQ PDYISWGTQE

Q
Length:451
Mass (Da):51,092
Last modified:October 1, 2000 - v1
Checksum:iFDE2CB5A33D92691
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti413 – 4131M → V.
Corresponds to variant rs1046097 [ dbSNP | Ensembl ].
VAR_020418

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225971 mRNA. Translation: AAF34188.1.
AK022324 mRNA. Translation: BAB14012.1.
AC067852 Genomic DNA. No translation available.
BC009670 mRNA. Translation: AAH09670.1.
BC051890 mRNA. Translation: AAH51890.1.
BC108739 mRNA. Translation: AAI08740.1.
CCDSiCCDS32658.1.
RefSeqiNP_057521.1. NM_016437.2.
UniGeneiHs.708059.

Genome annotation databases

EnsembliENST00000251412; ENSP00000251412; ENSG00000037042.
GeneIDi27175.
KEGGihsa:27175.
UCSCiuc002iap.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225971 mRNA. Translation: AAF34188.1.
AK022324 mRNA. Translation: BAB14012.1.
AC067852 Genomic DNA. No translation available.
BC009670 mRNA. Translation: AAH09670.1.
BC051890 mRNA. Translation: AAH51890.1.
BC108739 mRNA. Translation: AAI08740.1.
CCDSiCCDS32658.1.
RefSeqiNP_057521.1. NM_016437.2.
UniGeneiHs.708059.

3D structure databases

ProteinModelPortaliQ9NRH3.
SMRiQ9NRH3. Positions 2-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118052. 5 interactions.
IntActiQ9NRH3. 3 interactions.
MINTiMINT-134564.
STRINGi9606.ENSP00000251412.

PTM databases

PhosphoSiteiQ9NRH3.

Polymorphism and mutation databases

BioMutaiTUBG2.
DMDMi12585375.

Proteomic databases

MaxQBiQ9NRH3.
PaxDbiQ9NRH3.
PRIDEiQ9NRH3.

Protocols and materials databases

DNASUi27175.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251412; ENSP00000251412; ENSG00000037042.
GeneIDi27175.
KEGGihsa:27175.
UCSCiuc002iap.3. human.

Organism-specific databases

CTDi27175.
GeneCardsiGC17P040811.
HGNCiHGNC:12419. TUBG2.
HPAiCAB011495.
MIMi605785. gene.
neXtProtiNX_Q9NRH3.
PharmGKBiPA37081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5023.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000165714.
HOVERGENiHBG098558.
InParanoidiQ9NRH3.
KOiK10389.
OMAiDIFFYQA.
OrthoDBiEOG70S755.
PhylomeDBiQ9NRH3.
TreeFamiTF300477.

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15510. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

ChiTaRSiTUBG2. human.
GeneWikiiTUBG2.
GenomeRNAii27175.
NextBioi49982.
PROiQ9NRH3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NRH3.
CleanExiHS_TUBG2.
GenevisibleiQ9NRH3. HS.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gamma-tubulin gene family in humans."
    Wise D.O., Krahe R., Oakley B.R.
    Genomics 67:164-170(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.

Entry informationi

Entry nameiTBG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRH3
Secondary accession number(s): A6NDI4, Q32NB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.