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1 to 25 of 94  Show
  1. 1
    "Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family."
    De Deken X., Wang D., Many M.-C., Costagliola S., Libert F., Vassart G., Dumont J.E., Miot F.
    J. Biol. Chem. 275:23227-23233(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, VARIANT LEU-1067.
    Category: Expression, Sequences.
    Tissue: Thyroid.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 4 other entries.

  2. 2
    "Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox."
    Edens W.A., Sharling L., Cheng G., Shapira R., Kinkade J.M., Lee T., Edens H.A., Tang X., Sullards C., Flaherty D.B., Benian G.M., Lambeth J.D.
    J. Cell Biol. 154:879-891(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-138 AND LEU-1067, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Category: Expression, Sequences.
    Tissue: Pancreas and Thyroid.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  3. 3
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2395 other entries.

  4. 4
    "Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs."
    Dupuy C., Ohayon R., Valent A., Noel-Hudson M.-S., Deme D., Virion A.
    J. Biol. Chem. 274:37265-37269(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 339-1548, VARIANT LEU-1067.
    Category: Sequences.
    Tissue: Thyroid.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  5. 5
    "Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism."
    Hoste C., Rigutto S., Van Vliet G., Miot F., De Deken X.
    Hum. Mutat. 31:E1304-E1319(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1509-1548, VARIANT TDH6 SER-1518, CHARACTERIZATION OF VARIANT TDH6 SER-1518.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  6. 6
    "Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system."
    De Deken X., Wang D., Dumont J.E., Miot F.
    Exp. Cell Res. 273:187-196(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION.
    Category: PTM / Processing.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  7. 7
    "Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism."
    Moreno J.C., Bikker H., Kempers M.J.E., van Trotsenburg A.S., Baas F., de Vijlder J.J.M., Vulsma T., Ris-Stalpers C.
    N. Engl. J. Med. 347:95-102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN TDH6.
    Category: Pathology & Biotech.
    Source: UniProtKB/Swiss-Prot (reviewed).
  8. 8
    "Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense."
    Geiszt M., Witta J., Baffi J., Lekstrom K., Leto T.L.
    FASEB J. 17:1502-1504(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
    Category: Function, Expression.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  9. 9
    "NADPH oxidase-dependent acid production in airway epithelial cells."
    Schwarzer C., Machen T.E., Illek B., Fischer H.
    J. Biol. Chem. 279:36454-36461(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Category: Expression.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  10. 10
    Category: Subcellular Location, Expression.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 and mapped to 14 other entries.

  11. 11
    "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."
    Wang D., De Deken X., Milenkovic M., Song Y., Pirson I., Dumont J.E., Miot F.
    J. Biol. Chem. 280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TXNDC11; TPO AND CYBA.
    Category: Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 5 and mapped to 5 other entries.

  12. 12
    Cited for: CATALYTIC ACTIVITY, ENZYME REGULATION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 and mapped to 14 other entries.

  13. 13
    "Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings."
    Vigone M.C., Fugazzola L., Zamproni I., Passoni A., Di Candia S., Chiumello G., Persani L., Weber G.
    Hum. Mutat. 26:395-395(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH6 TRP-376.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  14. 14
    "Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A-->C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect."
    Varela V., Rivolta C.M., Esperante S.A., Gruneiro-Papendieck L., Chiesa A., Targovnik H.M.
    Clin. Chem. 52:182-191(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TDH6 HIS-36.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 14 other entries.

  15. 15
    "When an intramolecular disulfide bridge governs the interaction of DUOX2 with its partner DUOXA2."
    Carre A., Louzada R.A., Fortunato R.S., Ameziane-El-Hassani R., Morand S., Ogryzko V., de Carvalho D.P., Grasberger H., Leto T.L., Dupuy C.
    Antioxid. Redox Signal. 23:724-733(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, DISULFIDE BONDS.
    Category: PTM / Processing, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 15 other entries.

  16. 16
    Cited for: POSSIBLE INVOLVEMENT IN INFLAMMATORY BOWEL DISEASE, VARIANTS CYS-1211 AND CYS-1492, SUBCELLULAR LOCATION.
    Category: Subcellular Location, Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  17. 17
    "Targeting of the dual oxidase 2 N-terminal region to the plasma membrane."
    Morand S., Agnandji D., Noel-Hudson M.S., Nicolas V., Buisson S., Macon-Lemaitre L., Gnidehou S., Kaniewski J., Ohayon R., Virion A., Dupuy C.
    J. Biol. Chem. 279:30244-30251(2004) [PubMed] [Europe PMC] [Abstract]
    Annotation: the dual oxidase 2 N-terminal region is targeted to the plasma membraneImported.
    Source: GeneRIF:50506.

    This publication is mapped to 15 other entries.

  18. 18
    "Regulated hydrogen peroxide production by Duox in human airway epithelial cells."
    Forteza R., Salathe M., Miot F., Forteza R., Conner G.E.
    Am. J. Respir. Cell Mol. Biol. 32:462-469(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: These data suggest that Duox1 and 2 are the major NADPH oxidases expressed in airway epithelia and therefore contributors of hydrogen peroxide production in the airway lumen.Imported.
    Source: GeneRIF:50506.

    This publication is mapped to 21 other entries.

  19. 19
    "Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium."
    Harper R.W., Xu C., Eiserich J.P., Chen Y., Kao C.-Y., Thai P., Setiadi H., Wu R.
    FEBS Lett. 579:4911-4917(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Results demonstrate the regulation of Duox1 and 2 expression by Th1 and Th2 cytokines and suggest a mechanism by which ROS production can be regulated in the respiratory tract as part of the host defense response.Imported.
    Source: GeneRIF:50506.

    This publication is mapped to 20 other entries.

  20. 20
    "Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide."
    Gerard A.C., Boucquey M., van den Hove M.F., Colin I.M.
    Am. J. Physiol. Endocrinol. Metab. 291:E242-53(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: In conclusion incubation of normal or GD thyrocytes with Th1 cytokines induces a significant reduction in TSH-increased expression of both TPO and ThOXs an effect partially mediated by NO.Imported.
    Source: GeneRIF:50506.

    This publication is mapped to 34 other entries.

  21. 21
    "Genetic polymorphisms and susceptibility to lung disease."
    Lee P.L., West C., Crain K., Wang L.
    J Negat Results Biomed 5:5-5(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: Observational study of gene-disease association. (HuGE Navigator)Imported.
    Source: GeneRIF:50506.

    This publication is mapped to 59 other entries.

  22. 22
    "Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent."
    Grasberger H., Refetoff S.
    J. Biol. Chem. 281:18269-18272(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: co-expression with DUOXA2 an ER-resident transmembrane protein allows ER-to-Golgi transition maturation and translocation to the plasma membrane of functional DUOX2 in a heterologous systemImported.
    Source: GeneRIF:50506.

    This publication is cited by 1 and mapped to 16 other entries.

  23. 23
    "Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor."
    Grasberger H., De Deken X., Miot F., Pohlenz J., Refetoff S.
    Mol. Endocrinol. 21:1408-1421(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: DUOXA2 allows rapid ER exit of folded DUOX2 or enhanced degradation of mutant DUOX2 proteins not competent for ER exit.Imported.
    Source: GeneRIF:50506.

    This publication is mapped to 17 other entries.

  24. 24
    "New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations."
    Moreno J.C., Visser T.J.
    Endocr Dev 10:99-117(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: Analysis of point mutations opens possibility to ascertain whether transiency or permanency of DUOX2 phenotypes relate to monoallelic or biallelic inactivation of gene or if degree of pathogenic severity of mutations may also influence outcome. (Review)Imported.
    Source: GeneRIF:50506.

    This publication is mapped to 15 other entries.

  25. 25
    "Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease."
    Nagai K., Betsuyaku T., Suzuki M., Nasuhara Y., Kaga K., Kondo S., Nishimura M.
    Antioxid. Redox Signal. 10:705-714(2008) [PubMed] [Europe PMC] [Abstract]
    Annotation: Results imply that the airway expression of Duox2 is diversely associated with smoking and chronic obstructive pulmonary disease.Imported.
    Source: GeneRIF:50506.

    This publication is mapped to 21 other entries.

1 to 25 of 94  Show

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