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Q9NRH3

- TBG2_HUMAN

UniProt

Q9NRH3 - TBG2_HUMAN

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Protein

Tubulin gamma-2 chain

Gene

TUBG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1487GTPSequence Analysis

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. structural molecule activity Source: ProtInc

GO - Biological processi

  1. cytoplasmic microtubule organization Source: InterPro
  2. G2/M transition of mitotic cell cycle Source: Reactome
  3. microtubule nucleation Source: InterPro
  4. mitotic cell cycle Source: Reactome
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15510. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-2 chain
Alternative name(s):
Gamma-2-tubulin
Gene namesi
Name:TUBG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:12419. TUBG2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic microtubule Source: Ensembl
  2. cytosol Source: Reactome
  3. gamma-tubulin complex Source: InterPro
  4. microtubule Source: UniProtKB
  5. microtubule cytoskeleton Source: ProtInc
  6. pericentriolar material Source: Ensembl
  7. spindle microtubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Tubulin gamma-2 chainPRO_0000048468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei131 – 1311Phosphoserine; by BRSK1By similarity

Post-translational modificationi

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NRH3.
PaxDbiQ9NRH3.
PRIDEiQ9NRH3.

PTM databases

PhosphoSiteiQ9NRH3.

Expressioni

Gene expression databases

BgeeiQ9NRH3.
CleanExiHS_TUBG2.
GenevestigatoriQ9NRH3.

Organism-specific databases

HPAiCAB011495.

Interactioni

Protein-protein interaction databases

BioGridi118052. 7 interactions.
IntActiQ9NRH3. 3 interactions.
MINTiMINT-134564.
STRINGi9606.ENSP00000251412.

Structurei

3D structure databases

ProteinModelPortaliQ9NRH3.
SMRiQ9NRH3. Positions 2-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiCOG5023.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000165714.
HOVERGENiHBG098558.
InParanoidiQ9NRH3.
KOiK10389.
OMAiTTTLDVM.
OrthoDBiEOG70S755.
PhylomeDBiQ9NRH3.
TreeFamiTF300477.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NRH3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV
60 70 80 90 100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA
110 120 130 140 150
GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG
160 170 180 190 200
SYLLERLNDR YPKKLVQTYS VFPYQDEMSD VVVQPYNSLL TLKRLTQNAD
210 220 230 240 250
CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN
260 270 280 290 300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
310 320 330 340 350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP
360 370 380 390 400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFES SCQQFDKLRK
410 420 430 440 450
RDAFLEQFRK EDMFKDNFDE MDRSREVVQE LIDEYHAATQ PDYISWGTQE

Q
Length:451
Mass (Da):51,092
Last modified:October 1, 2000 - v1
Checksum:iFDE2CB5A33D92691
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti413 – 4131M → V.
Corresponds to variant rs1046097 [ dbSNP | Ensembl ].
VAR_020418

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225971 mRNA. Translation: AAF34188.1.
AK022324 mRNA. Translation: BAB14012.1.
AC067852 Genomic DNA. No translation available.
BC009670 mRNA. Translation: AAH09670.1.
BC051890 mRNA. Translation: AAH51890.1.
BC108739 mRNA. Translation: AAI08740.1.
CCDSiCCDS32658.1.
RefSeqiNP_057521.1. NM_016437.2.
UniGeneiHs.708059.

Genome annotation databases

EnsembliENST00000251412; ENSP00000251412; ENSG00000037042.
GeneIDi27175.
KEGGihsa:27175.
UCSCiuc002iap.3. human.

Polymorphism databases

DMDMi12585375.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225971 mRNA. Translation: AAF34188.1 .
AK022324 mRNA. Translation: BAB14012.1 .
AC067852 Genomic DNA. No translation available.
BC009670 mRNA. Translation: AAH09670.1 .
BC051890 mRNA. Translation: AAH51890.1 .
BC108739 mRNA. Translation: AAI08740.1 .
CCDSi CCDS32658.1.
RefSeqi NP_057521.1. NM_016437.2.
UniGenei Hs.708059.

3D structure databases

ProteinModelPortali Q9NRH3.
SMRi Q9NRH3. Positions 2-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118052. 7 interactions.
IntActi Q9NRH3. 3 interactions.
MINTi MINT-134564.
STRINGi 9606.ENSP00000251412.

PTM databases

PhosphoSitei Q9NRH3.

Polymorphism databases

DMDMi 12585375.

Proteomic databases

MaxQBi Q9NRH3.
PaxDbi Q9NRH3.
PRIDEi Q9NRH3.

Protocols and materials databases

DNASUi 27175.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251412 ; ENSP00000251412 ; ENSG00000037042 .
GeneIDi 27175.
KEGGi hsa:27175.
UCSCi uc002iap.3. human.

Organism-specific databases

CTDi 27175.
GeneCardsi GC17P040811.
HGNCi HGNC:12419. TUBG2.
HPAi CAB011495.
MIMi 605785. gene.
neXtProti NX_Q9NRH3.
PharmGKBi PA37081.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5023.
GeneTreei ENSGT00530000063251.
HOGENOMi HOG000165714.
HOVERGENi HBG098558.
InParanoidi Q9NRH3.
KOi K10389.
OMAi TTTLDVM.
OrthoDBi EOG70S755.
PhylomeDBi Q9NRH3.
TreeFami TF300477.

Enzyme and pathway databases

Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15510. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

ChiTaRSi TUBG2. human.
GeneWikii TUBG2.
GenomeRNAii 27175.
NextBioi 49982.
PROi Q9NRH3.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRH3.
CleanExi HS_TUBG2.
Genevestigatori Q9NRH3.

Family and domain databases

Gene3Di 1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProi IPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view ]
PANTHERi PTHR11588. PTHR11588. 1 hit.
Pfami PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view ]
PRINTSi PR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTi SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEi PS00227. TUBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gamma-tubulin gene family in humans."
    Wise D.O., Krahe R., Oakley B.R.
    Genomics 67:164-170(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.

Entry informationi

Entry nameiTBG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRH3
Secondary accession number(s): A6NDI4, Q32NB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3