Q9NRC9 (OTOR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Otoraplin

Alternative name(s):
Fibrocyte-derived protein
Melanoma inhibitory activity-like protein

Gene names

Name:	OTOR
Synonyms:	FDP, MIAL
ORF Names:	UNQ3054/PRO9873

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Highly expressed in cochlea.
Sequence similarities	Belongs to the MIA/OTOR family. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	SH3 domain Signal
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	sensory perception of sound Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Ref.8
	Chain	18 – 128	111	Otoraplin		PRO_0000019033
Regions
	Domain	39 – 110	72	SH3
Amino acid modifications
	Disulfide bond	32 ↔ 37		By similarity
	Disulfide bond	55 ↔ 127		By similarity
Natural variations
	Natural variant	31	1	L → P. Ref.6 Corresponds to variant rs6135876 [ dbSNP | Ensembl ].		VAR_024537

Sequences

	Sequence		Length	Mass (Da)
	Q9NRC9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 9BB52C7F5D4FB700	FASTA	128	14,332
	10 20 30 40 50 60 MARILLLFLP GLVAVCAVHG IFMDRLASKK LCADDECVYT ISLASAQEDY NAPDCRFINV 70 80 90 100 110 120 KKGQQIYVYS KLVKENGAGE FWAGSVYGDG QDEMGVVGYF PRNLVKEQRV YQEATKEVPT TDIDFFCE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping." Robertson N.G., Heller S., Lin J.S., Resendes B.L., Weremowicz S., Denis C.S., Bell A.M., Hudspeth A.J., Morton C.C. Genomics 66:242-248(2000) [PubMed: 10873378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cochlea.
[2]	"Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme." Cohen-Salmon M., Frenz D., Liu W., Verpy E., Voegeling S., Petit C. J. Biol. Chem. 275:40036-40041(2000) [PubMed: 10998416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation." Rendtorff N.D., Frodin M., Attie-Bitach T., Vekemans M., Tommerup N. Genomics 71:40-52(2001) [PubMed: 11161796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain and Cochlea.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-31.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[8]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 18-32.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF233261 mRNA. Translation: AAF82078.1. AF243505 mRNA. Translation: AAG42356.1. AJ242552 mRNA. Translation: CAC27443.1. AJ252324 , AJ252325, AJ252326, AJ252327 Genomic DNA. Translation: CAC28085.1. AY359082 mRNA. Translation: AAQ89441.1. AL034428 Genomic DNA. Translation: CAC16848.1. CH471133 Genomic DNA. Translation: EAX10282.1. CH471133 Genomic DNA. Translation: EAX10283.1. BC101688 mRNA. Translation: AAI01689.1. BC101690 mRNA. Translation: AAI01691.1.
IPI	IPI00016333.
RefSeq	NP_064542.1. NM_020157.2.
UniGene	Hs.41119.
3D structure databases
ProteinModelPortal	Q9NRC9.
SMR	Q9NRC9. Positions 23-128.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NRC9.
Polymorphism databases
DMDM	13124388.
Proteomic databases
PRIDE	Q9NRC9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000246081; ENSP00000246081; ENSG00000125879.
GeneID	56914.
KEGG	hsa:56914.
UCSC	uc002wpj.1. human.
Organism-specific databases
CTD	56914.
GeneCards	GC20P016677.
H-InvDB	HIX0040515.
HGNC	HGNC:8517. OTOR.
HPA	HPA024335.
MIM	606067. gene.
neXtProt	NX_Q9NRC9.
PharmGKB	PA32843.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20084.
GeneTree	ENSGT00390000010535.
HOGENOM	HBG446490.
HOVERGEN	HBG000503.
InParanoid	Q9NRC9.
OMA	EMGIVGY.
OrthoDB	EOG4Z62PX.
PhylomeDB	Q9NRC9.
Gene expression databases
ArrayExpress	Q9NRC9.
Bgee	Q9NRC9.
CleanEx	HS_OTOR.
Genevestigator	Q9NRC9.
GermOnline	ENSG00000125879. Homo sapiens.
Family and domain databases
InterPro	IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	62399.
SOURCE	Search...

Entry information

Entry name

OTOR_HUMAN

Accession

Primary (citable) accession number: Q9NRC9
Secondary accession number(s): D3DW22, Q3MIU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.