Toll-like receptor 8 precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9NR97 (TLR8_HUMAN)

Last modified February 9, 2010. Version 85. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Toll-like receptor 8
Alternative name(s):
CD_antigen=CD288

Gene names

Name:	TLR8
ORF Names:	UNQ249/PRO286

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1041 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.
Subunit structure	Binds MYD88 via their respective TIR domains By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
Sequence similarities	Belongs to the Toll-like receptor family. Contains 24 LRR (leucine-rich) repeats. Contains 1 TIR domain.

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Ontologies

Keywords
Biological process	Immune response Inflammatory response
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	I-kappaB kinase/NF-kappaB cascade Non-traceable author statement. Source: UniProtKB defense response to virus Inferred from mutant phenotype. Source: UniProtKB detection of virus Non-traceable author statement. Source: UniProtKB immunoglobulin mediated immune response Traceable author statement. Source: UniProtKB inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Non-traceable author statement. Source: UniProtKB positive regulation of innate immune response Inferred from direct assay. Source: UniProtKB positive regulation of interferon-alpha biosynthetic process Inferred from direct assay. Source: UniProtKB positive regulation of interferon-beta biosynthetic process Inferred from direct assay. Source: UniProtKB positive regulation of interferon-gamma biosynthetic process Inferred from direct assay. Source: UniProtKB positive regulation of interleukin-8 biosynthetic process Inferred from mutant phenotype. Source: UniProtKB
Cellular component	endosome membrane Inferred from Experiment. Source: Reactome integral to membrane Inferred by curator. Source: UniProtKB
Molecular function	DNA binding Inferred from direct assay. Source: UniProtKB Toll binding Non-traceable author statement. Source: UniProtKB double-stranded RNA binding Inferred from direct assay. Source: UniProtKB single-stranded RNA binding Inferred from direct assay. Source: UniProtKB transmembrane receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

Potential

Chain

27 – 1041

1015

Toll-like receptor 8

PRO_0000034735

Regions

Topological domain

27 – 827

801

Extracellular Potential

Transmembrane

828 – 848

Potential

Topological domain

849 – 1041

193

Cytoplasmic Potential

Repeat

61 – 85

LRR 1

Repeat

87 – 112

LRR 2

Repeat

124 – 147

LRR 3

Repeat

169 – 198

LRR 4

Repeat

200 – 223

LRR 5

Repeat

225 – 244

LRR 6

Repeat

246 – 267

LRR 7

Repeat

286 – 309

LRR 8

Repeat

311 – 334

LRR 9

Repeat

336 – 361

LRR 10

Repeat

366 – 389

LRR 11

Repeat

393 – 416

LRR 12

Repeat

418 – 440

LRR 13

Repeat

490 – 511

LRR 14

Repeat

529 – 552

LRR 15

Repeat

554 – 581

LRR 16

Repeat

583 – 607

LRR 17

Repeat

609 – 630

LRR 18

Repeat

638 – 661

LRR 19

Repeat

663 – 686

LRR 20

Repeat

687 – 710

LRR 21

Repeat

711 – 734

LRR 22

Repeat

736 – 758

LRR 23

Repeat

761 – 785

LRR 24

Domain

878 – 1025

148

TIR

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Ref.7

Glycosylation

N-linked (GlcNAc...) Ref.7

Glycosylation

115

N-linked (GlcNAc...) Potential

Glycosylation

160

N-linked (GlcNAc...) Potential

Glycosylation

247

N-linked (GlcNAc...) Potential

Glycosylation

285

N-linked (GlcNAc...) Potential

Glycosylation

293

N-linked (GlcNAc...) Potential

Glycosylation

358

N-linked (GlcNAc...) Potential

Glycosylation

362

N-linked (GlcNAc...) Potential

Glycosylation

395

N-linked (GlcNAc...) Potential

Glycosylation

416

N-linked (GlcNAc...) Potential

Glycosylation

443

N-linked (GlcNAc...) Potential

Glycosylation

511

N-linked (GlcNAc...) Potential

Glycosylation

546

N-linked (GlcNAc...) Potential

Glycosylation

582

N-linked (GlcNAc...) Potential

Glycosylation

590

N-linked (GlcNAc...) Potential

Glycosylation

640

N-linked (GlcNAc...) Potential

Glycosylation

680

N-linked (GlcNAc...) Potential

Glycosylation

752

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

M → V: dbSNP rs5744077.

VAR_024667

Natural variant

715

R → Q: dbSNP rs5744082.

VAR_052363

Experimental info

Sequence conflict

M → MKESSLQNSSCSLGKETKK Ref.1

Sequence conflict

217

P → S in AAF64061. Ref.1

Sequence conflict

328

A → V in AAQ88663. Ref.4

Sequence conflict

366

L → P in AAF64061. Ref.1

Sequence conflict

867

V → I in AAF64061. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9NR97-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 39A38B60629291C8
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FASTA

1,041

119,828

        10         20         30         40         50         60 
MENMFLQSSM LTCIFLLISG SCELCAEENF SRSYPCDEKK QNDSVIAECS NRRLQEVPQT 

        70         80         90        100        110        120 
VGKYVTELDL SDNFITHITN ESFQGLQNLT KINLNHNPNV QHQNGNPGIQ SNGLNITDGA 

       130        140        150        160        170        180 
FLNLKNLREL LLEDNQLPQI PSGLPESLTE LSLIQNNIYN ITKEGISRLI NLKNLYLAWN 

       190        200        210        220        230        240 
CYFNKVCEKT NIEDGVFETL TNLELLSLSF NSLSHVPPKL PSSLRKLFLS NTQIKYISEE 

       250        260        270        280        290        300 
DFKGLINLTL LDLSGNCPRC FNAPFPCVPC DGGASINIDR FAFQNLTQLR YLNLSSTSLR 

       310        320        330        340        350        360 
KINAAWFKNM PHLKVLDLEF NYLVGEIASG AFLTMLPRLE ILDLSFNYIK GSYPQHINIS 

       370        380        390        400        410        420 
RNFSKLLSLR ALHLRGYVFQ ELREDDFQPL MQLPNLSTIN LGINFIKQID FKLFQNFSNL 

       430        440        450        460        470        480 
EIIYLSENRI SPLVKDTRQS YANSSSFQRH IRKRRSTDFE FDPHSNFYHF TRPLIKPQCA 

       490        500        510        520        530        540 
AYGKALDLSL NSIFFIGPNQ FENLPDIACL NLSANSNAQV LSGTEFSAIP HVKYLDLTNN 

       550        560        570        580        590        600 
RLDFDNASAL TELSDLEVLD LSYNSHYFRI AGVTHHLEFI QNFTNLKVLN LSHNNIYTLT 

       610        620        630        640        650        660 
DKYNLESKSL VELVFSGNRL DILWNDDDNR YISIFKGLKN LTRLDLSLNR LKHIPNEAFL 

       670        680        690        700        710        720 
NLPASLTELH INDNMLKFFN WTLLQQFPRL ELLDLRGNKL LFLTDSLSDF TSSLRTLLLS 

       730        740        750        760        770        780 
HNRISHLPSG FLSEVSSLKH LDLSSNLLKT INKSALETKT TTKLSMLELH GNPFECTCDI 

       790        800        810        820        830        840 
GDFRRWMDEH LNVKIPRLVD VICASPGDQR GKSIVSLELT TCVSDVTAVI LFFFTFFITT 

       850        860        870        880        890        900 
MVMLAALAHH LFYWDVWFIY NVCLAKVKGY RSLSTSQTFY DAYISYDTKD ASVTDWVINE 

       910        920        930        940        950        960 
LRYHLEESRD KNVLLCLEER DWDPGLAIID NLMQSINQSK KTVFVLTKKY AKSWNFKTAF 

       970        980        990       1000       1010       1020 
YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EGLFWQTLRN 

      1030       1040 
VVLTENDSRY NNMYVDSIKQ Y

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three novel mammalian Toll-like receptors: gene structure, expression, and evolution." Du X., Poltorak A., Wei Y., Beutler B. Eur. Cytokine Netw. 11:362-371(2000) [PubMed: 11022119] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9." Chuang T.-H., Ulevitch R.J. Eur. Cytokine Netw. 11:372-378(2000) [PubMed: 11022120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"Natural selection in the TLR-related genes in the course of primate evolution." Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A. Immunogenetics 60:727-735(2008) [PubMed: 18810425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-80 AND ASN-88, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AF246971 mRNA. Translation: AAF64061.1. AF245703 mRNA. Translation: AAF78036.1. AB445666 mRNA. Translation: BAG55063.1. AY358296 mRNA. Translation: AAQ88663.1. CH471074 Genomic DNA. Translation: EAW98809.1. BC101076 mRNA. Translation: AAI01077.1. BC101077 mRNA. Translation: AAI01078.1.
IPI	IPI00009910.
RefSeq	NP_619542.1.
UniGene	Hs.660543
3D structure databases
SMR	Q9NR97. Positions 879-1021.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NR97.
PTM databases
PhosphoSite	Q9NR97.
Proteomic databases
PRIDE	Q9NR97.
Genome annotation databases
Ensembl	ENST00000218032; ENSP00000218032; ENSG00000101916; Homo sapiens. [Genome view]
GeneID	51311.
KEGG	hsa:51311.
UCSC	uc004cve.1. human.
Organism-specific databases
CTD	51311.
GeneCards	GC0XP012834.
H-InvDB	HIX0056159.
HGNC	HGNC:15632. TLR8.
HPA	HPA001608.
MIM	300366. gene.
PharmGKB	PA38009.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11974.
HOVERGEN	Q9NR97.
OrthoDB	EOG92VC1H.
Enzyme and pathway databases
Reactome	REACT_6900. Signaling in Immune system.
Gene expression databases
ArrayExpress	Q9NR97.
Bgee	Q9NR97.
CleanEx	HS_TLR8.
Genevestigator	Q9NR97.
GermOnline	ENSG00000101916. Homo sapiens.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. Toll-Interleukin_rcpt. IPR015764. Toll-like_rcpt8_LRR-contain. [Graphical view]
PANTHER	PTHR23154:SF59. L_r_r_TLR8. 1 hit.
Pfam	PF00560. LRR_1. 5 hits. PF01582. TIR. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 3 hits. SM00082. LRRCT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 20 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54647.
SOURCE	Search...

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Entry information

Entry name

TLR8_HUMAN

Accession

Primary (citable) accession number: Q9NR97
Secondary accession number(s): B3Y654

Q9NYG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents