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Protein

Teashirt homolog 2

Gene

TSHZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40425C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
DNA bindingi841 – 91171Homeobox; atypicalAdd
BLAST
Zinc fingeri926 – 94823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri994 – 101724C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 2
Alternative name(s):
Ovarian cancer-related protein 10-2
Short name:
OVC10-2
Zinc finger protein 218
Gene namesi
Name:TSHZ2
Synonyms:C20orf17, TSH2, ZNF218
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13010. TSHZ2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37589.

Polymorphism and mutation databases

BioMutaiTSHZ2.
DMDMi108935911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10341034Teashirt homolog 2PRO_0000047064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki480 – 480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei980 – 9801PhosphoserineBy similarity

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NRE2.
PaxDbiQ9NRE2.
PeptideAtlasiQ9NRE2.
PRIDEiQ9NRE2.

PTM databases

iPTMnetiQ9NRE2.
PhosphoSiteiQ9NRE2.

Expressioni

Tissue specificityi

Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.1 Publication

Gene expression databases

BgeeiENSG00000182463.
CleanExiHS_TSHZ2.
ExpressionAtlasiQ9NRE2. baseline and differential.
GenevisibleiQ9NRE2. HS.

Organism-specific databases

HPAiHPA038123.

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).By similarity

Protein-protein interaction databases

BioGridi126131. 3 interactions.
IntActiQ9NRE2. 1 interaction.
STRINGi9606.ENSP00000360552.

Structurei

3D structure databases

ProteinModelPortaliQ9NRE2.
SMRiQ9NRE2. Positions 201-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili13 – 3826Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40425C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri926 – 94823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri994 – 101724C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ7P. Eukaryota.
ENOG4110HP7. LUCA.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ9NRE2.
KOiK09236.
OMAiLFQTSEG.
OrthoDBiEOG091G01GX.
PhylomeDBiQ9NRE2.
TreeFamiTF328447.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRKQQAPK RAAGYAQEEQ LKEEEEIKEE EEEEDSGSVA QLQGGNDTGT
60 70 80 90 100
DEELETGPEQ KGCFSYQNSP GSHLSNQDAE NESLLSDASD QVSDIKSVCG
110 120 130 140 150
RDASDKKAHT HVRLPNEAHN CMDKMTAVYA NILSDSYWSG LGLGFKLSNS
160 170 180 190 200
ERRNCDTRNG SNKSDFDWHQ DALSKSLQQN LPSRSVSKPS LFSSVQLYRQ
210 220 230 240 250
SSKMCGTVFT GASRFRCRQC SAAYDTLVEL TVHMNETGHY QDDNRKKDKL
260 270 280 290 300
RPTSYSKPRK RAFQDMDKED AQKVLKCMFC GDSFDSLQDL SVHMIKTKHY
310 320 330 340 350
QKVPLKEPVP TISSKMVTPA KKRVFDVNRP CSPDSTTGSF ADSFSSQKNA
360 370 380 390 400
NLQLSSNNRY GYQNGASYTW QFEACKSQIL KCMECGSSHD TLQQLTTHMM
410 420 430 440 450
VTGHFLKVTS SASKKGKQLV LDPLAVEKMQ SLSEAPNSDS LAPKPSSNSA
460 470 480 490 500
SDCTASTTEL KKESKKERPE ETSKDEKVVK SEDYEDPLQK PLDPTIKYQY
510 520 530 540 550
LREEDLEDGS KGGGDILKSL ENTVTTAINK AQNGAPSWSA YPSIHAAYQL
560 570 580 590 600
SEGTKPPLPM GSQVLQIRPN LTNKLRPIAP KWKVMPLVSM PTHLAPYTQV
610 620 630 640 650
KKESEDKDEA VKECGKESPH EEASSFSHSE GDSFRKSETP PEAKKTELGP
660 670 680 690 700
LKEEEKLMKE GSEKEKPQPL EPTSALSNGC ALANHAPALP CINPLSALQS
710 720 730 740 750
VLNNHLGKAT EPLRSPSCSS PSSSTISMFH KSNLNVMDKP VLSPASTRSA
760 770 780 790 800
SVSRRYLFEN SDQPIDLTKS KSKKAESSQA QSCMSPPQKH ALSDIADMVK
810 820 830 840 850
VLPKATTPKP ASSSRVPPMK LEMDVRRFED VSSEVSTLHK RKGRQSNWNP
860 870 880 890 900
QHLLILQAQF ASSLFQTSEG KYLLSDLGPQ ERMQISKFTG LSMTTISHWL
910 920 930 940 950
ANVKYQLRKT GGTKFLKNMD KGHPIFYCSD CASQFRTPST YISHLESHLG
960 970 980 990 1000
FQMKDMTRLS VDQQSKVEQE ISRVSSAQRS PETIAAEEDT DSKFKCKLCC
1010 1020 1030
RTFVSKHAVK LHLSKTHSKS PEHHSQFVTD VDEE
Length:1,034
Mass (Da):115,005
Last modified:June 13, 2006 - v3
Checksum:i4FC14F93D4CD48F6
GO
Isoform 2 (identifier: Q9NRE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MPRRKQQAPKRAA → MMAAALLHYT

Note: No experimental confirmation available.
Show »
Length:1,031
Mass (Da):114,589
Checksum:i4195F81B388007E6
GO

Sequence cautioni

The sequence AAF76850 differs from that shown.The sequence differs from that shown due translation of a 3'-UTR region.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981Y → C in CAE45871 (PubMed:17974005).Curated
Sequence conflicti223 – 2231A → T in CAE45871 (PubMed:17974005).Curated
Sequence conflicti563 – 5631Q → R in BAC03610 (PubMed:14702039).Curated
Sequence conflicti916 – 9161L → P in CAE45871 (PubMed:17974005).Curated
Sequence conflicti983 – 9831T → A in BAH13747 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131R → S.2 Publications
Corresponds to variant rs739869 [ dbSNP | Ensembl ].
VAR_026679
Natural varianti681 – 6811A → T.
Corresponds to variant rs6097319 [ dbSNP | Ensembl ].
VAR_026680

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MPRRK…PKRAA → MMAAALLHYT in isoform 2. 1 PublicationVSP_046071Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091206 mRNA. Translation: BAC03610.1.
AK302570 mRNA. Translation: BAH13747.1.
BX640770 mRNA. Translation: CAE45871.1.
AL121902, BX276189 Genomic DNA. Translation: CAI95385.1.
BX276189, AL121902 Genomic DNA. Translation: CAI95730.1.
AL050316 Genomic DNA. No translation available.
AL109930 Genomic DNA. No translation available.
AL354772 Genomic DNA. No translation available.
AL354993 Genomic DNA. No translation available.
AL391097 Genomic DNA. No translation available.
AF230201 mRNA. Translation: AAF76850.1. Sequence problems.
CCDSiCCDS33490.1. [Q9NRE2-1]
CCDS54474.1. [Q9NRE2-2]
RefSeqiNP_001180350.1. NM_001193421.1. [Q9NRE2-2]
NP_775756.3. NM_173485.5. [Q9NRE2-1]
UniGeneiHs.473117.

Genome annotation databases

EnsembliENST00000329613; ENSP00000333114; ENSG00000182463. [Q9NRE2-2]
ENST00000371497; ENSP00000360552; ENSG00000182463. [Q9NRE2-1]
ENST00000603338; ENSP00000475114; ENSG00000182463. [Q9NRE2-2]
GeneIDi128553.
KEGGihsa:128553.
UCSCiuc002xwo.3. human. [Q9NRE2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091206 mRNA. Translation: BAC03610.1.
AK302570 mRNA. Translation: BAH13747.1.
BX640770 mRNA. Translation: CAE45871.1.
AL121902, BX276189 Genomic DNA. Translation: CAI95385.1.
BX276189, AL121902 Genomic DNA. Translation: CAI95730.1.
AL050316 Genomic DNA. No translation available.
AL109930 Genomic DNA. No translation available.
AL354772 Genomic DNA. No translation available.
AL354993 Genomic DNA. No translation available.
AL391097 Genomic DNA. No translation available.
AF230201 mRNA. Translation: AAF76850.1. Sequence problems.
CCDSiCCDS33490.1. [Q9NRE2-1]
CCDS54474.1. [Q9NRE2-2]
RefSeqiNP_001180350.1. NM_001193421.1. [Q9NRE2-2]
NP_775756.3. NM_173485.5. [Q9NRE2-1]
UniGeneiHs.473117.

3D structure databases

ProteinModelPortaliQ9NRE2.
SMRiQ9NRE2. Positions 201-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126131. 3 interactions.
IntActiQ9NRE2. 1 interaction.
STRINGi9606.ENSP00000360552.

PTM databases

iPTMnetiQ9NRE2.
PhosphoSiteiQ9NRE2.

Polymorphism and mutation databases

BioMutaiTSHZ2.
DMDMi108935911.

Proteomic databases

MaxQBiQ9NRE2.
PaxDbiQ9NRE2.
PeptideAtlasiQ9NRE2.
PRIDEiQ9NRE2.

Protocols and materials databases

DNASUi128553.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329613; ENSP00000333114; ENSG00000182463. [Q9NRE2-2]
ENST00000371497; ENSP00000360552; ENSG00000182463. [Q9NRE2-1]
ENST00000603338; ENSP00000475114; ENSG00000182463. [Q9NRE2-2]
GeneIDi128553.
KEGGihsa:128553.
UCSCiuc002xwo.3. human. [Q9NRE2-1]

Organism-specific databases

CTDi128553.
GeneCardsiTSHZ2.
HGNCiHGNC:13010. TSHZ2.
HPAiHPA038123.
MIMi614118. gene.
neXtProtiNX_Q9NRE2.
PharmGKBiPA37589.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ7P. Eukaryota.
ENOG4110HP7. LUCA.
GeneTreeiENSGT00390000014977.
HOGENOMiHOG000231480.
HOVERGENiHBG079626.
InParanoidiQ9NRE2.
KOiK09236.
OMAiLFQTSEG.
OrthoDBiEOG091G01GX.
PhylomeDBiQ9NRE2.
TreeFamiTF328447.

Miscellaneous databases

ChiTaRSiTSHZ2. human.
GenomeRNAii128553.
PROiQ9NRE2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182463.
CleanExiHS_TSHZ2.
ExpressionAtlasiQ9NRE2. baseline and differential.
GenevisibleiQ9NRE2. HS.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR027008. Teashirt_fam.
IPR027010. Tshz2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERiPTHR12487. PTHR12487. 1 hit.
PTHR12487:SF3. PTHR12487:SF3. 1 hit.
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSH2_HUMAN
AccessioniPrimary (citable) accession number: Q9NRE2
Secondary accession number(s): B7Z7W1
, J3KNQ0, Q4VXM4, Q6N003, Q8N260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.