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Q9NRE1

- MMP26_HUMAN

UniProt

Q9NRE1 - MMP26_HUMAN

Protein

Matrix metalloproteinase-26

Gene

MMP26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity
    Calcium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi82 – 821Zinc; in inhibited formBy similarity
    Metal bindingi208 – 2081Zinc; catalyticPROSITE-ProRule annotation
    Active sitei209 – 2091PROSITE-ProRule annotation
    Metal bindingi212 – 2121Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi218 – 2181Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. collagen catabolic process Source: UniProtKB-KW
    2. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Collagen degradation

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM10.029.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrix metalloproteinase-26 (EC:3.4.24.-)
    Short name:
    MMP-26
    Alternative name(s):
    Endometase
    Matrilysin-2
    Gene namesi
    Name:MMP26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14249. MMP26.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30883.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 8972By similarityPRO_0000028855Add
    BLAST
    Chaini90 – 261172Matrix metalloproteinase-26PRO_0000028856Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Zymogen

    PTM databases

    PhosphoSiteiQ9NRE1.

    Miscellaneous databases

    PMAP-CutDBQ9NRE1.

    Expressioni

    Tissue specificityi

    Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.

    Gene expression databases

    BgeeiQ9NRE1.
    CleanExiHS_MMP26.
    GenevestigatoriQ9NRE1.

    Organism-specific databases

    HPAiHPA022022.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000300762.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NRE1.
    SMRiQ9NRE1. Positions 31-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi80 – 878Cysteine switchBy similarity

    Domaini

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Belongs to the peptidase M10A family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG236071.
    HOGENOMiHOG000239471.
    HOVERGENiHBG052484.
    InParanoidiQ9NRE1.
    KOiK08004.
    OMAiVTPLIFQ.
    OrthoDBiEOG7K3TMK.
    PhylomeDBiQ9NRE1.
    TreeFamiTF315428.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR028736. MMP26.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR006026. Peptidase_Metallo.
    [Graphical view]
    PANTHERiPTHR10201:SF76. PTHR10201:SF76. 1 hit.
    PfamiPF00413. Peptidase_M10. 1 hit.
    [Graphical view]
    PRINTSiPR00138. MATRIXIN.
    SMARTiSM00235. ZnMc. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NRE1-1 [UniParc]FASTAAdd to Basket

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    MQLVILRVTI FLPWCFAVPV PPAADHKGWD FVEGYFHQFF LTKKESPLLT    50
    QETQTQLLQQ FHRNGTDLLD MQMHALLHQP HCGVPDGSDT SISPGRCKWN 100
    KHTLTYRIIN YPHDMKPSAV KDSIYNAVSI WSNVTPLIFQ QVQNGDADIK 150
    VSFWQWAHED GWPFDGPGGI LGHAFLPNSG NPGVVHFDKN EHWSASDTGY 200
    NLFLVATHEI GHSLGLQHSG NQSSIMYPTY WYHDPRTFQL SADDIQRIQH 250
    LYGEKCSSDI P 261
    Length:261
    Mass (Da):29,708
    Last modified:April 27, 2001 - v2
    Checksum:iA66D0DBE3ED7DE76
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711M → I in AAF80180. (PubMed:10824119)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431K → E.2 Publications
    Corresponds to variant rs2499953 [ dbSNP | Ensembl ].
    VAR_033489
    Natural varianti260 – 2601I → M.
    Corresponds to variant rs16908114 [ dbSNP | Ensembl ].
    VAR_033490

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF230354 mRNA. Translation: AAF80180.1.
    AJ251531 mRNA. Translation: CAC08821.1.
    AF248646 mRNA. Translation: AAF82359.1.
    AF291664 mRNA. Translation: AAG00603.1.
    AF291665 Genomic DNA. Translation: AAG02470.1.
    BC101541 mRNA. Translation: AAI01542.1.
    BC101543 mRNA. Translation: AAI01544.1.
    CCDSiCCDS7752.1.
    RefSeqiNP_068573.2. NM_021801.3.
    UniGeneiHs.204732.

    Genome annotation databases

    EnsembliENST00000300762; ENSP00000300762; ENSG00000167346.
    ENST00000380390; ENSP00000369753; ENSG00000167346.
    GeneIDi56547.
    KEGGihsa:56547.
    UCSCiuc001lzv.3. human.

    Polymorphism databases

    DMDMi13629493.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF230354 mRNA. Translation: AAF80180.1 .
    AJ251531 mRNA. Translation: CAC08821.1 .
    AF248646 mRNA. Translation: AAF82359.1 .
    AF291664 mRNA. Translation: AAG00603.1 .
    AF291665 Genomic DNA. Translation: AAG02470.1 .
    BC101541 mRNA. Translation: AAI01542.1 .
    BC101543 mRNA. Translation: AAI01544.1 .
    CCDSi CCDS7752.1.
    RefSeqi NP_068573.2. NM_021801.3.
    UniGenei Hs.204732.

    3D structure databases

    ProteinModelPortali Q9NRE1.
    SMRi Q9NRE1. Positions 31-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000300762.

    Chemistry

    BindingDBi Q9NRE1.
    ChEMBLi CHEMBL4707.

    Protein family/group databases

    MEROPSi M10.029.

    PTM databases

    PhosphoSitei Q9NRE1.

    Polymorphism databases

    DMDMi 13629493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300762 ; ENSP00000300762 ; ENSG00000167346 .
    ENST00000380390 ; ENSP00000369753 ; ENSG00000167346 .
    GeneIDi 56547.
    KEGGi hsa:56547.
    UCSCi uc001lzv.3. human.

    Organism-specific databases

    CTDi 56547.
    GeneCardsi GC11P004726.
    HGNCi HGNC:14249. MMP26.
    HPAi HPA022022.
    MIMi 605470. gene.
    neXtProti NX_Q9NRE1.
    PharmGKBi PA30883.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236071.
    HOGENOMi HOG000239471.
    HOVERGENi HBG052484.
    InParanoidi Q9NRE1.
    KOi K08004.
    OMAi VTPLIFQ.
    OrthoDBi EOG7K3TMK.
    PhylomeDBi Q9NRE1.
    TreeFami TF315428.

    Miscellaneous databases

    GeneWikii MMP26.
    GenomeRNAii 56547.
    NextBioi 62031.
    PMAP-CutDB Q9NRE1.
    PROi Q9NRE1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NRE1.
    CleanExi HS_MMP26.
    Genevestigatori Q9NRE1.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR028736. MMP26.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR006026. Peptidase_Metallo.
    [Graphical view ]
    PANTHERi PTHR10201:SF76. PTHR10201:SF76. 1 hit.
    Pfami PF00413. Peptidase_M10. 1 hit.
    [Graphical view ]
    PRINTSi PR00138. MATRIXIN.
    SMARTi SM00235. ZnMc. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity."
      Uria J.A., Lopez-Otin C.
      Cancer Res. 60:4745-4751(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification and characterization of Homo sapiens endometase (matrix metalloproteinase-26) from endometrial tumor."
      Park H.I., Ni J., Gerkema F.E., Liu D., Belozerov V.E., Sang Q.-X.A.
      J. Biol. Chem. 275:20540-20544(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-43.
    4. "Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin."
      Marchenko G.N., Ratnikov B.I., Rozanov D.V., Godzik A., Deryugina E.I., Strongin A.Y.
      Biochem. J. 356:705-718(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-43.
      Tissue: Kidney.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiMMP26_HUMAN
    AccessioniPrimary (citable) accession number: Q9NRE1
    Secondary accession number(s): Q3MJ78, Q9GZS2, Q9NR87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3