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Q9NRH2

- SNRK_HUMAN

UniProt

Q9NRH2 - SNRK_HUMAN

Protein

SNF-related serine/threonine-protein kinase

Gene

SNRK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.By similarity2 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.2 Publications

    Cofactori

    Magnesium.2 Publications

    Enzyme regulationi

    Activated by phosphorylation on Thr-173.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451ATPBy similarityPROSITE-ProRule annotation
    Active sitei139 – 1391Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 309ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. myeloid cell differentiation Source: UniProtKB
    2. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9NRH2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SNF-related serine/threonine-protein kinase (EC:2.7.11.1)
    Alternative name(s):
    SNF1-related kinase
    Gene namesi
    Name:SNRKImported
    Synonyms:KIAA0096Imported, SNFRKImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30598. SNRK.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi173 – 1731T → A or E: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication

    Organism-specific databases

    PharmGKBiPA142670894.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 765765SNF-related serine/threonine-protein kinaseCuratedPRO_0000225605Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei173 – 1731Phosphothreonine; by LKB11 Publication
    Modified residuei390 – 3901Phosphoserine1 Publication

    Post-translational modificationi

    Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NRH2.
    PaxDbiQ9NRH2.
    PRIDEiQ9NRH2.

    PTM databases

    PhosphoSiteiQ9NRH2.

    Expressioni

    Tissue specificityi

    Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.2 Publications

    Gene expression databases

    ArrayExpressiQ9NRH2.
    BgeeiQ9NRH2.
    CleanExiHS_SNRK.
    GenevestigatoriQ9NRH2.

    Organism-specific databases

    HPAiHPA042163.

    Interactioni

    Protein-protein interaction databases

    BioGridi120211. 4 interactions.
    IntActiQ9NRH2. 1 interaction.
    MINTiMINT-1338450.
    STRINGi9606.ENSP00000296088.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRH2.
    SMRiQ9NRH2. Positions 14-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 269254Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini291 – 33444UBAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000059616.
    HOVERGENiHBG093970.
    InParanoidiQ9NRH2.
    KOiK08802.
    OMAiTTSGRKC.
    OrthoDBiEOG7CZK55.
    PhylomeDBiQ9NRH2.
    TreeFamiTF351991.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 13 Publications (identifier: Q9NRH2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT    50
    KLDTLATGHL FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM 100
    FDYIMKHEEG LNEDLAKKYF AQIVHAISYC HKLHVVHRDL KPENVVFFEK 150
    QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY SAPEILLGDE YDAPAVDIWS 200
    LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPSHVSK ECKDLITRML 250
    QRDPKRRASL EEIENHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ 300
    RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA 350
    SPSNIKAQFR QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAADSVLN 400
    GHRSKGLCDS AKKDDLPELA GPALSTVPPA SLKPTASGRK CLFRVEEDEE 450
    EDEEDKKPMS LSTQVVLRRK PSVTNRLTSR KSAPVLNQIF EEGESDDEFD 500
    MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS SETSDDDSES 550
    RRRLDKDSGF TYSWHRRDSS EGPPGSEGDG GGQSKPSNAS GGVDKASPSE 600
    NNAGGGSPSS GSGGNPTNTS GTTRRCAGPS NSMQLASRSA GELVESLKLM 650
    SLCLGSQLHG STKYIIDPQN GLSFSSVKVQ EKSTWKMCIS STGNAGQVPA 700
    VGGIKFFSDH MADTTTELER IKSKNLKNNV LQLPLCEKTI SVNIQRNPKE 750
    GLLCASSPAS CCHVI 765
    Length:765
    Mass (Da):84,276
    Last modified:March 7, 2006 - v2
    Checksum:i06EF88CF7F8A393D
    GO
    Isoform 21 Publication (identifier: Q9NRH2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         244-244: D → E
         245-765: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:244
    Mass (Da):27,481
    Checksum:iC800B93190F76B4E
    GO

    Sequence cautioni

    The sequence BAA07744.2 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH18415.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971G → E in AAF86944. 1 PublicationCurated
    Sequence conflicti116 – 1161A → P in AAF86944. 1 PublicationCurated
    Sequence conflicti124 – 1241V → A in CAH18415. (PubMed:17974005)Curated
    Sequence conflicti181 – 1811S → P in CAH18415. (PubMed:17974005)Curated
    Sequence conflicti196 – 1961V → A in CAH18415. (PubMed:17974005)Curated
    Sequence conflicti211 – 2111G → E in BAA91023. (PubMed:14702039)Curated
    Sequence conflicti219 – 2191N → D in CAH18415. (PubMed:17974005)Curated
    Sequence conflicti259 – 2591S → Y in AAH71567. (PubMed:15489334)Curated
    Sequence conflicti445 – 4451V → A in CAH18415. (PubMed:17974005)Curated
    Sequence conflicti482 – 4821S → G in CAH18415. (PubMed:17974005)Curated
    Sequence conflicti486 – 4861L → V in AAH71567. (PubMed:15489334)Curated
    Sequence conflicti636 – 6361A → V in CAH18415. (PubMed:17974005)Curated
    Sequence conflicti722 – 7221K → R in AAH71567. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti260 – 2601L → S.1 Publication
    Corresponds to variant rs35624204 [ dbSNP | Ensembl ].
    VAR_041096
    Natural varianti391 – 3911P → S.1 Publication
    Corresponds to variant rs56104180 [ dbSNP | Ensembl ].
    VAR_041097
    Natural varianti611 – 6111G → S in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
    VAR_041098
    Natural varianti748 – 7481P → L in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
    VAR_041099
    Natural varianti765 – 7651I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication
    VAR_041100

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei244 – 2441D → E in isoform 2. 1 PublicationVSP_051959
    Alternative sequencei245 – 765521Missing in isoform 2. 1 PublicationVSP_051960Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43636 mRNA. Translation: BAA07744.2. Different initiation.
    AF226044 mRNA. Translation: AAF86944.1.
    AK000231 mRNA. Translation: BAA91023.1.
    AK314376 mRNA. Translation: BAG37003.1.
    CR749621 mRNA. Translation: CAH18415.1. Different initiation.
    CH471055 Genomic DNA. Translation: EAW64693.1.
    BC071567 mRNA. Translation: AAH71567.1.
    CCDSiCCDS43075.1. [Q9NRH2-1]
    RefSeqiNP_001094064.1. NM_001100594.1. [Q9NRH2-1]
    NP_060189.3. NM_017719.4. [Q9NRH2-1]
    XP_005265302.1. XM_005265245.1. [Q9NRH2-1]
    XP_005265303.1. XM_005265246.1. [Q9NRH2-1]
    UniGeneiHs.476052.

    Genome annotation databases

    EnsembliENST00000296088; ENSP00000296088; ENSG00000163788. [Q9NRH2-1]
    ENST00000429705; ENSP00000411375; ENSG00000163788. [Q9NRH2-1]
    ENST00000454177; ENSP00000401246; ENSG00000163788. [Q9NRH2-1]
    GeneIDi54861.
    KEGGihsa:54861.
    UCSCiuc003cms.4. human. [Q9NRH2-1]
    uc003cmu.3. human. [Q9NRH2-2]

    Polymorphism databases

    DMDMi90185235.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43636 mRNA. Translation: BAA07744.2 . Different initiation.
    AF226044 mRNA. Translation: AAF86944.1 .
    AK000231 mRNA. Translation: BAA91023.1 .
    AK314376 mRNA. Translation: BAG37003.1 .
    CR749621 mRNA. Translation: CAH18415.1 . Different initiation.
    CH471055 Genomic DNA. Translation: EAW64693.1 .
    BC071567 mRNA. Translation: AAH71567.1 .
    CCDSi CCDS43075.1. [Q9NRH2-1 ]
    RefSeqi NP_001094064.1. NM_001100594.1. [Q9NRH2-1 ]
    NP_060189.3. NM_017719.4. [Q9NRH2-1 ]
    XP_005265302.1. XM_005265245.1. [Q9NRH2-1 ]
    XP_005265303.1. XM_005265246.1. [Q9NRH2-1 ]
    UniGenei Hs.476052.

    3D structure databases

    ProteinModelPortali Q9NRH2.
    SMRi Q9NRH2. Positions 14-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120211. 4 interactions.
    IntActi Q9NRH2. 1 interaction.
    MINTi MINT-1338450.
    STRINGi 9606.ENSP00000296088.

    Chemistry

    BindingDBi Q9NRH2.
    ChEMBLi CHEMBL1908384.
    GuidetoPHARMACOLOGYi 2202.

    PTM databases

    PhosphoSitei Q9NRH2.

    Polymorphism databases

    DMDMi 90185235.

    Proteomic databases

    MaxQBi Q9NRH2.
    PaxDbi Q9NRH2.
    PRIDEi Q9NRH2.

    Protocols and materials databases

    DNASUi 54861.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296088 ; ENSP00000296088 ; ENSG00000163788 . [Q9NRH2-1 ]
    ENST00000429705 ; ENSP00000411375 ; ENSG00000163788 . [Q9NRH2-1 ]
    ENST00000454177 ; ENSP00000401246 ; ENSG00000163788 . [Q9NRH2-1 ]
    GeneIDi 54861.
    KEGGi hsa:54861.
    UCSCi uc003cms.4. human. [Q9NRH2-1 ]
    uc003cmu.3. human. [Q9NRH2-2 ]

    Organism-specific databases

    CTDi 54861.
    GeneCardsi GC03P043303.
    HGNCi HGNC:30598. SNRK.
    HPAi HPA042163.
    MIMi 612760. gene.
    neXtProti NX_Q9NRH2.
    PharmGKBi PA142670894.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000059616.
    HOVERGENi HBG093970.
    InParanoidi Q9NRH2.
    KOi K08802.
    OMAi TTSGRKC.
    OrthoDBi EOG7CZK55.
    PhylomeDBi Q9NRH2.
    TreeFami TF351991.

    Enzyme and pathway databases

    SignaLinki Q9NRH2.

    Miscellaneous databases

    ChiTaRSi SNRK. human.
    GeneWikii SNRK.
    GenomeRNAii 54861.
    NextBioi 57744.
    PROi Q9NRH2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NRH2.
    Bgeei Q9NRH2.
    CleanExi HS_SNRK.
    Genevestigatori Q9NRH2.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases."
      Kertesz N., Samson J., Debacker C., Wu H., Labastie M.-C.
      Gene 294:13-24(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AUTOPHOSPHORYLATION.
    2. "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate."
      Jaleel M., McBride A., Lizcano J.M., Deak M., Toth R., Morrice N.A., Alessi D.R.
      FEBS Lett. 579:1417-1423(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, PHOSPHORYLATION AT THR-173, MUTAGENESIS OF THR-173.
    3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
      DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrowCurated.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adrenal glandImported.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Colon mucosaImported.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: BrainImported.
    10. "Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases."
      Becker W., Heukelbach J., Kentrup H., Joost H.G.
      Eur. J. Biochem. 235:736-743(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-260; SER-391; SER-611; LEU-748 AND MET-765.

    Entry informationi

    Entry nameiSNRK_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRH2
    Secondary accession number(s): B2RAV6
    , Q14706, Q68D15, Q6IQ46, Q9NXI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3