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Protein

F-box only protein 8

Gene

FBXO8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 8
Alternative name(s):
F-box/SEC7 protein FBS
Gene namesi
Name:FBXO8
Synonyms:FBS, FBX8
ORF Names:DC10, UNQ1877/PRO4320
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164117.12.
HGNCiHGNC:13587. FBXO8.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi26269.
OpenTargetsiENSG00000164117.
PharmGKBiPA28048.

Polymorphism and mutation databases

BioMutaiFBXO8.
DMDMi13124142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202181 – 319F-box only protein 8Add BLAST319

Proteomic databases

PaxDbiQ9NRD0.
PeptideAtlasiQ9NRD0.
PRIDEiQ9NRD0.

PTM databases

iPTMnetiQ9NRD0.
PhosphoSitePlusiQ9NRD0.

Expressioni

Gene expression databases

BgeeiENSG00000164117.
CleanExiHS_FBXO8.
ExpressionAtlasiQ9NRD0. baseline and differential.
GenevisibleiQ9NRD0. HS.

Organism-specific databases

HPAiHPA002885.

Interactioni

Protein-protein interaction databases

BioGridi117653. 8 interactors.
IntActiQ9NRD0. 1 interactor.
STRINGi9606.ENSP00000377280.

Structurei

3D structure databases

ProteinModelPortaliQ9NRD0.
SMRiQ9NRD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 111F-boxPROSITE-ProRule annotationAdd BLAST44
Domaini146 – 276SEC7PROSITE-ProRule annotationAdd BLAST131

Phylogenomic databases

eggNOGiKOG0929. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOGENOMiHOG000006813.
HOVERGENiHBG018990.
InParanoidiQ9NRD0.
KOiK10294.
OMAiLHNFSNQ.
OrthoDBiEOG091G0H7Q.
PhylomeDBiQ9NRD0.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR036047. F-box_dom_like.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
IPR035999. Sec7_sf.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
PF01369. Sec7. 1 hit.
SMARTiView protein in SMART
SM00222. Sec7. 1 hit.
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.
PS50190. SEC7. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQGLWRVVR NQQLQQEGYS EQGYLTREQS RRMAASNISN TNHRKQVQGG
60 70 80 90 100
IDIYHLLKAR KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD
110 120 130 140 150
LANDELLWQG LCKSTWGHCS IYNKNPPLGF SFRKLYMQLD EGSLTFNANP
160 170 180 190 200
DEGVNYFMSK GILDDSPKEI AKFIFCTRTL NWKKLRIYLD ERRDVLDDLV
210 220 230 240 250
TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH RFCACNPDLM
260 270 280 290 300
RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS
310
EDFVGHLYDN IYLIGHVAA
Length:319
Mass (Da):37,068
Last modified:October 1, 2000 - v1
Checksum:i125D6D6B57CA7C79
GO
Isoform 2 (identifier: Q9NRD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-99: Missing.

Note: No experimental confirmation available.
Show »
Length:278
Mass (Da):32,426
Checksum:iD0615626C2EBF06F
GO

Sequence cautioni

Q9NRD0: The sequence AAF04517 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → D in AAQ89083 (PubMed:12975309).Curated1
Sequence conflicti119C → W in AAF86868 (Ref. 3) Curated1
Sequence conflicti135L → V in AAF86868 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07111851I → M1 PublicationCorresponds to variant dbSNP:rs17857220Ensembl.1
Natural variantiVAR_071119156Y → H1 PublicationCorresponds to variant dbSNP:rs17854000Ensembl.1
Natural variantiVAR_036157269L → I in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05588559 – 99Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174596 mRNA. Translation: AAF04517.1. Different initiation.
AF233224 mRNA. Translation: AAF67154.1.
AF201932 mRNA. Translation: AAF86868.1.
AY358721 mRNA. Translation: AAQ89083.1.
AK314483 mRNA. Translation: BAG37087.1.
AC097653 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04741.1.
CH471056 Genomic DNA. Translation: EAX04742.1.
CH471056 Genomic DNA. Translation: EAX04744.1.
BC014679 mRNA. Translation: AAH14679.1.
BC040456 mRNA. Translation: AAH40456.1.
CCDSiCCDS3820.1. [Q9NRD0-1]
RefSeqiNP_036312.2. NM_012180.2. [Q9NRD0-1]
UniGeneiHs.76917.

Genome annotation databases

EnsembliENST00000393674; ENSP00000377280; ENSG00000164117. [Q9NRD0-1]
ENST00000503293; ENSP00000422905; ENSG00000164117. [Q9NRD0-2]
ENST00000615392; ENSP00000484517; ENSG00000164117. [Q9NRD0-2]
GeneIDi26269.
KEGGihsa:26269.
UCSCiuc003itp.4. human. [Q9NRD0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFBX8_HUMAN
AccessioniPrimary (citable) accession number: Q9NRD0
Secondary accession number(s): B2RB40
, D3DP41, G5E9Z0, Q6UWN4, Q8IWE1, Q9NRP5, Q9UKC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot