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Q9NRC6

- SPTN5_HUMAN

UniProt

Q9NRC6 - SPTN5_HUMAN

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Protein

Spectrin beta chain, non-erythrocytic 5

Gene
SPTBN5, BSPECV, HUBSPECV, HUSPECV
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. dynactin binding Source: MGI
  3. dynein intermediate chain binding Source: MGI
  4. kinesin binding Source: MGI
  5. myosin tail binding Source: MGI
  6. protein self-association Source: MGI
  7. spectrin binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: UniProtKB
  2. actin filament capping Source: UniProtKB-KW
  3. axon guidance Source: Reactome
  4. Golgi organization Source: MGI
  5. lysosomal transport Source: MGI
  6. protein homooligomerization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_18334. NCAM signaling for neurite out-growth.
REACT_22266. Interaction between L1 and Ankyrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Spectrin beta chain, non-erythrocytic 5
Alternative name(s):
Beta-V spectrin
Gene namesi
Name:SPTBN5
Synonyms:BSPECV, HUBSPECV, HUSPECV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:15680. SPTBN5.

Subcellular locationi

Cytoplasmcytoskeleton
Note: Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. membrane Source: UniProtKB
  5. photoreceptor connecting cilium Source: MGI
  6. photoreceptor disc membrane Source: MGI
  7. spectrin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 36743674Spectrin beta chain, non-erythrocytic 5PRO_0000073466Add
BLAST

Proteomic databases

PaxDbiQ9NRC6.
PRIDEiQ9NRC6.

PTM databases

PhosphoSiteiQ9NRC6.

Expressioni

Tissue specificityi

Expressed at very low levels in many tissues, with strongest expression in cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder, and heart.

Gene expression databases

BgeeiQ9NRC6.
CleanExiHS_SPTBN4.
HS_SPTBN5.
GenevestigatoriQ9NRC6.

Interactioni

Subunit structurei

Probably associates with an alpha chain. Interacts (via C-terminus) with TRPC4.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000317790.

Structurei

3D structure databases

ProteinModelPortaliQ9NRC6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 279279Actin-bindingAdd
BLAST
Domaini54 – 159106CH 1Add
BLAST
Domaini177 – 279103CH 2Add
BLAST
Repeati306 – 416111Spectrin 1Add
BLAST
Repeati426 – 531106Spectrin 2Add
BLAST
Repeati533 – 637105Spectrin 3Add
BLAST
Repeati639 – 743105Spectrin 4Add
BLAST
Repeati745 – 81066Spectrin 5Add
BLAST
Repeati867 – 89428Spectrin 6Add
BLAST
Repeati896 – 998103Spectrin 7Add
BLAST
Repeati1102 – 1206105Spectrin 8Add
BLAST
Repeati1208 – 1312105Spectrin 9Add
BLAST
Repeati1314 – 1417104Spectrin 10Add
BLAST
Repeati1419 – 148870Spectrin 11Add
BLAST
Repeati1520 – 1624105Spectrin 12Add
BLAST
Repeati1626 – 1728103Spectrin 13Add
BLAST
Repeati1730 – 1835106Spectrin 14Add
BLAST
Repeati1837 – 1941105Spectrin 15Add
BLAST
Repeati1943 – 2047105Spectrin 16Add
BLAST
Repeati2049 – 214799Spectrin 17Add
BLAST
Repeati2149 – 2253105Spectrin 18Add
BLAST
Repeati2255 – 230147Spectrin 19Add
BLAST
Repeati2314 – 236249Spectrin 20Add
BLAST
Repeati2364 – 2468105Spectrin 21Add
BLAST
Repeati2470 – 2574105Spectrin 22Add
BLAST
Repeati2576 – 2680105Spectrin 23Add
BLAST
Repeati2682 – 2785104Spectrin 24Add
BLAST
Repeati2787 – 2891105Spectrin 25Add
BLAST
Repeati2893 – 2997105Spectrin 26Add
BLAST
Repeati2999 – 3103105Spectrin 27Add
BLAST
Repeati3105 – 3210106Spectrin 28Add
BLAST
Repeati3212 – 3312101Spectrin 29Add
BLAST
Repeati3314 – 3418105Spectrin 30Add
BLAST
Repeati3420 – 348263Spectrin 31Add
BLAST
Domaini3533 – 3641109PHAdd
BLAST

Sequence similaritiesi

Belongs to the spectrin family.
Contains 1 PH domain.
Contains 31 spectrin repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5069.
HOGENOMiHOG000168577.
InParanoidiQ9NRC6.
KOiK06115.
OrthoDBiEOG7KM5RV.
PhylomeDBiQ9NRC6.
TreeFamiTF313446.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF00435. Spectrin. 27 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00233. PH. 1 hit.
SM00150. SPEC. 29 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NRC6-1 [UniParc]FASTAAdd to Basket

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MAGQPHSPRE LLGAAGHRSR RPSTELRVPP SPSLTMDSQY ETGHIRKLQA     50
RHMQMQEKTF TKWINNVFQC GQAGIKIRNL YTELADGIHL LRLLELISGE 100
ALPPPSRGRL RVHFLENSSR ALAFLRAKVP VPLIGPENIV DGDQTLILGL 150
IWVIILRFQI SHISLDKEEF GASAALLSTK EALLVWCQRK TASYTNVNIT 200
DFSRSWSDGL GFNALIHAHR PDLLDYGSLR PDRPLHNLAF AFLVAEQELG 250
IAQLLDPEDV AAAQPDERSI MTYVSLYYHY CSRLHQGQTV QRRLTKILLQ 300
LQETELLQTQ YEQLVADLLR WIAEKQMQLE ARDFPDSLPA MRQLLAAFTI 350
FRTQEKPPRL QQRGAAEALL FRLQTALQAQ NRRPFLPHEG LGLAELSQCW 400
AGLEWAEAAR SQALQQRLLQ LQRLETLARR FQRKAALRES FLKDAEQVLD 450
QARAPPASLA TVEAAVQRLG MLEAGILPQE GRFQALAEIA DILRQEQYHS 500
WADVARRQEE VTVRWQRLLQ HLQGQRKQVA DMQAVLSLLQ EVEAASHQLE 550
ELQEPARSTA CGQQLAEVVE LLQRHDLLEA QVSAHGAHVS HLAQQTAELD 600
SSLGTSVEVL QAKARTLAQL QQSLVALVRA RRALLEQTLQ RAEFLRNCEE 650
EEAWLKECGQ RVGNAALGRD LSQIAGALQK HKALEAEVHR HQAVCVDLVR 700
RGRDLSARRP PTQPDPGERA EAVQGGWQLL QTRVVGRGAR LQTALLVLQY 750
FADAAEAASW LRERRSSLER ASCGQDQAAA ETLLRRHVRL ERVLRAFAAE 800
LRRLEEQGRA ASARASLFTV NSALSPPGES LRNPGPWSEA SCHPGPGDAW 850
KMALPAEPDP DFDPNTILQT QDHLSQDYES LRALAQLRRA RLEEAMALFG 900
FCSSCGELQL WLEKQTVLLQ RVQPQADTLE VMQLKYENFL TALAVGKGLW 950
AEVSSSAEQL RQRYPGNSTQ IQRQQEELSQ RWGQLEALKR EKAVQLAHSV 1000
EVCSFLQECG PTQVQLRDVL LQLEALQPGS SEDTRHALQL AQKKTLVLER 1050
RVYFLQSVVV KVEEPGYAES QPLQGQVETL QGLLKQVQEQ VAQRARRQAE 1100
TQARQSFLQE SQQLLLWAES VQAQLRSKEV SVDVASAQRL LREHQDLLEE 1150
IHLWQERLQQ LDAQSQPMAA LDCPDSQEVP NTLRVLGQQG QELKVLWEQR 1200
QQWLQEGLEL QKFGREVDGF TATCANHQAW LHLDNLGEDV REALSLLQQH 1250
REFGRLLSTL GPRAEALRAH GEKLVQSQHP AAHTVREQLQ SIQAQWTRLQ 1300
GRSEQRRRQL LASLQLQEWK QDVAELMQWM EEKGLMAAHE PSGARRNILQ 1350
TLKRHEAAES ELLATRRHVE ALQQVGRELL SRRPCGQEDI QTRLQGLRSK 1400
WEALNRKMTE RGDELQQAGQ QEQLLRQLQD AKEQLEQLEG ALQSSETGQD 1450
LRSSQRLQKR HQQLESESRT LAAKMAALAS MAHGMAASPA ILEETQKHLR 1500
RLELLQGHLA IRGLQLQASV ELHQFCHLSN MELSWVAEHM PHGSPTSYTE 1550
CLNGAQSLHR KHKELQVEVK AHQGQVQRVL SSGRSLAASG HPQAQHIVEQ 1600
CQELEGHWAE LERACEARAQ CLQQAVTFQQ YFLDVSELEG WVEEKRPLVS 1650
SRDYGRDEAA TLRLINKHQA LQEELAIYWS SMEELDQTAQ TLTGPEVPEQ 1700
QRVVQERLRE QLRALQELAA TRDRELEGTL RLHEFLREAE DLQGWLASQK 1750
QAAKGGESLG EDPEHALHLC TKFAKFQHQV EMGSQRVAAC RLLAESLLER 1800
GHSAGPMVRQ RQQDLQTAWS ELWELTQARG HALRDTETTL RVHRDLLEVL 1850
TQVQEKATSL PNNVARDLCG LEAQLRSHQG LERELVGTER QLQELLETAG 1900
RVQKLCPGPQ AHAVQQRQQA VTQAWAVLQR RMEQRRAQLE RARLLARFRT 1950
AVRDYASWAA RVRQDLQVEE SSQEPSSGPL KLSAHQWLRA ELEAREKLWQ 2000
QATQLGQQAL LAAGTPTKEV QEELRALQDQ RDQVYQTWAR KQERLQAEQQ 2050
EQLFLRECGR LEEILAAQEV SLKTSALGSS VEEVEQLIRK HEVFLKVLTA 2100
QDKKEAALRE RLKTLRRPRV RDRLPILLQR RMRVKELAES RGHALHASLL 2150
MASFTQAATQ AEDWIQAWAQ QLKEPVPPGD LRDKLKPLLK HQAFEAEVQA 2200
HEEVMTSVAK KGEALLAQSH PRAGEVSQRL QGLRKHWEDL RQAMALRGQE 2250
LEDRRNFLEF LQRVDLAEAW IQEKEVKMNV GDLGQDLEHC LQLRRRLREF 2300
RGNSAGDTVG DACIRSISDL SLQLKNRDPE EVKIICQRRS QLNNRWASFH 2350
GNLLRYQQQL EGALEIHVLS RELDNVTKRI QEKEALIQAL DCGKDLESVQ 2400
RLLRKHEELE REVHPIQAQV ESLEREVGRL CQRSPEAAHG LRHRQQEVAE 2450
SWWQLRSRAQ KRREALDALH QAQKLQAMLQ ELLVSAQRLR AQMDTSPAPR 2500
SPVEARRMLE EHQECKAELD SWTDSISLAR STGQQLLTAG HPFSSDIRQV 2550
LAGLEQELSS LEGAWQEHQL QLQQALELQL FLSSVEKMER WLCSKEDSLA 2600
SEGLWDPLAP MEPLLWKHKM LEWDLEVQAG KISALEATAR GLHQGGHPEA 2650
QSALGRCQAM LLRKEALFRQ AGTRRHRLEE LRQLQAFLQD SQEVAAWLRE 2700
KNLVALEEGL LDTAMLPAQL QKQQNFQAEL DASMHQQQEL QREGQRLLQG 2750
GHPASEAIQE RLEELGALWG ELQDNSQKKV AKLQKACEAL RLRRSMEELE 2800
NWLEPIEVEL RAPTVGQALP GVGELLGTQR ELEAAVDKKA RQAEALLGQA 2850
QAFVREGHCL AQDVEEQARR LLQRFKSLRE PLQERRTALE ARSLLLKFFR 2900
DADEEMAWVQ EKLPLAAAQD YGQSLSAVRH LQEQHQNLES EMSSHEALTR 2950
VVLGTGYKLV QAGHFAAHEV AARVQQLEKA MAHLRAEAAR RRLLLQQAQE 3000
AQQFLTELLE AGSWLAERGH VLDSEDMGHS AEATQALLRR LEATKRDLEA 3050
FSPRIERLQQ TAALLESRKN PESPKVLAQL QAVREAHAEL LRRAEARGHG 3100
LQEQLQLHQL ERETLLLDAW LTTKAATAES QDYGQDLEGV KVLEEKFDAF 3150
RKEVQSLGQA KVYALRKLAG TLERGAPRRY PHIQAQRSRI EAAWERLDQA 3200
IKARTENLAA AHEVHSFQQA AAELQGRMQE KTALMKGEDG GHSLSSVRTL 3250
QQQHRRLERE LEAMEKEVAR LQTEACRLGQ LHPAAPGGLA KVQEAWATLQ 3300
AKAQERGQWL AQAAQGHAFL GRCQELLAWA QERQELASSE ELAEDVAGAE 3350
QLLGQHEELG QEIRECRLQA QDLRQEGQQL VDNSHFMSAE VTECLQELEG 3400
RLQELEEAWA LRWQRCAESW GLQKLRQRLE QAEAWLACWE GLLLKPDYGH 3450
SVSDVELLLH RHQDLEKLLA AQEEKFAQMQ KTEMEQELLL QPQELKPGRA 3500
GSSLTSFQWR PSGHQGLGAQ LAETRDPQDA KGTPTMEGSL EFKQHLLPGG 3550
RQPSSSSWDS CRGTLQGSSL SLFLDERMAA EKVASIALLD LTGARCERLR 3600
GRHGRKHTFS LRLTSGAEIL FAAPSEEQAE SWWRALGSTA AQSLSPKLKA 3650
KPVSSLNECT TKDARPGCLL RSDP 3674
Length:3,674
Mass (Da):416,835
Last modified:October 1, 2000 - v1
Checksum:i8C0FDFA0DD0C7C18
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1345 – 13451R → H.
Corresponds to variant rs2290559 [ dbSNP | Ensembl ].
VAR_022050
Natural varianti1367 – 13671R → T.
Corresponds to variant rs2290558 [ dbSNP | Ensembl ].
VAR_024395
Natural varianti2862 – 28621Q → R.
Corresponds to variant rs1456235 [ dbSNP | Ensembl ].
VAR_024396
Natural varianti3275 – 32751A → G.
Corresponds to variant rs1197660 [ dbSNP | Ensembl ].
VAR_024397

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF233523 mRNA. Translation: AAF65317.1.
CCDSiCCDS61599.1.
RefSeqiNP_057726.4. NM_016642.3.
UniGeneiHs.709819.

Genome annotation databases

EnsembliENST00000320955; ENSP00000317790; ENSG00000137877.
GeneIDi51332.
KEGGihsa:51332.
UCSCiuc001zos.4. human.

Polymorphism databases

DMDMi17369320.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF233523 mRNA. Translation: AAF65317.1 .
CCDSi CCDS61599.1.
RefSeqi NP_057726.4. NM_016642.3.
UniGenei Hs.709819.

3D structure databases

ProteinModelPortali Q9NRC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000317790.

PTM databases

PhosphoSitei Q9NRC6.

Polymorphism databases

DMDMi 17369320.

Proteomic databases

PaxDbi Q9NRC6.
PRIDEi Q9NRC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320955 ; ENSP00000317790 ; ENSG00000137877 .
GeneIDi 51332.
KEGGi hsa:51332.
UCSCi uc001zos.4. human.

Organism-specific databases

CTDi 51332.
GeneCardsi GC15M042140.
H-InvDB HIX0012162.
HGNCi HGNC:15680. SPTBN5.
MIMi 605916. gene.
neXtProti NX_Q9NRC6.
PharmGKBi PA38020.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5069.
HOGENOMi HOG000168577.
InParanoidi Q9NRC6.
KOi K06115.
OrthoDBi EOG7KM5RV.
PhylomeDBi Q9NRC6.
TreeFami TF313446.

Enzyme and pathway databases

Reactomei REACT_18334. NCAM signaling for neurite out-growth.
REACT_22266. Interaction between L1 and Ankyrins.

Miscellaneous databases

GeneWikii SPTBN5.
GenomeRNAii 51332.
NextBioi 54747.
PROi Q9NRC6.
SOURCEi Search...

Gene expression databases

Bgeei Q9NRC6.
CleanExi HS_SPTBN4.
HS_SPTBN5.
Genevestigatori Q9NRC6.

Family and domain databases

Gene3Di 1.10.418.10. 2 hits.
2.30.29.30. 1 hit.
InterProi IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view ]
Pfami PF00307. CH. 2 hits.
PF00435. Spectrin. 27 hits.
[Graphical view ]
SMARTi SM00033. CH. 2 hits.
SM00233. PH. 1 hit.
SM00150. SPEC. 29 hits.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
PROSITEi PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin."
    Stabach P.R., Morrow J.S.
    J. Biol. Chem. 275:21385-21395(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum, Retina and Spinal cord.
  2. "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels."
    Odell A.F., Van Helden D.F., Scott J.L.
    J. Biol. Chem. 283:4395-4407(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRPC4.

Entry informationi

Entry nameiSPTN5_HUMAN
AccessioniPrimary (citable) accession number: Q9NRC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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