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Q9NRC6 (SPTN5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Spectrin beta chain, non-erythrocytic 5
Alternative name(s):
Beta-V spectrin
Gene names
Name:SPTBN5
Synonyms:BSPECV, HUBSPECV, HUSPECV
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3674 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Probably associates with an alpha chain. Interacts (via C-terminus) with TRPC4. Ref.2

Subcellular location

Cytoplasmcytoskeleton. Note: Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells.

Tissue specificity

Expressed at very low levels in many tissues, with strongest expression in cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder, and heart.

Sequence similarities

Belongs to the spectrin family.

Contains 2 CH (calponin-homology) domains.

Contains 1 PH domain.

Contains 31 spectrin repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityPolymorphism
   DomainRepeat
   LigandActin-binding
   Molecular functionActin capping
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Non-traceable author statement Ref.1. Source: UniProtKB

actin filament capping

Inferred from electronic annotation. Source: UniProtKB-KW

axon guidance

Traceable author statement. Source: Reactome

establishment of nucleus localization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

membrane

Non-traceable author statement Ref.1. Source: UniProtKB

nuclear envelope

Inferred from electronic annotation. Source: Ensembl

spectrin

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionactin binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 36743674Spectrin beta chain, non-erythrocytic 5
PRO_0000073466

Regions

Domain1 – 279279Actin-binding
Domain54 – 159106CH 1
Domain177 – 279103CH 2
Repeat306 – 416111Spectrin 1
Repeat426 – 531106Spectrin 2
Repeat533 – 637105Spectrin 3
Repeat639 – 743105Spectrin 4
Repeat745 – 81066Spectrin 5
Repeat867 – 89428Spectrin 6
Repeat896 – 998103Spectrin 7
Repeat1102 – 1206105Spectrin 8
Repeat1208 – 1312105Spectrin 9
Repeat1314 – 1417104Spectrin 10
Repeat1419 – 148870Spectrin 11
Repeat1520 – 1624105Spectrin 12
Repeat1626 – 1728103Spectrin 13
Repeat1730 – 1835106Spectrin 14
Repeat1837 – 1941105Spectrin 15
Repeat1943 – 2047105Spectrin 16
Repeat2049 – 214799Spectrin 17
Repeat2149 – 2253105Spectrin 18
Repeat2255 – 230147Spectrin 19
Repeat2314 – 236249Spectrin 20
Repeat2364 – 2468105Spectrin 21
Repeat2470 – 2574105Spectrin 22
Repeat2576 – 2680105Spectrin 23
Repeat2682 – 2785104Spectrin 24
Repeat2787 – 2891105Spectrin 25
Repeat2893 – 2997105Spectrin 26
Repeat2999 – 3103105Spectrin 27
Repeat3105 – 3210106Spectrin 28
Repeat3212 – 3312101Spectrin 29
Repeat3314 – 3418105Spectrin 30
Repeat3420 – 348263Spectrin 31
Domain3533 – 3641109PH

Natural variations

Natural variant13451R → H.
Corresponds to variant rs2290559 [ dbSNP | Ensembl ].
VAR_022050
Natural variant13671R → T.
Corresponds to variant rs2290558 [ dbSNP | Ensembl ].
VAR_024395
Natural variant28621Q → R.
Corresponds to variant rs1456235 [ dbSNP | Ensembl ].
VAR_024396
Natural variant32751A → G.
Corresponds to variant rs1197660 [ dbSNP | Ensembl ].
VAR_024397

Sequences

Sequence LengthMass (Da)Tools
Q9NRC6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8C0FDFA0DD0C7C18

FASTA3,674416,835
        10         20         30         40         50         60 
MAGQPHSPRE LLGAAGHRSR RPSTELRVPP SPSLTMDSQY ETGHIRKLQA RHMQMQEKTF 

        70         80         90        100        110        120 
TKWINNVFQC GQAGIKIRNL YTELADGIHL LRLLELISGE ALPPPSRGRL RVHFLENSSR 

       130        140        150        160        170        180 
ALAFLRAKVP VPLIGPENIV DGDQTLILGL IWVIILRFQI SHISLDKEEF GASAALLSTK 

       190        200        210        220        230        240 
EALLVWCQRK TASYTNVNIT DFSRSWSDGL GFNALIHAHR PDLLDYGSLR PDRPLHNLAF 

       250        260        270        280        290        300 
AFLVAEQELG IAQLLDPEDV AAAQPDERSI MTYVSLYYHY CSRLHQGQTV QRRLTKILLQ 

       310        320        330        340        350        360 
LQETELLQTQ YEQLVADLLR WIAEKQMQLE ARDFPDSLPA MRQLLAAFTI FRTQEKPPRL 

       370        380        390        400        410        420 
QQRGAAEALL FRLQTALQAQ NRRPFLPHEG LGLAELSQCW AGLEWAEAAR SQALQQRLLQ 

       430        440        450        460        470        480 
LQRLETLARR FQRKAALRES FLKDAEQVLD QARAPPASLA TVEAAVQRLG MLEAGILPQE 

       490        500        510        520        530        540 
GRFQALAEIA DILRQEQYHS WADVARRQEE VTVRWQRLLQ HLQGQRKQVA DMQAVLSLLQ 

       550        560        570        580        590        600 
EVEAASHQLE ELQEPARSTA CGQQLAEVVE LLQRHDLLEA QVSAHGAHVS HLAQQTAELD 

       610        620        630        640        650        660 
SSLGTSVEVL QAKARTLAQL QQSLVALVRA RRALLEQTLQ RAEFLRNCEE EEAWLKECGQ 

       670        680        690        700        710        720 
RVGNAALGRD LSQIAGALQK HKALEAEVHR HQAVCVDLVR RGRDLSARRP PTQPDPGERA 

       730        740        750        760        770        780 
EAVQGGWQLL QTRVVGRGAR LQTALLVLQY FADAAEAASW LRERRSSLER ASCGQDQAAA 

       790        800        810        820        830        840 
ETLLRRHVRL ERVLRAFAAE LRRLEEQGRA ASARASLFTV NSALSPPGES LRNPGPWSEA 

       850        860        870        880        890        900 
SCHPGPGDAW KMALPAEPDP DFDPNTILQT QDHLSQDYES LRALAQLRRA RLEEAMALFG 

       910        920        930        940        950        960 
FCSSCGELQL WLEKQTVLLQ RVQPQADTLE VMQLKYENFL TALAVGKGLW AEVSSSAEQL 

       970        980        990       1000       1010       1020 
RQRYPGNSTQ IQRQQEELSQ RWGQLEALKR EKAVQLAHSV EVCSFLQECG PTQVQLRDVL 

      1030       1040       1050       1060       1070       1080 
LQLEALQPGS SEDTRHALQL AQKKTLVLER RVYFLQSVVV KVEEPGYAES QPLQGQVETL 

      1090       1100       1110       1120       1130       1140 
QGLLKQVQEQ VAQRARRQAE TQARQSFLQE SQQLLLWAES VQAQLRSKEV SVDVASAQRL 

      1150       1160       1170       1180       1190       1200 
LREHQDLLEE IHLWQERLQQ LDAQSQPMAA LDCPDSQEVP NTLRVLGQQG QELKVLWEQR 

      1210       1220       1230       1240       1250       1260 
QQWLQEGLEL QKFGREVDGF TATCANHQAW LHLDNLGEDV REALSLLQQH REFGRLLSTL 

      1270       1280       1290       1300       1310       1320 
GPRAEALRAH GEKLVQSQHP AAHTVREQLQ SIQAQWTRLQ GRSEQRRRQL LASLQLQEWK 

      1330       1340       1350       1360       1370       1380 
QDVAELMQWM EEKGLMAAHE PSGARRNILQ TLKRHEAAES ELLATRRHVE ALQQVGRELL 

      1390       1400       1410       1420       1430       1440 
SRRPCGQEDI QTRLQGLRSK WEALNRKMTE RGDELQQAGQ QEQLLRQLQD AKEQLEQLEG 

      1450       1460       1470       1480       1490       1500 
ALQSSETGQD LRSSQRLQKR HQQLESESRT LAAKMAALAS MAHGMAASPA ILEETQKHLR 

      1510       1520       1530       1540       1550       1560 
RLELLQGHLA IRGLQLQASV ELHQFCHLSN MELSWVAEHM PHGSPTSYTE CLNGAQSLHR 

      1570       1580       1590       1600       1610       1620 
KHKELQVEVK AHQGQVQRVL SSGRSLAASG HPQAQHIVEQ CQELEGHWAE LERACEARAQ 

      1630       1640       1650       1660       1670       1680 
CLQQAVTFQQ YFLDVSELEG WVEEKRPLVS SRDYGRDEAA TLRLINKHQA LQEELAIYWS 

      1690       1700       1710       1720       1730       1740 
SMEELDQTAQ TLTGPEVPEQ QRVVQERLRE QLRALQELAA TRDRELEGTL RLHEFLREAE 

      1750       1760       1770       1780       1790       1800 
DLQGWLASQK QAAKGGESLG EDPEHALHLC TKFAKFQHQV EMGSQRVAAC RLLAESLLER 

      1810       1820       1830       1840       1850       1860 
GHSAGPMVRQ RQQDLQTAWS ELWELTQARG HALRDTETTL RVHRDLLEVL TQVQEKATSL 

      1870       1880       1890       1900       1910       1920 
PNNVARDLCG LEAQLRSHQG LERELVGTER QLQELLETAG RVQKLCPGPQ AHAVQQRQQA 

      1930       1940       1950       1960       1970       1980 
VTQAWAVLQR RMEQRRAQLE RARLLARFRT AVRDYASWAA RVRQDLQVEE SSQEPSSGPL 

      1990       2000       2010       2020       2030       2040 
KLSAHQWLRA ELEAREKLWQ QATQLGQQAL LAAGTPTKEV QEELRALQDQ RDQVYQTWAR 

      2050       2060       2070       2080       2090       2100 
KQERLQAEQQ EQLFLRECGR LEEILAAQEV SLKTSALGSS VEEVEQLIRK HEVFLKVLTA 

      2110       2120       2130       2140       2150       2160 
QDKKEAALRE RLKTLRRPRV RDRLPILLQR RMRVKELAES RGHALHASLL MASFTQAATQ 

      2170       2180       2190       2200       2210       2220 
AEDWIQAWAQ QLKEPVPPGD LRDKLKPLLK HQAFEAEVQA HEEVMTSVAK KGEALLAQSH 

      2230       2240       2250       2260       2270       2280 
PRAGEVSQRL QGLRKHWEDL RQAMALRGQE LEDRRNFLEF LQRVDLAEAW IQEKEVKMNV 

      2290       2300       2310       2320       2330       2340 
GDLGQDLEHC LQLRRRLREF RGNSAGDTVG DACIRSISDL SLQLKNRDPE EVKIICQRRS 

      2350       2360       2370       2380       2390       2400 
QLNNRWASFH GNLLRYQQQL EGALEIHVLS RELDNVTKRI QEKEALIQAL DCGKDLESVQ 

      2410       2420       2430       2440       2450       2460 
RLLRKHEELE REVHPIQAQV ESLEREVGRL CQRSPEAAHG LRHRQQEVAE SWWQLRSRAQ 

      2470       2480       2490       2500       2510       2520 
KRREALDALH QAQKLQAMLQ ELLVSAQRLR AQMDTSPAPR SPVEARRMLE EHQECKAELD 

      2530       2540       2550       2560       2570       2580 
SWTDSISLAR STGQQLLTAG HPFSSDIRQV LAGLEQELSS LEGAWQEHQL QLQQALELQL 

      2590       2600       2610       2620       2630       2640 
FLSSVEKMER WLCSKEDSLA SEGLWDPLAP MEPLLWKHKM LEWDLEVQAG KISALEATAR 

      2650       2660       2670       2680       2690       2700 
GLHQGGHPEA QSALGRCQAM LLRKEALFRQ AGTRRHRLEE LRQLQAFLQD SQEVAAWLRE 

      2710       2720       2730       2740       2750       2760 
KNLVALEEGL LDTAMLPAQL QKQQNFQAEL DASMHQQQEL QREGQRLLQG GHPASEAIQE 

      2770       2780       2790       2800       2810       2820 
RLEELGALWG ELQDNSQKKV AKLQKACEAL RLRRSMEELE NWLEPIEVEL RAPTVGQALP 

      2830       2840       2850       2860       2870       2880 
GVGELLGTQR ELEAAVDKKA RQAEALLGQA QAFVREGHCL AQDVEEQARR LLQRFKSLRE 

      2890       2900       2910       2920       2930       2940 
PLQERRTALE ARSLLLKFFR DADEEMAWVQ EKLPLAAAQD YGQSLSAVRH LQEQHQNLES 

      2950       2960       2970       2980       2990       3000 
EMSSHEALTR VVLGTGYKLV QAGHFAAHEV AARVQQLEKA MAHLRAEAAR RRLLLQQAQE 

      3010       3020       3030       3040       3050       3060 
AQQFLTELLE AGSWLAERGH VLDSEDMGHS AEATQALLRR LEATKRDLEA FSPRIERLQQ 

      3070       3080       3090       3100       3110       3120 
TAALLESRKN PESPKVLAQL QAVREAHAEL LRRAEARGHG LQEQLQLHQL ERETLLLDAW 

      3130       3140       3150       3160       3170       3180 
LTTKAATAES QDYGQDLEGV KVLEEKFDAF RKEVQSLGQA KVYALRKLAG TLERGAPRRY 

      3190       3200       3210       3220       3230       3240 
PHIQAQRSRI EAAWERLDQA IKARTENLAA AHEVHSFQQA AAELQGRMQE KTALMKGEDG 

      3250       3260       3270       3280       3290       3300 
GHSLSSVRTL QQQHRRLERE LEAMEKEVAR LQTEACRLGQ LHPAAPGGLA KVQEAWATLQ 

      3310       3320       3330       3340       3350       3360 
AKAQERGQWL AQAAQGHAFL GRCQELLAWA QERQELASSE ELAEDVAGAE QLLGQHEELG 

      3370       3380       3390       3400       3410       3420 
QEIRECRLQA QDLRQEGQQL VDNSHFMSAE VTECLQELEG RLQELEEAWA LRWQRCAESW 

      3430       3440       3450       3460       3470       3480 
GLQKLRQRLE QAEAWLACWE GLLLKPDYGH SVSDVELLLH RHQDLEKLLA AQEEKFAQMQ 

      3490       3500       3510       3520       3530       3540 
KTEMEQELLL QPQELKPGRA GSSLTSFQWR PSGHQGLGAQ LAETRDPQDA KGTPTMEGSL 

      3550       3560       3570       3580       3590       3600 
EFKQHLLPGG RQPSSSSWDS CRGTLQGSSL SLFLDERMAA EKVASIALLD LTGARCERLR 

      3610       3620       3630       3640       3650       3660 
GRHGRKHTFS LRLTSGAEIL FAAPSEEQAE SWWRALGSTA AQSLSPKLKA KPVSSLNECT 

      3670 
TKDARPGCLL RSDP 

« Hide

References

[1]"Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin."
Stabach P.R., Morrow J.S.
J. Biol. Chem. 275:21385-21395(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cerebellum, Retina and Spinal cord.
[2]"The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels."
Odell A.F., Van Helden D.F., Scott J.L.
J. Biol. Chem. 283:4395-4407(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRPC4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF233523 mRNA. Translation: AAF65317.1.
RefSeqNP_057726.4. NM_016642.3.
UniGeneHs.709819.

3D structure databases

ProteinModelPortalQ9NRC6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000317790.

PTM databases

PhosphoSiteQ9NRC6.

Polymorphism databases

DMDM17369320.

Proteomic databases

PaxDbQ9NRC6.
PRIDEQ9NRC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320955; ENSP00000317790; ENSG00000137877.
GeneID51332.
KEGGhsa:51332.
UCSCuc001zos.4. human.

Organism-specific databases

CTD51332.
GeneCardsGC15M042140.
H-InvDBHIX0012162.
HGNCHGNC:15680. SPTBN5.
MIM605916. gene.
neXtProtNX_Q9NRC6.
PharmGKBPA38020.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5069.
HOGENOMHOG000168577.
InParanoidQ9NRC6.
KOK06115.
OrthoDBEOG7KM5RV.
PhylomeDBQ9NRC6.
TreeFamTF313446.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_188576. Developmental Biology.

Gene expression databases

BgeeQ9NRC6.
CleanExHS_SPTBN4.
HS_SPTBN5.
GenevestigatorQ9NRC6.

Family and domain databases

Gene3D1.10.418.10. 2 hits.
2.30.29.30. 1 hit.
InterProIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamPF00307. CH. 2 hits.
PF00435. Spectrin. 27 hits.
[Graphical view]
SMARTSM00033. CH. 2 hits.
SM00233. PH. 1 hit.
SM00150. SPEC. 29 hits.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
PROSITEPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSPTBN5.
GenomeRNAi51332.
NextBio54747.
PROQ9NRC6.
SOURCESearch...

Entry information

Entry nameSPTN5_HUMAN
AccessionPrimary (citable) accession number: Q9NRC6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM