##gff-version 3 Q9NRA8 UniProtKB Chain 1 985 . . . ID=PRO_0000064381;Note=Eukaryotic translation initiation factor 4E transporter Q9NRA8 UniProtKB Region 1 24 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Region 131 161 . . . Note=Interaction with CSDE1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27342281;Dbxref=PMID:27342281 Q9NRA8 UniProtKB Region 208 230 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Region 219 240 . . . Note=Interaction with DDX6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27342281;Dbxref=PMID:27342281 Q9NRA8 UniProtKB Region 448 490 . . . Note=Interaction with LSM14A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26027925;Dbxref=PMID:26027925 Q9NRA8 UniProtKB Region 664 693 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Region 695 713 . . . Note=Interaction with PATL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26027925;Dbxref=PMID:26027925 Q9NRA8 UniProtKB Region 707 803 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Region 922 953 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Region 940 985 . . . Note=Interaction with LSM14A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26027925;Dbxref=PMID:26027925 Q9NRA8 UniProtKB Motif 30 36 . . . Note=YXXXXLphi motif;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10856257,ECO:0000269|PubMed:24335285;Dbxref=PMID:10856257,PMID:24335285 Q9NRA8 UniProtKB Motif 195 211 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:10856257;Dbxref=PMID:10856257 Q9NRA8 UniProtKB Motif 438 447 . . . Note=Nuclear export signal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:10856257;Dbxref=PMID:10856257 Q9NRA8 UniProtKB Motif 613 638 . . . Note=Nuclear export signal;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:10856257;Dbxref=PMID:10856257 Q9NRA8 UniProtKB Compositional bias 1 15 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Compositional bias 665 693 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Compositional bias 707 734 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Compositional bias 735 778 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NRA8 UniProtKB Modified residue 5 5 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:20068231,PMID:23186163 Q9NRA8 UniProtKB Modified residue 74 74 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NRA8 UniProtKB Modified residue 78 78 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NRA8 UniProtKB Modified residue 115 115 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NRA8 UniProtKB Modified residue 120 120 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9NRA8 UniProtKB Modified residue 136 136 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9NRA8 UniProtKB Modified residue 138 138 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9NRA8 UniProtKB Modified residue 301 301 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:22966201,ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231,PMID:22966201 Q9NRA8 UniProtKB Modified residue 345 345 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9NRA8 UniProtKB Modified residue 353 353 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9NRA8 UniProtKB Modified residue 374 374 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22966201;Dbxref=PMID:22966201 Q9NRA8 UniProtKB Modified residue 417 417 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9NRA8 UniProtKB Modified residue 486 486 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Q9NRA8 UniProtKB Modified residue 513 513 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:22966201,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:22966201,PMID:23186163 Q9NRA8 UniProtKB Modified residue 564 564 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163 Q9NRA8 UniProtKB Modified residue 587 587 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:22966201,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:22966201,PMID:23186163 Q9NRA8 UniProtKB Modified residue 693 693 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:22966201,ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332,PMID:22966201 Q9NRA8 UniProtKB Modified residue 752 752 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22966201;Dbxref=PMID:22966201 Q9NRA8 UniProtKB Modified residue 920 920 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18088087;Dbxref=PMID:18088087 Q9NRA8 UniProtKB Modified residue 951 951 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163,PMID:24275569 Q9NRA8 UniProtKB Cross-link 410 410 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9NRA8 UniProtKB Alternative sequence 100 262 . . . ID=VSP_003783;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9NRA8 UniProtKB Alternative sequence 493 504 . . . ID=VSP_003784;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9NRA8 UniProtKB Alternative sequence 616 616 . . . ID=VSP_047042;Note=In isoform 2 and isoform 3. Q->QQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q9NRA8 UniProtKB Mutagenesis 30 36 . . . Note=Abolished interaction with EIF4E2. YTKEELL->ATKEEAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23991149,ECO:0000269|PubMed:28487484;Dbxref=PMID:23991149,PMID:28487484 Q9NRA8 UniProtKB Mutagenesis 30 30 . . . Note=Abolishes interaction with EIF4E and EIF4E2. Impaired ability to repress mRNA translation. Y->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10856257,ECO:0000269|PubMed:16157702,ECO:0000269|PubMed:24335285,ECO:0000269|PubMed:28487484;Dbxref=PMID:10856257,PMID:16157702,PMID:24335285,PMID:28487484 Q9NRA8 UniProtKB Mutagenesis 35 36 . . . Note=Abolished interaction with EIF4E2. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23991149;Dbxref=PMID:23991149 Q9NRA8 UniProtKB Mutagenesis 54 61 . . . Note=Strongly reduced interaction with EIF4E and EIF4E2. KYDSDGVW->ADSDAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23991149;Dbxref=PMID:23991149 Q9NRA8 UniProtKB Mutagenesis 195 196 . . . Note=Abolishes the nuclear localization. RR->NS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10856257;Dbxref=PMID:10856257 Q9NRA8 UniProtKB Mutagenesis 301 301 . . . Note=In S6A mutant%3B abolished phosphorylation by MAPK8/JNK1%3B impaired P-body assembly in response to oxidative stress when associated with A-374%2C A-513%2C A-587%2C A-693 and A-752. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22966201;Dbxref=PMID:22966201 Q9NRA8 UniProtKB Mutagenesis 374 374 . . . Note=In S6A mutant%3B abolished phosphorylation by MAPK8/JNK1%3B impaired P-body assembly in response to oxidative stress when associated with A-301%2C A-513%2C A-587%2C A-693 and A-752. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22966201;Dbxref=PMID:22966201 Q9NRA8 UniProtKB Mutagenesis 513 513 . . . Note=In S6A mutant%3B abolished phosphorylation by MAPK8/JNK1%3B impaired P-body assembly in response to oxidative stress when associated with A-301%2C A-374%2C A-587%2C A-693 and A-752. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22966201;Dbxref=PMID:22966201 Q9NRA8 UniProtKB Mutagenesis 587 587 . . . Note=In S6A mutant%3B abolished phosphorylation by MAPK8/JNK1%3B impaired P-body assembly in response to oxidative stress when associated with A-301%2C A-374%2C A-513%2C A-693 and A-752. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22966201;Dbxref=PMID:22966201 Q9NRA8 UniProtKB Mutagenesis 693 693 . . . Note=In S6A mutant%3B abolished phosphorylation by MAPK8/JNK1%3B impaired P-body assembly in response to oxidative stress when associated with A-301%2C A-374%2C A-513%2C A-587 and A-752. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22966201;Dbxref=PMID:22966201 Q9NRA8 UniProtKB Mutagenesis 752 752 . . . Note=In S6A mutant%3B abolished phosphorylation by MAPK8/JNK1%3B impaired P-body assembly in response to oxidative stress when associated with A-301%2C A-374%2C A-513%2C A-587 and A-693. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22966201;Dbxref=PMID:22966201 Q9NRA8 UniProtKB Mutagenesis 955 958 . . . Note=Abolished interaction with LSM14A. LAKW->AAKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29510985;Dbxref=PMID:29510985 Q9NRA8 UniProtKB Mutagenesis 958 958 . . . Note=Abolished interaction with LSM14A. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29510985;Dbxref=PMID:29510985 Q9NRA8 UniProtKB Mutagenesis 959 959 . . . Note=Abolished interaction with LSM14A. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29510985;Dbxref=PMID:29510985 Q9NRA8 UniProtKB Mutagenesis 961 961 . . . Note=Does not affect interaction with LSM14A. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29510985;Dbxref=PMID:29510985 Q9NRA8 UniProtKB Mutagenesis 970 970 . . . Note=Does not affect interaction with LSM14A. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29510985;Dbxref=PMID:29510985 Q9NRA8 UniProtKB Mutagenesis 978 981 . . . Note=Abolished interaction with LSM14A. VDEL->ADEA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29510985;Dbxref=PMID:29510985 Q9NRA8 UniProtKB Mutagenesis 978 978 . . . Note=Abolished interaction with LSM14A. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29510985;Dbxref=PMID:29510985 Q9NRA8 UniProtKB Mutagenesis 982 982 . . . Note=Abolished interaction with LSM14A. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29510985;Dbxref=PMID:29510985 Q9NRA8 UniProtKB Sequence conflict 114 114 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NRA8 UniProtKB Sequence conflict 825 825 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NRA8 UniProtKB Helix 220 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5ANR Q9NRA8 UniProtKB Helix 435 443 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6X2R Q9NRA8 UniProtKB Helix 955 957 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6F9W Q9NRA8 UniProtKB Helix 961 965 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6F9W Q9NRA8 UniProtKB Beta strand 975 977 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6F9W Q9NRA8 UniProtKB Helix 978 984 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6F9W