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Protein

Otoraplin

Gene

OTOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cartilage condensation Source: Ensembl
  • sensory perception of sound Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Otoraplin
Alternative name(s):
Fibrocyte-derived protein
Melanoma inhibitory activity-like protein
Gene namesi
Name:OTOR
Synonyms:FDP, MIAL
ORF Names:UNQ3054/PRO9873
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:8517. OTOR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32843.

Polymorphism and mutation databases

BioMutaiOTOR.
DMDMi13124388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 128111OtoraplinPRO_0000019033Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 37By similarity
Disulfide bondi55 ↔ 127By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9NRC9.
PRIDEiQ9NRC9.

PTM databases

iPTMnetiQ9NRC9.
PhosphoSiteiQ9NRC9.

Expressioni

Tissue specificityi

Highly expressed in cochlea.

Gene expression databases

BgeeiENSG00000125879.
CleanExiHS_OTOR.
GenevisibleiQ9NRC9. HS.

Organism-specific databases

HPAiHPA024335.

Structurei

3D structure databases

ProteinModelPortaliQ9NRC9.
SMRiQ9NRC9. Positions 23-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 11072SH3Add
BLAST

Sequence similaritiesi

Belongs to the MIA/OTOR family.Curated
Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain, Signal

Phylogenomic databases

eggNOGiENOG410IY1J. Eukaryota.
ENOG4111P4M. LUCA.
GeneTreeiENSGT00390000010535.
HOGENOMiHOG000063668.
HOVERGENiHBG000503.
InParanoidiQ9NRC9.
OMAiHVYQEAT.
OrthoDBiEOG091G0RVX.
PhylomeDBiQ9NRC9.
TreeFamiTF332724.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NRC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARILLLFLP GLVAVCAVHG IFMDRLASKK LCADDECVYT ISLASAQEDY
60 70 80 90 100
NAPDCRFINV KKGQQIYVYS KLVKENGAGE FWAGSVYGDG QDEMGVVGYF
110 120
PRNLVKEQRV YQEATKEVPT TDIDFFCE
Length:128
Mass (Da):14,332
Last modified:October 1, 2000 - v1
Checksum:i9BB52C7F5D4FB700
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311L → P.1 Publication
Corresponds to variant rs6135876 [ dbSNP | Ensembl ].
VAR_024537

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233261 mRNA. Translation: AAF82078.1.
AF243505 mRNA. Translation: AAG42356.1.
AJ242552 mRNA. Translation: CAC27443.1.
AJ252324
, AJ252325, AJ252326, AJ252327 Genomic DNA. Translation: CAC28085.1.
AY359082 mRNA. Translation: AAQ89441.1.
AL034428 Genomic DNA. Translation: CAC16848.1.
CH471133 Genomic DNA. Translation: EAX10282.1.
CH471133 Genomic DNA. Translation: EAX10283.1.
BC101688 mRNA. Translation: AAI01689.1.
BC101690 mRNA. Translation: AAI01691.1.
CCDSiCCDS13124.1.
RefSeqiNP_064542.1. NM_020157.3.
UniGeneiHs.41119.

Genome annotation databases

EnsembliENST00000246081; ENSP00000246081; ENSG00000125879.
GeneIDi56914.
KEGGihsa:56914.
UCSCiuc002wpj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233261 mRNA. Translation: AAF82078.1.
AF243505 mRNA. Translation: AAG42356.1.
AJ242552 mRNA. Translation: CAC27443.1.
AJ252324
, AJ252325, AJ252326, AJ252327 Genomic DNA. Translation: CAC28085.1.
AY359082 mRNA. Translation: AAQ89441.1.
AL034428 Genomic DNA. Translation: CAC16848.1.
CH471133 Genomic DNA. Translation: EAX10282.1.
CH471133 Genomic DNA. Translation: EAX10283.1.
BC101688 mRNA. Translation: AAI01689.1.
BC101690 mRNA. Translation: AAI01691.1.
CCDSiCCDS13124.1.
RefSeqiNP_064542.1. NM_020157.3.
UniGeneiHs.41119.

3D structure databases

ProteinModelPortaliQ9NRC9.
SMRiQ9NRC9. Positions 23-127.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9NRC9.
PhosphoSiteiQ9NRC9.

Polymorphism and mutation databases

BioMutaiOTOR.
DMDMi13124388.

Proteomic databases

PaxDbiQ9NRC9.
PRIDEiQ9NRC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246081; ENSP00000246081; ENSG00000125879.
GeneIDi56914.
KEGGihsa:56914.
UCSCiuc002wpj.5. human.

Organism-specific databases

CTDi56914.
GeneCardsiOTOR.
HGNCiHGNC:8517. OTOR.
HPAiHPA024335.
MIMi606067. gene.
neXtProtiNX_Q9NRC9.
PharmGKBiPA32843.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY1J. Eukaryota.
ENOG4111P4M. LUCA.
GeneTreeiENSGT00390000010535.
HOGENOMiHOG000063668.
HOVERGENiHBG000503.
InParanoidiQ9NRC9.
OMAiHVYQEAT.
OrthoDBiEOG091G0RVX.
PhylomeDBiQ9NRC9.
TreeFamiTF332724.

Miscellaneous databases

GeneWikiiOTOR.
GenomeRNAii56914.
PROiQ9NRC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125879.
CleanExiHS_OTOR.
GenevisibleiQ9NRC9. HS.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOTOR_HUMAN
AccessioniPrimary (citable) accession number: Q9NRC9
Secondary accession number(s): D3DW22, Q3MIU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.