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Protein

Chromatin accessibility complex protein 1

Gene

CHRAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-directed DNA polymerase activity Source: UniProtKB
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

  • chromatin remodeling Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin accessibility complex protein 1
Short name:
CHRAC-1
Alternative name(s):
Chromatin accessibility complex 15 kDa protein
Short name:
CHRAC-15
Short name:
HuCHRAC15
DNA polymerase epsilon subunit p15
Gene namesi
Name:CHRAC1
Synonyms:CHRAC15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104472.9.
HGNCiHGNC:13544. CHRAC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104472.
PharmGKBiPA26481.

Polymorphism and mutation databases

BioMutaiCHRAC1.
DMDMi22653683.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000896562 – 131Chromatin accessibility complex protein 1Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei102N6-acetyllysineCombined sources1
Modified residuei124PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NRG0.
MaxQBiQ9NRG0.
PaxDbiQ9NRG0.
PeptideAtlasiQ9NRG0.
PRIDEiQ9NRG0.
TopDownProteomicsiQ9NRG0.

PTM databases

iPTMnetiQ9NRG0.
PhosphoSitePlusiQ9NRG0.

Expressioni

Tissue specificityi

Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

BgeeiENSG00000104472.
CleanExiHS_CHRAC1.
ExpressionAtlasiQ9NRG0. baseline and differential.
GenevisibleiQ9NRG0. HS.

Organism-specific databases

HPAiHPA059008.

Interactioni

Subunit structurei

Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119904. 30 interactors.
CORUMiQ9NRG0.
IntActiQ9NRG0. 2 interactors.
STRINGi9606.ENSP00000220913.

Structurei

3D structure databases

ProteinModelPortaliQ9NRG0.
SMRiQ9NRG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 124Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1657. Eukaryota.
COG5208. LUCA.
GeneTreeiENSGT00510000048543.
HOGENOMiHOG000068045.
HOVERGENiHBG050946.
InParanoidiQ9NRG0.
KOiK11656.
OMAiKIRVHEF.
OrthoDBiEOG091G0Y96.
PhylomeDBiQ9NRG0.
TreeFamiTF350392.

Family and domain databases

InterProiView protein in InterPro
IPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
PfamiView protein in Pfam
PF00808. CBFD_NFYB_HMF. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVVVGKDK GGEQRLISLP LSRIRVIMKS SPEVSSINQE ALVLTAKATE
60 70 80 90 100
LFVQCLATYS YRHGSGKEKK VLTYSDLANT AQQSETFQFL ADILPKKILA
110 120 130
SKYLKMLKEE KREEDEENDN DNESDHDEAD S
Length:131
Mass (Da):14,711
Last modified:October 1, 2000 - v1
Checksum:iBC58A99CF58ACF74
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01375555C → Y. Corresponds to variant dbSNP:rs2231522Ensembl.1
Natural variantiVAR_013756126H → R. Corresponds to variant dbSNP:rs2231524Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226076 mRNA. Translation: AAF72416.1.
AK023537 mRNA. Translation: BAB14601.1.
BC015891 mRNA. Translation: AAH15891.1.
CCDSiCCDS6379.1.
RefSeqiNP_059140.1. NM_017444.5.
UniGeneiHs.279704.

Genome annotation databases

EnsembliENST00000220913; ENSP00000220913; ENSG00000104472.
GeneIDi54108.
KEGGihsa:54108.
UCSCiuc003yvl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCHRC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NRG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot