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Protein

Matrix-remodeling-associated protein 5

Gene

MXRA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix-remodeling-associated protein 5
Alternative name(s):
Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan
Short name:
Adlican
Gene namesi
Name:MXRA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:7539. MXRA5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Lung cancer (LNCR)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
See also OMIM:211980
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981A → D in LNCR; unknown pathological significance. 1 Publication
VAR_072405
Natural varianti481 – 4811P → H in LNCR; unknown pathological significance. 1 Publication
VAR_072406
Natural varianti611 – 6111W → C in LNCR; unknown pathological significance. 1 Publication
VAR_072407
Natural varianti862 – 8621S → N in LNCR. 1 Publication
VAR_072408
Natural varianti1028 – 10281V → F in LNCR; unknown pathological significance. 1 Publication
VAR_072409
Natural varianti1491 – 14911P → A in LNCR; unknown pathological significance. 1 Publication
VAR_072410
Natural varianti2300 – 23001R → H in LNCR; unknown pathological significance. 1 Publication
VAR_072411
Natural varianti2349 – 23491R → W in LNCR; unknown pathological significance. 1 Publication
VAR_072412
Natural varianti2678 – 26781H → R in LNCR; unknown pathological significance. 1 Publication
VAR_072413
Natural varianti2716 – 27161E → A in LNCR; unknown pathological significance. 1 Publication
VAR_072414
Natural varianti2763 – 27631A → G in LNCR; unknown pathological significance. 1 Publication
VAR_072415

Organism-specific databases

MalaCardsiMXRA5.
MIMi211980. phenotype.
PharmGKBiPA31340.

Polymorphism and mutation databases

BioMutaiMXRA5.
DMDMi317373412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 28282802Matrix-remodeling-associated protein 5PRO_0000254131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence analysis
Disulfide bondi501 ↔ 555PROSITE-ProRule annotation
Disulfide bondi599 ↔ 651PROSITE-ProRule annotation
Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence analysis
Glycosylationi1403 – 14031N-linked (GlcNAc...)Sequence analysis
Glycosylationi1735 – 17351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1875 ↔ 1928PROSITE-ProRule annotation
Disulfide bondi1972 ↔ 2025PROSITE-ProRule annotation
Glycosylationi2007 – 20071N-linked (GlcNAc...)Sequence analysis
Glycosylationi2056 – 20561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2069 ↔ 2122PROSITE-ProRule annotation
Disulfide bondi2168 ↔ 2221PROSITE-ProRule annotation
Disulfide bondi2265 ↔ 2324PROSITE-ProRule annotation
Disulfide bondi2368 ↔ 2418PROSITE-ProRule annotation
Disulfide bondi2466 ↔ 2518PROSITE-ProRule annotation
Disulfide bondi2564 ↔ 2616PROSITE-ProRule annotation
Disulfide bondi2659 ↔ 2711PROSITE-ProRule annotation
Glycosylationi2693 – 26931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2755 ↔ 2810PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NR99.
PaxDbiQ9NR99.
PRIDEiQ9NR99.

PTM databases

iPTMnetiQ9NR99.
PhosphoSiteiQ9NR99.

Expressioni

Developmental stagei

Over-expressed in centenarians. Expression is reduced from young to old but increased from old to centenarians.1 Publication

Gene expression databases

BgeeiQ9NR99.
CleanExiHS_MXRA5.
GenevisibleiQ9NR99. HS.

Organism-specific databases

HPAiHPA000508.

Interactioni

Protein-protein interaction databases

BioGridi117392. 1 interaction.
STRINGi9606.ENSP00000217939.

Structurei

3D structure databases

ProteinModelPortaliQ9NR99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 5529LRRNTAdd
BLAST
Repeati56 – 7722LRR 1Add
BLAST
Repeati80 – 10122LRR 2Add
BLAST
Repeati104 – 12522LRR 3Add
BLAST
Repeati128 – 14922LRR 4Add
BLAST
Repeati152 – 17322LRR 5Add
BLAST
Repeati184 – 20522LRR 6Add
BLAST
Domaini217 – 27761LRRCTAdd
BLAST
Domaini481 – 57191Ig-like C2-type 1Add
BLAST
Domaini575 – 66995Ig-like C2-type 2Add
BLAST
Repeati1410 – 143425LRR 7Add
BLAST
Domaini1853 – 194694Ig-like C2-type 3Add
BLAST
Domaini1950 – 204192Ig-like C2-type 4Add
BLAST
Domaini2046 – 214095Ig-like C2-type 5Add
BLAST
Domaini2146 – 223994Ig-like C2-type 6Add
BLAST
Domaini2242 – 2343102Ig-like C2-type 7Add
BLAST
Domaini2345 – 243288Ig-like C2-type 8Add
BLAST
Domaini2440 – 253495Ig-like C2-type 9Add
BLAST
Domaini2542 – 263089Ig-like C2-type 10Add
BLAST
Domaini2637 – 272286Ig-like C2-type 11Add
BLAST
Domaini2733 – 282896Ig-like C2-type 12Add
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129722.
HOGENOMiHOG000168306.
InParanoidiQ9NR99.
OMAiGTSPQRT.
OrthoDBiEOG7HHWR7.
PhylomeDBiQ9NR99.
TreeFamiTF326318.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 6 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 12 hits.
SM00408. IGc2. 12 hits.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NR99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRAHWGAL SVVLILLWGH PRVALACPHP CACYVPSEVH CTFRSLASVP
60 70 80 90 100
AGIAKHVERI NLGFNSIQAL SETSFAGLTK LELLMIHGNE IPSIPDGALR
110 120 130 140 150
DLSSLQVFKF SYNKLRVITG QTLQGLSNLM RLHIDHNKIE FIHPQAFNGL
160 170 180 190 200
TSLRLLHLEG NLLHQLHPST FSTFTFLDYF RLSTIRHLYL AENMVRTLPA
210 220 230 240 250
SMLRNMPLLE NLYLQGNPWT CDCEMRWFLE WDAKSRGILK CKKDKAYEGG
260 270 280 290 300
QLCAMCFSPK KLYKHEIHKL KDMTCLKPSI ESPLRQNRSR SIEEEQEQEE
310 320 330 340 350
DGGSQLILEK FQLPQWSISL NMTDEHGNMV NLVCDIKKPM DVYKIHLNQT
360 370 380 390 400
DPPDIDINAT VALDFECPMT RENYEKLWKL IAYYSEVPVK LHRELMLSKD
410 420 430 440 450
PRVSYQYRQD ADEEALYYTG VRAQILAEPE WVMQPSIDIQ LNRRQSTAKK
460 470 480 490 500
VLLSYYTQYS QTISTKDTRQ ARGRSWVMIE PSGAVQRDQT VLEGGPCQLS
510 520 530 540 550
CNVKASESPS IFWVLPDGSI LKAPMDDPDS KFSILSSGWL RIKSMEPSDS
560 570 580 590 600
GLYQCIAQVR DEMDRMVYRV LVQSPSTQPA EKDTVTIGKN PGESVTLPCN
610 620 630 640 650
ALAIPEAHLS WILPNRRIIN DLANTSHVYM LPNGTLSIPK VQVSDSGYYR
660 670 680 690 700
CVAVNQQGAD HFTVGITVTK KGSGLPSKRG RRPGAKALSR VREDIVEDEG
710 720 730 740 750
GSGMGDEENT SRRLLHPKDQ EVFLKTKDDA INGDKKAKKG RRKLKLWKHS
760 770 780 790 800
EKEPETNVAE GRRVFESRRR INMANKQINP ERWADILAKV RGKNLPKGTE
810 820 830 840 850
VPPLIKTTSP PSLSLEVTPP FPAISPPSAS PVQTVTSAEE SSADVPLLGE
860 870 880 890 900
EEHVLGTISS ASMGLEHNHN GVILVEPEVT STPLEEVVDD LSEKTEEITS
910 920 930 940 950
TEGDLKGTAA PTLISEPYEP SPTLHTLDTV YEKPTHEETA TEGWSAADVG
960 970 980 990 1000
SSPEPTSSEY EPPLDAVSLA ESEPMQYFDP DLETKSQPDE DKMKEDTFAH
1010 1020 1030 1040 1050
LTPTPTIWVN DSSTSQLFED STIGEPGVPG QSHLQGLTDN IHLVKSSLST
1060 1070 1080 1090 1100
QDTLLIKKGM KEMSQTLQGG NMLEGDPTHS RSSESEGQES KSITLPDSTL
1110 1120 1130 1140 1150
GIMSSMSPVK KPAETTVGTL LDKDTTTATT TPRQKVAPSS TMSTHPSRRR
1160 1170 1180 1190 1200
PNGRRRLRPN KFRHRHKQTP PTTFAPSETF STQPTQAPDI KISSQVESSL
1210 1220 1230 1240 1250
VPTAWVDNTV NTPKQLEMEK NAEPTSKGTP RRKHGKRPNK HRYTPSTVSS
1260 1270 1280 1290 1300
RASGSKPSPS PENKHRNIVT PSSETILLPR TVSLKTEGPY DSLDYMTTTR
1310 1320 1330 1340 1350
KIYSSYPKVQ ETLPVTYKPT SDGKEIKDDV ATNVDKHKSD ILVTGESITN
1360 1370 1380 1390 1400
AIPTSRSLVS TMGEFKEESS PVGFPGTPTW NPSRTAQPGR LQTGIPVTTS
1410 1420 1430 1440 1450
GENLTDPPLL KELEDVDFTS EFLSSLTVST PFHQEEAGSS TTLSSIKVEV
1460 1470 1480 1490 1500
ASSQAETTTL DQDHLETTVA ILLSETRPQN HTPTAARMKE PASSSPSTIL
1510 1520 1530 1540 1550
MSLGQTTTTK PALPSPRISQ ASRDSKENVF LNYVGNPETE ATPVNNEGTQ
1560 1570 1580 1590 1600
HMSGPNELST PSSDQDAFNL STKLELEKQV FGSRSLPRGP DSQRQDGRVH
1610 1620 1630 1640 1650
ASHQLTRVPA KPILPTATVR LPEMSTQSAS RYFVTSQSPR HWTNKPEITT
1660 1670 1680 1690 1700
YPSGALPENK QFTTPRLSST TIPLPLHMSK PSIPSKFTDR RTDQFNGYSK
1710 1720 1730 1740 1750
VFGNNNIPEA RNPVGKPPSP RIPHYSNGRL PFFTNKTLSF PQLGVTRRPQ
1760 1770 1780 1790 1800
IPTSPAPVMR ERKVIPGSYN RIHSHSTFHL DFGPPAPPLL HTPQTTGSPS
1810 1820 1830 1840 1850
TNLQNIPMVS STQSSISFIT SSVQSSGSFH QSSSKFFAGG PPASKFWSLG
1860 1870 1880 1890 1900
EKPQILTKSP QTVSVTAETD TVFPCEATGK PKPFVTWTKV STGALMTPNT
1910 1920 1930 1940 1950
RIQRFEVLKN GTLVIRKVQV QDRGQYMCTA SNLHGLDRMV VLLSVTVQQP
1960 1970 1980 1990 2000
QILASHYQDV TVYLGDTIAM ECLAKGTPAP QISWIFPDRR VWQTVSPVEG
2010 2020 2030 2040 2050
RITLHENRTL SIKEASFSDR GVYKCVASNA AGADSLAIRL HVAALPPVIH
2060 2070 2080 2090 2100
QEKLENISLP PGLSIHIHCT AKAAPLPSVR WVLGDGTQIR PSQFLHGNLF
2110 2120 2130 2140 2150
VFPNGTLYIR NLAPKDSGRY ECVAANLVGS ARRTVQLNVQ RAAANARITG
2160 2170 2180 2190 2200
TSPRRTDVRY GGTLKLDCSA SGDPWPRILW RLPSKRMIDA LFSFDSRIKV
2210 2220 2230 2240 2250
FANGTLVVKS VTDKDAGDYL CVARNKVGDD YVVLKVDVVM KPAKIEHKEE
2260 2270 2280 2290 2300
NDHKVFYGGD LKVDCVATGL PNPEISWSLP DGSLVNSFMQ SDDSGGRTKR
2310 2320 2330 2340 2350
YVVFNNGTLY FNEVGMREEG DYTCFAENQV GKDEMRVRVK VVTAPATIRN
2360 2370 2380 2390 2400
KTYLAVQVPY GDVVTVACEA KGEPMPKVTW LSPTNKVIPT SSEKYQIYQD
2410 2420 2430 2440 2450
GTLLIQKAQR SDSGNYTCLV RNSAGEDRKT VWIHVNVQPP KINGNPNPIT
2460 2470 2480 2490 2500
TVREIAAGGS RKLIDCKAEG IPTPRVLWAF PEGVVLPAPY YGNRITVHGN
2510 2520 2530 2540 2550
GSLDIRSLRK SDSVQLVCMA RNEGGEARLI LQLTVLEPME KPIFHDPISE
2560 2570 2580 2590 2600
KITAMAGHTI SLNCSAAGTP TPSLVWVLPN GTDLQSGQQL QRFYHKADGM
2610 2620 2630 2640 2650
LHISGLSSVD AGAYRCVARN AAGHTERLVS LKVGLKPEAN KQYHNLVSII
2660 2670 2680 2690 2700
NGETLKLPCT PPGAGQGRFS WTLPNGMHLE GPQTLGRVSL LDNGTLTVRE
2710 2720 2730 2740 2750
ASVFDRGTYV CRMETEYGPS VTSIPVIVIA YPPRITSEPT PVIYTRPGNT
2760 2770 2780 2790 2800
VKLNCMAMGI PKADITWELP DKSHLKAGVQ ARLYGNRFLH PQGSLTIQHA
2810 2820
TQRDAGFYKC MAKNILGSDS KTTYIHVF
Length:2,828
Mass (Da):312,150
Last modified:January 11, 2011 - v3
Checksum:i0534732CE87C9A8F
GO

Sequence cautioni

The sequence AAH11846.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64986.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH80586.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551K → R in AAF86402 (Ref. 1) Curated
Sequence conflicti1565 – 15651Q → R in AAF86402 (Ref. 1) Curated
Sequence conflicti2245 – 22451I → V in CAB43220 (PubMed:17974005).Curated
Sequence conflicti2353 – 23531Y → C in CAB43220 (PubMed:17974005).Curated
Sequence conflicti2640 – 26401N → S in CAB43220 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981A → D in LNCR; unknown pathological significance. 1 Publication
VAR_072405
Natural varianti481 – 4811P → H in LNCR; unknown pathological significance. 1 Publication
VAR_072406
Natural varianti611 – 6111W → C in LNCR; unknown pathological significance. 1 Publication
VAR_072407
Natural varianti764 – 7641V → L.
Corresponds to variant rs5983120 [ dbSNP | Ensembl ].
VAR_056057
Natural varianti824 – 8241I → V.1 Publication
Corresponds to variant rs5983119 [ dbSNP | Ensembl ].
VAR_060357
Natural varianti862 – 8621S → N in LNCR. 1 Publication
VAR_072408
Natural varianti1028 – 10281V → F in LNCR; unknown pathological significance. 1 Publication
VAR_072409
Natural varianti1128 – 11281A → V.1 Publication
Corresponds to variant rs1635246 [ dbSNP | Ensembl ].
VAR_060358
Natural varianti1394 – 13941G → D.1 Publication
Corresponds to variant rs1726199 [ dbSNP | Ensembl ].
VAR_060359
Natural varianti1484 – 14841T → A.
Corresponds to variant rs12396910 [ dbSNP | Ensembl ].
VAR_056058
Natural varianti1491 – 14911P → A in LNCR; unknown pathological significance. 1 Publication
VAR_072410
Natural varianti1665 – 16651P → S.
Corresponds to variant rs1974522 [ dbSNP | Ensembl ].
VAR_056059
Natural varianti2000 – 20001G → S.1 Publication
Corresponds to variant rs1635242 [ dbSNP | Ensembl ].
VAR_060360
Natural varianti2300 – 23001R → H in LNCR; unknown pathological significance. 1 Publication
VAR_072411
Natural varianti2349 – 23491R → W in LNCR; unknown pathological significance. 1 Publication
VAR_072412
Natural varianti2531 – 25311L → V.1 Publication
Corresponds to variant rs1726208 [ dbSNP | Ensembl ].
VAR_028821
Natural varianti2678 – 26781H → R in LNCR; unknown pathological significance. 1 Publication
VAR_072413
Natural varianti2716 – 27161E → A in LNCR; unknown pathological significance. 1 Publication
VAR_072414
Natural varianti2763 – 27631A → G in LNCR; unknown pathological significance. 1 Publication
VAR_072415

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245505 mRNA. Translation: AAF86402.1.
AC004616 Genomic DNA. No translation available.
BC011846 mRNA. Translation: AAH11846.1. Sequence problems.
BC064986 mRNA. Translation: AAH64986.1. Sequence problems.
BC080586 mRNA. Translation: AAH80586.1. Sequence problems.
AL049946 mRNA. Translation: CAB43220.1.
CCDSiCCDS14124.1.
PIRiT08678.
RefSeqiNP_056234.2. NM_015419.3.
UniGeneiHs.369422.

Genome annotation databases

EnsembliENST00000217939; ENSP00000217939; ENSG00000101825.
GeneIDi25878.
KEGGihsa:25878.
UCSCiuc004crg.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245505 mRNA. Translation: AAF86402.1.
AC004616 Genomic DNA. No translation available.
BC011846 mRNA. Translation: AAH11846.1. Sequence problems.
BC064986 mRNA. Translation: AAH64986.1. Sequence problems.
BC080586 mRNA. Translation: AAH80586.1. Sequence problems.
AL049946 mRNA. Translation: CAB43220.1.
CCDSiCCDS14124.1.
PIRiT08678.
RefSeqiNP_056234.2. NM_015419.3.
UniGeneiHs.369422.

3D structure databases

ProteinModelPortaliQ9NR99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117392. 1 interaction.
STRINGi9606.ENSP00000217939.

PTM databases

iPTMnetiQ9NR99.
PhosphoSiteiQ9NR99.

Polymorphism and mutation databases

BioMutaiMXRA5.
DMDMi317373412.

Proteomic databases

EPDiQ9NR99.
PaxDbiQ9NR99.
PRIDEiQ9NR99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217939; ENSP00000217939; ENSG00000101825.
GeneIDi25878.
KEGGihsa:25878.
UCSCiuc004crg.6. human.

Organism-specific databases

CTDi25878.
GeneCardsiMXRA5.
H-InvDBHIX0016637.
HGNCiHGNC:7539. MXRA5.
HPAiHPA000508.
MalaCardsiMXRA5.
MIMi211980. phenotype.
300938. gene.
neXtProtiNX_Q9NR99.
PharmGKBiPA31340.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129722.
HOGENOMiHOG000168306.
InParanoidiQ9NR99.
OMAiGTSPQRT.
OrthoDBiEOG7HHWR7.
PhylomeDBiQ9NR99.
TreeFamiTF326318.

Miscellaneous databases

GeneWikiiMXRA5.
GenomeRNAii25878.
PROiQ9NR99.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NR99.
CleanExiHS_MXRA5.
GenevisibleiQ9NR99. HS.

Family and domain databases

Gene3Di2.60.40.10. 12 hits.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 6 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 12 hits.
SM00408. IGc2. 12 hits.
SM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 12 hits.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the gene encoding adlican, a novel protein expressed in human arthritic tissues."
    Crowl R.M., Luk D.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-824; VAL-1128; ASP-1394; SER-2000 AND VAL-2531.
    Tissue: Placenta.
  2. "Cloning of differentially expressed genes in skin fibroblasts from centenarians."
    Chondrogianni N., Simoes D.C.M., Franceschi C., Gonos E.S.
    Biogerontology 5:401-409(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-739.
    Tissue: Muscle.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2245-2828.
    Tissue: Brain.
  6. "Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients."
    Xiong D., Li G., Li K., Xu Q., Pan Z., Ding F., Vedell P., Liu P., Cui P., Hua X., Jiang H., Yin Y., Zhu Z., Li X., Zhang B., Ma D., Wang Y., You M.
    Carcinogenesis 33:1797-1805(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LNCR ASP-98; HIS-481; CYS-611; ASN-862; PHE-1028; ALA-1491; HIS-2300; TRP-2349; ARG-2678; ALA-2716 AND GLY-2763.

Entry informationi

Entry nameiMXRA5_HUMAN
AccessioniPrimary (citable) accession number: Q9NR99
Secondary accession number(s): Q6P1M7, Q9Y3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 11, 2011
Last modified: June 8, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.