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Protein

Matrix-remodeling-associated protein 5

Gene

MXRA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101825-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix-remodeling-associated protein 5
Alternative name(s):
Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan
Short name:
Adlican
Gene namesi
Name:MXRA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:7539. MXRA5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Lung cancer (LNCR)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
See also OMIM:211980
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07240598A → D in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072406481P → H in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072407611W → C in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072408862S → N in LNCR. 1 Publication1
Natural variantiVAR_0724091028V → F in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724101491P → A in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724112300R → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant rs776590689dbSNPEnsembl.1
Natural variantiVAR_0724122349R → W in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant rs369042203dbSNPEnsembl.1
Natural variantiVAR_0724132678H → R in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724142716E → A in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724152763A → G in LNCR; unknown pathological significance. 1 Publication1

Organism-specific databases

DisGeNETi25878.
MalaCardsiMXRA5.
MIMi211980. phenotype.
OpenTargetsiENSG00000101825.
PharmGKBiPA31340.

Polymorphism and mutation databases

BioMutaiMXRA5.
DMDMi317373412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000025413127 – 2828Matrix-remodeling-associated protein 5Add BLAST2802

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi501 ↔ 555PROSITE-ProRule annotation
Disulfide bondi599 ↔ 651PROSITE-ProRule annotation
Glycosylationi633N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1403N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1735N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1875 ↔ 1928PROSITE-ProRule annotation
Disulfide bondi1972 ↔ 2025PROSITE-ProRule annotation
Glycosylationi2007N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2056N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2069 ↔ 2122PROSITE-ProRule annotation
Disulfide bondi2168 ↔ 2221PROSITE-ProRule annotation
Disulfide bondi2265 ↔ 2324PROSITE-ProRule annotation
Disulfide bondi2368 ↔ 2418PROSITE-ProRule annotation
Disulfide bondi2466 ↔ 2518PROSITE-ProRule annotation
Disulfide bondi2564 ↔ 2616PROSITE-ProRule annotation
Disulfide bondi2659 ↔ 2711PROSITE-ProRule annotation
Glycosylationi2693N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2755 ↔ 2810PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NR99.
PaxDbiQ9NR99.
PeptideAtlasiQ9NR99.
PRIDEiQ9NR99.

PTM databases

iPTMnetiQ9NR99.
PhosphoSitePlusiQ9NR99.

Expressioni

Developmental stagei

Over-expressed in centenarians. Expression is reduced from young to old but increased from old to centenarians.1 Publication

Gene expression databases

BgeeiENSG00000101825.
CleanExiHS_MXRA5.
GenevisibleiQ9NR99. HS.

Organism-specific databases

HPAiHPA000508.

Interactioni

Protein-protein interaction databases

BioGridi117392. 1 interactor.
STRINGi9606.ENSP00000217939.

Structurei

3D structure databases

ProteinModelPortaliQ9NR99.
SMRiQ9NR99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 55LRRNTAdd BLAST29
Repeati56 – 77LRR 1Add BLAST22
Repeati80 – 101LRR 2Add BLAST22
Repeati104 – 125LRR 3Add BLAST22
Repeati128 – 149LRR 4Add BLAST22
Repeati152 – 173LRR 5Add BLAST22
Repeati184 – 205LRR 6Add BLAST22
Domaini217 – 277LRRCTAdd BLAST61
Domaini481 – 571Ig-like C2-type 1Add BLAST91
Domaini575 – 669Ig-like C2-type 2Add BLAST95
Repeati1410 – 1434LRR 7Add BLAST25
Domaini1853 – 1946Ig-like C2-type 3Add BLAST94
Domaini1950 – 2041Ig-like C2-type 4Add BLAST92
Domaini2046 – 2140Ig-like C2-type 5Add BLAST95
Domaini2146 – 2239Ig-like C2-type 6Add BLAST94
Domaini2242 – 2343Ig-like C2-type 7Add BLAST102
Domaini2345 – 2432Ig-like C2-type 8Add BLAST88
Domaini2440 – 2534Ig-like C2-type 9Add BLAST95
Domaini2542 – 2630Ig-like C2-type 10Add BLAST89
Domaini2637 – 2722Ig-like C2-type 11Add BLAST86
Domaini2733 – 2828Ig-like C2-type 12Add BLAST96

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133679.
HOGENOMiHOG000168306.
InParanoidiQ9NR99.
OMAiLIDCQAE.
OrthoDBiEOG091G002I.
PhylomeDBiQ9NR99.
TreeFamiTF326318.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 6 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 12 hits.
SM00408. IGc2. 12 hits.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NR99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRAHWGAL SVVLILLWGH PRVALACPHP CACYVPSEVH CTFRSLASVP
60 70 80 90 100
AGIAKHVERI NLGFNSIQAL SETSFAGLTK LELLMIHGNE IPSIPDGALR
110 120 130 140 150
DLSSLQVFKF SYNKLRVITG QTLQGLSNLM RLHIDHNKIE FIHPQAFNGL
160 170 180 190 200
TSLRLLHLEG NLLHQLHPST FSTFTFLDYF RLSTIRHLYL AENMVRTLPA
210 220 230 240 250
SMLRNMPLLE NLYLQGNPWT CDCEMRWFLE WDAKSRGILK CKKDKAYEGG
260 270 280 290 300
QLCAMCFSPK KLYKHEIHKL KDMTCLKPSI ESPLRQNRSR SIEEEQEQEE
310 320 330 340 350
DGGSQLILEK FQLPQWSISL NMTDEHGNMV NLVCDIKKPM DVYKIHLNQT
360 370 380 390 400
DPPDIDINAT VALDFECPMT RENYEKLWKL IAYYSEVPVK LHRELMLSKD
410 420 430 440 450
PRVSYQYRQD ADEEALYYTG VRAQILAEPE WVMQPSIDIQ LNRRQSTAKK
460 470 480 490 500
VLLSYYTQYS QTISTKDTRQ ARGRSWVMIE PSGAVQRDQT VLEGGPCQLS
510 520 530 540 550
CNVKASESPS IFWVLPDGSI LKAPMDDPDS KFSILSSGWL RIKSMEPSDS
560 570 580 590 600
GLYQCIAQVR DEMDRMVYRV LVQSPSTQPA EKDTVTIGKN PGESVTLPCN
610 620 630 640 650
ALAIPEAHLS WILPNRRIIN DLANTSHVYM LPNGTLSIPK VQVSDSGYYR
660 670 680 690 700
CVAVNQQGAD HFTVGITVTK KGSGLPSKRG RRPGAKALSR VREDIVEDEG
710 720 730 740 750
GSGMGDEENT SRRLLHPKDQ EVFLKTKDDA INGDKKAKKG RRKLKLWKHS
760 770 780 790 800
EKEPETNVAE GRRVFESRRR INMANKQINP ERWADILAKV RGKNLPKGTE
810 820 830 840 850
VPPLIKTTSP PSLSLEVTPP FPAISPPSAS PVQTVTSAEE SSADVPLLGE
860 870 880 890 900
EEHVLGTISS ASMGLEHNHN GVILVEPEVT STPLEEVVDD LSEKTEEITS
910 920 930 940 950
TEGDLKGTAA PTLISEPYEP SPTLHTLDTV YEKPTHEETA TEGWSAADVG
960 970 980 990 1000
SSPEPTSSEY EPPLDAVSLA ESEPMQYFDP DLETKSQPDE DKMKEDTFAH
1010 1020 1030 1040 1050
LTPTPTIWVN DSSTSQLFED STIGEPGVPG QSHLQGLTDN IHLVKSSLST
1060 1070 1080 1090 1100
QDTLLIKKGM KEMSQTLQGG NMLEGDPTHS RSSESEGQES KSITLPDSTL
1110 1120 1130 1140 1150
GIMSSMSPVK KPAETTVGTL LDKDTTTATT TPRQKVAPSS TMSTHPSRRR
1160 1170 1180 1190 1200
PNGRRRLRPN KFRHRHKQTP PTTFAPSETF STQPTQAPDI KISSQVESSL
1210 1220 1230 1240 1250
VPTAWVDNTV NTPKQLEMEK NAEPTSKGTP RRKHGKRPNK HRYTPSTVSS
1260 1270 1280 1290 1300
RASGSKPSPS PENKHRNIVT PSSETILLPR TVSLKTEGPY DSLDYMTTTR
1310 1320 1330 1340 1350
KIYSSYPKVQ ETLPVTYKPT SDGKEIKDDV ATNVDKHKSD ILVTGESITN
1360 1370 1380 1390 1400
AIPTSRSLVS TMGEFKEESS PVGFPGTPTW NPSRTAQPGR LQTGIPVTTS
1410 1420 1430 1440 1450
GENLTDPPLL KELEDVDFTS EFLSSLTVST PFHQEEAGSS TTLSSIKVEV
1460 1470 1480 1490 1500
ASSQAETTTL DQDHLETTVA ILLSETRPQN HTPTAARMKE PASSSPSTIL
1510 1520 1530 1540 1550
MSLGQTTTTK PALPSPRISQ ASRDSKENVF LNYVGNPETE ATPVNNEGTQ
1560 1570 1580 1590 1600
HMSGPNELST PSSDQDAFNL STKLELEKQV FGSRSLPRGP DSQRQDGRVH
1610 1620 1630 1640 1650
ASHQLTRVPA KPILPTATVR LPEMSTQSAS RYFVTSQSPR HWTNKPEITT
1660 1670 1680 1690 1700
YPSGALPENK QFTTPRLSST TIPLPLHMSK PSIPSKFTDR RTDQFNGYSK
1710 1720 1730 1740 1750
VFGNNNIPEA RNPVGKPPSP RIPHYSNGRL PFFTNKTLSF PQLGVTRRPQ
1760 1770 1780 1790 1800
IPTSPAPVMR ERKVIPGSYN RIHSHSTFHL DFGPPAPPLL HTPQTTGSPS
1810 1820 1830 1840 1850
TNLQNIPMVS STQSSISFIT SSVQSSGSFH QSSSKFFAGG PPASKFWSLG
1860 1870 1880 1890 1900
EKPQILTKSP QTVSVTAETD TVFPCEATGK PKPFVTWTKV STGALMTPNT
1910 1920 1930 1940 1950
RIQRFEVLKN GTLVIRKVQV QDRGQYMCTA SNLHGLDRMV VLLSVTVQQP
1960 1970 1980 1990 2000
QILASHYQDV TVYLGDTIAM ECLAKGTPAP QISWIFPDRR VWQTVSPVEG
2010 2020 2030 2040 2050
RITLHENRTL SIKEASFSDR GVYKCVASNA AGADSLAIRL HVAALPPVIH
2060 2070 2080 2090 2100
QEKLENISLP PGLSIHIHCT AKAAPLPSVR WVLGDGTQIR PSQFLHGNLF
2110 2120 2130 2140 2150
VFPNGTLYIR NLAPKDSGRY ECVAANLVGS ARRTVQLNVQ RAAANARITG
2160 2170 2180 2190 2200
TSPRRTDVRY GGTLKLDCSA SGDPWPRILW RLPSKRMIDA LFSFDSRIKV
2210 2220 2230 2240 2250
FANGTLVVKS VTDKDAGDYL CVARNKVGDD YVVLKVDVVM KPAKIEHKEE
2260 2270 2280 2290 2300
NDHKVFYGGD LKVDCVATGL PNPEISWSLP DGSLVNSFMQ SDDSGGRTKR
2310 2320 2330 2340 2350
YVVFNNGTLY FNEVGMREEG DYTCFAENQV GKDEMRVRVK VVTAPATIRN
2360 2370 2380 2390 2400
KTYLAVQVPY GDVVTVACEA KGEPMPKVTW LSPTNKVIPT SSEKYQIYQD
2410 2420 2430 2440 2450
GTLLIQKAQR SDSGNYTCLV RNSAGEDRKT VWIHVNVQPP KINGNPNPIT
2460 2470 2480 2490 2500
TVREIAAGGS RKLIDCKAEG IPTPRVLWAF PEGVVLPAPY YGNRITVHGN
2510 2520 2530 2540 2550
GSLDIRSLRK SDSVQLVCMA RNEGGEARLI LQLTVLEPME KPIFHDPISE
2560 2570 2580 2590 2600
KITAMAGHTI SLNCSAAGTP TPSLVWVLPN GTDLQSGQQL QRFYHKADGM
2610 2620 2630 2640 2650
LHISGLSSVD AGAYRCVARN AAGHTERLVS LKVGLKPEAN KQYHNLVSII
2660 2670 2680 2690 2700
NGETLKLPCT PPGAGQGRFS WTLPNGMHLE GPQTLGRVSL LDNGTLTVRE
2710 2720 2730 2740 2750
ASVFDRGTYV CRMETEYGPS VTSIPVIVIA YPPRITSEPT PVIYTRPGNT
2760 2770 2780 2790 2800
VKLNCMAMGI PKADITWELP DKSHLKAGVQ ARLYGNRFLH PQGSLTIQHA
2810 2820
TQRDAGFYKC MAKNILGSDS KTTYIHVF
Length:2,828
Mass (Da):312,150
Last modified:January 11, 2011 - v3
Checksum:i0534732CE87C9A8F
GO

Sequence cautioni

The sequence AAH11846 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64986 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH80586 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55K → R in AAF86402 (Ref. 1) Curated1
Sequence conflicti1565Q → R in AAF86402 (Ref. 1) Curated1
Sequence conflicti2245I → V in CAB43220 (PubMed:17974005).Curated1
Sequence conflicti2353Y → C in CAB43220 (PubMed:17974005).Curated1
Sequence conflicti2640N → S in CAB43220 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07240598A → D in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072406481P → H in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_072407611W → C in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_056057764V → L.Corresponds to variant rs5983120dbSNPEnsembl.1
Natural variantiVAR_060357824I → V.1 PublicationCorresponds to variant rs5983119dbSNPEnsembl.1
Natural variantiVAR_072408862S → N in LNCR. 1 Publication1
Natural variantiVAR_0724091028V → F in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0603581128A → V.1 PublicationCorresponds to variant rs1635246dbSNPEnsembl.1
Natural variantiVAR_0762571163R → H.1 PublicationCorresponds to variant rs139106444dbSNPEnsembl.1
Natural variantiVAR_0603591394G → D.1 PublicationCorresponds to variant rs1726199dbSNPEnsembl.1
Natural variantiVAR_0560581484T → A.Corresponds to variant rs12396910dbSNPEnsembl.1
Natural variantiVAR_0724101491P → A in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0560591665P → S.Corresponds to variant rs1974522dbSNPEnsembl.1
Natural variantiVAR_0603602000G → S.1 PublicationCorresponds to variant rs1635242dbSNPEnsembl.1
Natural variantiVAR_0724112300R → H in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant rs776590689dbSNPEnsembl.1
Natural variantiVAR_0724122349R → W in LNCR; unknown pathological significance. 1 PublicationCorresponds to variant rs369042203dbSNPEnsembl.1
Natural variantiVAR_0764372426E → D Polymorhism; found in a patient with MRT52. 1 PublicationCorresponds to variant rs148675322dbSNPEnsembl.1
Natural variantiVAR_0288212531L → V.1 PublicationCorresponds to variant rs1726208dbSNPEnsembl.1
Natural variantiVAR_0762582663G → W.1 PublicationCorresponds to variant rs143264543dbSNPEnsembl.1
Natural variantiVAR_0724132678H → R in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724142716E → A in LNCR; unknown pathological significance. 1 Publication1
Natural variantiVAR_0724152763A → G in LNCR; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245505 mRNA. Translation: AAF86402.1.
AC004616 Genomic DNA. No translation available.
BC011846 mRNA. Translation: AAH11846.1. Sequence problems.
BC064986 mRNA. Translation: AAH64986.1. Sequence problems.
BC080586 mRNA. Translation: AAH80586.1. Sequence problems.
AL049946 mRNA. Translation: CAB43220.1.
CCDSiCCDS14124.1.
PIRiT08678.
RefSeqiNP_056234.2. NM_015419.3.
UniGeneiHs.369422.

Genome annotation databases

EnsembliENST00000217939; ENSP00000217939; ENSG00000101825.
GeneIDi25878.
KEGGihsa:25878.
UCSCiuc004crg.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245505 mRNA. Translation: AAF86402.1.
AC004616 Genomic DNA. No translation available.
BC011846 mRNA. Translation: AAH11846.1. Sequence problems.
BC064986 mRNA. Translation: AAH64986.1. Sequence problems.
BC080586 mRNA. Translation: AAH80586.1. Sequence problems.
AL049946 mRNA. Translation: CAB43220.1.
CCDSiCCDS14124.1.
PIRiT08678.
RefSeqiNP_056234.2. NM_015419.3.
UniGeneiHs.369422.

3D structure databases

ProteinModelPortaliQ9NR99.
SMRiQ9NR99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117392. 1 interactor.
STRINGi9606.ENSP00000217939.

PTM databases

iPTMnetiQ9NR99.
PhosphoSitePlusiQ9NR99.

Polymorphism and mutation databases

BioMutaiMXRA5.
DMDMi317373412.

Proteomic databases

EPDiQ9NR99.
PaxDbiQ9NR99.
PeptideAtlasiQ9NR99.
PRIDEiQ9NR99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217939; ENSP00000217939; ENSG00000101825.
GeneIDi25878.
KEGGihsa:25878.
UCSCiuc004crg.6. human.

Organism-specific databases

CTDi25878.
DisGeNETi25878.
GeneCardsiMXRA5.
H-InvDBHIX0016637.
HGNCiHGNC:7539. MXRA5.
HPAiHPA000508.
MalaCardsiMXRA5.
MIMi211980. phenotype.
300938. gene.
neXtProtiNX_Q9NR99.
OpenTargetsiENSG00000101825.
PharmGKBiPA31340.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133679.
HOGENOMiHOG000168306.
InParanoidiQ9NR99.
OMAiLIDCQAE.
OrthoDBiEOG091G002I.
PhylomeDBiQ9NR99.
TreeFamiTF326318.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101825-MONOMER.

Miscellaneous databases

GeneWikiiMXRA5.
GenomeRNAii25878.
PROiQ9NR99.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101825.
CleanExiHS_MXRA5.
GenevisibleiQ9NR99. HS.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 6 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 12 hits.
SM00408. IGc2. 12 hits.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMXRA5_HUMAN
AccessioniPrimary (citable) accession number: Q9NR99
Secondary accession number(s): Q6P1M7, Q9Y3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.