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Protein

Tubulin gamma-2 chain

Gene

TUBG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • structural molecule activity Source: ProtInc

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-2 chain
Alternative name(s):
Gamma-2-tubulin
Gene namesi
Name:TUBG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000037042.8
HGNCiHGNC:12419 TUBG2
MIMi605785 gene
neXtProtiNX_Q9NRH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi27175
OpenTargetsiENSG00000037042
PharmGKBiPA37081

Polymorphism and mutation databases

BioMutaiTUBG2
DMDMi12585375

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484681 – 451Tubulin gamma-2 chainAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131Phosphoserine; by BRSK1By similarity1

Post-translational modificationi

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NRH3
MaxQBiQ9NRH3
PaxDbiQ9NRH3
PeptideAtlasiQ9NRH3
PRIDEiQ9NRH3

PTM databases

iPTMnetiQ9NRH3
PhosphoSitePlusiQ9NRH3

Expressioni

Gene expression databases

BgeeiENSG00000037042
CleanExiHS_TUBG2
GenevisibleiQ9NRH3 HS

Organism-specific databases

HPAiCAB011495

Interactioni

Protein-protein interaction databases

BioGridi118052, 22 interactors
IntActiQ9NRH3, 9 interactors
MINTiQ9NRH3
STRINGi9606.ENSP00000251412

Structurei

3D structure databases

ProteinModelPortaliQ9NRH3
SMRiQ9NRH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00910000144217
HOGENOMiHOG000165714
HOVERGENiHBG098558
InParanoidiQ9NRH3
KOiK10389
OMAiRRESMFK
OrthoDBiEOG091G08A9
PhylomeDBiQ9NRH3
TreeFamiTF300477

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NRH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV
60 70 80 90 100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA
110 120 130 140 150
GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG
160 170 180 190 200
SYLLERLNDR YPKKLVQTYS VFPYQDEMSD VVVQPYNSLL TLKRLTQNAD
210 220 230 240 250
CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN
260 270 280 290 300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
310 320 330 340 350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP
360 370 380 390 400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFES SCQQFDKLRK
410 420 430 440 450
RDAFLEQFRK EDMFKDNFDE MDRSREVVQE LIDEYHAATQ PDYISWGTQE

Q
Length:451
Mass (Da):51,092
Last modified:October 1, 2000 - v1
Checksum:iFDE2CB5A33D92691
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020418413M → V. Corresponds to variant dbSNP:rs1046097Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225971 mRNA Translation: AAF34188.1
AK022324 mRNA Translation: BAB14012.1
AC067852 Genomic DNA No translation available.
BC009670 mRNA Translation: AAH09670.1
BC051890 mRNA Translation: AAH51890.1
BC108739 mRNA Translation: AAI08740.1
CCDSiCCDS32658.1
RefSeqiNP_057521.1, NM_016437.2
UniGeneiHs.279669
Hs.708059

Genome annotation databases

EnsembliENST00000251412; ENSP00000251412; ENSG00000037042
GeneIDi27175
KEGGihsa:27175
UCSCiuc010wgr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTBG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRH3
Secondary accession number(s): A6NDI4, Q32NB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health