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Q9NRH3

- TBG2_HUMAN

UniProt

Q9NRH3 - TBG2_HUMAN

Protein

Tubulin gamma-2 chain

Gene

TUBG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi142 – 1487GTPSequence Analysis

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. structural molecule activity Source: ProtInc

    GO - Biological processi

    1. cytoplasmic microtubule organization Source: InterPro
    2. G2/M transition of mitotic cell cycle Source: Reactome
    3. microtubule nucleation Source: InterPro
    4. mitotic cell cycle Source: Reactome
    5. protein polymerization Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15510. Recruitment of NuMA to mitotic centrosomes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tubulin gamma-2 chain
    Alternative name(s):
    Gamma-2-tubulin
    Gene namesi
    Name:TUBG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:12419. TUBG2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic microtubule Source: Ensembl
    2. cytosol Source: Reactome
    3. gamma-tubulin complex Source: InterPro
    4. microtubule Source: UniProtKB
    5. microtubule cytoskeleton Source: ProtInc
    6. pericentriolar material Source: Ensembl
    7. spindle microtubule Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37081.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451Tubulin gamma-2 chainPRO_0000048468Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei131 – 1311Phosphoserine; by BRSK1By similarity

    Post-translational modificationi

    Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NRH3.
    PaxDbiQ9NRH3.
    PRIDEiQ9NRH3.

    PTM databases

    PhosphoSiteiQ9NRH3.

    Expressioni

    Gene expression databases

    BgeeiQ9NRH3.
    CleanExiHS_TUBG2.
    GenevestigatoriQ9NRH3.

    Organism-specific databases

    HPAiCAB011495.

    Interactioni

    Protein-protein interaction databases

    BioGridi118052. 7 interactions.
    IntActiQ9NRH3. 3 interactions.
    MINTiMINT-134564.
    STRINGi9606.ENSP00000251412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRH3.
    SMRiQ9NRH3. Positions 2-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tubulin family.Curated

    Phylogenomic databases

    eggNOGiCOG5023.
    HOGENOMiHOG000165714.
    HOVERGENiHBG098558.
    InParanoidiQ9NRH3.
    KOiK10389.
    OMAiTTTLDVM.
    OrthoDBiEOG70S755.
    PhylomeDBiQ9NRH3.
    TreeFamiTF300477.

    Family and domain databases

    Gene3Di1.10.287.600. 1 hit.
    3.30.1330.20. 1 hit.
    3.40.50.1440. 1 hit.
    InterProiIPR002454. Gamma_tubulin.
    IPR008280. Tub_FtsZ_C.
    IPR000217. Tubulin.
    IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
    IPR023123. Tubulin_C.
    IPR017975. Tubulin_CS.
    IPR003008. Tubulin_FtsZ_GTPase.
    [Graphical view]
    PANTHERiPTHR11588. PTHR11588. 1 hit.
    PfamiPF00091. Tubulin. 1 hit.
    PF03953. Tubulin_C. 1 hit.
    [Graphical view]
    PRINTSiPR01164. GAMMATUBULIN.
    PR01161. TUBULIN.
    SMARTiSM00864. Tubulin. 1 hit.
    SM00865. Tubulin_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52490. SSF52490. 1 hit.
    SSF55307. SSF55307. 1 hit.
    PROSITEiPS00227. TUBULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NRH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV    50
    FFYQADDEHY IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA 100
    GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG 150
    SYLLERLNDR YPKKLVQTYS VFPYQDEMSD VVVQPYNSLL TLKRLTQNAD 200
    CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN 250
    NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP 300
    KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP 350
    WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFES SCQQFDKLRK 400
    RDAFLEQFRK EDMFKDNFDE MDRSREVVQE LIDEYHAATQ PDYISWGTQE 450
    Q 451
    Length:451
    Mass (Da):51,092
    Last modified:October 1, 2000 - v1
    Checksum:iFDE2CB5A33D92691
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti413 – 4131M → V.
    Corresponds to variant rs1046097 [ dbSNP | Ensembl ].
    VAR_020418

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF225971 mRNA. Translation: AAF34188.1.
    AK022324 mRNA. Translation: BAB14012.1.
    AC067852 Genomic DNA. No translation available.
    BC009670 mRNA. Translation: AAH09670.1.
    BC051890 mRNA. Translation: AAH51890.1.
    BC108739 mRNA. Translation: AAI08740.1.
    CCDSiCCDS32658.1.
    RefSeqiNP_057521.1. NM_016437.2.
    UniGeneiHs.708059.

    Genome annotation databases

    EnsembliENST00000251412; ENSP00000251412; ENSG00000037042.
    GeneIDi27175.
    KEGGihsa:27175.
    UCSCiuc002iap.3. human.

    Polymorphism databases

    DMDMi12585375.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF225971 mRNA. Translation: AAF34188.1 .
    AK022324 mRNA. Translation: BAB14012.1 .
    AC067852 Genomic DNA. No translation available.
    BC009670 mRNA. Translation: AAH09670.1 .
    BC051890 mRNA. Translation: AAH51890.1 .
    BC108739 mRNA. Translation: AAI08740.1 .
    CCDSi CCDS32658.1.
    RefSeqi NP_057521.1. NM_016437.2.
    UniGenei Hs.708059.

    3D structure databases

    ProteinModelPortali Q9NRH3.
    SMRi Q9NRH3. Positions 2-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118052. 7 interactions.
    IntActi Q9NRH3. 3 interactions.
    MINTi MINT-134564.
    STRINGi 9606.ENSP00000251412.

    PTM databases

    PhosphoSitei Q9NRH3.

    Polymorphism databases

    DMDMi 12585375.

    Proteomic databases

    MaxQBi Q9NRH3.
    PaxDbi Q9NRH3.
    PRIDEi Q9NRH3.

    Protocols and materials databases

    DNASUi 27175.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000251412 ; ENSP00000251412 ; ENSG00000037042 .
    GeneIDi 27175.
    KEGGi hsa:27175.
    UCSCi uc002iap.3. human.

    Organism-specific databases

    CTDi 27175.
    GeneCardsi GC17P040811.
    HGNCi HGNC:12419. TUBG2.
    HPAi CAB011495.
    MIMi 605785. gene.
    neXtProti NX_Q9NRH3.
    PharmGKBi PA37081.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5023.
    HOGENOMi HOG000165714.
    HOVERGENi HBG098558.
    InParanoidi Q9NRH3.
    KOi K10389.
    OMAi TTTLDVM.
    OrthoDBi EOG70S755.
    PhylomeDBi Q9NRH3.
    TreeFami TF300477.

    Enzyme and pathway databases

    Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15510. Recruitment of NuMA to mitotic centrosomes.

    Miscellaneous databases

    ChiTaRSi TUBG2. human.
    GeneWikii TUBG2.
    GenomeRNAii 27175.
    NextBioi 49982.
    PROi Q9NRH3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NRH3.
    CleanExi HS_TUBG2.
    Genevestigatori Q9NRH3.

    Family and domain databases

    Gene3Di 1.10.287.600. 1 hit.
    3.30.1330.20. 1 hit.
    3.40.50.1440. 1 hit.
    InterProi IPR002454. Gamma_tubulin.
    IPR008280. Tub_FtsZ_C.
    IPR000217. Tubulin.
    IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
    IPR023123. Tubulin_C.
    IPR017975. Tubulin_CS.
    IPR003008. Tubulin_FtsZ_GTPase.
    [Graphical view ]
    PANTHERi PTHR11588. PTHR11588. 1 hit.
    Pfami PF00091. Tubulin. 1 hit.
    PF03953. Tubulin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01164. GAMMATUBULIN.
    PR01161. TUBULIN.
    SMARTi SM00864. Tubulin. 1 hit.
    SM00865. Tubulin_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52490. SSF52490. 1 hit.
    SSF55307. SSF55307. 1 hit.
    PROSITEi PS00227. TUBULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gamma-tubulin gene family in humans."
      Wise D.O., Krahe R., Oakley B.R.
      Genomics 67:164-170(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lung.

    Entry informationi

    Entry nameiTBG2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRH3
    Secondary accession number(s): A6NDI4, Q32NB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3