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Protein

SNF-related serine/threonine-protein kinase

Gene

SNRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactori

Mg2+2 Publications

Enzyme regulationi

Activated by phosphorylation on Thr-173.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotationBy similarity1
Active sitei139Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • myeloid cell differentiation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9NRH2
SIGNORiQ9NRH2

Names & Taxonomyi

Protein namesi
Recommended name:
SNF-related serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
SNF1-related kinase
Gene namesi
Name:SNRKImported
Synonyms:KIAA0096Imported, SNFRKImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163788.13
HGNCiHGNC:30598 SNRK
MIMi612760 gene
neXtProtiNX_Q9NRH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi173T → A or E: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication1

Organism-specific databases

DisGeNETi54861
OpenTargetsiENSG00000163788
PharmGKBiPA142670894

Chemistry databases

ChEMBLiCHEMBL1908384
GuidetoPHARMACOLOGYi2202

Polymorphism and mutation databases

BioMutaiSNRK
DMDMi90185235

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256051 – 765SNF-related serine/threonine-protein kinaseCuratedAdd BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineBy similarity1
Modified residuei173Phosphothreonine; by LKB11 Publication1
Modified residuei362PhosphoserineBy similarity1
Modified residuei390PhosphoserineCombined sources1
Modified residuei482PhosphoserineBy similarity1
Modified residuei495PhosphoserineBy similarity1
Modified residuei518PhosphoserineCombined sources1
Modified residuei534Omega-N-methylarginineBy similarity1
Modified residuei607PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NRH2
MaxQBiQ9NRH2
PaxDbiQ9NRH2
PeptideAtlasiQ9NRH2
PRIDEiQ9NRH2

PTM databases

iPTMnetiQ9NRH2
PhosphoSitePlusiQ9NRH2

Expressioni

Tissue specificityi

Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.2 Publications

Gene expression databases

BgeeiENSG00000163788
CleanExiHS_SNRK
ExpressionAtlasiQ9NRH2 baseline and differential
GenevisibleiQ9NRH2 HS

Organism-specific databases

HPAiHPA042163

Interactioni

Protein-protein interaction databases

BioGridi120211, 7 interactors
IntActiQ9NRH2, 4 interactors
MINTiQ9NRH2
STRINGi9606.ENSP00000296088

Chemistry databases

BindingDBiQ9NRH2

Structurei

Secondary structure

1765
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Beta strandi36 – 52Combined sources17
Helixi54 – 67Combined sources14
Beta strandi78 – 83Combined sources6
Beta strandi85 – 92Combined sources8
Helixi100 – 105Combined sources6
Helixi113 – 132Combined sources20
Helixi142 – 144Combined sources3
Beta strandi145 – 148Combined sources4
Turni149 – 152Combined sources4
Beta strandi153 – 156Combined sources4
Turni162 – 164Combined sources3
Helixi183 – 187Combined sources5
Helixi193 – 210Combined sources18
Helixi220 – 229Combined sources10
Helixi240 – 249Combined sources10
Turni254 – 256Combined sources3
Helixi260 – 265Combined sources6
Helixi267 – 269Combined sources3
Helixi284 – 286Combined sources3
Helixi292 – 304Combined sources13
Helixi310 – 319Combined sources10
Helixi324 – 343Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YKSX-ray2.90A/B1-356[»]
ProteinModelPortaliQ9NRH2
SMRiQ9NRH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 269Protein kinasePROSITE-ProRule annotationAdd BLAST254
Domaini291 – 334UBAPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4717 Eukaryota
ENOG410XR6N LUCA
GeneTreeiENSGT00900000140806
HOGENOMiHOG000059616
HOVERGENiHBG093970
InParanoidiQ9NRH2
KOiK08802
OMAiNVLNGHR
OrthoDBiEOG091G08XV
PhylomeDBiQ9NRH2
TreeFamiTF351991

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR015940 UBA
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 13 Publications (identifier: Q9NRH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT
60 70 80 90 100
KLDTLATGHL FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM
110 120 130 140 150
FDYIMKHEEG LNEDLAKKYF AQIVHAISYC HKLHVVHRDL KPENVVFFEK
160 170 180 190 200
QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY SAPEILLGDE YDAPAVDIWS
210 220 230 240 250
LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPSHVSK ECKDLITRML
260 270 280 290 300
QRDPKRRASL EEIENHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ
310 320 330 340 350
RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA
360 370 380 390 400
SPSNIKAQFR QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAADSVLN
410 420 430 440 450
GHRSKGLCDS AKKDDLPELA GPALSTVPPA SLKPTASGRK CLFRVEEDEE
460 470 480 490 500
EDEEDKKPMS LSTQVVLRRK PSVTNRLTSR KSAPVLNQIF EEGESDDEFD
510 520 530 540 550
MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS SETSDDDSES
560 570 580 590 600
RRRLDKDSGF TYSWHRRDSS EGPPGSEGDG GGQSKPSNAS GGVDKASPSE
610 620 630 640 650
NNAGGGSPSS GSGGNPTNTS GTTRRCAGPS NSMQLASRSA GELVESLKLM
660 670 680 690 700
SLCLGSQLHG STKYIIDPQN GLSFSSVKVQ EKSTWKMCIS STGNAGQVPA
710 720 730 740 750
VGGIKFFSDH MADTTTELER IKSKNLKNNV LQLPLCEKTI SVNIQRNPKE
760
GLLCASSPAS CCHVI
Length:765
Mass (Da):84,276
Last modified:March 7, 2006 - v2
Checksum:i06EF88CF7F8A393D
GO
Isoform 21 Publication (identifier: Q9NRH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-244: D → E
     245-765: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:244
Mass (Da):27,481
Checksum:iC800B93190F76B4E
GO

Sequence cautioni

The sequence BAA07744 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH18415 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97G → E in AAF86944 (Ref. 5) Curated1
Sequence conflicti116A → P in AAF86944 (Ref. 5) Curated1
Sequence conflicti124V → A in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti181S → P in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti196V → A in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti211G → E in BAA91023 (PubMed:14702039).Curated1
Sequence conflicti219N → D in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti259S → Y in AAH71567 (PubMed:15489334).Curated1
Sequence conflicti445V → A in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti482S → G in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti486L → V in AAH71567 (PubMed:15489334).Curated1
Sequence conflicti636A → V in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti722K → R in AAH71567 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041096260L → S1 PublicationCorresponds to variant dbSNP:rs35624204Ensembl.1
Natural variantiVAR_041097391P → S1 PublicationCorresponds to variant dbSNP:rs56104180Ensembl.1
Natural variantiVAR_041098611G → S in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs368877591Ensembl.1
Natural variantiVAR_041099748P → L in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041100765I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051959244D → E in isoform 2. 1 Publication1
Alternative sequenceiVSP_051960245 – 765Missing in isoform 2. 1 PublicationAdd BLAST521

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43636 mRNA Translation: BAA07744.2 Different initiation.
AF226044 mRNA Translation: AAF86944.1
AK000231 mRNA Translation: BAA91023.1
AK314376 mRNA Translation: BAG37003.1
CR749621 mRNA Translation: CAH18415.1 Different initiation.
CH471055 Genomic DNA Translation: EAW64693.1
BC071567 mRNA Translation: AAH71567.1
CCDSiCCDS43075.1 [Q9NRH2-1]
RefSeqiNP_001094064.1, NM_001100594.1 [Q9NRH2-1]
NP_001317679.1, NM_001330750.1
NP_060189.3, NM_017719.4 [Q9NRH2-1]
XP_005265302.1, XM_005265245.3 [Q9NRH2-1]
UniGeneiHs.476052

Genome annotation databases

EnsembliENST00000296088; ENSP00000296088; ENSG00000163788 [Q9NRH2-1]
ENST00000429705; ENSP00000411375; ENSG00000163788 [Q9NRH2-1]
ENST00000454177; ENSP00000401246; ENSG00000163788 [Q9NRH2-1]
GeneIDi54861
KEGGihsa:54861
UCSCiuc003cms.5 human [Q9NRH2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNRK_HUMAN
AccessioniPrimary (citable) accession number: Q9NRH2
Secondary accession number(s): B2RAV6
, Q14706, Q68D15, Q6IQ46, Q9NXI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health