Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spectrin beta chain, non-erythrocytic 5

Gene

SPTBN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • dynactin binding Source: MGI
  • dynein intermediate chain binding Source: MGI
  • kinesin binding Source: MGI
  • myosin tail binding Source: MGI
  • protein self-association Source: MGI
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • spectrin binding Source: MGI

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • actin filament capping Source: UniProtKB-KW
  • axon guidance Source: Reactome
  • ER to Golgi vesicle-mediated transport Source: Reactome
  • Golgi organization Source: MGI
  • lysosomal transport Source: MGI
  • MAPK cascade Source: Reactome
  • protein homooligomerization Source: MGI

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-375165. NCAM signaling for neurite out-growth.
R-HSA-445095. Interaction between L1 and Ankyrins.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Spectrin beta chain, non-erythrocytic 5
Alternative name(s):
Beta-V spectrin
Gene namesi
Name:SPTBN5
Synonyms:BSPECV, HUBSPECV, HUSPECV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137877.9.
HGNCiHGNC:15680. SPTBN5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi51332.
OpenTargetsiENSG00000137877.
PharmGKBiPA38020.

Polymorphism and mutation databases

DMDMi17369320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000734661 – 3674Spectrin beta chain, non-erythrocytic 5Add BLAST3674

Proteomic databases

EPDiQ9NRC6.
PaxDbiQ9NRC6.
PeptideAtlasiQ9NRC6.
PRIDEiQ9NRC6.

PTM databases

iPTMnetiQ9NRC6.
PhosphoSitePlusiQ9NRC6.

Expressioni

Tissue specificityi

Expressed at very low levels in many tissues, with strongest expression in cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder, and heart.

Gene expression databases

BgeeiENSG00000137877.
CleanExiHS_SPTBN4.
HS_SPTBN5.
GenevisibleiQ9NRC6. HS.

Interactioni

Subunit structurei

Probably associates with an alpha chain. Interacts (via C-terminus) with TRPC4.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • dynactin binding Source: MGI
  • dynein intermediate chain binding Source: MGI
  • kinesin binding Source: MGI
  • myosin tail binding Source: MGI
  • protein self-association Source: MGI
  • spectrin binding Source: MGI

Protein-protein interaction databases

BioGridi119479. 4 interactors.
IntActiQ9NRC6. 1 interactor.
STRINGi9606.ENSP00000317790.

Structurei

3D structure databases

ProteinModelPortaliQ9NRC6.
SMRiQ9NRC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 159Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST106
Domaini177 – 279Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST103
Repeati307 – 416Spectrin 1Sequence analysisAdd BLAST110
Repeati428 – 529Spectrin 2Sequence analysisAdd BLAST102
Repeati642 – 742Spectrin 3Sequence analysisAdd BLAST101
Repeati747 – 810Spectrin 4Sequence analysisAdd BLAST64
Repeati900 – 996Spectrin 5Sequence analysisAdd BLAST97
Repeati1103 – 1206Spectrin 6Sequence analysisAdd BLAST104
Repeati1209 – 1311Spectrin 7Sequence analysisAdd BLAST103
Repeati1315 – 1417Spectrin 8Sequence analysisAdd BLAST103
Repeati1521 – 1624Spectrin 9Sequence analysisAdd BLAST104
Repeati1628 – 1727Spectrin 10Sequence analysisAdd BLAST100
Repeati1731 – 1835Spectrin 11Sequence analysisAdd BLAST105
Repeati1842 – 1940Spectrin 12Sequence analysisAdd BLAST99
Repeati1944 – 2046Spectrin 13Sequence analysisAdd BLAST103
Repeati2052 – 2146Spectrin 14Sequence analysisAdd BLAST95
Repeati2150 – 2253Spectrin 15Sequence analysisAdd BLAST104
Repeati2256 – 2361Spectrin 16Sequence analysisAdd BLAST106
Repeati2366 – 2467Spectrin 17Sequence analysisAdd BLAST102
Repeati2471 – 2574Spectrin 18Sequence analysisAdd BLAST104
Repeati2577 – 2680Spectrin 19Sequence analysisAdd BLAST104
Repeati2683 – 2784Spectrin 20Sequence analysisAdd BLAST102
Repeati2791 – 2890Spectrin 21Sequence analysisAdd BLAST100
Repeati2894 – 2997Spectrin 22Sequence analysisAdd BLAST104
Repeati3000 – 3103Spectrin 23Sequence analysisAdd BLAST104
Repeati3106 – 3209Spectrin 24Sequence analysisAdd BLAST104
Repeati3213 – 3311Spectrin 25Sequence analysisAdd BLAST99
Repeati3318 – 3415Spectrin 26Sequence analysisAdd BLAST98
Repeati3422 – 3488Spectrin 27Sequence analysisAdd BLAST67
Domaini3533 – 3641PHPROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 279Actin-bindingAdd BLAST279

Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000168577.
InParanoidiQ9NRC6.
KOiK06115.
OMAiQSFRKNQ.
OrthoDBiEOG091G002Y.
PhylomeDBiQ9NRC6.
TreeFamiTF313446.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
PfamiView protein in Pfam
PF00307. CH. 2 hits.
PF00435. Spectrin. 27 hits.
SMARTiView protein in SMART
SM00033. CH. 2 hits.
SM00233. PH. 1 hit.
SM00150. SPEC. 30 hits.
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NRC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQPHSPRE LLGAAGHRSR RPSTELRVPP SPSLTMDSQY ETGHIRKLQA
60 70 80 90 100
RHMQMQEKTF TKWINNVFQC GQAGIKIRNL YTELADGIHL LRLLELISGE
110 120 130 140 150
ALPPPSRGRL RVHFLENSSR ALAFLRAKVP VPLIGPENIV DGDQTLILGL
160 170 180 190 200
IWVIILRFQI SHISLDKEEF GASAALLSTK EALLVWCQRK TASYTNVNIT
210 220 230 240 250
DFSRSWSDGL GFNALIHAHR PDLLDYGSLR PDRPLHNLAF AFLVAEQELG
260 270 280 290 300
IAQLLDPEDV AAAQPDERSI MTYVSLYYHY CSRLHQGQTV QRRLTKILLQ
310 320 330 340 350
LQETELLQTQ YEQLVADLLR WIAEKQMQLE ARDFPDSLPA MRQLLAAFTI
360 370 380 390 400
FRTQEKPPRL QQRGAAEALL FRLQTALQAQ NRRPFLPHEG LGLAELSQCW
410 420 430 440 450
AGLEWAEAAR SQALQQRLLQ LQRLETLARR FQHKAALRES FLKDAEQVLD
460 470 480 490 500
QARAPPASLA TVEAAVQRLG MLEAGILPQE GRFQALAEIA DILRQEQYHS
510 520 530 540 550
WADVARRQEE VTVRWQRLLQ HLQGQRKQVA DMQAVLSLLQ EVEAASHQLE
560 570 580 590 600
ELQEPARSTA CGQQLAEVVE LLQRHDLLEA QVSAHGAHVS HLAQQTAELD
610 620 630 640 650
SSLGTSVEVL QAKARTLAQL QQSLVALVRA RRALLEQTLQ RAEFLRNCEE
660 670 680 690 700
EEAWLKECGQ RVGNAALGRD LSQIAGALQK HKALEAEVHR HQAVCVDLVR
710 720 730 740 750
RGRDLSARRP PTQPDPGERA EAVQGGWQLL QTRVVGRGAR LQTALLVLQY
760 770 780 790 800
FADAAEAASW LRERRSSLER ASCGQDQAAA ETLLRRHVRL ERVLRAFAAE
810 820 830 840 850
LRRLEEQGRA ASARASLFTV NSALSPPGES LRNPGPWSEA SCHPGPGDAW
860 870 880 890 900
KMALPAEPDP DFDPNTILQT QDHLSQDYES LRALAQLRRA RLEEAMALFG
910 920 930 940 950
FCSSCGELQL WLEKQTVLLQ RVQPQADTLE VMQLKYENFL TALAVGKGLW
960 970 980 990 1000
AEVSSSAEQL RQRYPGNSTQ IQRQQEELSQ RWGQLEALKR EKAVQLAHSV
1010 1020 1030 1040 1050
EVCSFLQECG PTQVQLRDVL LQLEALQPGS SEDTCHALQL AQKKTLVLER
1060 1070 1080 1090 1100
RVHFLQSVVV KVEEPGYAES QPLQGQVETL QGLLKQVQEQ VAQRARRQAE
1110 1120 1130 1140 1150
TQARQSFLQE SQQLLLWAES VQAQLRSKEV SVDVASAQRL LREHQDLLEE
1160 1170 1180 1190 1200
IHLWQERLQQ LDAQSQPMAA LDCPDSQEVP NTLRVLGQQG QELKVLWEQR
1210 1220 1230 1240 1250
QQWLQEGLEL QKFGREVDGF TATCANHQAW LHLDNLGEDV REALSLLQQH
1260 1270 1280 1290 1300
REFGRLLSTL GPRAEALRAH GEKLVQSQHP AAHTVREQLQ SIQAQWTRLQ
1310 1320 1330 1340 1350
GRSEQRRRQL LASLQLQEWK QDVAELMQWM EEKGLMAAHE PSGARRNILQ
1360 1370 1380 1390 1400
TLKRHEAAES ELLATRRHVE ALQQVGRELL SRRPCGQEDI QTRLQGLRSK
1410 1420 1430 1440 1450
WEALNRKMTE RGDELQQAGQ QEQLLRQLQD AKEQLEQLEG ALQSSETGQD
1460 1470 1480 1490 1500
LRSSQRLQKR HQQLESESRT LAAKMAALAS MAHGMAASPA ILEETQKHLR
1510 1520 1530 1540 1550
RLELLQGHLA IRGLQLQASV ELHQFCHLSN MELSWVAEHM PHGSPTSYTE
1560 1570 1580 1590 1600
CLNGAQSLHR KHKELQVEVK AHQGQVQRVL SSGRSLAASG HPQAQHIVEQ
1610 1620 1630 1640 1650
CQELEGHWAE LERACEARAQ CLQQAVTFQQ YFLDVSELEG WVEEKRPLVS
1660 1670 1680 1690 1700
SRDYGRDEAA TLRLINKHQA LQEELAIYWS SMEELDQTAQ TLTGPEVPEQ
1710 1720 1730 1740 1750
QRVVQERLRE QLRALQELAA TRDRELEGTL RLHEFLREAE DLQGWLASQK
1760 1770 1780 1790 1800
QAAKGGESLG EDPEHALHLC TKFAKFQHQV EMGSQRVAAC RLLAESLLER
1810 1820 1830 1840 1850
GHSAGPMVRQ RQQDLQTAWS ELWELTQARG HALRDTETTL RVHRDLLEVL
1860 1870 1880 1890 1900
TQVQEKATSL PNNVARDLCG LEAQLRSHQG LERELVGTER QLQELLETAG
1910 1920 1930 1940 1950
RVQKLCPGPQ AHAVQQRQQA VTQAWAVLQR RMEQRRAQLE RARLLARFRT
1960 1970 1980 1990 2000
AVRDYASWAA RVRQDLQVEE SSQEPSSGPL KLSAHQWLRA ELEAREKLWQ
2010 2020 2030 2040 2050
QATQLGQQAL LAAGTPTKEV QEELRALQDQ RDQVYQTWAR KQERLQAEQQ
2060 2070 2080 2090 2100
EQLFLRECGR LEEILAAQEV SLKTSALGSS VEEVEQLIRK HEVFLKVLTA
2110 2120 2130 2140 2150
QDKKEAALRE RLKTLRRPRV RDRLPILLQR RMRVKELAES RGHALHASLL
2160 2170 2180 2190 2200
MASFTQAATQ AEDWIQAWAQ QLKEPVPPGD LRDKLKPLLK HQAFEAEVQA
2210 2220 2230 2240 2250
HEEVMTSVAK KGEALLAQSH PRAGEVSQRL QGLRKHWEDL RQAMALRGQE
2260 2270 2280 2290 2300
LEDRRNFLEF LQRVDLAEAW IQEKEVKMNV GDLGQDLEHC LQLRRRLREF
2310 2320 2330 2340 2350
RGNSAGDTVG DACIRSISDL SLQLKNRDPE EVKIICQRRS QLNNRWASFH
2360 2370 2380 2390 2400
GNLLRYQQQL EGALEIHVLS RELDNVTKRI QEKEALIQAL DCGKDLESVQ
2410 2420 2430 2440 2450
RLLRKHEELE REVHPIQAQV ESLEREVGRL CQRSPEAAHG LRHRQQEVAE
2460 2470 2480 2490 2500
SWWQLRSRAQ KRREALDALH QAQKLQAMLQ ELLVSAQRLR AQMDTSPAPR
2510 2520 2530 2540 2550
SPVEARRMLE EHQECKAELD SWTDSISLAR STGQQLLTAG HPFSSDIRQV
2560 2570 2580 2590 2600
LAGLEQELSS LEGAWQEHQL QLQQALELQL FLSSVEKMER WLCSKEDSLA
2610 2620 2630 2640 2650
SEGLWDPLAP MEPLLWKHKM LEWDLEVQAG KISALEATAR GLHQGGHPEA
2660 2670 2680 2690 2700
QSALGRCQAM LLRKEALFRQ AGTRRHRLEE LRQLQAFLQD SQEVAAWLRE
2710 2720 2730 2740 2750
KNLVALEEGL LDTAMLPAQL QKQQNFQAEL DASMHQQQEL QREGQRLLQG
2760 2770 2780 2790 2800
GHPASEAIQE RLEELGALWG ELQDNSQKKV AKLQKACEAL RLRRSMEELE
2810 2820 2830 2840 2850
NWLEPIEVEL RAPTVGQALP GVGELLGTQR ELEAAVDKKA RQAEALLGQA
2860 2870 2880 2890 2900
QAFVREGHCL AQDVEEQARR LLQRFKSLRE PLQERRTALE ARSLLLKFFR
2910 2920 2930 2940 2950
DADEEMAWVQ EKLPLAAAQD YGQSLSAVRH LQEQHQNLES EMSSHEALTR
2960 2970 2980 2990 3000
VVLGTGYKLV QAGHFAAHEV AARVQQLEKA MAHLRAEAAR RRLLLQQAQE
3010 3020 3030 3040 3050
AQQFLTELLE AGSWLAERGH VLDSEDMGHS AEATQALLRR LEATKRDLEA
3060 3070 3080 3090 3100
FSPRIERLQQ TAALLESRKN PESPKVLAQL QAVREAHAEL LRRAEARGHG
3110 3120 3130 3140 3150
LQEQLQLHQL ERETLLLDAW LTTKAATAES QDYGQDLEGV KVLEEKFDAF
3160 3170 3180 3190 3200
RKEVQSLGQA KVYALRKLAG TLERGAPRRY PHIQAQRSRI EAAWERLDQA
3210 3220 3230 3240 3250
IKARTENLAA AHEVHSFQQA AAELQGRMQE KTALMKGEDG GHSLSSVRTL
3260 3270 3280 3290 3300
QQQHRRLERE LEAMEKEVAR LQTEACRLGQ LHPAAPGGLA KVQEAWATLQ
3310 3320 3330 3340 3350
AKAQERGQWL AQAAQGHAFL GRCQELLAWA QERQELASSE ELAEDVAGAE
3360 3370 3380 3390 3400
QLLGQHEELG QEIRECRLQA QDLRQEGQQL VDNSHFMSAE VTECLQELEG
3410 3420 3430 3440 3450
RLQELEEAWA LRWQRCAESW GLQKLRQRLE QAEAWLACWE GLLLKPDYGH
3460 3470 3480 3490 3500
SVSDVELLLH RHQDLEKLLA AQEEKFAQMQ KTEMEQELLL QPQELKPGRA
3510 3520 3530 3540 3550
GSSLTSFQWR PSGHQGLGAQ LAETRDPQDA KGTPTMEGSL EFKQHLLPGG
3560 3570 3580 3590 3600
RQPSSSSWDS CRGNLQGSSL SLFLDERMAA EKVASIALLD LTGARCERLR
3610 3620 3630 3640 3650
GRHGRKHTFS LRLTSGAEIL FAAPSEEQAE SWWRALGSTA AQSLSPKLKA
3660 3670
KPVSSLNECT TKDARPGCLL RSDP
Length:3,674
Mass (Da):416,750
Last modified:October 1, 2014 - v2
Checksum:i83D1F94ADE670E13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti433H → R in AAF65317 (PubMed:10764729).Curated1
Sequence conflicti1035C → R in AAF65317 (PubMed:10764729).Curated1
Sequence conflicti1053H → Y in AAF65317 (PubMed:10764729).Curated1
Sequence conflicti3564N → T in AAF65317 (PubMed:10764729).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0220501345R → H. Corresponds to variant dbSNP:rs2290559Ensembl.1
Natural variantiVAR_0243951367R → T. Corresponds to variant dbSNP:rs2290558Ensembl.1
Natural variantiVAR_0243962862Q → R. Corresponds to variant dbSNP:rs1456235Ensembl.1
Natural variantiVAR_0243973275A → G. Corresponds to variant dbSNP:rs1197660Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233523 mRNA. Translation: AAF65317.1.
AC020659 Genomic DNA. No translation available.
CCDSiCCDS61599.1.
RefSeqiNP_057726.4. NM_016642.3.
UniGeneiHs.709819.

Genome annotation databases

EnsembliENST00000320955; ENSP00000317790; ENSG00000137877.
GeneIDi51332.
KEGGihsa:51332.
UCSCiuc001zos.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPTN5_HUMAN
AccessioniPrimary (citable) accession number: Q9NRC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2014
Last modified: September 27, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families