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Protein

Chromatin accessibility complex protein 1

Gene

CHRAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-directed DNA polymerase activity Source: UniProtKB
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

  • chromatin remodeling Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin accessibility complex protein 1
Short name:
CHRAC-1
Alternative name(s):
Chromatin accessibility complex 15 kDa protein
Short name:
CHRAC-15
Short name:
HuCHRAC15
DNA polymerase epsilon subunit p15
Gene namesi
Name:CHRAC1
Synonyms:CHRAC15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104472.9
HGNCiHGNC:13544 CHRAC1
MIMi607268 gene
neXtProtiNX_Q9NRG0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104472
PharmGKBiPA26481

Polymorphism and mutation databases

BioMutaiCHRAC1
DMDMi22653683

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000896562 – 131Chromatin accessibility complex protein 1Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei102N6-acetyllysineCombined sources1
Modified residuei124PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NRG0
MaxQBiQ9NRG0
PaxDbiQ9NRG0
PeptideAtlasiQ9NRG0
PRIDEiQ9NRG0
TopDownProteomicsiQ9NRG0

PTM databases

iPTMnetiQ9NRG0
PhosphoSitePlusiQ9NRG0

Expressioni

Tissue specificityi

Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000104472
CleanExiHS_CHRAC1
ExpressionAtlasiQ9NRG0 baseline and differential
GenevisibleiQ9NRG0 HS

Organism-specific databases

HPAiHPA059008

Interactioni

Subunit structurei

Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119904, 30 interactors
CORUMiQ9NRG0
IntActiQ9NRG0, 2 interactors
MINTiQ9NRG0
STRINGi9606.ENSP00000220913

Structurei

3D structure databases

ProteinModelPortaliQ9NRG0
SMRiQ9NRG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 124Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1657 Eukaryota
COG5208 LUCA
GeneTreeiENSGT00510000048543
HOGENOMiHOG000068045
HOVERGENiHBG050946
InParanoidiQ9NRG0
KOiK11656
OMAiKIRVHEF
OrthoDBiEOG091G0Y96
PhylomeDBiQ9NRG0
TreeFamiTF350392

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVVVGKDK GGEQRLISLP LSRIRVIMKS SPEVSSINQE ALVLTAKATE
60 70 80 90 100
LFVQCLATYS YRHGSGKEKK VLTYSDLANT AQQSETFQFL ADILPKKILA
110 120 130
SKYLKMLKEE KREEDEENDN DNESDHDEAD S
Length:131
Mass (Da):14,711
Last modified:October 1, 2000 - v1
Checksum:iBC58A99CF58ACF74
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01375555C → Y. Corresponds to variant dbSNP:rs2231522Ensembl.1
Natural variantiVAR_013756126H → R. Corresponds to variant dbSNP:rs2231524Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226076 mRNA Translation: AAF72416.1
AK023537 mRNA Translation: BAB14601.1
BC015891 mRNA Translation: AAH15891.1
CCDSiCCDS6379.1
RefSeqiNP_059140.1, NM_017444.5
UniGeneiHs.279704

Genome annotation databases

EnsembliENST00000220913; ENSP00000220913; ENSG00000104472
GeneIDi54108
KEGGihsa:54108
UCSCiuc003yvl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCHRC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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