Reviewed, UniProtKB/Swiss-Prot Q9NRC9 (OTOR_HUMAN)

Names and origin

Protein names

Recommended name:
    Otoraplin
Alternative name(s):
    Fibrocyte-derived protein
    Melanoma inhibitory activity-like protein

Gene names

Name:	OTOR
Synonyms:	FDP, MIAL
ORF Names:	UNQ3054/PRO9873

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Highly expressed in cochlea.
Sequence similarities	Belongs to the MIA/OTOR family. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	SH3 domain Signal
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	sensory perception of sound Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Ref.7
	Chain	18 – 128	111	Otoraplin		PRO_0000019033
Regions
	Domain	39 – 110	72	SH3
Amino acid modifications
	Disulfide bond	32 ↔ 37		By similarity
	Disulfide bond	55 ↔ 127		By similarity
Natural variations
	Natural variant	31	1	L → P: dbSNP rs6135876.		VAR_024537

Sequences

	Sequence		Length	Mass (Da)
	Q9NRC9-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 9BB52C7F5D4FB700	FASTA	128	14,332
	10 20 30 40 50 60 MARILLLFLP GLVAVCAVHG IFMDRLASKK LCADDECVYT ISLASAQEDY NAPDCRFINV 70 80 90 100 110 120 KKGQQIYVYS KLVKENGAGE FWAGSVYGDG QDEMGVVGYF PRNLVKEQRV YQEATKEVPT TDIDFFCE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping." Robertson N.G., Heller S., Lin J.S., Resendes B.L., Weremowicz S., Denis C.S., Bell A.M., Hudspeth A.J., Morton C.C. Genomics 66:242-248(2000) [PubMed: 10873378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cochlea.
[2]	"Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme." Cohen-Salmon M., Frenz D., Liu W., Verpy E., Voegeling S., Petit C. J. Biol. Chem. 275:40036-40041(2000) [PubMed: 10998416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation." Rendtorff N.D., Frodin M., Attie-Bitach T., Vekemans M., Tommerup N. Genomics 71:40-52(2001) [PubMed: 11161796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain and Cochlea.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 18-32.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF233261 mRNA. Translation: AAF82078.1. AF243505 mRNA. Translation: AAG42356.1. AJ242552 mRNA. Translation: CAC27443.1. AJ252324 , AJ252325, AJ252326, AJ252327 Genomic DNA. Translation: CAC28085.1. AY359082 mRNA. Translation: AAQ89441.1. AL034428 Genomic DNA. Translation: CAC16848.1. BC101688 mRNA. Translation: AAI01689.1. BC101690 mRNA. Translation: AAI01691.1.
IPI	IPI00016333.
RefSeq	NP_064542.1.
UniGene	Hs.41119
3D structure databases
HSSP	HSSP built from PDB template 1I1J based on UniProtKB Q16674.
ModBase	Search...
Proteomic databases
PRIDE	Q9NRC9.
Genome annotation databases
Ensembl	ENSG00000125879. Homo sapiens. [Contig view]
GeneID	56914.
KEGG	hsa:56914.
Organism-specific databases
GeneCards	GC20P016677.
H-InvDB	HIX0040515.
HGNC	HGNC:8517. OTOR.
MIM	606067. gene.
PharmGKB	PA32843.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NRC9.
HOVERGEN	Q9NRC9.
OMA	Q9NRC9. EMGIVGY.
Gene expression databases
ArrayExpress	Q9NRC9.
Bgee	Q9NRC9.
CleanEx	HS_OTOR.
GermOnline	ENSG00000125879. Homo sapiens.
Family and domain databases
InterPro	IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50002. SH3. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	62399.
SOURCE	Search...

Entry information

Entry name

OTOR_HUMAN

Accession

Primary (citable) accession number: Q9NRC9
Secondary accession number(s): Q3MIU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)