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Protein

Eukaryotic translation initiation factor 4E transporter

Gene

EIF4ENIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.1 Publication

GO - Molecular functioni

  • mRNA binding Source: Ensembl
  • protein transporter activity Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNORiQ9NRA8

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E transporter
Short name:
4E-T
Short name:
eIF4E transporter
Alternative name(s):
Eukaryotic translation initiation factor 4E nuclear import factor 1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000184708.17
HGNCiHGNC:16687 EIF4ENIF1
MIMi607445 gene
neXtProtiNX_Q9NRA8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30Y → A: Abolishes interaction with EIF4E. 1 Publication1
Mutagenesisi195 – 196RR → NS: Abolishes the nuclear localization. 1 Publication2

Organism-specific databases

DisGeNETi56478
OpenTargetsiENSG00000184708
Orphaneti619 Primary ovarian failure
PharmGKBiPA38410

Polymorphism and mutation databases

BioMutaiEIF4ENIF1
DMDMi22095430

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643811 – 985Eukaryotic translation initiation factor 4E transporterAdd BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei417PhosphoserineCombined sources1
Modified residuei486N6-acetyllysineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei693PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NRA8
MaxQBiQ9NRA8
PaxDbiQ9NRA8
PeptideAtlasiQ9NRA8
PRIDEiQ9NRA8

PTM databases

iPTMnetiQ9NRA8
PhosphoSitePlusiQ9NRA8

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000184708
CleanExiHS_EIF4ENIF1
ExpressionAtlasiQ9NRA8 baseline and differential
GenevisibleiQ9NRA8 HS

Organism-specific databases

HPAiHPA001619
HPA002078

Interactioni

Subunit structurei

Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121148, 60 interactors
CORUMiQ9NRA8
IntActiQ9NRA8, 65 interactors
MINTiQ9NRA8
STRINGi9606.ENSP00000328103

Structurei

Secondary structure

1985
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi220 – 223Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ANRX-ray2.10C199-239[»]
ProteinModelPortaliQ9NRA8
SMRiQ9NRA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 36EIF4E-binding7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi195 – 211Nuclear localization signalAdd BLAST17
Motifi438 – 447Nuclear export signal10
Motifi613 – 638Nuclear export signalAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi148 – 210Arg-richAdd BLAST63

Phylogenomic databases

eggNOGiENOG410IG0J Eukaryota
ENOG41110MN LUCA
GeneTreeiENSGT00390000012071
HOGENOMiHOG000232370
HOVERGENiHBG023298
InParanoidiQ9NRA8
KOiK18728
OMAiHQVPLVP
OrthoDBiEOG091G04PY
PhylomeDBiQ9NRA8
TreeFamiTF101531

Family and domain databases

InterProiView protein in InterPro
IPR018862 eIF4E-T
PANTHERiPTHR12269 PTHR12269, 1 hit
PfamiView protein in Pfam
PF10477 EIF4E-T, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NRA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRRSMGETE SGDAFLDLKK PPASKCPHRY TKEELLDIKE LPHSKQRPSC
60 70 80 90 100
LSEKYDSDGV WDPEKWHASL YPASGRSSPV ESLKKELDTD RPSLVRRIVD
110 120 130 140 150
PRERVKEDDL DVVLSPQRRS FGGGCHVTAA VSSRRSGSPL EKDSDGLRLL
160 170 180 190 200
GGRRIGSGRI ISARTFEKDH RLSDKDLRDL RDRDRERDFK DKRFRREFGD
210 220 230 240 250
SKRVFGERRR NDSYTEEEPE WFSAGPTSQS ETIELTGFDD KILEEDHKGR
260 270 280 290 300
KRTRRRTASV KEGIVECNGG VAEEDEVEVI LAQEPAADQE VPRDAVLPEQ
310 320 330 340 350
SPGDFDFNEF FNLDKVPCLA SMIEDVLGEG SVSASRFSRW FSNPSRSGSR
360 370 380 390 400
SSSLGSTPHE ELERLAGLEQ AILSPGQNSG NYFAPIPLED HAENKVDILE
410 420 430 440 450
MLQKAKVDLK PLLSSLSANK EKLKESSHSG VVLSVEEVEA GLKGLKVDQQ
460 470 480 490 500
VKNSTPFMAE HLEETLSAVT NNRQLKKDGD MTAFNKLVST MKASGTLPSQ
510 520 530 540 550
PKVSRNLESH LMSPAEIPGQ PVPKNILQEL LGQPVQRPAS SNLLSGLMGS
560 570 580 590 600
LEPTTSLLGQ RAPSPPLSQV FQTRAASADY LRPRIPSPIG FTPGPQQLLG
610 620 630 640 650
DPFQGMRKPM SPITAQMSQL ELQQAALEGL ALPHDLAVQA ANFYQPGFGK
660 670 680 690 700
PQVDRTRDGF RNRQQRVTKS PAPVHRGNSS SPAPAASITS MLSPSFTPTS
710 720 730 740 750
VIRKMYESKE KSKEEPASGK AALGDSKEDT QKASEENLLS SSSVPSADRD
760 770 780 790 800
SSPTTNSKLS ALQRSSCSTP LSQANRYTKE QDYRPKATGR KTPTLASPVP
810 820 830 840 850
TTPFLRPVHQ VPLVPHVPMV RPAHQLHPGL VQRMLAQGVH PQHLPSLLQT
860 870 880 890 900
GVLPPGMDLS HLQGISGPIL GQPFYPLPAA SHPLLNPRPG TPLHLAMVQQ
910 920 930 940 950
QLQRSVLHPP GSGSHAAAVS VQTTPQNVPS RSGLPHMHSQ LEHRPSQRSS
960 970 980
SPVGLAKWFG SDVLQQPLPS MPAKVISVDE LEYRQ
Length:985
Mass (Da):108,201
Last modified:August 2, 2002 - v2
Checksum:i4C898E0488903C04
GO
Isoform 2 (identifier: Q9NRA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-262: Missing.
     493-504: Missing.
     616-616: Q → QQ

Note: No experimental confirmation available.
Show »
Length:811
Mass (Da):88,226
Checksum:iB93D3AE24B15E7C0
GO
Isoform 3 (identifier: Q9NRA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-616: Q → QQ

Note: No experimental confirmation available.
Show »
Length:986
Mass (Da):108,329
Checksum:iCBED6CC9160D72C0
GO

Sequence cautioni

The sequence BAB15092 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11194 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114L → F in AAF81693 (PubMed:10856257).Curated1
Sequence conflicti825Q → R in AAH33028 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003783100 – 262Missing in isoform 2. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_003784493 – 504Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_047042616Q → QQ in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240775 mRNA Translation: AAF81693.1
CR456386 mRNA Translation: CAG30272.1
AK025254 mRNA Translation: BAB15092.1 Different initiation.
AK074768 mRNA Translation: BAC11194.1 Different initiation.
AK314636 mRNA Translation: BAG37198.1
AL096701 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59977.1
BC032941 mRNA Translation: AAH32941.1
BC033028 mRNA Translation: AAH33028.1
CCDSiCCDS13898.1 [Q9NRA8-1]
CCDS54520.1 [Q9NRA8-2]
RefSeqiNP_001157973.1, NM_001164501.1 [Q9NRA8-1]
NP_001157974.1, NM_001164502.1 [Q9NRA8-2]
NP_062817.2, NM_019843.3 [Q9NRA8-1]
XP_005261743.1, XM_005261686.2 [Q9NRA8-3]
XP_005261744.1, XM_005261687.2 [Q9NRA8-3]
XP_005261745.1, XM_005261688.2 [Q9NRA8-3]
XP_011528582.1, XM_011530280.1 [Q9NRA8-1]
XP_011528583.1, XM_011530281.2 [Q9NRA8-3]
XP_016884353.1, XM_017028864.1 [Q9NRA8-1]
UniGeneiHs.517559

Genome annotation databases

EnsembliENST00000330125; ENSP00000328103; ENSG00000184708 [Q9NRA8-1]
ENST00000344710; ENSP00000342927; ENSG00000184708 [Q9NRA8-2]
ENST00000397525; ENSP00000380659; ENSG00000184708 [Q9NRA8-1]
GeneIDi56478
KEGGihsa:56478
UCSCiuc003akz.3 human [Q9NRA8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei4ET_HUMAN
AccessioniPrimary (citable) accession number: Q9NRA8
Secondary accession number(s): B1AKL2
, B1AKL3, B2RBF1, Q8NCF2, Q9H708
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: March 28, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health