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Q9NRE1

- MMP26_HUMAN

UniProt

Q9NRE1 - MMP26_HUMAN

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Protein

Matrix metalloproteinase-26

Gene

MMP26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.

Cofactori

Binds 1 zinc ion per subunit.By similarity
Calcium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Zinc; in inhibited formBy similarity
Metal bindingi208 – 2081Zinc; catalyticPROSITE-ProRule annotation
Active sitei209 – 2091PROSITE-ProRule annotation
Metal bindingi212 – 2121Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi218 – 2181Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB-KW
  2. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM10.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinase-26 (EC:3.4.24.-)
Short name:
MMP-26
Alternative name(s):
Endometase
Matrilysin-2
Gene namesi
Name:MMP26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14249. MMP26.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 8972By similarityPRO_0000028855Add
BLAST
Chaini90 – 261172Matrix metalloproteinase-26PRO_0000028856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Zymogen

PTM databases

PhosphoSiteiQ9NRE1.

Miscellaneous databases

PMAP-CutDBQ9NRE1.

Expressioni

Tissue specificityi

Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.

Gene expression databases

BgeeiQ9NRE1.
CleanExiHS_MMP26.
GenevestigatoriQ9NRE1.

Organism-specific databases

HPAiHPA022022.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300762.

Structurei

3D structure databases

ProteinModelPortaliQ9NRE1.
SMRiQ9NRE1. Positions 31-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi80 – 878Cysteine switchBy similarity

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG236071.
GeneTreeiENSGT00760000119132.
HOGENOMiHOG000239471.
HOVERGENiHBG052484.
InParanoidiQ9NRE1.
KOiK08004.
OMAiVTPLIFQ.
OrthoDBiEOG7K3TMK.
PhylomeDBiQ9NRE1.
TreeFamiTF315428.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR028736. MMP26.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PANTHERiPTHR10201:SF76. PTHR10201:SF76. 1 hit.
PfamiPF00413. Peptidase_M10. 1 hit.
[Graphical view]
PRINTSiPR00138. MATRIXIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLVILRVTI FLPWCFAVPV PPAADHKGWD FVEGYFHQFF LTKKESPLLT
60 70 80 90 100
QETQTQLLQQ FHRNGTDLLD MQMHALLHQP HCGVPDGSDT SISPGRCKWN
110 120 130 140 150
KHTLTYRIIN YPHDMKPSAV KDSIYNAVSI WSNVTPLIFQ QVQNGDADIK
160 170 180 190 200
VSFWQWAHED GWPFDGPGGI LGHAFLPNSG NPGVVHFDKN EHWSASDTGY
210 220 230 240 250
NLFLVATHEI GHSLGLQHSG NQSSIMYPTY WYHDPRTFQL SADDIQRIQH
260
LYGEKCSSDI P
Length:261
Mass (Da):29,708
Last modified:April 27, 2001 - v2
Checksum:iA66D0DBE3ED7DE76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711M → I in AAF80180. (PubMed:10824119)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431K → E.2 Publications
Corresponds to variant rs2499953 [ dbSNP | Ensembl ].
VAR_033489
Natural varianti260 – 2601I → M.
Corresponds to variant rs16908114 [ dbSNP | Ensembl ].
VAR_033490

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF230354 mRNA. Translation: AAF80180.1.
AJ251531 mRNA. Translation: CAC08821.1.
AF248646 mRNA. Translation: AAF82359.1.
AF291664 mRNA. Translation: AAG00603.1.
AF291665 Genomic DNA. Translation: AAG02470.1.
BC101541 mRNA. Translation: AAI01542.1.
BC101543 mRNA. Translation: AAI01544.1.
CCDSiCCDS7752.1.
RefSeqiNP_068573.2. NM_021801.3.
UniGeneiHs.204732.

Genome annotation databases

EnsembliENST00000300762; ENSP00000300762; ENSG00000167346.
ENST00000380390; ENSP00000369753; ENSG00000167346.
GeneIDi56547.
KEGGihsa:56547.
UCSCiuc001lzv.3. human.

Polymorphism databases

DMDMi13629493.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF230354 mRNA. Translation: AAF80180.1 .
AJ251531 mRNA. Translation: CAC08821.1 .
AF248646 mRNA. Translation: AAF82359.1 .
AF291664 mRNA. Translation: AAG00603.1 .
AF291665 Genomic DNA. Translation: AAG02470.1 .
BC101541 mRNA. Translation: AAI01542.1 .
BC101543 mRNA. Translation: AAI01544.1 .
CCDSi CCDS7752.1.
RefSeqi NP_068573.2. NM_021801.3.
UniGenei Hs.204732.

3D structure databases

ProteinModelPortali Q9NRE1.
SMRi Q9NRE1. Positions 31-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000300762.

Chemistry

BindingDBi Q9NRE1.
ChEMBLi CHEMBL4707.
DrugBanki DB00786. Marimastat.

Protein family/group databases

MEROPSi M10.029.

PTM databases

PhosphoSitei Q9NRE1.

Polymorphism databases

DMDMi 13629493.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300762 ; ENSP00000300762 ; ENSG00000167346 .
ENST00000380390 ; ENSP00000369753 ; ENSG00000167346 .
GeneIDi 56547.
KEGGi hsa:56547.
UCSCi uc001lzv.3. human.

Organism-specific databases

CTDi 56547.
GeneCardsi GC11P004726.
HGNCi HGNC:14249. MMP26.
HPAi HPA022022.
MIMi 605470. gene.
neXtProti NX_Q9NRE1.
PharmGKBi PA30883.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236071.
GeneTreei ENSGT00760000119132.
HOGENOMi HOG000239471.
HOVERGENi HBG052484.
InParanoidi Q9NRE1.
KOi K08004.
OMAi VTPLIFQ.
OrthoDBi EOG7K3TMK.
PhylomeDBi Q9NRE1.
TreeFami TF315428.

Miscellaneous databases

GeneWikii MMP26.
GenomeRNAii 56547.
NextBioi 62031.
PMAP-CutDB Q9NRE1.
PROi Q9NRE1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRE1.
CleanExi HS_MMP26.
Genevestigatori Q9NRE1.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR028736. MMP26.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR006026. Peptidase_Metallo.
[Graphical view ]
PANTHERi PTHR10201:SF76. PTHR10201:SF76. 1 hit.
Pfami PF00413. Peptidase_M10. 1 hit.
[Graphical view ]
PRINTSi PR00138. MATRIXIN.
SMARTi SM00235. ZnMc. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity."
    Uria J.A., Lopez-Otin C.
    Cancer Res. 60:4745-4751(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification and characterization of Homo sapiens endometase (matrix metalloproteinase-26) from endometrial tumor."
    Park H.I., Ni J., Gerkema F.E., Liu D., Belozerov V.E., Sang Q.-X.A.
    J. Biol. Chem. 275:20540-20544(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-43.
  4. "Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin."
    Marchenko G.N., Ratnikov B.I., Rozanov D.V., Godzik A., Deryugina E.I., Strongin A.Y.
    Biochem. J. 356:705-718(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-43.
    Tissue: Kidney.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiMMP26_HUMAN
AccessioniPrimary (citable) accession number: Q9NRE1
Secondary accession number(s): Q3MJ78, Q9GZS2, Q9NR87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3