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Protein

Toll-like receptor 9

Gene

TLR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.2 Publications

GO - Molecular functioni

  • 1-phosphatidylinositol-3-kinase activity Source: Reactome
  • interleukin-1 receptor binding Source: UniProtKB
  • siRNA binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  • defense response to bacterium Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • I-kappaB phosphorylation Source: BHF-UCL
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: BHF-UCL
  • maintenance of gastrointestinal epithelium Source: BHF-UCL
  • MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  • negative regulation of calcium-transporting ATPase activity Source: CACAO
  • negative regulation of interleukin-6 production Source: BHF-UCL
  • negative regulation of interleukin-8 production Source: BHF-UCL
  • negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • negative regulation of toll-like receptor signaling pathway Source: BHF-UCL
  • positive regulation of chemokine production Source: BHF-UCL
  • positive regulation of gene expression Source: CACAO
  • positive regulation of granulocyte macrophage colony-stimulating factor production Source: CACAO
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  • positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  • positive regulation of interferon-beta production Source: BHF-UCL
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • positive regulation of interleukin-10 production Source: BHF-UCL
  • positive regulation of interleukin-12 production Source: BHF-UCL
  • positive regulation of interleukin-18 production Source: BHF-UCL
  • positive regulation of interleukin-6 production Source: BHF-UCL
  • positive regulation of interleukin-8 production Source: BHF-UCL
  • positive regulation of JNK cascade Source: BHF-UCL
  • positive regulation of JUN kinase activity Source: BHF-UCL
  • positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  • positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
  • positive regulation of toll-like receptor signaling pathway Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of tumor necrosis factor production Source: BHF-UCL
  • regulation of cytokine secretion Source: InterPro
  • response to molecule of bacterial origin Source: BHF-UCL
  • toll-like receptor 9 signaling pathway Source: Reactome
  • toll-like receptor signaling pathway Source: Reactome
  • tumor necrosis factor production Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173366-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1679131. Trafficking and processing of endosomal TLR.
R-HSA-168138. Toll Like Receptor 9 (TLR9) Cascade.
R-HSA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-HSA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-HSA-975155. MyD88 dependent cascade initiated on endosome.
SIGNORiQ9NR96.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 9
Alternative name(s):
CD_antigen: CD289
Gene namesi
Name:TLR9
ORF Names:UNQ5798/PRO19605
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:15633. TLR9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 818ExtracellularSequence analysisAdd BLAST793
Transmembranei819 – 839HelicalSequence analysisAdd BLAST21
Topological domaini840 – 1032CytoplasmicSequence analysisAdd BLAST193

GO - Cellular componenti

  • apical plasma membrane Source: BHF-UCL
  • basolateral plasma membrane Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • early phagosome Source: UniProtKB
  • endolysosome membrane Source: Reactome
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: Reactome
  • endosome Source: UniProtKB
  • endosome membrane Source: Reactome
  • extracellular region Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • lysosome Source: UniProtKB
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54106.
OpenTargetsiENSG00000239732.
PharmGKBiPA38010.

Chemistry databases

ChEMBLiCHEMBL5804.
DrugBankiDB00608. Chloroquine.
DB01611. Hydroxychloroquine.
GuidetoPHARMACOLOGYi1759.

Polymorphism and mutation databases

BioMutaiTLR9.
DMDMi20140872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003473726 – 1032Toll-like receptor 9Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi513N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1
Glycosylationi694N-linked (GlcNAc...)Sequence analysis1
Glycosylationi731N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NR96.
PaxDbiQ9NR96.
PeptideAtlasiQ9NR96.
PRIDEiQ9NR96.

PTM databases

iPTMnetiQ9NR96.
PhosphoSitePlusiQ9NR96.

Expressioni

Tissue specificityi

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Gene expression databases

BgeeiENSG00000239732.
CleanExiHS_TLR9.
GenevisibleiQ9NR96. HS.

Organism-specific databases

HPAiHPA004731.

Interactioni

Subunit structurei

Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B (By similarity).By similarity2 Publications

GO - Molecular functioni

  • interleukin-1 receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119902. 19 interactors.
IntActiQ9NR96. 8 interactors.
STRINGi9606.ENSP00000417517.

Chemistry databases

BindingDBiQ9NR96.

Structurei

3D structure databases

ProteinModelPortaliQ9NR96.
SMRiQ9NR96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 85LRR 1Add BLAST24
Repeati87 – 110LRR 2Add BLAST24
Repeati122 – 147LRR 3Add BLAST26
Repeati150 – 166LRR 4Add BLAST17
Repeati167 – 190LRR 5Add BLAST24
Repeati198 – 221LRR 6Add BLAST24
Repeati223 – 242LRR 7Add BLAST20
Repeati243 – 268LRR 8Add BLAST26
Repeati283 – 306LRR 9Add BLAST24
Repeati308 – 332LRR 10Add BLAST25
Repeati333 – 356LRR 11Add BLAST24
Repeati363 – 386LRR 12Add BLAST24
Repeati390 – 413LRR 13Add BLAST24
Repeati415 – 440LRR 14Add BLAST26
Repeati470 – 494LRR 15Add BLAST25
Repeati496 – 519LRR 16Add BLAST24
Repeati520 – 543LRR 17Add BLAST24
Repeati545 – 572LRR 18Add BLAST28
Repeati574 – 598LRR 19Add BLAST25
Repeati600 – 622LRR 20Add BLAST23
Repeati627 – 650LRR 21Add BLAST24
Repeati652 – 675LRR 22Add BLAST24
Repeati676 – 699LRR 23Add BLAST24
Repeati701 – 723LRR 24Add BLAST23
Repeati724 – 747LRR 25Add BLAST24
Repeati749 – 772LRR 26Add BLAST24
Domaini868 – 1016TIRPROSITE-ProRule annotationAdd BLAST149

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 26 LRR (leucine-rich) repeats.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1747. Eukaryota.
KOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOVERGENiHBG018601.
InParanoidiQ9NR96.
KOiK10161.
OrthoDBiEOG091G0BWK.
PhylomeDBiQ9NR96.
TreeFamiTF325595.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 3 hits.
PfamiPF13516. LRR_6. 2 hits.
PF13855. LRR_8. 7 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 18 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9NR96-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL
60 70 80 90 100
KSVPHFSMAA PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP
110 120 130 140 150
VGLSPMHFPC HMTIEPSTFL AVPTLEELNL SYNNIMTVPA LPKSLISLSL
160 170 180 190 200
SHTNILMLDS ASLAGLHALR FLFMDGNCYY KNPCRQALEV APGALLGLGN
210 220 230 240 250
LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL ANLTALRVLD
260 270 280 290 300
VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN
310 320 330 340 350
ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS
360 370 380 390 400
FAHLSLAPSF GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM
410 420 430 440 450
NFINQAQLGI FRAFPGLRYV DLSDNRISGA SELTATMGEA DGGEKVWLQP
460 470 480 490 500
GDLAPAPVDT PSSEDFRPNC STLNFTLDLS RNNLVTVQPE MFAQLSHLQC
510 520 530 540 550
LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS FTELPRLEAL
560 570 580 590 600
DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL
610 620 630 640 650
RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN
660 670 680 690 700
LPKSLQVLRL RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG
710 720 730 740 750
TRLRRLDVSC NSISFVAPGF FSKAKELREL NLSANALKTV DHSWFGPLAS
760 770 780 790 800
ALQILDVSAN PLHCACGAAF MDFLLEVQAA VPGLPSRVKC GSPGQLQGLS
810 820 830 840 850
IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG WDLWYCFHLC
860 870 880 890 900
LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG
910 920 930 940 950
RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS
960 970 980 990 1000
FLLAQQRLLE DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS
1010 1020 1030
GQRSFWAQLG MALTRDNHHF YNRNFCQGPT AE
Length:1,032
Mass (Da):115,860
Last modified:January 31, 2002 - v2
Checksum:i71280AA9680EDCE2
GO
Isoform 2 (identifier: Q9NR96-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:975
Mass (Da):109,628
Checksum:i61D105163587A75F
GO
Isoform 3 (identifier: Q9NR96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPMKWSGWRWSWGPATHTALPPPQ

Show »
Length:1,055
Mass (Da):118,517
Checksum:i4072A104D14022F6
GO
Isoform 4 (identifier: Q9NR96-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLYSSCKSRLLDSVEQDFHLEIAKK

Show »
Length:1,056
Mass (Da):118,652
Checksum:i9159C051473E88FC
GO
Isoform 5 (identifier: Q9NR96-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGFCRSALHPLSLLVQ → M

Show »
Length:1,017
Mass (Da):114,237
Checksum:i7EF80765E4675C9C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200N → S in AAQ89443 (PubMed:12975309).Curated1
Sequence conflicti330F → L in AAQ89443 (PubMed:12975309).Curated1
Sequence conflicti530H → R in AAF78037 (PubMed:11022120).Curated1
Sequence conflicti688Q → R in AAF78037 (PubMed:11022120).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0246685R → C.Corresponds to variant rs5743842dbSNPEnsembl.1
Natural variantiVAR_05236479H → Q.Corresponds to variant rs5743843dbSNPEnsembl.1
Natural variantiVAR_034555863R → Q.Corresponds to variant rs5743845dbSNPEnsembl.1
Natural variantiVAR_052365882A → T.Corresponds to variant rs5743846dbSNPEnsembl.1
Natural variantiVAR_036077901R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs755472700dbSNPEnsembl.1
Natural variantiVAR_036078933T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs746622200dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0065201 – 57Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0065231 – 16MGFCR…SLLVQ → M in isoform 5. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0065211M → MPMKWSGWRWSWGPATHTAL PPPQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_0065221M → MLYSSCKSRLLDSVEQDFHL EIAKK in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259262 mRNA. Translation: AAF72189.1.
AF259263 mRNA. Translation: AAF72190.1.
AF245704 mRNA. Translation: AAF78037.1.
AF246972 mRNA. Translation: AAG01734.1.
AF246973 mRNA. Translation: AAG01735.1.
AF246974 mRNA. Translation: AAG01736.1.
AB045180 mRNA. Translation: BAB19259.1.
EU170540 Genomic DNA. Translation: ABW37075.1.
EU170541 Genomic DNA. Translation: ABW37076.1.
EU170542 Genomic DNA. Translation: ABW37077.1.
EU170543 Genomic DNA. Translation: ABW37078.1.
AB445673 mRNA. Translation: BAG55070.1.
DQ019992 Genomic DNA. Translation: AAZ95513.1.
DQ019993 Genomic DNA. Translation: AAZ95514.1.
DQ019994 Genomic DNA. Translation: AAZ95515.1.
DQ019995 Genomic DNA. Translation: AAZ95516.1.
DQ019996 Genomic DNA. Translation: AAZ95517.1.
DQ019999 Genomic DNA. Translation: AAZ95520.1.
AY359085 mRNA. Translation: AAQ89443.1.
CH471055 Genomic DNA. Translation: EAW65191.1.
BC032713 mRNA. Translation: AAH32713.1.
CCDSiCCDS2848.1. [Q9NR96-1]
RefSeqiNP_059138.1. NM_017442.3. [Q9NR96-1]
UniGeneiHs.87968.

Genome annotation databases

EnsembliENST00000360658; ENSP00000353874; ENSG00000239732. [Q9NR96-1]
GeneIDi54106.
KEGGihsa:54106.
UCSCiuc003dda.2. human. [Q9NR96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259262 mRNA. Translation: AAF72189.1.
AF259263 mRNA. Translation: AAF72190.1.
AF245704 mRNA. Translation: AAF78037.1.
AF246972 mRNA. Translation: AAG01734.1.
AF246973 mRNA. Translation: AAG01735.1.
AF246974 mRNA. Translation: AAG01736.1.
AB045180 mRNA. Translation: BAB19259.1.
EU170540 Genomic DNA. Translation: ABW37075.1.
EU170541 Genomic DNA. Translation: ABW37076.1.
EU170542 Genomic DNA. Translation: ABW37077.1.
EU170543 Genomic DNA. Translation: ABW37078.1.
AB445673 mRNA. Translation: BAG55070.1.
DQ019992 Genomic DNA. Translation: AAZ95513.1.
DQ019993 Genomic DNA. Translation: AAZ95514.1.
DQ019994 Genomic DNA. Translation: AAZ95515.1.
DQ019995 Genomic DNA. Translation: AAZ95516.1.
DQ019996 Genomic DNA. Translation: AAZ95517.1.
DQ019999 Genomic DNA. Translation: AAZ95520.1.
AY359085 mRNA. Translation: AAQ89443.1.
CH471055 Genomic DNA. Translation: EAW65191.1.
BC032713 mRNA. Translation: AAH32713.1.
CCDSiCCDS2848.1. [Q9NR96-1]
RefSeqiNP_059138.1. NM_017442.3. [Q9NR96-1]
UniGeneiHs.87968.

3D structure databases

ProteinModelPortaliQ9NR96.
SMRiQ9NR96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119902. 19 interactors.
IntActiQ9NR96. 8 interactors.
STRINGi9606.ENSP00000417517.

Chemistry databases

BindingDBiQ9NR96.
ChEMBLiCHEMBL5804.
DrugBankiDB00608. Chloroquine.
DB01611. Hydroxychloroquine.
GuidetoPHARMACOLOGYi1759.

PTM databases

iPTMnetiQ9NR96.
PhosphoSitePlusiQ9NR96.

Polymorphism and mutation databases

BioMutaiTLR9.
DMDMi20140872.

Proteomic databases

MaxQBiQ9NR96.
PaxDbiQ9NR96.
PeptideAtlasiQ9NR96.
PRIDEiQ9NR96.

Protocols and materials databases

DNASUi54106.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360658; ENSP00000353874; ENSG00000239732. [Q9NR96-1]
GeneIDi54106.
KEGGihsa:54106.
UCSCiuc003dda.2. human. [Q9NR96-1]

Organism-specific databases

CTDi54106.
DisGeNETi54106.
GeneCardsiTLR9.
H-InvDBHIX0163454.
HGNCiHGNC:15633. TLR9.
HPAiHPA004731.
MIMi605474. gene.
neXtProtiNX_Q9NR96.
OpenTargetsiENSG00000239732.
PharmGKBiPA38010.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1747. Eukaryota.
KOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOVERGENiHBG018601.
InParanoidiQ9NR96.
KOiK10161.
OrthoDBiEOG091G0BWK.
PhylomeDBiQ9NR96.
TreeFamiTF325595.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173366-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1679131. Trafficking and processing of endosomal TLR.
R-HSA-168138. Toll Like Receptor 9 (TLR9) Cascade.
R-HSA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-HSA-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-HSA-975155. MyD88 dependent cascade initiated on endosome.
SIGNORiQ9NR96.

Miscellaneous databases

ChiTaRSiTLR9. human.
GeneWikiiTLR9.
GenomeRNAii54106.
PROiQ9NR96.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239732.
CleanExiHS_TLR9.
GenevisibleiQ9NR96. HS.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 3 hits.
PfamiPF13516. LRR_6. 2 hits.
PF13855. LRR_8. 7 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 18 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR9_HUMAN
AccessioniPrimary (citable) accession number: Q9NR96
Secondary accession number(s): B3Y661
, D1CS56, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: November 2, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.