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Protein

Matrix metalloproteinase-26

Gene

MMP26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

Cofactori

Protein has several cofactor binding sites:
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
  • Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Zinc; in inhibited formBy similarity1
Metal bindingi208Zinc; catalyticPROSITE-ProRule annotation1
Active sitei209PROSITE-ProRule annotation1
Metal bindingi212Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi218Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • collagen catabolic process Source: UniProtKB-KW
  • negative regulation of inflammatory response Source: CACAO
  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167346-MONOMER.
BRENDAi3.4.24.B7. 2681.

Protein family/group databases

MEROPSiM10.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinase-26 (EC:3.4.24.-)
Short name:
MMP-26
Alternative name(s):
Endometase
Matrilysin-2
Gene namesi
Name:MMP26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14249. MMP26.

Subcellular locationi

GO - Cellular componenti

  • proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56547.
OpenTargetsiENSG00000167346.
PharmGKBiPA30883.

Chemistry databases

ChEMBLiCHEMBL4707.
DrugBankiDB00786. Marimastat.
GuidetoPHARMACOLOGYi1648.

Polymorphism and mutation databases

BioMutaiMMP26.
DMDMi13629493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002885518 – 89By similarityAdd BLAST72
ChainiPRO_000002885690 – 261Matrix metalloproteinase-26Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9NRE1.
PRIDEiQ9NRE1.

PTM databases

iPTMnetiQ9NRE1.
PhosphoSitePlusiQ9NRE1.

Miscellaneous databases

PMAP-CutDBQ9NRE1.

Expressioni

Tissue specificityi

Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.

Gene expression databases

BgeeiENSG00000167346.
CleanExiHS_MMP26.
GenevisibleiQ9NRE1. HS.

Organism-specific databases

HPAiCAB033770.

Interactioni

Protein-protein interaction databases

BioGridi121151. 14 interactors.
STRINGi9606.ENSP00000300762.

Chemistry databases

BindingDBiQ9NRE1.

Structurei

3D structure databases

ProteinModelPortaliQ9NRE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi80 – 87Cysteine switchBy similarity8

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00860000133713.
HOGENOMiHOG000239471.
HOVERGENiHBG052484.
InParanoidiQ9NRE1.
KOiK08004.
OMAiNEHWSTS.
OrthoDBiEOG091G03DP.
PhylomeDBiQ9NRE1.
TreeFamiTF315428.

Family and domain databases

CDDicd04278. ZnMc_MMP. 1 hit.
Gene3Di3.40.390.10. 1 hit.
InterProiIPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR028736. MMP26.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PANTHERiPTHR10201:SF76. PTHR10201:SF76. 1 hit.
PfamiPF00413. Peptidase_M10. 1 hit.
[Graphical view]
PRINTSiPR00138. MATRIXIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLVILRVTI FLPWCFAVPV PPAADHKGWD FVEGYFHQFF LTKKESPLLT
60 70 80 90 100
QETQTQLLQQ FHRNGTDLLD MQMHALLHQP HCGVPDGSDT SISPGRCKWN
110 120 130 140 150
KHTLTYRIIN YPHDMKPSAV KDSIYNAVSI WSNVTPLIFQ QVQNGDADIK
160 170 180 190 200
VSFWQWAHED GWPFDGPGGI LGHAFLPNSG NPGVVHFDKN EHWSASDTGY
210 220 230 240 250
NLFLVATHEI GHSLGLQHSG NQSSIMYPTY WYHDPRTFQL SADDIQRIQH
260
LYGEKCSSDI P
Length:261
Mass (Da):29,708
Last modified:April 27, 2001 - v2
Checksum:iA66D0DBE3ED7DE76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71M → I in AAF80180 (PubMed:10824119).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03348943K → E.2 PublicationsCorresponds to variant rs2499953dbSNPEnsembl.1
Natural variantiVAR_033490260I → M.Corresponds to variant rs16908114dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230354 mRNA. Translation: AAF80180.1.
AJ251531 mRNA. Translation: CAC08821.1.
AF248646 mRNA. Translation: AAF82359.1.
AF291664 mRNA. Translation: AAG00603.1.
AF291665 Genomic DNA. Translation: AAG02470.1.
BC101541 mRNA. Translation: AAI01542.1.
BC101543 mRNA. Translation: AAI01544.1.
CCDSiCCDS7752.1.
RefSeqiNP_068573.2. NM_021801.4.
UniGeneiHs.204732.

Genome annotation databases

EnsembliENST00000300762; ENSP00000300762; ENSG00000167346.
ENST00000380390; ENSP00000369753; ENSG00000167346.
GeneIDi56547.
KEGGihsa:56547.
UCSCiuc001lzv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230354 mRNA. Translation: AAF80180.1.
AJ251531 mRNA. Translation: CAC08821.1.
AF248646 mRNA. Translation: AAF82359.1.
AF291664 mRNA. Translation: AAG00603.1.
AF291665 Genomic DNA. Translation: AAG02470.1.
BC101541 mRNA. Translation: AAI01542.1.
BC101543 mRNA. Translation: AAI01544.1.
CCDSiCCDS7752.1.
RefSeqiNP_068573.2. NM_021801.4.
UniGeneiHs.204732.

3D structure databases

ProteinModelPortaliQ9NRE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121151. 14 interactors.
STRINGi9606.ENSP00000300762.

Chemistry databases

BindingDBiQ9NRE1.
ChEMBLiCHEMBL4707.
DrugBankiDB00786. Marimastat.
GuidetoPHARMACOLOGYi1648.

Protein family/group databases

MEROPSiM10.029.

PTM databases

iPTMnetiQ9NRE1.
PhosphoSitePlusiQ9NRE1.

Polymorphism and mutation databases

BioMutaiMMP26.
DMDMi13629493.

Proteomic databases

PaxDbiQ9NRE1.
PRIDEiQ9NRE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300762; ENSP00000300762; ENSG00000167346.
ENST00000380390; ENSP00000369753; ENSG00000167346.
GeneIDi56547.
KEGGihsa:56547.
UCSCiuc001lzv.4. human.

Organism-specific databases

CTDi56547.
DisGeNETi56547.
GeneCardsiMMP26.
HGNCiHGNC:14249. MMP26.
HPAiCAB033770.
MIMi605470. gene.
neXtProtiNX_Q9NRE1.
OpenTargetsiENSG00000167346.
PharmGKBiPA30883.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00860000133713.
HOGENOMiHOG000239471.
HOVERGENiHBG052484.
InParanoidiQ9NRE1.
KOiK08004.
OMAiNEHWSTS.
OrthoDBiEOG091G03DP.
PhylomeDBiQ9NRE1.
TreeFamiTF315428.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167346-MONOMER.
BRENDAi3.4.24.B7. 2681.

Miscellaneous databases

GeneWikiiMMP26.
GenomeRNAii56547.
PMAP-CutDBQ9NRE1.
PROiQ9NRE1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167346.
CleanExiHS_MMP26.
GenevisibleiQ9NRE1. HS.

Family and domain databases

CDDicd04278. ZnMc_MMP. 1 hit.
Gene3Di3.40.390.10. 1 hit.
InterProiIPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR028736. MMP26.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PANTHERiPTHR10201:SF76. PTHR10201:SF76. 1 hit.
PfamiPF00413. Peptidase_M10. 1 hit.
[Graphical view]
PRINTSiPR00138. MATRIXIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMMP26_HUMAN
AccessioniPrimary (citable) accession number: Q9NRE1
Secondary accession number(s): Q3MJ78, Q9GZS2, Q9NR87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.