ID FBX8_HUMAN Reviewed; 319 AA. AC Q9NRD0; B2RB40; D3DP41; G5E9Z0; Q6UWN4; Q8IWE1; Q9NRP5; Q9UKC4; DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 27-MAR-2024, entry version 181. DE RecName: Full=F-box only protein 8; DE AltName: Full=F-box/SEC7 protein FBS; GN Name=FBXO8; Synonyms=FBS, FBX8; ORFNames=DC10, UNQ1877/PRO4320; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=10531035; DOI=10.1016/s0960-9822(00)80020-2; RA Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., RA Pagano M.; RT "Identification of a family of human F-box proteins."; RL Curr. Biol. 9:1177-1179(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=10945468; DOI=10.1006/geno.2000.6211; RA Ilyin G.P., Rialland M., Pigeon C., Guguen-Guillouzo C.; RT "cDNA cloning and expression analysis of new members of the mammalian F-box RT protein family."; RL Genomics 67:40-47(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Dendritic cell; RA Li Y., Peng Y., Qian B., Zhang Z., Han Z., Fu G., Chen Z.; RT "Novel genes expressed in human dendritic cell."; RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS RP MET-51 AND HIS-156. RC TISSUE=Brain, and Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP VARIANT [LARGE SCALE ANALYSIS] ILE-269. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: May promote guanine-nucleotide exchange on an ARF. Promotes CC the activation of ARF through replacement of GDP with GTP (Potential). CC {ECO:0000305}. CC -!- INTERACTION: CC Q9NRD0; P09211: GSTP1; NbExp=3; IntAct=EBI-11615366, EBI-353467; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9NRD0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9NRD0-2; Sequence=VSP_055885; CC -!- SEQUENCE CAUTION: CC Sequence=AAF04517.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF174596; AAF04517.1; ALT_INIT; mRNA. DR EMBL; AF233224; AAF67154.1; -; mRNA. DR EMBL; AF201932; AAF86868.1; -; mRNA. DR EMBL; AY358721; AAQ89083.1; -; mRNA. DR EMBL; AK314483; BAG37087.1; -; mRNA. DR EMBL; AC097653; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471056; EAX04741.1; -; Genomic_DNA. DR EMBL; CH471056; EAX04742.1; -; Genomic_DNA. DR EMBL; CH471056; EAX04744.1; -; Genomic_DNA. DR EMBL; BC014679; AAH14679.1; -; mRNA. DR EMBL; BC040456; AAH40456.1; -; mRNA. DR CCDS; CCDS3820.1; -. [Q9NRD0-1] DR RefSeq; NP_036312.2; NM_012180.2. [Q9NRD0-1] DR AlphaFoldDB; Q9NRD0; -. DR SMR; Q9NRD0; -. DR BioGRID; 117653; 12. DR ComplexPortal; CPX-7921; SCF E3 ubiquitin ligase complex, FBXO8 variant. DR IntAct; Q9NRD0; 4. DR STRING; 9606.ENSP00000377280; -. DR iPTMnet; Q9NRD0; -. DR PhosphoSitePlus; Q9NRD0; -. DR BioMuta; FBXO8; -. DR DMDM; 13124142; -. DR EPD; Q9NRD0; -. DR MassIVE; Q9NRD0; -. DR PaxDb; 9606-ENSP00000377280; -. DR PeptideAtlas; Q9NRD0; -. DR ProteomicsDB; 34088; -. DR ProteomicsDB; 82337; -. [Q9NRD0-1] DR Antibodypedia; 1238; 281 antibodies from 25 providers. DR DNASU; 26269; -. DR Ensembl; ENST00000393674.7; ENSP00000377280.2; ENSG00000164117.14. [Q9NRD0-1] DR Ensembl; ENST00000503293.5; ENSP00000422905.1; ENSG00000164117.14. [Q9NRD0-2] DR Ensembl; ENST00000615392.4; ENSP00000484517.1; ENSG00000164117.14. [Q9NRD0-2] DR GeneID; 26269; -. DR KEGG; hsa:26269; -. DR MANE-Select; ENST00000393674.7; ENSP00000377280.2; NM_012180.3; NP_036312.2. DR UCSC; uc003itp.4; human. [Q9NRD0-1] DR AGR; HGNC:13587; -. DR CTD; 26269; -. DR DisGeNET; 26269; -. DR GeneCards; FBXO8; -. DR HGNC; HGNC:13587; FBXO8. DR HPA; ENSG00000164117; Low tissue specificity. DR MIM; 605649; gene. DR neXtProt; NX_Q9NRD0; -. DR OpenTargets; ENSG00000164117; -. DR PharmGKB; PA28048; -. DR VEuPathDB; HostDB:ENSG00000164117; -. DR eggNOG; KOG0929; Eukaryota. DR GeneTree; ENSGT00940000158356; -. DR HOGENOM; CLU_057531_0_0_1; -. DR InParanoid; Q9NRD0; -. DR OMA; NANPHEG; -. DR OrthoDB; 204547at2759; -. DR PhylomeDB; Q9NRD0; -. DR PathwayCommons; Q9NRD0; -. DR SignaLink; Q9NRD0; -. DR SIGNOR; Q9NRD0; -. DR BioGRID-ORCS; 26269; 16 hits in 1196 CRISPR screens. DR ChiTaRS; FBXO8; human. DR GenomeRNAi; 26269; -. DR Pharos; Q9NRD0; Tbio. DR PRO; PR:Q9NRD0; -. DR Proteomes; UP000005640; Chromosome 4. DR RNAct; Q9NRD0; Protein. DR Bgee; ENSG00000164117; Expressed in jejunal mucosa and 180 other cell types or tissues. DR ExpressionAtlas; Q9NRD0; baseline and differential. DR GO; GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; NAS:UniProtKB. DR CDD; cd22088; F-box_FBXO8; 1. DR CDD; cd00171; Sec7; 1. DR Gene3D; 1.10.220.20; -; 1. DR Gene3D; 1.20.1280.50; -; 1. DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1. DR InterPro; IPR036047; F-box-like_dom_sf. DR InterPro; IPR001810; F-box_dom. DR InterPro; IPR048003; FBXO8_F-box. DR InterPro; IPR023394; Sec7_C_sf. DR InterPro; IPR000904; Sec7_dom. DR InterPro; IPR035999; Sec7_dom_sf. DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1. DR Pfam; PF12937; F-box-like; 1. DR Pfam; PF01369; Sec7; 1. DR SMART; SM00222; Sec7; 1. DR SUPFAM; SSF81383; F-box domain; 1. DR SUPFAM; SSF48425; Sec7 domain; 1. DR PROSITE; PS50181; FBOX; 1. DR PROSITE; PS50190; SEC7; 1. DR Genevisible; Q9NRD0; HS. PE 1: Evidence at protein level; KW Alternative splicing; Guanine-nucleotide releasing factor; KW Reference proteome. FT CHAIN 1..319 FT /note="F-box only protein 8" FT /id="PRO_0000120218" FT DOMAIN 68..111 FT /note="F-box" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080" FT DOMAIN 146..276 FT /note="SEC7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00189" FT VAR_SEQ 59..99 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_055885" FT VARIANT 51 FT /note="I -> M (in dbSNP:rs17857220)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_071118" FT VARIANT 156 FT /note="Y -> H (in dbSNP:rs17854000)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_071119" FT VARIANT 269 FT /note="L -> I (in a breast cancer sample; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_036157" FT CONFLICT 34 FT /note="A -> D (in Ref. 4; AAQ89083)" FT /evidence="ECO:0000305" FT CONFLICT 119 FT /note="C -> W (in Ref. 3; AAF86868)" FT /evidence="ECO:0000305" FT CONFLICT 135 FT /note="L -> V (in Ref. 3; AAF86868)" FT /evidence="ECO:0000305" SQ SEQUENCE 319 AA; 37068 MW; 125D6D6B57CA7C79 CRC64; MGQGLWRVVR NQQLQQEGYS EQGYLTREQS RRMAASNISN TNHRKQVQGG IDIYHLLKAR KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD LANDELLWQG LCKSTWGHCS IYNKNPPLGF SFRKLYMQLD EGSLTFNANP DEGVNYFMSK GILDDSPKEI AKFIFCTRTL NWKKLRIYLD ERRDVLDDLV TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH RFCACNPDLM RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS EDFVGHLYDN IYLIGHVAA //