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Protein

F-box only protein 8

Gene

FBXO8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 8
Alternative name(s):
F-box/SEC7 protein FBS
Gene namesi
Name:FBXO8
Synonyms:FBS, FBX8
ORF Names:DC10, UNQ1877/PRO4320
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:13587. FBXO8.

Subcellular locationi

GO - Cellular componenti

  • trans-Golgi network Source: GO_Central
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28048.

Polymorphism and mutation databases

BioMutaiFBXO8.
DMDMi13124142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319F-box only protein 8PRO_0000120218Add
BLAST

Proteomic databases

PaxDbiQ9NRD0.
PRIDEiQ9NRD0.

PTM databases

PhosphoSiteiQ9NRD0.

Expressioni

Gene expression databases

BgeeiQ9NRD0.
CleanExiHS_FBXO8.
ExpressionAtlasiQ9NRD0. baseline and differential.
GenevisibleiQ9NRD0. HS.

Organism-specific databases

HPAiHPA002885.

Interactioni

Protein-protein interaction databases

BioGridi117653. 7 interactions.
STRINGi9606.ENSP00000377280.

Structurei

3D structure databases

ProteinModelPortaliQ9NRD0.
SMRiQ9NRD0. Positions 139-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 11144F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini146 – 276131SEC7PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5307.
GeneTreeiENSGT00780000122046.
HOGENOMiHOG000006813.
HOVERGENiHBG018990.
InParanoidiQ9NRD0.
KOiK10294.
OMAiFSNQFLP.
OrthoDBiEOG7K3TM8.
PhylomeDBiQ9NRD0.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiIPR001810. F-box_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGLWRVVR NQQLQQEGYS EQGYLTREQS RRMAASNISN TNHRKQVQGG
60 70 80 90 100
IDIYHLLKAR KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD
110 120 130 140 150
LANDELLWQG LCKSTWGHCS IYNKNPPLGF SFRKLYMQLD EGSLTFNANP
160 170 180 190 200
DEGVNYFMSK GILDDSPKEI AKFIFCTRTL NWKKLRIYLD ERRDVLDDLV
210 220 230 240 250
TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH RFCACNPDLM
260 270 280 290 300
RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS
310
EDFVGHLYDN IYLIGHVAA
Length:319
Mass (Da):37,068
Last modified:October 1, 2000 - v1
Checksum:i125D6D6B57CA7C79
GO
Isoform 2 (identifier: Q9NRD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-99: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):32,426
Checksum:iD0615626C2EBF06F
GO

Sequence cautioni

The sequence AAF04517.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341A → D in AAQ89083 (PubMed:12975309).Curated
Sequence conflicti119 – 1191C → W in AAF86868 (Ref. 3) Curated
Sequence conflicti135 – 1351L → V in AAF86868 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511I → M.1 Publication
Corresponds to variant rs17857220 [ dbSNP | Ensembl ].
VAR_071118
Natural varianti156 – 1561Y → H.1 Publication
Corresponds to variant rs17854000 [ dbSNP | Ensembl ].
VAR_071119
Natural varianti269 – 2691L → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_036157

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei59 – 9941Missing in isoform 2. 1 PublicationVSP_055885Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174596 mRNA. Translation: AAF04517.1. Different initiation.
AF233224 mRNA. Translation: AAF67154.1.
AF201932 mRNA. Translation: AAF86868.1.
AY358721 mRNA. Translation: AAQ89083.1.
AK314483 mRNA. Translation: BAG37087.1.
AC097653 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04741.1.
CH471056 Genomic DNA. Translation: EAX04742.1.
CH471056 Genomic DNA. Translation: EAX04744.1.
BC014679 mRNA. Translation: AAH14679.1.
BC040456 mRNA. Translation: AAH40456.1.
CCDSiCCDS3820.1. [Q9NRD0-1]
RefSeqiNP_036312.2. NM_012180.2. [Q9NRD0-1]
UniGeneiHs.76917.

Genome annotation databases

EnsembliENST00000393674; ENSP00000377280; ENSG00000164117. [Q9NRD0-1]
ENST00000503293; ENSP00000422905; ENSG00000164117. [Q9NRD0-2]
ENST00000615392; ENSP00000484517; ENSG00000164117. [Q9NRD0-2]
GeneIDi26269.
KEGGihsa:26269.
UCSCiuc003itp.3. human. [Q9NRD0-1]
uc003itq.3. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174596 mRNA. Translation: AAF04517.1. Different initiation.
AF233224 mRNA. Translation: AAF67154.1.
AF201932 mRNA. Translation: AAF86868.1.
AY358721 mRNA. Translation: AAQ89083.1.
AK314483 mRNA. Translation: BAG37087.1.
AC097653 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04741.1.
CH471056 Genomic DNA. Translation: EAX04742.1.
CH471056 Genomic DNA. Translation: EAX04744.1.
BC014679 mRNA. Translation: AAH14679.1.
BC040456 mRNA. Translation: AAH40456.1.
CCDSiCCDS3820.1. [Q9NRD0-1]
RefSeqiNP_036312.2. NM_012180.2. [Q9NRD0-1]
UniGeneiHs.76917.

3D structure databases

ProteinModelPortaliQ9NRD0.
SMRiQ9NRD0. Positions 139-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117653. 7 interactions.
STRINGi9606.ENSP00000377280.

PTM databases

PhosphoSiteiQ9NRD0.

Polymorphism and mutation databases

BioMutaiFBXO8.
DMDMi13124142.

Proteomic databases

PaxDbiQ9NRD0.
PRIDEiQ9NRD0.

Protocols and materials databases

DNASUi26269.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393674; ENSP00000377280; ENSG00000164117. [Q9NRD0-1]
ENST00000503293; ENSP00000422905; ENSG00000164117. [Q9NRD0-2]
ENST00000615392; ENSP00000484517; ENSG00000164117. [Q9NRD0-2]
GeneIDi26269.
KEGGihsa:26269.
UCSCiuc003itp.3. human. [Q9NRD0-1]
uc003itq.3. human.

Organism-specific databases

CTDi26269.
GeneCardsiGC04M175157.
HGNCiHGNC:13587. FBXO8.
HPAiHPA002885.
MIMi605649. gene.
neXtProtiNX_Q9NRD0.
PharmGKBiPA28048.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5307.
GeneTreeiENSGT00780000122046.
HOGENOMiHOG000006813.
HOVERGENiHBG018990.
InParanoidiQ9NRD0.
KOiK10294.
OMAiFSNQFLP.
OrthoDBiEOG7K3TM8.
PhylomeDBiQ9NRD0.

Miscellaneous databases

GenomeRNAii26269.
NextBioi35518274.
PROiQ9NRD0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NRD0.
CleanExiHS_FBXO8.
ExpressionAtlasiQ9NRD0. baseline and differential.
GenevisibleiQ9NRD0. HS.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiIPR001810. F-box_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "cDNA cloning and expression analysis of new members of the mammalian F-box protein family."
    Ilyin G.P., Rialland M., Pigeon C., Guguen-Guillouzo C.
    Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Novel genes expressed in human dendritic cell."
    Li Y., Peng Y., Qian B., Zhang Z., Han Z., Fu G., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS MET-51 AND HIS-156.
    Tissue: Brain and Ovary.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-269.

Entry informationi

Entry nameiFBX8_HUMAN
AccessioniPrimary (citable) accession number: Q9NRD0
Secondary accession number(s): B2RB40
, D3DP41, G5E9Z0, Q6UWN4, Q8IWE1, Q9NRP5, Q9UKC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.