Q9NRE1 (MMP26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Matrix metalloproteinase-26
Short name=MMP-26
EC=3.4.24.-

Alternative name(s):
Endometase
Matrilysin-2

Gene names

Name:

MMP26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.
Cofactor	Binds 1 zinc ion per subunit By similarity. Calcium By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.
Domain	The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence similarities	Belongs to the peptidase M10A family.

Ontologies

Keywords
Biological process	Collagen degradation
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Calcium Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	collagen catabolic process Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Non-traceable author statement Ref.2. Source: UniProtKB
Cellular_component	proteinaceous extracellular matrix Non-traceable author statement Ref.3. Source: UniProtKB
Molecular_function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Propeptide	18 – 89	72	By similarity		PRO_0000028855
	Chain	90 – 261	172	Matrix metalloproteinase-26		PRO_0000028856
Regions
	Motif	80 – 87	8	Cysteine switch By similarity
Sites
	Active site	209	1	By similarity
	Metal binding	82	1	Zinc; in inhibited form By similarity
	Metal binding	208	1	Zinc; catalytic By similarity
	Metal binding	212	1	Zinc; catalytic By similarity
	Metal binding	218	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	221	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	43	1	K → E. Ref.3 Ref.4 Corresponds to variant rs2499953 [ dbSNP | Ensembl ].		VAR_033489
	Natural variant	260	1	I → M. Corresponds to variant rs16908114 [ dbSNP | Ensembl ].		VAR_033490
Experimental info
	Sequence conflict	71	1	M → I in AAF80180. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NRE1 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: A66D0DBE3ED7DE76	FASTA	261	29,708
	10 20 30 40 50 60 MQLVILRVTI FLPWCFAVPV PPAADHKGWD FVEGYFHQFF LTKKESPLLT QETQTQLLQQ 70 80 90 100 110 120 FHRNGTDLLD MQMHALLHQP HCGVPDGSDT SISPGRCKWN KHTLTYRIIN YPHDMKPSAV 130 140 150 160 170 180 KDSIYNAVSI WSNVTPLIFQ QVQNGDADIK VSFWQWAHED GWPFDGPGGI LGHAFLPNSG 190 200 210 220 230 240 NPGVVHFDKN EHWSASDTGY NLFLVATHEI GHSLGLQHSG NQSSIMYPTY WYHDPRTFQL 250 260 SADDIQRIQH LYGEKCSSDI P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of MMP-26 A novel matrilysin-like proteinase." Begnoit de Coignac A., Elson G.C.A., Delneste Y., Magistrelli G., Jeannin P., Aubry J.-P., Berthier O., Schmitt D., Bonnefoy J.-Y., Gauchat J.-F. Eur. J. Biochem. 267:3323-3329(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity." Uria J.A., Lopez-Otin C. Cancer Res. 60:4745-4751(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification and characterization of Homo sapiens endometase (matrix metalloproteinase-26) from endometrial tumor." Park H.I., Ni J., Gerkema F.E., Liu D., Belozerov V.E., Sang Q.-X.A. J. Biol. Chem. 275:20540-20544(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-43.
[4]	"Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin." Marchenko G.N., Ratnikov B.I., Rozanov D.V., Godzik A., Deryugina E.I., Strongin A.Y. Biochem. J. 356:705-718(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-43. Tissue: Kidney.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF230354 mRNA. Translation: AAF80180.1. AJ251531 mRNA. Translation: CAC08821.1. AF248646 mRNA. Translation: AAF82359.1. AF291664 mRNA. Translation: AAG00603.1. AF291665 Genomic DNA. Translation: AAG02470.1. BC101541 mRNA. Translation: AAI01542.1. BC101543 mRNA. Translation: AAI01544.1.
IPI	IPI00299784.
RefSeq	NP_068573.2. NM_021801.3.
UniGene	Hs.204732.
3D structure databases
ProteinModelPortal	Q9NRE1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000300762.
Protein family/group databases
MEROPS	M10.029.
PTM databases
PhosphoSite	Q9NRE1.
Polymorphism databases
DMDM	13629493.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300762; ENSP00000300762; ENSG00000167346. ENST00000380390; ENSP00000369753; ENSG00000167346.
GeneID	56547.
KEGG	hsa:56547.
UCSC	uc001lzv.3. human.
Organism-specific databases
CTD	56547.
GeneCards	GC11P004726.
HGNC	HGNC:14249. MMP26.
HPA	HPA022022.
MIM	605470. gene.
neXtProt	NX_Q9NRE1.
PharmGKB	PA30883.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG236071.
HOGENOM	HOG000239471.
HOVERGEN	HBG052484.
InParanoid	Q9NRE1.
KO	K08004.
OMA	DIKISFW.
OrthoDB	EOG4S7JQK.
PhylomeDB	Q9NRE1.
Gene expression databases
Bgee	Q9NRE1.
CleanEx	HS_MMP26.
Genevestigator	Q9NRE1.
GermOnline	ENSG00000167346. Homo sapiens.
Family and domain databases
Gene3D	3.40.390.10. 1 hit.
InterPro	IPR024079. MetalloPept_cat_dom. IPR001818. Pept_M10_metallopeptidase. IPR021190. Pept_M10A. IPR006026. Peptidase_Metallo. [Graphical view]
Pfam	PF00413. Peptidase_M10. 1 hit. [Graphical view]
PRINTS	PR00138. MATRIXIN.
SMART	SM00235. ZnMc. 1 hit. [Graphical view]
PROSITE	PS00546. CYSTEINE_SWITCH. False negative. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9NRE1.
ChEMBL	CHEMBL4707.
GenomeRNAi	56547.
NextBio	62031.
PMAP-CutDB	Q9NRE1.
SOURCE	Search...

Entry information

Entry name

MMP26_HUMAN

Accession

Primary (citable) accession number: Q9NRE1
Secondary accession number(s): Q3MJ78, Q9GZS2, Q9NR87

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	May 29, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.