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Q9NR96

- TLR9_HUMAN

UniProt

Q9NR96 - TLR9_HUMAN

Protein

Toll-like receptor 9

Gene

TLR9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (31 Jan 2002)
      Previous versions | rss
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    Functioni

    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.2 Publications

    GO - Molecular functioni

    1. interleukin-1 receptor binding Source: UniProtKB
    2. siRNA binding Source: UniProtKB
    3. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB
    2. defense response to Gram-negative bacterium Source: UniProt
    3. I-kappaB phosphorylation Source: BHF-UCL
    4. inflammatory response Source: UniProtKB-KW
    5. innate immune response Source: BHF-UCL
    6. insulin receptor signaling pathway Source: Reactome
    7. maintenance of gastrointestinal epithelium Source: BHF-UCL
    8. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    9. negative regulation of interleukin-6 production Source: BHF-UCL
    10. negative regulation of interleukin-8 production Source: BHF-UCL
    11. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    12. negative regulation of toll-like receptor signaling pathway Source: BHF-UCL
    13. positive regulation of chemokine production Source: BHF-UCL
    14. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
    15. positive regulation of inflammatory response Source: BHF-UCL
    16. positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
    17. positive regulation of interferon-beta biosynthetic process Source: UniProtKB
    18. positive regulation of interferon-beta production Source: BHF-UCL
    19. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
    20. positive regulation of interleukin-10 production Source: BHF-UCL
    21. positive regulation of interleukin-12 production Source: BHF-UCL
    22. positive regulation of interleukin-18 production Source: BHF-UCL
    23. positive regulation of interleukin-6 production Source: BHF-UCL
    24. positive regulation of interleukin-8 production Source: BHF-UCL
    25. positive regulation of JNK cascade Source: BHF-UCL
    26. positive regulation of JUN kinase activity Source: BHF-UCL
    27. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
    28. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    29. positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
    30. positive regulation of toll-like receptor signaling pathway Source: BHF-UCL
    31. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    32. positive regulation of tumor necrosis factor production Source: BHF-UCL
    33. regulation of cytokine secretion Source: InterPro
    34. response to molecule of bacterial origin Source: BHF-UCL
    35. toll-like receptor 9 signaling pathway Source: Reactome
    36. toll-like receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_118632. Trafficking and processing of endosomal TLR.
    REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
    REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_25222. MyD88 dependent cascade initiated on endosome.
    REACT_9047. Toll Like Receptor 9 (TLR9) Cascade.
    REACT_976. PI3K Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 9
    Alternative name(s):
    CD_antigen: CD289
    Gene namesi
    Name:TLR9
    ORF Names:UNQ5798/PRO19605
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:15633. TLR9.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity. Endosome By similarity. Lysosome By similarity. Cytoplasmic vesiclephagosome By similarity
    Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: BHF-UCL
    2. basolateral plasma membrane Source: BHF-UCL
    3. cytoplasm Source: BHF-UCL
    4. early phagosome Source: UniProtKB
    5. endolysosome membrane Source: Reactome
    6. endoplasmic reticulum Source: UniProtKB
    7. endoplasmic reticulum membrane Source: Reactome
    8. endosome Source: UniProtKB
    9. endosome membrane Source: Reactome
    10. extracellular region Source: UniProtKB
    11. Golgi membrane Source: Reactome
    12. integral component of membrane Source: UniProtKB-KW
    13. lysosome Source: UniProtKB
    14. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38010.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 10321007Toll-like receptor 9PRO_0000034737Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi694 – 6941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi731 – 7311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9NR96.
    PaxDbiQ9NR96.
    PRIDEiQ9NR96.

    PTM databases

    PhosphoSiteiQ9NR96.

    Expressioni

    Tissue specificityi

    Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

    Gene expression databases

    BgeeiQ9NR96.
    CleanExiHS_TLR9.
    GenevestigatoriQ9NR96.

    Organism-specific databases

    HPAiHPA004731.

    Interactioni

    Subunit structurei

    Interacts with MYD88 via their respective TIR domains By similarity. Interacts (via transmembrane domain) with UNC93B1 By similarity. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses By similarity. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi119902. 19 interactions.
    IntActiQ9NR96. 8 interactions.
    STRINGi9606.ENSP00000353874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NR96.
    SMRiQ9NR96. Positions 65-809, 868-1013.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 818793ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini840 – 1032193CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei819 – 83921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati62 – 8524LRR 1Add
    BLAST
    Repeati87 – 11024LRR 2Add
    BLAST
    Repeati122 – 14726LRR 3Add
    BLAST
    Repeati150 – 16617LRR 4Add
    BLAST
    Repeati167 – 19024LRR 5Add
    BLAST
    Repeati198 – 22124LRR 6Add
    BLAST
    Repeati223 – 24220LRR 7Add
    BLAST
    Repeati243 – 26826LRR 8Add
    BLAST
    Repeati283 – 30624LRR 9Add
    BLAST
    Repeati308 – 33225LRR 10Add
    BLAST
    Repeati333 – 35624LRR 11Add
    BLAST
    Repeati363 – 38624LRR 12Add
    BLAST
    Repeati390 – 41324LRR 13Add
    BLAST
    Repeati415 – 44026LRR 14Add
    BLAST
    Repeati470 – 49425LRR 15Add
    BLAST
    Repeati496 – 51924LRR 16Add
    BLAST
    Repeati520 – 54324LRR 17Add
    BLAST
    Repeati545 – 57228LRR 18Add
    BLAST
    Repeati574 – 59825LRR 19Add
    BLAST
    Repeati600 – 62223LRR 20Add
    BLAST
    Repeati627 – 65024LRR 21Add
    BLAST
    Repeati652 – 67524LRR 22Add
    BLAST
    Repeati676 – 69924LRR 23Add
    BLAST
    Repeati701 – 72323LRR 24Add
    BLAST
    Repeati724 – 74724LRR 25Add
    BLAST
    Repeati749 – 77224LRR 26Add
    BLAST
    Domaini868 – 1016149TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 26 LRR (leucine-rich) repeats.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOVERGENiHBG018601.
    InParanoidiQ9NR96.
    KOiK10161.
    OrthoDBiEOG7C8GGD.
    PhylomeDBiQ9NR96.
    TreeFamiTF325595.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027181. TLR9.
    [Graphical view]
    PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
    PfamiPF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 6 hits.
    PF01582. TIR. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 2 hits.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 17 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9NR96-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL     50
    KSVPHFSMAA PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP 100
    VGLSPMHFPC HMTIEPSTFL AVPTLEELNL SYNNIMTVPA LPKSLISLSL 150
    SHTNILMLDS ASLAGLHALR FLFMDGNCYY KNPCRQALEV APGALLGLGN 200
    LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL ANLTALRVLD 250
    VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN 300
    ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS 350
    FAHLSLAPSF GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM 400
    NFINQAQLGI FRAFPGLRYV DLSDNRISGA SELTATMGEA DGGEKVWLQP 450
    GDLAPAPVDT PSSEDFRPNC STLNFTLDLS RNNLVTVQPE MFAQLSHLQC 500
    LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS FTELPRLEAL 550
    DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL 600
    RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN 650
    LPKSLQVLRL RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG 700
    TRLRRLDVSC NSISFVAPGF FSKAKELREL NLSANALKTV DHSWFGPLAS 750
    ALQILDVSAN PLHCACGAAF MDFLLEVQAA VPGLPSRVKC GSPGQLQGLS 800
    IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG WDLWYCFHLC 850
    LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG 900
    RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS 950
    FLLAQQRLLE DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS 1000
    GQRSFWAQLG MALTRDNHHF YNRNFCQGPT AE 1032
    Length:1,032
    Mass (Da):115,860
    Last modified:January 31, 2002 - v2
    Checksum:i71280AA9680EDCE2
    GO
    Isoform 2 (identifier: Q9NR96-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-57: Missing.

    Show »
    Length:975
    Mass (Da):109,628
    Checksum:i61D105163587A75F
    GO
    Isoform 3 (identifier: Q9NR96-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPMKWSGWRWSWGPATHTALPPPQ

    Show »
    Length:1,055
    Mass (Da):118,517
    Checksum:i4072A104D14022F6
    GO
    Isoform 4 (identifier: Q9NR96-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLYSSCKSRLLDSVEQDFHLEIAKK

    Show »
    Length:1,056
    Mass (Da):118,652
    Checksum:i9159C051473E88FC
    GO
    Isoform 5 (identifier: Q9NR96-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: MGFCRSALHPLSLLVQ → M

    Show »
    Length:1,017
    Mass (Da):114,237
    Checksum:i7EF80765E4675C9C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti200 – 2001N → S in AAQ89443. (PubMed:12975309)Curated
    Sequence conflicti330 – 3301F → L in AAQ89443. (PubMed:12975309)Curated
    Sequence conflicti530 – 5301H → R in AAF78037. (PubMed:11022120)Curated
    Sequence conflicti688 – 6881Q → R in AAF78037. (PubMed:11022120)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51R → C.
    Corresponds to variant rs5743842 [ dbSNP | Ensembl ].
    VAR_024668
    Natural varianti79 – 791H → Q.
    Corresponds to variant rs5743843 [ dbSNP | Ensembl ].
    VAR_052364
    Natural varianti863 – 8631R → Q.
    Corresponds to variant rs5743845 [ dbSNP | Ensembl ].
    VAR_034555
    Natural varianti882 – 8821A → T.
    Corresponds to variant rs5743846 [ dbSNP | Ensembl ].
    VAR_052365
    Natural varianti901 – 9011R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036077
    Natural varianti933 – 9331T → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036078

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5757Missing in isoform 2. 1 PublicationVSP_006520Add
    BLAST
    Alternative sequencei1 – 1616MGFCR…SLLVQ → M in isoform 5. 1 PublicationVSP_006523Add
    BLAST
    Alternative sequencei1 – 11M → MPMKWSGWRWSWGPATHTAL PPPQ in isoform 3. 1 PublicationVSP_006521
    Alternative sequencei1 – 11M → MLYSSCKSRLLDSVEQDFHL EIAKK in isoform 4. 1 PublicationVSP_006522

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF259262 mRNA. Translation: AAF72189.1.
    AF259263 mRNA. Translation: AAF72190.1.
    AF245704 mRNA. Translation: AAF78037.1.
    AF246972 mRNA. Translation: AAG01734.1.
    AF246973 mRNA. Translation: AAG01735.1.
    AF246974 mRNA. Translation: AAG01736.1.
    AB045180 mRNA. Translation: BAB19259.1.
    EU170540 Genomic DNA. Translation: ABW37075.1.
    EU170541 Genomic DNA. Translation: ABW37076.1.
    EU170542 Genomic DNA. Translation: ABW37077.1.
    EU170543 Genomic DNA. Translation: ABW37078.1.
    AB445673 mRNA. Translation: BAG55070.1.
    DQ019992 Genomic DNA. Translation: AAZ95513.1.
    DQ019993 Genomic DNA. Translation: AAZ95514.1.
    DQ019994 Genomic DNA. Translation: AAZ95515.1.
    DQ019995 Genomic DNA. Translation: AAZ95516.1.
    DQ019996 Genomic DNA. Translation: AAZ95517.1.
    DQ019999 Genomic DNA. Translation: AAZ95520.1.
    AY359085 mRNA. Translation: AAQ89443.1.
    CH471055 Genomic DNA. Translation: EAW65191.1.
    BC032713 mRNA. Translation: AAH32713.1.
    CCDSiCCDS2848.1. [Q9NR96-1]
    RefSeqiNP_059138.1. NM_017442.3. [Q9NR96-1]
    UniGeneiHs.87968.

    Genome annotation databases

    EnsembliENST00000360658; ENSP00000353874; ENSG00000239732. [Q9NR96-1]
    GeneIDi54106.
    KEGGihsa:54106.
    UCSCiuc003dda.2. human. [Q9NR96-1]

    Polymorphism databases

    DMDMi20140872.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF259262 mRNA. Translation: AAF72189.1 .
    AF259263 mRNA. Translation: AAF72190.1 .
    AF245704 mRNA. Translation: AAF78037.1 .
    AF246972 mRNA. Translation: AAG01734.1 .
    AF246973 mRNA. Translation: AAG01735.1 .
    AF246974 mRNA. Translation: AAG01736.1 .
    AB045180 mRNA. Translation: BAB19259.1 .
    EU170540 Genomic DNA. Translation: ABW37075.1 .
    EU170541 Genomic DNA. Translation: ABW37076.1 .
    EU170542 Genomic DNA. Translation: ABW37077.1 .
    EU170543 Genomic DNA. Translation: ABW37078.1 .
    AB445673 mRNA. Translation: BAG55070.1 .
    DQ019992 Genomic DNA. Translation: AAZ95513.1 .
    DQ019993 Genomic DNA. Translation: AAZ95514.1 .
    DQ019994 Genomic DNA. Translation: AAZ95515.1 .
    DQ019995 Genomic DNA. Translation: AAZ95516.1 .
    DQ019996 Genomic DNA. Translation: AAZ95517.1 .
    DQ019999 Genomic DNA. Translation: AAZ95520.1 .
    AY359085 mRNA. Translation: AAQ89443.1 .
    CH471055 Genomic DNA. Translation: EAW65191.1 .
    BC032713 mRNA. Translation: AAH32713.1 .
    CCDSi CCDS2848.1. [Q9NR96-1 ]
    RefSeqi NP_059138.1. NM_017442.3. [Q9NR96-1 ]
    UniGenei Hs.87968.

    3D structure databases

    ProteinModelPortali Q9NR96.
    SMRi Q9NR96. Positions 65-809, 868-1013.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119902. 19 interactions.
    IntActi Q9NR96. 8 interactions.
    STRINGi 9606.ENSP00000353874.

    Chemistry

    BindingDBi Q9NR96.
    ChEMBLi CHEMBL2111471.
    DrugBanki DB00608. Chloroquine.
    GuidetoPHARMACOLOGYi 1759.

    PTM databases

    PhosphoSitei Q9NR96.

    Polymorphism databases

    DMDMi 20140872.

    Proteomic databases

    MaxQBi Q9NR96.
    PaxDbi Q9NR96.
    PRIDEi Q9NR96.

    Protocols and materials databases

    DNASUi 54106.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360658 ; ENSP00000353874 ; ENSG00000239732 . [Q9NR96-1 ]
    GeneIDi 54106.
    KEGGi hsa:54106.
    UCSCi uc003dda.2. human. [Q9NR96-1 ]

    Organism-specific databases

    CTDi 54106.
    GeneCardsi GC03M052255.
    H-InvDB HIX0163454.
    HGNCi HGNC:15633. TLR9.
    HPAi HPA004731.
    MIMi 605474. gene.
    neXtProti NX_Q9NR96.
    PharmGKBi PA38010.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOVERGENi HBG018601.
    InParanoidi Q9NR96.
    KOi K10161.
    OrthoDBi EOG7C8GGD.
    PhylomeDBi Q9NR96.
    TreeFami TF325595.

    Enzyme and pathway databases

    Reactomei REACT_118632. Trafficking and processing of endosomal TLR.
    REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
    REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_25222. MyD88 dependent cascade initiated on endosome.
    REACT_9047. Toll Like Receptor 9 (TLR9) Cascade.
    REACT_976. PI3K Cascade.

    Miscellaneous databases

    GeneWikii TLR9.
    GenomeRNAii 54106.
    NextBioi 56466.
    PROi Q9NR96.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NR96.
    CleanExi HS_TLR9.
    Genevestigatori Q9NR96.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027181. TLR9.
    [Graphical view ]
    PANTHERi PTHR24373:SF37. PTHR24373:SF37. 1 hit.
    Pfami PF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 6 hits.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 17 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."
      Du X., Poltorak A., Wei Y., Beutler B.
      Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Monocytic leukemia.
    2. "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."
      Chuang T.-H., Ulevitch R.J.
      Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5).
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. Liu Z., Wang J., Xiao W.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
      Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
      Georgel P., Macquin C., Bahram S.
      PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph.
    10. "Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells."
      Takeshita F., Leifer C.A., Gursel I., Ishii K.J., Takeshita S., Gursel M., Klinman D.M.
      J. Immunol. 167:3555-3558(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase."
      Doyle S.L., Jefferies C.A., Feighery C., O'Neill L.A.
      J. Biol. Chem. 282:36953-36960(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BTK.
    12. "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
      Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
      Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNPY3 AND HSP90B1.
    13. Erratum
      Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
      Nat. Commun. 3:653-653(2012)
    14. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-901 AND MET-933.

    Entry informationi

    Entry nameiTLR9_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR96
    Secondary accession number(s): B3Y661
    , D1CS56, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: January 31, 2002
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3