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Q9NRD0

- FBX8_HUMAN

UniProt

Q9NRD0 - FBX8_HUMAN

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Protein

F-box only protein 8

Gene
FBXO8, FBS, FBX8, DC10, UNQ1877/PRO4320
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP Reviewed prediction.

GO - Molecular functioni

  1. ARF guanyl-nucleotide exchange factor activity Source: RefGenome

GO - Biological processi

  1. actin cytoskeleton organization Source: RefGenome
  2. regulation of ARF protein signal transduction Source: InterPro
  3. regulation of GTPase activity Source: GOC
  4. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 8
Alternative name(s):
F-box/SEC7 protein FBS
Gene namesi
Name:FBXO8
Synonyms:FBS, FBX8
ORF Names:DC10, UNQ1877/PRO4320
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:13587. FBXO8.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: RefGenome
  2. nucleus Source: RefGenome
  3. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319F-box only protein 8PRO_0000120218Add
BLAST

Proteomic databases

PaxDbiQ9NRD0.
PRIDEiQ9NRD0.

PTM databases

PhosphoSiteiQ9NRD0.

Expressioni

Gene expression databases

ArrayExpressiQ9NRD0.
BgeeiQ9NRD0.
CleanExiHS_FBXO8.
GenevestigatoriQ9NRD0.

Organism-specific databases

HPAiHPA002885.

Interactioni

Protein-protein interaction databases

BioGridi117653. 6 interactions.
STRINGi9606.ENSP00000377280.

Structurei

3D structure databases

ProteinModelPortaliQ9NRD0.
SMRiQ9NRD0. Positions 146-311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 11144F-boxAdd
BLAST
Domaini146 – 276131SEC7Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.
Contains 1 SEC7 domain.

Phylogenomic databases

eggNOGiCOG5307.
HOGENOMiHOG000006813.
HOVERGENiHBG018990.
InParanoidiQ9NRD0.
KOiK10294.
OMAiSNTSHRK.
OrthoDBiEOG7K3TM8.
PhylomeDBiQ9NRD0.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiIPR001810. F-box_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NRD0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGQGLWRVVR NQQLQQEGYS EQGYLTREQS RRMAASNISN TNHRKQVQGG    50
IDIYHLLKAR KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD 100
LANDELLWQG LCKSTWGHCS IYNKNPPLGF SFRKLYMQLD EGSLTFNANP 150
DEGVNYFMSK GILDDSPKEI AKFIFCTRTL NWKKLRIYLD ERRDVLDDLV 200
TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH RFCACNPDLM 250
RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS 300
EDFVGHLYDN IYLIGHVAA 319
Length:319
Mass (Da):37,068
Last modified:October 1, 2000 - v1
Checksum:i125D6D6B57CA7C79
GO
Isoform 2 (identifier: Q9NRD0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-99: Missing.

Note: No experimental confirmation available.

Show »
Length:278
Mass (Da):32,426
Checksum:iD0615626C2EBF06F
GO

Sequence cautioni

The sequence AAF04517.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511I → M.
Corresponds to variant rs17857220 [ dbSNP | Ensembl ].
VAR_071118
Natural varianti156 – 1561Y → H.
Corresponds to variant rs17854000 [ dbSNP | Ensembl ].
VAR_071119
Natural varianti269 – 2691L → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_036157

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei59 – 9941Missing in isoform 2. VSP_055885Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341A → D in AAQ89083. 1 Publication
Sequence conflicti119 – 1191C → W in AAF86868. 1 Publication
Sequence conflicti135 – 1351L → V in AAF86868. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF174596 mRNA. Translation: AAF04517.1. Different initiation.
AF233224 mRNA. Translation: AAF67154.1.
AF201932 mRNA. Translation: AAF86868.1.
AY358721 mRNA. Translation: AAQ89083.1.
AK314483 mRNA. Translation: BAG37087.1.
AC097653 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04741.1.
CH471056 Genomic DNA. Translation: EAX04742.1.
CH471056 Genomic DNA. Translation: EAX04744.1.
BC014679 mRNA. Translation: AAH14679.1.
BC040456 mRNA. Translation: AAH40456.1.
CCDSiCCDS3820.1.
RefSeqiNP_036312.2. NM_012180.2.
UniGeneiHs.76917.

Genome annotation databases

EnsembliENST00000393674; ENSP00000377280; ENSG00000164117.
ENST00000503293; ENSP00000422905; ENSG00000164117.
GeneIDi26269.
KEGGihsa:26269.
UCSCiuc003itp.3. human.

Polymorphism databases

DMDMi13124142.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF174596 mRNA. Translation: AAF04517.1 . Different initiation.
AF233224 mRNA. Translation: AAF67154.1 .
AF201932 mRNA. Translation: AAF86868.1 .
AY358721 mRNA. Translation: AAQ89083.1 .
AK314483 mRNA. Translation: BAG37087.1 .
AC097653 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04741.1 .
CH471056 Genomic DNA. Translation: EAX04742.1 .
CH471056 Genomic DNA. Translation: EAX04744.1 .
BC014679 mRNA. Translation: AAH14679.1 .
BC040456 mRNA. Translation: AAH40456.1 .
CCDSi CCDS3820.1.
RefSeqi NP_036312.2. NM_012180.2.
UniGenei Hs.76917.

3D structure databases

ProteinModelPortali Q9NRD0.
SMRi Q9NRD0. Positions 146-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117653. 6 interactions.
STRINGi 9606.ENSP00000377280.

PTM databases

PhosphoSitei Q9NRD0.

Polymorphism databases

DMDMi 13124142.

Proteomic databases

PaxDbi Q9NRD0.
PRIDEi Q9NRD0.

Protocols and materials databases

DNASUi 26269.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000393674 ; ENSP00000377280 ; ENSG00000164117 .
ENST00000503293 ; ENSP00000422905 ; ENSG00000164117 .
GeneIDi 26269.
KEGGi hsa:26269.
UCSCi uc003itp.3. human.

Organism-specific databases

CTDi 26269.
GeneCardsi GC04M175157.
HGNCi HGNC:13587. FBXO8.
HPAi HPA002885.
MIMi 605649. gene.
neXtProti NX_Q9NRD0.
PharmGKBi PA28048.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5307.
HOGENOMi HOG000006813.
HOVERGENi HBG018990.
InParanoidi Q9NRD0.
KOi K10294.
OMAi SNTSHRK.
OrthoDBi EOG7K3TM8.
PhylomeDBi Q9NRD0.

Miscellaneous databases

GenomeRNAii 26269.
NextBioi 48553.
PROi Q9NRD0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NRD0.
Bgeei Q9NRD0.
CleanExi HS_FBXO8.
Genevestigatori Q9NRD0.

Family and domain databases

Gene3Di 1.10.1000.11. 1 hit.
InterProi IPR001810. F-box_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view ]
SMARTi SM00222. Sec7. 1 hit.
[Graphical view ]
SUPFAMi SSF48425. SSF48425. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "cDNA cloning and expression analysis of new members of the mammalian F-box protein family."
    Ilyin G.P., Rialland M., Pigeon C., Guguen-Guillouzo C.
    Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Novel genes expressed in human dendritic cell."
    Li Y., Peng Y., Qian B., Zhang Z., Han Z., Fu G., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS MET-51 AND HIS-156.
    Tissue: Brain and Ovary.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-269.

Entry informationi

Entry nameiFBX8_HUMAN
AccessioniPrimary (citable) accession number: Q9NRD0
Secondary accession number(s): B2RB40
, D3DP41, G5E9Z0, Q6UWN4, Q8IWE1, Q9NRP5, Q9UKC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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