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Reviewed, UniProtKB/Swiss-Prot Q9NRD1 (FBX6_HUMAN)

Last modified June 16, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    F-box only protein 6
Alternative name(s):
    F-box/G-domain protein 2
Gene names
Name: FBXO6
Synonyms: FBG2, FBX6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Subunit structure

Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Sequence similarities

Contains 1 F-box domain.

Contains 1 FBA (F-box associated) domain.

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Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityPolymorphism
Gene Ontology (GO)
   Biological processmodification-dependent protein catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293F-box only protein 6
PRO_0000119882

Regions

Domain10 – 5748F-box
Domain78 – 259182FBA

Natural variations

Natural variant601R → Q: dbSNP rs3125818.
VAR_049039
Natural variant2011P → T: dbSNP rs2294639.
VAR_022158

Experimental info

Sequence conflict181E → D in AAF04470. Ref.1
Sequence conflict511M → L in AAF04470. Ref.1
Sequence conflict611E → K in AAF04470. Ref.1
Sequence conflict961E → N in AAF04470. Ref.1
Sequence conflict1141E → D in AAF04470. Ref.1
Sequence conflict1231D → E in AAF04470. Ref.1
Sequence conflict1321Y → S in AAF04470. Ref.1
Sequence conflict1391M → L in AAF04470. Ref.1
Sequence conflict143 – 1442SQ → WE in AAF04470. Ref.1
Sequence conflict149 – 1524VAEG → LADR in AAF04470. Ref.1
Sequence conflict2871R → G in AAF04470. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q9NRD1-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: EA4235CD9CCD80FF

FASTA29333,933
        10         20         30         40         50         60 
MDAPHSKAAL DSINELPENI LLELFTHVPA RQLLLNCRLV CSLWRDLIDL MTLWKRKCLR 

        70         80         90        100        110        120 
EGFITKDWDQ PVADWKIFYF LRSLHRNLLR NPCAEEDMFA WQIDFNGGDR WKVESLPGAH 

       130        140        150        160        170        180 
GTDFPDPKVK KYFVTSYEMC LKSQLVDLVA EGYWEELLDT FRPDIVVKDW FAARADCGCT 

       190        200        210        220        230        240 
YQLKVQLASA DYFVLASFEP PPVTIQQWNN ATWTEVSYTF SDYPRGVRYI LFQHGGRDTQ 

       250        260        270        280        290 
YWAGWYGPRV TNSSIVVSPK MTRNQASSEA QPGQKHGQEE AAQSPYRAVV QIF

« Hide

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References

« Hide 'large scale' references
[1]"Identification of a family of human F-box proteins."
Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M.
Curr. Biol. 9:1177-1179(1999) [PubMed: 10531035] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"cDNA cloning and expression analysis of new members of the mammalian F-box protein family."
Ilyin G.P., Rialland M., Pigeon C., Guguen-Guillouzo C.
Genomics 67:40-47(2000) [PubMed: 10945468] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF129536 mRNA. Translation: AAF04470.1. Different initiation.
AF233223 mRNA. Translation: AAF67153.1.
AL031731 Genomic DNA. Translation: CAI20214.1.
BC020880 mRNA. Translation: AAH20880.1.
IPIIPI00171291.
RefSeqNP_060908.1.
UniGeneHs.464419

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ9NRD1.

Genome annotation databases

EnsemblENSG00000116663. Homo sapiens. [Contig view]
GeneID26270.
KEGGhsa:26270.

Organism-specific databases

GeneCardsGC01P011658.
H-InvDBHIX0023158.
HGNCHGNC:13585. FBXO6.
MIM605647. gene.
PharmGKBPA28046.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9NRD1.
HOVERGENQ9NRD1.
OMAQ9NRD1. APRADCG.

Gene expression databases

ArrayExpressQ9NRD1.
BgeeQ9NRD1.
CleanExHS_FBXO6.
GermOnlineENSG00000116663. Homo sapiens.

Family and domain databases

InterProIPR001810. F-box.
IPR007397. FBA_region.
[Graphical view]
PfamPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
[Graphical view]
PROSITEPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio48557.
SOURCESearch...

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Entry information

Entry nameFBX6_HUMAN
AccessionPrimary (citable) accession number: Q9NRD1
Secondary accession number(s): Q9UKT3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 1, 2000
Last modified: June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents