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Q9NRC9 (OTOR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Otoraplin
Alternative name(s):
Fibrocyte-derived protein
Melanoma inhibitory activity-like protein
Gene names
Name:OTOR
Synonyms:FDP, MIAL
ORF Names:UNQ3054/PRO9873
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Potential.

Tissue specificity

Highly expressed in cochlea.

Sequence similarities

Belongs to the MIA/OTOR family.

Contains 1 SH3 domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSH3 domain
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processsensory perception of sound

Traceable author statement. Source: ProtInc

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Ref.8
Chain18 – 128111Otoraplin
PRO_0000019033

Regions

Domain39 – 11072SH3

Amino acid modifications

Disulfide bond32 ↔ 37 By similarity
Disulfide bond55 ↔ 127 By similarity

Natural variations

Natural variant311L → P. Ref.6
Corresponds to variant rs6135876 [ dbSNP | Ensembl ].
VAR_024537

Sequences

Sequence LengthMass (Da)Tools
Q9NRC9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9BB52C7F5D4FB700

FASTA12814,332
        10         20         30         40         50         60 
MARILLLFLP GLVAVCAVHG IFMDRLASKK LCADDECVYT ISLASAQEDY NAPDCRFINV 

        70         80         90        100        110        120 
KKGQQIYVYS KLVKENGAGE FWAGSVYGDG QDEMGVVGYF PRNLVKEQRV YQEATKEVPT 


TDIDFFCE 

« Hide

References

« Hide 'large scale' references
[1]"A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping."
Robertson N.G., Heller S., Lin J.S., Resendes B.L., Weremowicz S., Denis C.S., Bell A.M., Hudspeth A.J., Morton C.C.
Genomics 66:242-248(2000) [PubMed: 10873378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cochlea.
[2]"Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme."
Cohen-Salmon M., Frenz D., Liu W., Verpy E., Voegeling S., Petit C.
J. Biol. Chem. 275:40036-40041(2000) [PubMed: 10998416] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation."
Rendtorff N.D., Frodin M., Attie-Bitach T., Vekemans M., Tommerup N.
Genomics 71:40-52(2001) [PubMed: 11161796] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain and Cochlea.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-31.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 18-32.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF233261 mRNA. Translation: AAF82078.1.
AF243505 mRNA. Translation: AAG42356.1.
AJ242552 mRNA. Translation: CAC27443.1.
AJ252324 expand/collapse EMBL AC list , AJ252325, AJ252326, AJ252327 Genomic DNA. Translation: CAC28085.1.
AY359082 mRNA. Translation: AAQ89441.1.
AL034428 Genomic DNA. Translation: CAC16848.1.
CH471133 Genomic DNA. Translation: EAX10282.1.
CH471133 Genomic DNA. Translation: EAX10283.1.
BC101688 mRNA. Translation: AAI01689.1.
BC101690 mRNA. Translation: AAI01691.1.
IPIIPI00016333.
RefSeqNP_064542.1. NM_020157.2.
UniGeneHs.41119.

3D structure databases

ProteinModelPortalQ9NRC9.
SMRQ9NRC9. Positions 23-128.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9NRC9.

Polymorphism databases

DMDM13124388.

Proteomic databases

PRIDEQ9NRC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246081; ENSP00000246081; ENSG00000125879.
GeneID56914.
KEGGhsa:56914.
UCSCuc002wpj.1. human.

Organism-specific databases

CTD56914.
GeneCardsGC20P016677.
H-InvDBHIX0040515.
HGNCHGNC:8517. OTOR.
HPAHPA024335.
MIM606067. gene.
neXtProtNX_Q9NRC9.
PharmGKBPA32843.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20084.
GeneTreeENSGT00390000010535.
HOGENOMHBG446490.
HOVERGENHBG000503.
InParanoidQ9NRC9.
OMAEMGIVGY.
OrthoDBEOG4Z62PX.
PhylomeDBQ9NRC9.

Gene expression databases

ArrayExpressQ9NRC9.
BgeeQ9NRC9.
CleanExHS_OTOR.
GenevestigatorQ9NRC9.
GermOnlineENSG00000125879. Homo sapiens.

Family and domain databases

InterProIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SH3. 1 hit.
PROSITEPS50002. SH3. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio62399.
SOURCESearch...

Entry information

Entry nameOTOR_HUMAN
AccessionPrimary (citable) accession number: Q9NRC9
Secondary accession number(s): D3DW22, Q3MIU6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: December 14, 2011
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families