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Protein

SNF-related serine/threonine-protein kinase

Gene

SNRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactori

Mg2+2 Publications

Enzyme regulationi

Activated by phosphorylation on Thr-173.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45ATPPROSITE-ProRule annotationBy similarity1
Active sitei139Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • myeloid cell differentiation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08935-MONOMER.
SignaLinkiQ9NRH2.
SIGNORiQ9NRH2.

Names & Taxonomyi

Protein namesi
Recommended name:
SNF-related serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
SNF1-related kinase
Gene namesi
Name:SNRKImported
Synonyms:KIAA0096Imported, SNFRKImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30598. SNRK.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi173T → A or E: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication1

Organism-specific databases

DisGeNETi54861.
OpenTargetsiENSG00000163788.
PharmGKBiPA142670894.

Chemistry databases

ChEMBLiCHEMBL1908384.
GuidetoPHARMACOLOGYi2202.

Polymorphism and mutation databases

BioMutaiSNRK.
DMDMi90185235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256051 – 765SNF-related serine/threonine-protein kinaseCuratedAdd BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineBy similarity1
Modified residuei173Phosphothreonine; by LKB11 Publication1
Modified residuei362PhosphoserineBy similarity1
Modified residuei390PhosphoserineCombined sources1
Modified residuei482PhosphoserineBy similarity1
Modified residuei495PhosphoserineBy similarity1
Modified residuei518PhosphoserineCombined sources1
Modified residuei534Omega-N-methylarginineBy similarity1
Modified residuei607PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NRH2.
MaxQBiQ9NRH2.
PaxDbiQ9NRH2.
PeptideAtlasiQ9NRH2.
PRIDEiQ9NRH2.

PTM databases

iPTMnetiQ9NRH2.
PhosphoSitePlusiQ9NRH2.

Expressioni

Tissue specificityi

Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.2 Publications

Gene expression databases

BgeeiENSG00000163788.
CleanExiHS_SNRK.
ExpressionAtlasiQ9NRH2. baseline and differential.
GenevisibleiQ9NRH2. HS.

Organism-specific databases

HPAiHPA042163.

Interactioni

Protein-protein interaction databases

BioGridi120211. 7 interactors.
IntActiQ9NRH2. 2 interactors.
MINTiMINT-1338450.
STRINGi9606.ENSP00000296088.

Chemistry databases

BindingDBiQ9NRH2.

Structurei

3D structure databases

ProteinModelPortaliQ9NRH2.
SMRiQ9NRH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 269Protein kinasePROSITE-ProRule annotationAdd BLAST254
Domaini291 – 334UBAPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4717. Eukaryota.
ENOG410XR6N. LUCA.
GeneTreeiENSGT00860000133728.
HOGENOMiHOG000059616.
HOVERGENiHBG093970.
InParanoidiQ9NRH2.
KOiK08802.
OMAiTTSGRKC.
OrthoDBiEOG091G08XV.
PhylomeDBiQ9NRH2.
TreeFamiTF351991.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 13 Publications (identifier: Q9NRH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT
60 70 80 90 100
KLDTLATGHL FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM
110 120 130 140 150
FDYIMKHEEG LNEDLAKKYF AQIVHAISYC HKLHVVHRDL KPENVVFFEK
160 170 180 190 200
QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY SAPEILLGDE YDAPAVDIWS
210 220 230 240 250
LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPSHVSK ECKDLITRML
260 270 280 290 300
QRDPKRRASL EEIENHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ
310 320 330 340 350
RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA
360 370 380 390 400
SPSNIKAQFR QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAADSVLN
410 420 430 440 450
GHRSKGLCDS AKKDDLPELA GPALSTVPPA SLKPTASGRK CLFRVEEDEE
460 470 480 490 500
EDEEDKKPMS LSTQVVLRRK PSVTNRLTSR KSAPVLNQIF EEGESDDEFD
510 520 530 540 550
MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS SETSDDDSES
560 570 580 590 600
RRRLDKDSGF TYSWHRRDSS EGPPGSEGDG GGQSKPSNAS GGVDKASPSE
610 620 630 640 650
NNAGGGSPSS GSGGNPTNTS GTTRRCAGPS NSMQLASRSA GELVESLKLM
660 670 680 690 700
SLCLGSQLHG STKYIIDPQN GLSFSSVKVQ EKSTWKMCIS STGNAGQVPA
710 720 730 740 750
VGGIKFFSDH MADTTTELER IKSKNLKNNV LQLPLCEKTI SVNIQRNPKE
760
GLLCASSPAS CCHVI
Length:765
Mass (Da):84,276
Last modified:March 7, 2006 - v2
Checksum:i06EF88CF7F8A393D
GO
Isoform 21 Publication (identifier: Q9NRH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-244: D → E
     245-765: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:244
Mass (Da):27,481
Checksum:iC800B93190F76B4E
GO

Sequence cautioni

The sequence BAA07744 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH18415 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97G → E in AAF86944 (Ref. 5) Curated1
Sequence conflicti116A → P in AAF86944 (Ref. 5) Curated1
Sequence conflicti124V → A in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti181S → P in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti196V → A in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti211G → E in BAA91023 (PubMed:14702039).Curated1
Sequence conflicti219N → D in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti259S → Y in AAH71567 (PubMed:15489334).Curated1
Sequence conflicti445V → A in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti482S → G in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti486L → V in AAH71567 (PubMed:15489334).Curated1
Sequence conflicti636A → V in CAH18415 (PubMed:17974005).Curated1
Sequence conflicti722K → R in AAH71567 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041096260L → S.1 PublicationCorresponds to variant rs35624204dbSNPEnsembl.1
Natural variantiVAR_041097391P → S.1 PublicationCorresponds to variant rs56104180dbSNPEnsembl.1
Natural variantiVAR_041098611G → S in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs368877591dbSNPEnsembl.1
Natural variantiVAR_041099748P → L in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041100765I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051959244D → E in isoform 2. 1 Publication1
Alternative sequenceiVSP_051960245 – 765Missing in isoform 2. 1 PublicationAdd BLAST521

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43636 mRNA. Translation: BAA07744.2. Different initiation.
AF226044 mRNA. Translation: AAF86944.1.
AK000231 mRNA. Translation: BAA91023.1.
AK314376 mRNA. Translation: BAG37003.1.
CR749621 mRNA. Translation: CAH18415.1. Different initiation.
CH471055 Genomic DNA. Translation: EAW64693.1.
BC071567 mRNA. Translation: AAH71567.1.
CCDSiCCDS43075.1. [Q9NRH2-1]
RefSeqiNP_001094064.1. NM_001100594.1. [Q9NRH2-1]
NP_001317679.1. NM_001330750.1.
NP_060189.3. NM_017719.4. [Q9NRH2-1]
XP_005265302.1. XM_005265245.3. [Q9NRH2-1]
UniGeneiHs.476052.

Genome annotation databases

EnsembliENST00000296088; ENSP00000296088; ENSG00000163788. [Q9NRH2-1]
ENST00000429705; ENSP00000411375; ENSG00000163788. [Q9NRH2-1]
ENST00000454177; ENSP00000401246; ENSG00000163788. [Q9NRH2-1]
GeneIDi54861.
KEGGihsa:54861.
UCSCiuc003cms.5. human. [Q9NRH2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43636 mRNA. Translation: BAA07744.2. Different initiation.
AF226044 mRNA. Translation: AAF86944.1.
AK000231 mRNA. Translation: BAA91023.1.
AK314376 mRNA. Translation: BAG37003.1.
CR749621 mRNA. Translation: CAH18415.1. Different initiation.
CH471055 Genomic DNA. Translation: EAW64693.1.
BC071567 mRNA. Translation: AAH71567.1.
CCDSiCCDS43075.1. [Q9NRH2-1]
RefSeqiNP_001094064.1. NM_001100594.1. [Q9NRH2-1]
NP_001317679.1. NM_001330750.1.
NP_060189.3. NM_017719.4. [Q9NRH2-1]
XP_005265302.1. XM_005265245.3. [Q9NRH2-1]
UniGeneiHs.476052.

3D structure databases

ProteinModelPortaliQ9NRH2.
SMRiQ9NRH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120211. 7 interactors.
IntActiQ9NRH2. 2 interactors.
MINTiMINT-1338450.
STRINGi9606.ENSP00000296088.

Chemistry databases

BindingDBiQ9NRH2.
ChEMBLiCHEMBL1908384.
GuidetoPHARMACOLOGYi2202.

PTM databases

iPTMnetiQ9NRH2.
PhosphoSitePlusiQ9NRH2.

Polymorphism and mutation databases

BioMutaiSNRK.
DMDMi90185235.

Proteomic databases

EPDiQ9NRH2.
MaxQBiQ9NRH2.
PaxDbiQ9NRH2.
PeptideAtlasiQ9NRH2.
PRIDEiQ9NRH2.

Protocols and materials databases

DNASUi54861.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296088; ENSP00000296088; ENSG00000163788. [Q9NRH2-1]
ENST00000429705; ENSP00000411375; ENSG00000163788. [Q9NRH2-1]
ENST00000454177; ENSP00000401246; ENSG00000163788. [Q9NRH2-1]
GeneIDi54861.
KEGGihsa:54861.
UCSCiuc003cms.5. human. [Q9NRH2-1]

Organism-specific databases

CTDi54861.
DisGeNETi54861.
GeneCardsiSNRK.
HGNCiHGNC:30598. SNRK.
HPAiHPA042163.
MIMi612760. gene.
neXtProtiNX_Q9NRH2.
OpenTargetsiENSG00000163788.
PharmGKBiPA142670894.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4717. Eukaryota.
ENOG410XR6N. LUCA.
GeneTreeiENSGT00860000133728.
HOGENOMiHOG000059616.
HOVERGENiHBG093970.
InParanoidiQ9NRH2.
KOiK08802.
OMAiTTSGRKC.
OrthoDBiEOG091G08XV.
PhylomeDBiQ9NRH2.
TreeFamiTF351991.

Enzyme and pathway databases

BioCyciZFISH:HS08935-MONOMER.
SignaLinkiQ9NRH2.
SIGNORiQ9NRH2.

Miscellaneous databases

ChiTaRSiSNRK. human.
GeneWikiiSNRK.
GenomeRNAii54861.
PROiQ9NRH2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163788.
CleanExiHS_SNRK.
ExpressionAtlasiQ9NRH2. baseline and differential.
GenevisibleiQ9NRH2. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNRK_HUMAN
AccessioniPrimary (citable) accession number: Q9NRH2
Secondary accession number(s): B2RAV6
, Q14706, Q68D15, Q6IQ46, Q9NXI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.