Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CTP synthase 2

Gene

CTPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.2 Publications

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase, CTP synthase 1 (CTPS1), CTP synthase, CTP synthase (CTPS2), CTP synthase 2 (CTPS2)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei399For GATase activityPROSITE-ProRule annotation1
Active sitei526For GATase activityPROSITE-ProRule annotation1
Active sitei528For GATase activityPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS00585-MONOMER
BRENDAi6.3.4.2 2681
ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates
SIGNORiQ9NRF8
UniPathwayiUPA00159; UER00277

Protein family/group databases

MEROPSiC26.A36

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthase 2 (EC:6.3.4.2)
Alternative name(s):
CTP synthetase 2
UTP--ammonia ligase 2
Gene namesi
Name:CTPS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000047230.14
HGNCiHGNC:2520 CTPS2
MIMi300380 gene
neXtProtiNX_Q9NRF8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi56474
OpenTargetsiENSG00000047230
PharmGKBiPA27021

Polymorphism and mutation databases

BioMutaiCTPS2
DMDMi74752919

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470331 – 586CTP synthase 2Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei568PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NRF8
MaxQBiQ9NRF8
PaxDbiQ9NRF8
PeptideAtlasiQ9NRF8
PRIDEiQ9NRF8

PTM databases

iPTMnetiQ9NRF8
PhosphoSitePlusiQ9NRF8

Expressioni

Gene expression databases

BgeeiENSG00000047230
CleanExiHS_CTPS2
ExpressionAtlasiQ9NRF8 baseline and differential
GenevisibleiQ9NRF8 HS

Organism-specific databases

HPAiHPA017437

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SPG21Q9NZD84EBI-740874,EBI-742688

Protein-protein interaction databases

BioGridi121144, 33 interactors
IntActiQ9NRF8, 11 interactors
STRINGi9606.ENSP00000352222

Structurei

Secondary structure

1586
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Beta strandi10 – 15Combined sources6
Helixi16 – 28Combined sources13
Turni29 – 31Combined sources3
Beta strandi34 – 40Combined sources7
Beta strandi48 – 50Combined sources3
Beta strandi58 – 60Combined sources3
Beta strandi87 – 89Combined sources3
Helixi90 – 102Combined sources13
Turni103 – 108Combined sources6
Helixi113 – 129Combined sources17
Beta strandi141 – 147Combined sources7
Helixi154 – 156Combined sources3
Helixi157 – 169Combined sources13
Helixi172 – 174Combined sources3
Beta strandi175 – 182Combined sources8
Turni187 – 189Combined sources3
Helixi195 – 206Combined sources12
Beta strandi212 – 220Combined sources9
Helixi224 – 233Combined sources10
Helixi238 – 240Combined sources3
Beta strandi241 – 245Combined sources5
Helixi252 – 259Combined sources8
Helixi262 – 270Combined sources9
Beta strandi297 – 306Combined sources10
Helixi312 – 314Combined sources3
Helixi315 – 327Combined sources13
Beta strandi330 – 338Combined sources9
Helixi339 – 342Combined sources4
Helixi344 – 349Combined sources6
Helixi351 – 363Combined sources13
Beta strandi365 – 369Combined sources5
Helixi378 – 390Combined sources13
Beta strandi395 – 398Combined sources4
Helixi400 – 413Combined sources14
Beta strandi419 – 422Combined sources4
Beta strandi429 – 435Combined sources7
Beta strandi449 – 458Combined sources10
Helixi463 – 467Combined sources5
Beta strandi472 – 480Combined sources9
Beta strandi482 – 484Combined sources3
Helixi486 – 488Combined sources3
Helixi490 – 492Combined sources3
Beta strandi495 – 503Combined sources9
Beta strandi508 – 518Combined sources11
Beta strandi520 – 526Combined sources7
Helixi527 – 530Combined sources4
Helixi538 – 548Combined sources11
Helixi551 – 556Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V4UX-ray2.30A297-562[»]
2VKTX-ray2.50A297-562[»]
3IHLX-ray2.80A/B1-275[»]
ProteinModelPortaliQ9NRF8
SMRiQ9NRF8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NRF8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 554Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd BLAST255

Sequence similaritiesi

Belongs to the CTP synthase family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiKOG2387 Eukaryota
COG0504 LUCA
GeneTreeiENSGT00910000144179
HOGENOMiHOG000077514
HOVERGENiHBG002243
InParanoidiQ9NRF8
KOiK01937
OMAiFSEPRIA
OrthoDBiEOG091G03OK
PhylomeDBiQ9NRF8
TreeFamiTF300379

Family and domain databases

CDDicd01746 GATase1_CTP_Synthase, 1 hit
Gene3Di3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR004468 CTP_synthase
IPR017456 CTP_synthase_N
IPR017926 GATASE
IPR033828 GATase1_CTP_Synthase
IPR027417 P-loop_NTPase
PANTHERiPTHR11550 PTHR11550, 1 hit
PfamiView protein in Pfam
PF06418 CTP_synth_N, 1 hit
PF00117 GATase, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00337 PyrG, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NRF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYILVTGGV ISGIGKGIIA SSIGTILKSC GLRVTAIKID PYINIDAGTF
60 70 80 90 100
SPYEHGEVFV LNDGGEVDLD LGNYERFLDI NLYKDNNITT GKIYQHVINK
110 120 130 140 150
ERRGDYLGKT VQVVPHITDA VQEWVMNQAK VPVDGNKEEP QICVIELGGT
160 170 180 190 200
IGDIEGMPFV EAFRQFQFKA KRENFCNIHV SLVPQLSATG EQKTKPTQNS
210 220 230 240 250
VRALRGLGLS PDLIVCRSST PIEMAVKEKI SMFCHVNPEQ VICIHDVSST
260 270 280 290 300
YRVPVLLEEQ SIVKYFKERL HLPIGDSASN LLFKWRNMAD RYERLQKICS
310 320 330 340 350
IALVGKYTKL RDCYASVFKA LEHSALAINH KLNLMYIDSI DLEKITETED
360 370 380 390 400
PVKFHEAWQK LCKADGILVP GGFGIRGTLG KLQAISWART KKIPFLGVCL
410 420 430 440 450
GMQLAVIEFA RNCLNLKDAD STEFRPNAPV PLVIDMPEHN PGNLGGTMRL
460 470 480 490 500
GIRRTVFKTE NSILRKLYGD VPFIEERHRH RFEVNPNLIK QFEQNDLSFV
510 520 530 540 550
GQDVDGDRME IIELANHPYF VGVQFHPEFS SRPMKPSPPY LGLLLAATGN
560 570 580
LNAYLQQGCK LSSSDRYSDA SDDSFSEPRI AELEIS
Length:586
Mass (Da):65,678
Last modified:October 1, 2000 - v1
Checksum:iAC1CF2E67D89741B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220T → S in BAB14814 (PubMed:14702039).Curated1
Sequence conflicti233F → L in BAB14607 (PubMed:14702039).Curated1
Sequence conflicti304V → A in BAB14607 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226667 mRNA Translation: AAF91241.1
AK023549 mRNA Translation: BAB14607.1
AK024070 mRNA Translation: BAB14814.1
AK125332 mRNA Translation: BAG54184.1
AK125348 mRNA Translation: BAG54188.1
AC073909 Genomic DNA No translation available.
AL445467 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98912.1
BC006256 mRNA Translation: AAH06256.2
BC034986 mRNA Translation: AAH34986.1
CCDSiCCDS14175.1
RefSeqiNP_001137474.1, NM_001144002.1
NP_062831.3, NM_019857.4
NP_787055.1, NM_175859.2
XP_005274619.1, XM_005274562.3
XP_006724566.1, XM_006724503.3
UniGeneiHs.227049

Genome annotation databases

EnsembliENST00000359276; ENSP00000352222; ENSG00000047230
ENST00000380241; ENSP00000369590; ENSG00000047230
ENST00000443824; ENSP00000401264; ENSG00000047230
GeneIDi56474
KEGGihsa:56474
UCSCiuc004cxk.4 human

Similar proteinsi

Entry informationi

Entry nameiPYRG2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRF8
Secondary accession number(s): B3KWM2
, Q9BRI0, Q9H809, Q9H8K9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health