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Q9NR96

- TLR9_HUMAN

UniProt

Q9NR96 - TLR9_HUMAN

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Protein

Toll-like receptor 9

Gene

TLR9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.2 Publications

GO - Molecular functioni

  1. interleukin-1 receptor binding Source: UniProtKB
  2. siRNA binding Source: UniProtKB
  3. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB
  2. defense response to Gram-negative bacterium Source: UniProt
  3. I-kappaB phosphorylation Source: BHF-UCL
  4. inflammatory response Source: UniProtKB-KW
  5. innate immune response Source: BHF-UCL
  6. insulin receptor signaling pathway Source: Reactome
  7. maintenance of gastrointestinal epithelium Source: BHF-UCL
  8. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  9. negative regulation of interleukin-6 production Source: BHF-UCL
  10. negative regulation of interleukin-8 production Source: BHF-UCL
  11. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  12. negative regulation of toll-like receptor signaling pathway Source: BHF-UCL
  13. positive regulation of chemokine production Source: BHF-UCL
  14. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  15. positive regulation of inflammatory response Source: BHF-UCL
  16. positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  17. positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  18. positive regulation of interferon-beta production Source: BHF-UCL
  19. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  20. positive regulation of interleukin-10 production Source: BHF-UCL
  21. positive regulation of interleukin-12 production Source: BHF-UCL
  22. positive regulation of interleukin-18 production Source: BHF-UCL
  23. positive regulation of interleukin-6 production Source: BHF-UCL
  24. positive regulation of interleukin-8 production Source: BHF-UCL
  25. positive regulation of JNK cascade Source: BHF-UCL
  26. positive regulation of JUN kinase activity Source: BHF-UCL
  27. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  28. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  29. positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
  30. positive regulation of toll-like receptor signaling pathway Source: BHF-UCL
  31. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  32. positive regulation of tumor necrosis factor production Source: BHF-UCL
  33. regulation of cytokine secretion Source: InterPro
  34. response to molecule of bacterial origin Source: BHF-UCL
  35. toll-like receptor 9 signaling pathway Source: Reactome
  36. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_118632. Trafficking and processing of endosomal TLR.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_25222. MyD88 dependent cascade initiated on endosome.
REACT_9047. Toll Like Receptor 9 (TLR9) Cascade.
REACT_976. PI3K Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 9
Alternative name(s):
CD_antigen: CD289
Gene namesi
Name:TLR9
ORF Names:UNQ5798/PRO19605
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:15633. TLR9.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity. Endosome By similarity. Lysosome By similarity. Cytoplasmic vesiclephagosome By similarity
Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: BHF-UCL
  2. basolateral plasma membrane Source: BHF-UCL
  3. cytoplasm Source: BHF-UCL
  4. early phagosome Source: UniProtKB
  5. endolysosome membrane Source: Reactome
  6. endoplasmic reticulum Source: UniProtKB
  7. endoplasmic reticulum membrane Source: Reactome
  8. endosome Source: UniProtKB
  9. endosome membrane Source: Reactome
  10. extracellular region Source: UniProtKB
  11. Golgi membrane Source: Reactome
  12. integral component of membrane Source: UniProtKB-KW
  13. lysosome Source: UniProtKB
  14. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 10321007Toll-like receptor 9PRO_0000034737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi694 – 6941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NR96.
PaxDbiQ9NR96.
PRIDEiQ9NR96.

PTM databases

PhosphoSiteiQ9NR96.

Expressioni

Tissue specificityi

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Gene expression databases

BgeeiQ9NR96.
CleanExiHS_TLR9.
ExpressionAtlasiQ9NR96. baseline.
GenevestigatoriQ9NR96.

Organism-specific databases

HPAiHPA004731.

Interactioni

Subunit structurei

Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.By similarity2 Publications

Protein-protein interaction databases

BioGridi119902. 19 interactions.
IntActiQ9NR96. 8 interactions.
STRINGi9606.ENSP00000353874.

Structurei

3D structure databases

ProteinModelPortaliQ9NR96.
SMRiQ9NR96. Positions 34-803, 868-1013.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 818793ExtracellularSequence AnalysisAdd
BLAST
Topological domaini840 – 1032193CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei819 – 83921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 8524LRR 1Add
BLAST
Repeati87 – 11024LRR 2Add
BLAST
Repeati122 – 14726LRR 3Add
BLAST
Repeati150 – 16617LRR 4Add
BLAST
Repeati167 – 19024LRR 5Add
BLAST
Repeati198 – 22124LRR 6Add
BLAST
Repeati223 – 24220LRR 7Add
BLAST
Repeati243 – 26826LRR 8Add
BLAST
Repeati283 – 30624LRR 9Add
BLAST
Repeati308 – 33225LRR 10Add
BLAST
Repeati333 – 35624LRR 11Add
BLAST
Repeati363 – 38624LRR 12Add
BLAST
Repeati390 – 41324LRR 13Add
BLAST
Repeati415 – 44026LRR 14Add
BLAST
Repeati470 – 49425LRR 15Add
BLAST
Repeati496 – 51924LRR 16Add
BLAST
Repeati520 – 54324LRR 17Add
BLAST
Repeati545 – 57228LRR 18Add
BLAST
Repeati574 – 59825LRR 19Add
BLAST
Repeati600 – 62223LRR 20Add
BLAST
Repeati627 – 65024LRR 21Add
BLAST
Repeati652 – 67524LRR 22Add
BLAST
Repeati676 – 69924LRR 23Add
BLAST
Repeati701 – 72323LRR 24Add
BLAST
Repeati724 – 74724LRR 25Add
BLAST
Repeati749 – 77224LRR 26Add
BLAST
Domaini868 – 1016149TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 26 LRR (leucine-rich) repeats.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000119006.
HOVERGENiHBG018601.
InParanoidiQ9NR96.
KOiK10161.
OrthoDBiEOG7C8GGD.
PhylomeDBiQ9NR96.
TreeFamiTF325595.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 6 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9NR96-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL
60 70 80 90 100
KSVPHFSMAA PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP
110 120 130 140 150
VGLSPMHFPC HMTIEPSTFL AVPTLEELNL SYNNIMTVPA LPKSLISLSL
160 170 180 190 200
SHTNILMLDS ASLAGLHALR FLFMDGNCYY KNPCRQALEV APGALLGLGN
210 220 230 240 250
LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL ANLTALRVLD
260 270 280 290 300
VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN
310 320 330 340 350
ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS
360 370 380 390 400
FAHLSLAPSF GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM
410 420 430 440 450
NFINQAQLGI FRAFPGLRYV DLSDNRISGA SELTATMGEA DGGEKVWLQP
460 470 480 490 500
GDLAPAPVDT PSSEDFRPNC STLNFTLDLS RNNLVTVQPE MFAQLSHLQC
510 520 530 540 550
LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS FTELPRLEAL
560 570 580 590 600
DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL
610 620 630 640 650
RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN
660 670 680 690 700
LPKSLQVLRL RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG
710 720 730 740 750
TRLRRLDVSC NSISFVAPGF FSKAKELREL NLSANALKTV DHSWFGPLAS
760 770 780 790 800
ALQILDVSAN PLHCACGAAF MDFLLEVQAA VPGLPSRVKC GSPGQLQGLS
810 820 830 840 850
IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG WDLWYCFHLC
860 870 880 890 900
LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG
910 920 930 940 950
RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS
960 970 980 990 1000
FLLAQQRLLE DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS
1010 1020 1030
GQRSFWAQLG MALTRDNHHF YNRNFCQGPT AE
Length:1,032
Mass (Da):115,860
Last modified:January 31, 2002 - v2
Checksum:i71280AA9680EDCE2
GO
Isoform 2 (identifier: Q9NR96-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:975
Mass (Da):109,628
Checksum:i61D105163587A75F
GO
Isoform 3 (identifier: Q9NR96-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPMKWSGWRWSWGPATHTALPPPQ

Show »
Length:1,055
Mass (Da):118,517
Checksum:i4072A104D14022F6
GO
Isoform 4 (identifier: Q9NR96-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLYSSCKSRLLDSVEQDFHLEIAKK

Show »
Length:1,056
Mass (Da):118,652
Checksum:i9159C051473E88FC
GO
Isoform 5 (identifier: Q9NR96-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGFCRSALHPLSLLVQ → M

Show »
Length:1,017
Mass (Da):114,237
Checksum:i7EF80765E4675C9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001N → S in AAQ89443. (PubMed:12975309)Curated
Sequence conflicti330 – 3301F → L in AAQ89443. (PubMed:12975309)Curated
Sequence conflicti530 – 5301H → R in AAF78037. (PubMed:11022120)Curated
Sequence conflicti688 – 6881Q → R in AAF78037. (PubMed:11022120)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51R → C.
Corresponds to variant rs5743842 [ dbSNP | Ensembl ].
VAR_024668
Natural varianti79 – 791H → Q.
Corresponds to variant rs5743843 [ dbSNP | Ensembl ].
VAR_052364
Natural varianti863 – 8631R → Q.
Corresponds to variant rs5743845 [ dbSNP | Ensembl ].
VAR_034555
Natural varianti882 – 8821A → T.
Corresponds to variant rs5743846 [ dbSNP | Ensembl ].
VAR_052365
Natural varianti901 – 9011R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036077
Natural varianti933 – 9331T → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036078

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5757Missing in isoform 2. 1 PublicationVSP_006520Add
BLAST
Alternative sequencei1 – 1616MGFCR…SLLVQ → M in isoform 5. 1 PublicationVSP_006523Add
BLAST
Alternative sequencei1 – 11M → MPMKWSGWRWSWGPATHTAL PPPQ in isoform 3. 1 PublicationVSP_006521
Alternative sequencei1 – 11M → MLYSSCKSRLLDSVEQDFHL EIAKK in isoform 4. 1 PublicationVSP_006522

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF259262 mRNA. Translation: AAF72189.1.
AF259263 mRNA. Translation: AAF72190.1.
AF245704 mRNA. Translation: AAF78037.1.
AF246972 mRNA. Translation: AAG01734.1.
AF246973 mRNA. Translation: AAG01735.1.
AF246974 mRNA. Translation: AAG01736.1.
AB045180 mRNA. Translation: BAB19259.1.
EU170540 Genomic DNA. Translation: ABW37075.1.
EU170541 Genomic DNA. Translation: ABW37076.1.
EU170542 Genomic DNA. Translation: ABW37077.1.
EU170543 Genomic DNA. Translation: ABW37078.1.
AB445673 mRNA. Translation: BAG55070.1.
DQ019992 Genomic DNA. Translation: AAZ95513.1.
DQ019993 Genomic DNA. Translation: AAZ95514.1.
DQ019994 Genomic DNA. Translation: AAZ95515.1.
DQ019995 Genomic DNA. Translation: AAZ95516.1.
DQ019996 Genomic DNA. Translation: AAZ95517.1.
DQ019999 Genomic DNA. Translation: AAZ95520.1.
AY359085 mRNA. Translation: AAQ89443.1.
CH471055 Genomic DNA. Translation: EAW65191.1.
BC032713 mRNA. Translation: AAH32713.1.
CCDSiCCDS2848.1. [Q9NR96-1]
RefSeqiNP_059138.1. NM_017442.3. [Q9NR96-1]
UniGeneiHs.87968.

Genome annotation databases

EnsembliENST00000360658; ENSP00000353874; ENSG00000239732. [Q9NR96-1]
GeneIDi54106.
KEGGihsa:54106.
UCSCiuc003dda.2. human. [Q9NR96-1]

Polymorphism databases

DMDMi20140872.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF259262 mRNA. Translation: AAF72189.1 .
AF259263 mRNA. Translation: AAF72190.1 .
AF245704 mRNA. Translation: AAF78037.1 .
AF246972 mRNA. Translation: AAG01734.1 .
AF246973 mRNA. Translation: AAG01735.1 .
AF246974 mRNA. Translation: AAG01736.1 .
AB045180 mRNA. Translation: BAB19259.1 .
EU170540 Genomic DNA. Translation: ABW37075.1 .
EU170541 Genomic DNA. Translation: ABW37076.1 .
EU170542 Genomic DNA. Translation: ABW37077.1 .
EU170543 Genomic DNA. Translation: ABW37078.1 .
AB445673 mRNA. Translation: BAG55070.1 .
DQ019992 Genomic DNA. Translation: AAZ95513.1 .
DQ019993 Genomic DNA. Translation: AAZ95514.1 .
DQ019994 Genomic DNA. Translation: AAZ95515.1 .
DQ019995 Genomic DNA. Translation: AAZ95516.1 .
DQ019996 Genomic DNA. Translation: AAZ95517.1 .
DQ019999 Genomic DNA. Translation: AAZ95520.1 .
AY359085 mRNA. Translation: AAQ89443.1 .
CH471055 Genomic DNA. Translation: EAW65191.1 .
BC032713 mRNA. Translation: AAH32713.1 .
CCDSi CCDS2848.1. [Q9NR96-1 ]
RefSeqi NP_059138.1. NM_017442.3. [Q9NR96-1 ]
UniGenei Hs.87968.

3D structure databases

ProteinModelPortali Q9NR96.
SMRi Q9NR96. Positions 34-803, 868-1013.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119902. 19 interactions.
IntActi Q9NR96. 8 interactions.
STRINGi 9606.ENSP00000353874.

Chemistry

BindingDBi Q9NR96.
ChEMBLi CHEMBL2111471.
DrugBanki DB00608. Chloroquine.
DB01611. Hydroxychloroquine.
GuidetoPHARMACOLOGYi 1759.

PTM databases

PhosphoSitei Q9NR96.

Polymorphism databases

DMDMi 20140872.

Proteomic databases

MaxQBi Q9NR96.
PaxDbi Q9NR96.
PRIDEi Q9NR96.

Protocols and materials databases

DNASUi 54106.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360658 ; ENSP00000353874 ; ENSG00000239732 . [Q9NR96-1 ]
GeneIDi 54106.
KEGGi hsa:54106.
UCSCi uc003dda.2. human. [Q9NR96-1 ]

Organism-specific databases

CTDi 54106.
GeneCardsi GC03M052255.
H-InvDB HIX0163454.
HGNCi HGNC:15633. TLR9.
HPAi HPA004731.
MIMi 605474. gene.
neXtProti NX_Q9NR96.
PharmGKBi PA38010.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000119006.
HOVERGENi HBG018601.
InParanoidi Q9NR96.
KOi K10161.
OrthoDBi EOG7C8GGD.
PhylomeDBi Q9NR96.
TreeFami TF325595.

Enzyme and pathway databases

Reactomei REACT_118632. Trafficking and processing of endosomal TLR.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_25222. MyD88 dependent cascade initiated on endosome.
REACT_9047. Toll Like Receptor 9 (TLR9) Cascade.
REACT_976. PI3K Cascade.

Miscellaneous databases

GeneWikii TLR9.
GenomeRNAii 54106.
NextBioi 56466.
PROi Q9NR96.
SOURCEi Search...

Gene expression databases

Bgeei Q9NR96.
CleanExi HS_TLR9.
ExpressionAtlasi Q9NR96. baseline.
Genevestigatori Q9NR96.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view ]
PANTHERi PTHR24373:SF37. PTHR24373:SF37. 1 hit.
Pfami PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 6 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."
    Du X., Poltorak A., Wei Y., Beutler B.
    Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Monocytic leukemia.
  2. "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."
    Chuang T.-H., Ulevitch R.J.
    Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5).
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Liu Z., Wang J., Xiao W.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Natural selection in the TLR-related genes in the course of primate evolution."
    Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
    Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
    Georgel P., Macquin C., Bahram S.
    PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  10. "Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells."
    Takeshita F., Leifer C.A., Gursel I., Ishii K.J., Takeshita S., Gursel M., Klinman D.M.
    J. Immunol. 167:3555-3558(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase."
    Doyle S.L., Jefferies C.A., Feighery C., O'Neill L.A.
    J. Biol. Chem. 282:36953-36960(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BTK.
  12. "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
    Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
    Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNPY3 AND HSP90B1.
  13. Erratum
    Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
    Nat. Commun. 3:653-653(2012)
  14. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-901 AND MET-933.

Entry informationi

Entry nameiTLR9_HUMAN
AccessioniPrimary (citable) accession number: Q9NR96
Secondary accession number(s): B3Y661
, D1CS56, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: October 29, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3