Reviewed,
UniProtKB/Swiss-Prot Q9NRC9 (OTOR_HUMAN)
Last modified
June 16, 2009.
Version 74.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Otoraplin Alternative name(s): Fibrocyte-derived protein Melanoma inhibitory activity-like protein | ||||||
| Gene names |
| ||||||
| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 128 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subcellular location | Secreted Potential. |
| Tissue specificity | Highly expressed in cochlea. |
| Sequence similarities | Belongs to the MIA/OTOR family. Contains 1 SH3 domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | SH3 domain Signal |
| PTM | Disulfide bond |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | sensory perception of sound Ref.1 Traceable author statement. Source: ProtInc |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Ref.7 | ||||||||
| Chain | 18 – 128 | 111 | Otoraplin | PRO_0000019033 | |||||||
Regions | |||||||||||
| Domain | 39 – 110 | 72 | SH3 | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 32 ↔ 37 | By similarity | |||||||||
| Disulfide bond | 55 ↔ 127 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 31 | 1 | L → P: dbSNP rs6135876. | VAR_024537 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping." Robertson N.G., Heller S., Lin J.S., Resendes B.L., Weremowicz S., Denis C.S., Bell A.M., Hudspeth A.J., Morton C.C. Genomics 66:242-248(2000) [PubMed: 10873378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cochlea. |
| [2] | "Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme." Cohen-Salmon M., Frenz D., Liu W., Verpy E., Voegeling S., Petit C. J. Biol. Chem. 275:40036-40041(2000) [PubMed: 10998416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation." Rendtorff N.D., Frodin M., Attie-Bitach T., Vekemans M., Tommerup N. Genomics 71:40-52(2001) [PubMed: 11161796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain and Cochlea. |
| [4] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum. |
| [7] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 18-32. |
Cross-references
Sequence databases | |
|---|---|
| AF233261 mRNA. Translation: AAF82078.1. AF243505 mRNA. Translation: AAG42356.1. AJ242552 mRNA. Translation: CAC27443.1. AJ252324 AJ252327 Genomic DNA. Translation: CAC28085.1. AY359082 mRNA. Translation: AAQ89441.1. AL034428 Genomic DNA. Translation: CAC16848.1. BC101688 mRNA. Translation: AAI01689.1. BC101690 mRNA. Translation: AAI01691.1. | |
| IPI | IPI00016333. |
| RefSeq | NP_064542.1. |
| UniGene | Hs.41119 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1I1J based on UniProtKB Q16674. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9NRC9. |
Genome annotation databases | |
| Ensembl | ENSG00000125879. Homo sapiens. [Contig view] |
| GeneID | 56914. |
| KEGG | hsa:56914. |
Organism-specific databases | |
| GeneCards | GC20P016677. |
| H-InvDB | HIX0040515. |
| HGNC | HGNC:8517. OTOR. |
| MIM | 606067. gene. |
| PharmGKB | PA32843. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NRC9. |
| HOVERGEN | Q9NRC9. |
| OMA | Q9NRC9. EMGIVGY. |
Gene expression databases | |
| ArrayExpress | Q9NRC9. |
| Bgee | Q9NRC9. |
| CleanEx | HS_OTOR. |
| GermOnline | ENSG00000125879. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view] |
| Pfam | PF07653. SH3_2. 1 hit. [Graphical view] |
| SMART | SM00326. SH3. 1 hit. [Graphical view] |
| PROSITE | PS50002. SH3. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 62399. |
| SOURCE | Search... |
Entry information
| Entry name | OTOR_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NRC9 Secondary accession number(s): Q3MIU6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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