Q9NR96 (TLR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Toll-like receptor 9

Alternative name(s):
CD_antigen=CD289

Gene names

Name:	TLR9
ORF Names:	UNQ5798/PRO19605

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1032 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Ref.10 Ref.11
Subunit structure	Interacts with MYD88 via their respective TIR domains By similarity. Interacts (via transmembrane domain) with UNC93B1 By similarity. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses By similarity. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Ref.11 Ref.12
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Endosome By similarity. Lysosome By similarity. Cytoplasmic vesicle › phagosome By similarity. Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist By similarity.
Tissue specificity	Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Sequence similarities	Belongs to the Toll-like receptor family. Contains 26 LRR (leucine-rich) repeats. Contains 1 TIR domain.

Ontologies

Keywords
Biological process	Immunity Inflammatory response Innate immunity
Cellular component	Cytoplasmic vesicle Endoplasmic reticulum Endosome Lysosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	I-kappaB phosphorylation Inferred from direct assay PubMed 19740627. Source: BHF-UCL MyD88-dependent toll-like receptor signaling pathway Inferred from electronic annotation. Source: InterPro defense response to bacterium Non-traceable author statement Ref.3. Source: UniProtKB inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Traceable author statement PubMed 15356140. Source: BHF-UCL insulin receptor signaling pathway Traceable author statement. Source: Reactome maintenance of gastrointestinal epithelium Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of NF-kappaB transcription factor activity Inferred from direct assay PubMed 17128265. Source: BHF-UCL negative regulation of interleukin-6 production Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of interleukin-8 production Inferred from direct assay PubMed 17128265. Source: BHF-UCL negative regulation of toll-like receptor signaling pathway Inferred from direct assay PubMed 17128265. Source: BHF-UCL positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay PubMed 17128265. Source: BHF-UCL positive regulation of JNK cascade Inferred by curator PubMed 17128265. Source: BHF-UCL positive regulation of JUN kinase activity Inferred from direct assay PubMed 17128265. Source: BHF-UCL positive regulation of NF-kappaB import into nucleus Inferred from direct assay PubMed 19740627. Source: BHF-UCL positive regulation of NF-kappaB transcription factor activity Inferred from direct assay PubMed 17128265. Source: BHF-UCL positive regulation of chemokine production Inferred from direct assay PubMed 19740627. Source: BHF-UCL positive regulation of inflammatory response Inferred by curator PubMed 19740627. Source: BHF-UCL positive regulation of interferon-alpha biosynthetic process Inferred from direct assay PubMed 16286015. Source: UniProtKB positive regulation of interferon-beta biosynthetic process Inferred from direct assay PubMed 16286015. Source: UniProtKB positive regulation of interferon-beta production Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of interferon-gamma biosynthetic process Inferred from direct assay PubMed 16286015. Source: UniProtKB positive regulation of interleukin-10 production Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of interleukin-12 production Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of interleukin-18 production Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of interleukin-6 production Inferred from direct assay PubMed 19740627. Source: BHF-UCL positive regulation of interleukin-8 production Inferred from direct assay PubMed 17128265PubMed 19740627. Source: BHF-UCL positive regulation of nitric-oxide synthase biosynthetic process Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of toll-like receptor signaling pathway Inferred from direct assay PubMed 17128265. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of tumor necrosis factor production Inferred from sequence or structural similarity. Source: BHF-UCL regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro response to molecule of bacterial origin Traceable author statement PubMed 15356140. Source: BHF-UCL toll-like receptor 9 signaling pathway Traceable author statement. Source: Reactome
Cellular_component	Golgi membrane Traceable author statement. Source: Reactome apical plasma membrane Inferred from direct assay PubMed 17128265. Source: BHF-UCL basolateral plasma membrane Inferred from direct assay PubMed 17128265. Source: BHF-UCL early phagosome Inferred from sequence or structural similarity. Source: UniProtKB endolysosome membrane Traceable author statement. Source: Reactome endoplasmic reticulum membrane Traceable author statement. Source: Reactome extracellular region Non-traceable author statement Ref.3. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	siRNA binding Inferred from mutant phenotype PubMed 15723075. Source: UniProtKB transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9NR96-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NR96-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Isoform 3 (identifier: Q9NR96-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPMKWSGWRWSWGPATHTALPPPQ

Isoform 4 (identifier: Q9NR96-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLYSSCKSRLLDSVEQDFHLEIAKK

Isoform 5 (identifier: Q9NR96-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGFCRSALHPLSLLVQ → M

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 1032	1007	Toll-like receptor 9		PRO_0000034737
Regions
	Topological domain	26 – 818	793	Extracellular Potential
	Transmembrane	819 – 839	21	Helical; Potential
	Topological domain	840 – 1032	193	Cytoplasmic Potential
	Repeat	62 – 85	24	LRR 1
	Repeat	87 – 110	24	LRR 2
	Repeat	122 – 147	26	LRR 3
	Repeat	150 – 166	17	LRR 4
	Repeat	167 – 190	24	LRR 5
	Repeat	198 – 221	24	LRR 6
	Repeat	223 – 242	20	LRR 7
	Repeat	243 – 268	26	LRR 8
	Repeat	283 – 306	24	LRR 9
	Repeat	308 – 332	25	LRR 10
	Repeat	333 – 356	24	LRR 11
	Repeat	363 – 386	24	LRR 12
	Repeat	390 – 413	24	LRR 13
	Repeat	415 – 440	26	LRR 14
	Repeat	470 – 494	25	LRR 15
	Repeat	496 – 519	24	LRR 16
	Repeat	520 – 543	24	LRR 17
	Repeat	545 – 572	28	LRR 18
	Repeat	574 – 598	25	LRR 19
	Repeat	600 – 622	23	LRR 20
	Repeat	627 – 650	24	LRR 21
	Repeat	652 – 675	24	LRR 22
	Repeat	676 – 699	24	LRR 23
	Repeat	701 – 723	23	LRR 24
	Repeat	724 – 747	24	LRR 25
	Repeat	749 – 772	24	LRR 26
	Domain	868 – 1016	149	TIR
Amino acid modifications
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	129	1	N-linked (GlcNAc...) Potential
	Glycosylation	200	1	N-linked (GlcNAc...) Potential
	Glycosylation	210	1	N-linked (GlcNAc...) Potential
	Glycosylation	242	1	N-linked (GlcNAc...) Potential
	Glycosylation	300	1	N-linked (GlcNAc...) Potential
	Glycosylation	340	1	N-linked (GlcNAc...) Potential
	Glycosylation	469	1	N-linked (GlcNAc...) Potential
	Glycosylation	474	1	N-linked (GlcNAc...) Potential
	Glycosylation	513	1	N-linked (GlcNAc...) Potential
	Glycosylation	567	1	N-linked (GlcNAc...) Potential
	Glycosylation	694	1	N-linked (GlcNAc...) Potential
	Glycosylation	731	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 57	57	Missing in isoform 2.		VSP_006520
	Alternative sequence	1 – 16	16	MGFCR…SLLVQ → M in isoform 5.		VSP_006523
	Alternative sequence	1	1	M → MPMKWSGWRWSWGPATHTAL PPPQ in isoform 3.		VSP_006521
	Alternative sequence	1	1	M → MLYSSCKSRLLDSVEQDFHL EIAKK in isoform 4.		VSP_006522
	Natural variant	5	1	R → C. Corresponds to variant rs5743842 [ dbSNP | Ensembl ].		VAR_024668
	Natural variant	79	1	H → Q. Corresponds to variant rs5743843 [ dbSNP | Ensembl ].		VAR_052364
	Natural variant	863	1	R → Q. Corresponds to variant rs5743845 [ dbSNP | Ensembl ].		VAR_034555
	Natural variant	882	1	A → T. Corresponds to variant rs5743846 [ dbSNP | Ensembl ].		VAR_052365
	Natural variant	901	1	R → H in a colorectal cancer sample; somatic mutation. Ref.14		VAR_036077
	Natural variant	933	1	T → M in a colorectal cancer sample; somatic mutation. Ref.14		VAR_036078
Experimental info
	Sequence conflict	200	1	N → S in AAQ89443. Ref.7
	Sequence conflict	330	1	F → L in AAQ89443. Ref.7
	Sequence conflict	530	1	H → R in AAF78037. Ref.2
	Sequence conflict	688	1	Q → R in AAF78037. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified January 31, 2002. Version 2. Checksum: 71280AA9680EDCE2	FASTA	1,032	115,860
	10 20 30 40 50 60 MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL KSVPHFSMAA 70 80 90 100 110 120 PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP VGLSPMHFPC HMTIEPSTFL 130 140 150 160 170 180 AVPTLEELNL SYNNIMTVPA LPKSLISLSL SHTNILMLDS ASLAGLHALR FLFMDGNCYY 190 200 210 220 230 240 KNPCRQALEV APGALLGLGN LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL 250 260 270 280 290 300 ANLTALRVLD VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN 310 320 330 340 350 360 ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS FAHLSLAPSF 370 380 390 400 410 420 GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM NFINQAQLGI FRAFPGLRYV 430 440 450 460 470 480 DLSDNRISGA SELTATMGEA DGGEKVWLQP GDLAPAPVDT PSSEDFRPNC STLNFTLDLS 490 500 510 520 530 540 RNNLVTVQPE MFAQLSHLQC LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS 550 560 570 580 590 600 FTELPRLEAL DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL 610 620 630 640 650 660 RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN LPKSLQVLRL 670 680 690 700 710 720 RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG TRLRRLDVSC NSISFVAPGF 730 740 750 760 770 780 FSKAKELREL NLSANALKTV DHSWFGPLAS ALQILDVSAN PLHCACGAAF MDFLLEVQAA 790 800 810 820 830 840 VPGLPSRVKC GSPGQLQGLS IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG 850 860 870 880 890 900 WDLWYCFHLC LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG 910 920 930 940 950 960 RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS FLLAQQRLLE 970 980 990 1000 1010 1020 DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS GQRSFWAQLG MALTRDNHHF 1030 YNRNFCQGPT AE
	Isoform 2 (B) [UniParc]. Checksum: 61D105163587A75F	FASTA	975	109,628
	10 20 30 40 50 60 MAAPRGNVTS LSLSSNRIHH LHDSDFAHLP SLRHLNLKWN CPPVGLSPMH FPCHMTIEPS 70 80 90 100 110 120 TFLAVPTLEE LNLSYNNIMT VPALPKSLIS LSLSHTNILM LDSASLAGLH ALRFLFMDGN 130 140 150 160 170 180 CYYKNPCRQA LEVAPGALLG LGNLTHLSLK YNNLTVVPRN LPSSLEYLLL SYNRIVKLAP 190 200 210 220 230 240 EDLANLTALR VLDVGGNCRR CDHAPNPCME CPRHFPQLHP DTFSHLSRLE GLVLKDSSLS 250 260 270 280 290 300 WLNASWFRGL GNLRVLDLSE NFLYKCITKT KAFQGLTQLR KLNLSFNYQK RVSFAHLSLA 310 320 330 340 350 360 PSFGSLVALK ELDMHGIFFR SLDETTLRPL ARLPMLQTLR LQMNFINQAQ LGIFRAFPGL 370 380 390 400 410 420 RYVDLSDNRI SGASELTATM GEADGGEKVW LQPGDLAPAP VDTPSSEDFR PNCSTLNFTL 430 440 450 460 470 480 DLSRNNLVTV QPEMFAQLSH LQCLRLSHNC ISQAVNGSQF LPLTGLQVLD LSHNKLDLYH 490 500 510 520 530 540 EHSFTELPRL EALDLSYNSQ PFGMQGVGHN FSFVAHLRTL RHLSLAHNNI HSQVSQQLCS 550 560 570 580 590 600 TSLRALDFSG NALGHMWAEG DLYLHFFQGL SGLIWLDLSQ NRLHTLLPQT LRNLPKSLQV 610 620 630 640 650 660 LRLRDNYLAF FKWWSLHFLP KLEVLDLAGN QLKALTNGSL PAGTRLRRLD VSCNSISFVA 670 680 690 700 710 720 PGFFSKAKEL RELNLSANAL KTVDHSWFGP LASALQILDV SANPLHCACG AAFMDFLLEV 730 740 750 760 770 780 QAAVPGLPSR VKCGSPGQLQ GLSIFAQDLR LCLDEALSWD CFALSLLAVA LGLGVPMLHH 790 800 810 820 830 840 LCGWDLWYCF HLCLAWLPWR GRQSGRDEDA LPYDAFVVFD KTQSAVADWV YNELRGQLEE 850 860 870 880 890 900 CRGRWALRLC LEERDWLPGK TLFENLWASV YGSRKTLFVL AHTDRVSGLL RASFLLAQQR 910 920 930 940 950 960 LLEDRKDVVV LVILSPDGRR SRYVRLRQRL CRQSVLLWPH QPSGQRSFWA QLGMALTRDN 970 HHFYNRNFCQ GPTAE
	Isoform 3 [UniParc]. Checksum: 4072A104D14022F6	FASTA	1,055	118,517
	10 20 30 40 50 60 MPMKWSGWRW SWGPATHTAL PPPQGFCRSA LHPLSLLVQA IMLAMTLALG TLPAFLPCEL 70 80 90 100 110 120 QPHGLVNCNW LFLKSVPHFS MAAPRGNVTS LSLSSNRIHH LHDSDFAHLP SLRHLNLKWN 130 140 150 160 170 180 CPPVGLSPMH FPCHMTIEPS TFLAVPTLEE LNLSYNNIMT VPALPKSLIS LSLSHTNILM 190 200 210 220 230 240 LDSASLAGLH ALRFLFMDGN CYYKNPCRQA LEVAPGALLG LGNLTHLSLK YNNLTVVPRN 250 260 270 280 290 300 LPSSLEYLLL SYNRIVKLAP EDLANLTALR VLDVGGNCRR CDHAPNPCME CPRHFPQLHP 310 320 330 340 350 360 DTFSHLSRLE GLVLKDSSLS WLNASWFRGL GNLRVLDLSE NFLYKCITKT KAFQGLTQLR 370 380 390 400 410 420 KLNLSFNYQK RVSFAHLSLA PSFGSLVALK ELDMHGIFFR SLDETTLRPL ARLPMLQTLR 430 440 450 460 470 480 LQMNFINQAQ LGIFRAFPGL RYVDLSDNRI SGASELTATM GEADGGEKVW LQPGDLAPAP 490 500 510 520 530 540 VDTPSSEDFR PNCSTLNFTL DLSRNNLVTV QPEMFAQLSH LQCLRLSHNC ISQAVNGSQF 550 560 570 580 590 600 LPLTGLQVLD LSHNKLDLYH EHSFTELPRL EALDLSYNSQ PFGMQGVGHN FSFVAHLRTL 610 620 630 640 650 660 RHLSLAHNNI HSQVSQQLCS TSLRALDFSG NALGHMWAEG DLYLHFFQGL SGLIWLDLSQ 670 680 690 700 710 720 NRLHTLLPQT LRNLPKSLQV LRLRDNYLAF FKWWSLHFLP KLEVLDLAGN QLKALTNGSL 730 740 750 760 770 780 PAGTRLRRLD VSCNSISFVA PGFFSKAKEL RELNLSANAL KTVDHSWFGP LASALQILDV 790 800 810 820 830 840 SANPLHCACG AAFMDFLLEV QAAVPGLPSR VKCGSPGQLQ GLSIFAQDLR LCLDEALSWD 850 860 870 880 890 900 CFALSLLAVA LGLGVPMLHH LCGWDLWYCF HLCLAWLPWR GRQSGRDEDA LPYDAFVVFD 910 920 930 940 950 960 KTQSAVADWV YNELRGQLEE CRGRWALRLC LEERDWLPGK TLFENLWASV YGSRKTLFVL 970 980 990 1000 1010 1020 AHTDRVSGLL RASFLLAQQR LLEDRKDVVV LVILSPDGRR SRYVRLRQRL CRQSVLLWPH 1030 1040 1050 QPSGQRSFWA QLGMALTRDN HHFYNRNFCQ GPTAE
	Isoform 4 [UniParc]. Checksum: 9159C051473E88FC	FASTA	1,056	118,652
	10 20 30 40 50 60 MLYSSCKSRL LDSVEQDFHL EIAKKGFCRS ALHPLSLLVQ AIMLAMTLAL GTLPAFLPCE 70 80 90 100 110 120 LQPHGLVNCN WLFLKSVPHF SMAAPRGNVT SLSLSSNRIH HLHDSDFAHL PSLRHLNLKW 130 140 150 160 170 180 NCPPVGLSPM HFPCHMTIEP STFLAVPTLE ELNLSYNNIM TVPALPKSLI SLSLSHTNIL 190 200 210 220 230 240 MLDSASLAGL HALRFLFMDG NCYYKNPCRQ ALEVAPGALL GLGNLTHLSL KYNNLTVVPR 250 260 270 280 290 300 NLPSSLEYLL LSYNRIVKLA PEDLANLTAL RVLDVGGNCR RCDHAPNPCM ECPRHFPQLH 310 320 330 340 350 360 PDTFSHLSRL EGLVLKDSSL SWLNASWFRG LGNLRVLDLS ENFLYKCITK TKAFQGLTQL 370 380 390 400 410 420 RKLNLSFNYQ KRVSFAHLSL APSFGSLVAL KELDMHGIFF RSLDETTLRP LARLPMLQTL 430 440 450 460 470 480 RLQMNFINQA QLGIFRAFPG LRYVDLSDNR ISGASELTAT MGEADGGEKV WLQPGDLAPA 490 500 510 520 530 540 PVDTPSSEDF RPNCSTLNFT LDLSRNNLVT VQPEMFAQLS HLQCLRLSHN CISQAVNGSQ 550 560 570 580 590 600 FLPLTGLQVL DLSHNKLDLY HEHSFTELPR LEALDLSYNS QPFGMQGVGH NFSFVAHLRT 610 620 630 640 650 660 LRHLSLAHNN IHSQVSQQLC STSLRALDFS GNALGHMWAE GDLYLHFFQG LSGLIWLDLS 670 680 690 700 710 720 QNRLHTLLPQ TLRNLPKSLQ VLRLRDNYLA FFKWWSLHFL PKLEVLDLAG NQLKALTNGS 730 740 750 760 770 780 LPAGTRLRRL DVSCNSISFV APGFFSKAKE LRELNLSANA LKTVDHSWFG PLASALQILD 790 800 810 820 830 840 VSANPLHCAC GAAFMDFLLE VQAAVPGLPS RVKCGSPGQL QGLSIFAQDL RLCLDEALSW 850 860 870 880 890 900 DCFALSLLAV ALGLGVPMLH HLCGWDLWYC FHLCLAWLPW RGRQSGRDED ALPYDAFVVF 910 920 930 940 950 960 DKTQSAVADW VYNELRGQLE ECRGRWALRL CLEERDWLPG KTLFENLWAS VYGSRKTLFV 970 980 990 1000 1010 1020 LAHTDRVSGL LRASFLLAQQ RLLEDRKDVV VLVILSPDGR RSRYVRLRQR LCRQSVLLWP 1030 1040 1050 HQPSGQRSFW AQLGMALTRD NHHFYNRNFC QGPTAE
	Isoform 5 [UniParc]. Checksum: 7EF80765E4675C9C	FASTA	1,017	114,237
	10 20 30 40 50 60 MAIMLAMTLA LGTLPAFLPC ELQPHGLVNC NWLFLKSVPH FSMAAPRGNV TSLSLSSNRI 70 80 90 100 110 120 HHLHDSDFAH LPSLRHLNLK WNCPPVGLSP MHFPCHMTIE PSTFLAVPTL EELNLSYNNI 130 140 150 160 170 180 MTVPALPKSL ISLSLSHTNI LMLDSASLAG LHALRFLFMD GNCYYKNPCR QALEVAPGAL 190 200 210 220 230 240 LGLGNLTHLS LKYNNLTVVP RNLPSSLEYL LLSYNRIVKL APEDLANLTA LRVLDVGGNC 250 260 270 280 290 300 RRCDHAPNPC MECPRHFPQL HPDTFSHLSR LEGLVLKDSS LSWLNASWFR GLGNLRVLDL 310 320 330 340 350 360 SENFLYKCIT KTKAFQGLTQ LRKLNLSFNY QKRVSFAHLS LAPSFGSLVA LKELDMHGIF 370 380 390 400 410 420 FRSLDETTLR PLARLPMLQT LRLQMNFINQ AQLGIFRAFP GLRYVDLSDN RISGASELTA 430 440 450 460 470 480 TMGEADGGEK VWLQPGDLAP APVDTPSSED FRPNCSTLNF TLDLSRNNLV TVQPEMFAQL 490 500 510 520 530 540 SHLQCLRLSH NCISQAVNGS QFLPLTGLQV LDLSHNKLDL YHEHSFTELP RLEALDLSYN 550 560 570 580 590 600 SQPFGMQGVG HNFSFVAHLR TLRHLSLAHN NIHSQVSQQL CSTSLRALDF SGNALGHMWA 610 620 630 640 650 660 EGDLYLHFFQ GLSGLIWLDL SQNRLHTLLP QTLRNLPKSL QVLRLRDNYL AFFKWWSLHF 670 680 690 700 710 720 LPKLEVLDLA GNQLKALTNG SLPAGTRLRR LDVSCNSISF VAPGFFSKAK ELRELNLSAN 730 740 750 760 770 780 ALKTVDHSWF GPLASALQIL DVSANPLHCA CGAAFMDFLL EVQAAVPGLP SRVKCGSPGQ 790 800 810 820 830 840 LQGLSIFAQD LRLCLDEALS WDCFALSLLA VALGLGVPML HHLCGWDLWY CFHLCLAWLP 850 860 870 880 890 900 WRGRQSGRDE DALPYDAFVV FDKTQSAVAD WVYNELRGQL EECRGRWALR LCLEERDWLP 910 920 930 940 950 960 GKTLFENLWA SVYGSRKTLF VLAHTDRVSG LLRASFLLAQ QRLLEDRKDV VVLVILSPDG 970 980 990 1000 1010 RRSRYVRLRQ RLCRQSVLLW PHQPSGQRSF WAQLGMALTR DNHHFYNRNF CQGPTAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three novel mammalian Toll-like receptors: gene structure, expression, and evolution." Du X., Poltorak A., Wei Y., Beutler B. Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Monocytic leukemia.
[2]	"Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9." Chuang T.-H., Ulevitch R.J. Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5). Tissue: Placenta.
[3]	"A Toll-like receptor recognizes bacterial DNA." Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., Akira S. Nature 408:740-745(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	Liu Z., Wang J., Xiao W. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Natural selection in the TLR-related genes in the course of primate evolution." Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A. Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes." Georgel P., Macquin C., Bahram S. PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[7]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph.
[10]	"Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells." Takeshita F., Leifer C.A., Gursel I., Ishii K.J., Takeshita S., Gursel M., Klinman D.M. J. Immunol. 167:3555-3558(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase." Doyle S.L., Jefferies C.A., Feighery C., O'Neill L.A. J. Biol. Chem. 282:36953-36960(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH BTK.
[12]	"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone." Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z. Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CNPY3 AND HSP90B1.
[13]	Erratum Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z. Nat. Commun. 3:653-653(2012)
[14]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-901 AND MET-933.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF259262 mRNA. Translation: AAF72189.1. AF259263 mRNA. Translation: AAF72190.1. AF245704 mRNA. Translation: AAF78037.1. AF246972 mRNA. Translation: AAG01734.1. AF246973 mRNA. Translation: AAG01735.1. AF246974 mRNA. Translation: AAG01736.1. AB045180 mRNA. Translation: BAB19259.1. EU170540 Genomic DNA. Translation: ABW37075.1. EU170541 Genomic DNA. Translation: ABW37076.1. EU170542 Genomic DNA. Translation: ABW37077.1. EU170543 Genomic DNA. Translation: ABW37078.1. AB445673 mRNA. Translation: BAG55070.1. DQ019992 Genomic DNA. Translation: AAZ95513.1. DQ019993 Genomic DNA. Translation: AAZ95514.1. DQ019994 Genomic DNA. Translation: AAZ95515.1. DQ019995 Genomic DNA. Translation: AAZ95516.1. DQ019996 Genomic DNA. Translation: AAZ95517.1. DQ019999 Genomic DNA. Translation: AAZ95520.1. AY359085 mRNA. Translation: AAQ89443.1. CH471055 Genomic DNA. Translation: EAW65191.1. BC032713 mRNA. Translation: AAH32713.1.
IPI	IPI00010140. IPI00219487. IPI00219488. IPI00219490. IPI00914987.
RefSeq	NP_059138.1. NM_017442.3.
UniGene	Hs.87968.
3D structure databases
ProteinModelPortal	Q9NR96.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NR96. 8 interactions.
STRING	9606.ENSP00000353874.
PTM databases
PhosphoSite	Q9NR96.
Polymorphism databases
DMDM	20140872.
Proteomic databases
PaxDb	Q9NR96.
PRIDE	Q9NR96.
Protocols and materials databases
DNASU	54106.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360658; ENSP00000353874; ENSG00000239732. ENST00000597542; ENSP00000471046; ENSG00000239732.
GeneID	54106.
KEGG	hsa:54106.
UCSC	uc003dda.2. human.
Organism-specific databases
CTD	54106.
GeneCards	GC03M052255.
H-InvDB	HIX0163454.
HGNC	HGNC:15633. TLR9.
HPA	HPA004731.
MIM	605474. gene.
neXtProt	NX_Q9NR96.
PharmGKB	PA38010.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4886.
HOVERGEN	HBG018601.
InParanoid	Q9NR96.
KO	K10161.
OrthoDB	EOG47SSDD.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q9NR96.
Bgee	Q9NR96.
CleanEx	HS_TLR9.
Genevestigator	Q9NR96.
GermOnline	ENSG00000173366. Homo sapiens.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. TIR_dom. IPR027181. TLR9. [Graphical view]
PANTHER	PTHR24373:SF37. PTHR24373:SF37. 1 hit.
Pfam	PF00560. LRR_1. 1 hit. PF01582. TIR. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 2 hits. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 17 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9NR96.
ChEMBL	CHEMBL5804.
DrugBank	DB00608. Chloroquine.
GenomeRNAi	54106.
NextBio	56466.
SOURCE	Search...

Entry information

Entry name

TLR9_HUMAN

Accession

Primary (citable) accession number: Q9NR96
Secondary accession number(s): B3Y661 , D1CS56, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	January 31, 2002
Last modified:	May 29, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.