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Q9NR96

- TLR9_HUMAN

UniProt

Q9NR96 - TLR9_HUMAN

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Protein
Toll-like receptor 9
Gene
TLR9, UNQ5798/PRO19605
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.2 Publications

GO - Molecular functioni

  1. interleukin-1 receptor binding Source: UniProtKB
  2. siRNA binding Source: UniProtKB
  3. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. I-kappaB phosphorylation Source: BHF-UCL
  2. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  3. defense response to Gram-negative bacterium Source: UniProt
  4. defense response to bacterium Source: UniProtKB
  5. inflammatory response Source: UniProtKB-KW
  6. innate immune response Source: BHF-UCL
  7. insulin receptor signaling pathway Source: Reactome
  8. maintenance of gastrointestinal epithelium Source: BHF-UCL
  9. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  10. negative regulation of interleukin-6 production Source: BHF-UCL
  11. negative regulation of interleukin-8 production Source: BHF-UCL
  12. negative regulation of toll-like receptor signaling pathway Source: BHF-UCL
  13. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
  14. positive regulation of JNK cascade Source: BHF-UCL
  15. positive regulation of JUN kinase activity Source: BHF-UCL
  16. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
  17. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  18. positive regulation of chemokine production Source: BHF-UCL
  19. positive regulation of inflammatory response Source: BHF-UCL
  20. positive regulation of interferon-alpha biosynthetic process Source: UniProtKB
  21. positive regulation of interferon-beta biosynthetic process Source: UniProtKB
  22. positive regulation of interferon-beta production Source: BHF-UCL
  23. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  24. positive regulation of interleukin-10 production Source: BHF-UCL
  25. positive regulation of interleukin-12 production Source: BHF-UCL
  26. positive regulation of interleukin-18 production Source: BHF-UCL
  27. positive regulation of interleukin-6 production Source: BHF-UCL
  28. positive regulation of interleukin-8 production Source: BHF-UCL
  29. positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
  30. positive regulation of toll-like receptor signaling pathway Source: BHF-UCL
  31. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  32. positive regulation of tumor necrosis factor production Source: BHF-UCL
  33. regulation of cytokine secretion Source: InterPro
  34. response to molecule of bacterial origin Source: BHF-UCL
  35. toll-like receptor 9 signaling pathway Source: Reactome
  36. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_118632. Trafficking and processing of endosomal TLR.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_25222. MyD88 dependent cascade initiated on endosome.
REACT_9047. Toll Like Receptor 9 (TLR9) Cascade.
REACT_976. PI3K Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 9
Alternative name(s):
CD_antigen: CD289
Gene namesi
Name:TLR9
ORF Names:UNQ5798/PRO19605
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:15633. TLR9.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Endosome By similarity. Lysosome By similarity. Cytoplasmic vesiclephagosome By similarity
Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 818793Extracellular Reviewed prediction
Add
BLAST
Transmembranei819 – 83921Helical; Reviewed prediction
Add
BLAST
Topological domaini840 – 1032193Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: Reactome
  2. apical plasma membrane Source: BHF-UCL
  3. basolateral plasma membrane Source: BHF-UCL
  4. cytoplasm Source: BHF-UCL
  5. early phagosome Source: UniProtKB
  6. endolysosome membrane Source: Reactome
  7. endoplasmic reticulum Source: UniProtKB
  8. endoplasmic reticulum membrane Source: Reactome
  9. endosome Source: UniProtKB
  10. endosome membrane Source: Reactome
  11. extracellular region Source: UniProtKB
  12. integral component of membrane Source: UniProtKB-KW
  13. lysosome Source: UniProtKB
  14. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 10321007Toll-like receptor 9
PRO_0000034737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi129 – 1291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi469 – 4691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi567 – 5671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi694 – 6941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi731 – 7311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NR96.
PaxDbiQ9NR96.
PRIDEiQ9NR96.

PTM databases

PhosphoSiteiQ9NR96.

Expressioni

Tissue specificityi

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Gene expression databases

BgeeiQ9NR96.
CleanExiHS_TLR9.
GenevestigatoriQ9NR96.

Organism-specific databases

HPAiHPA004731.

Interactioni

Subunit structurei

Interacts with MYD88 via their respective TIR domains By similarity. Interacts (via transmembrane domain) with UNC93B1 By similarity. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses By similarity. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.2 Publications

Protein-protein interaction databases

BioGridi119902. 19 interactions.
IntActiQ9NR96. 8 interactions.
STRINGi9606.ENSP00000353874.

Structurei

3D structure databases

ProteinModelPortaliQ9NR96.
SMRiQ9NR96. Positions 65-809, 868-1013.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 8524LRR 1
Add
BLAST
Repeati87 – 11024LRR 2
Add
BLAST
Repeati122 – 14726LRR 3
Add
BLAST
Repeati150 – 16617LRR 4
Add
BLAST
Repeati167 – 19024LRR 5
Add
BLAST
Repeati198 – 22124LRR 6
Add
BLAST
Repeati223 – 24220LRR 7
Add
BLAST
Repeati243 – 26826LRR 8
Add
BLAST
Repeati283 – 30624LRR 9
Add
BLAST
Repeati308 – 33225LRR 10
Add
BLAST
Repeati333 – 35624LRR 11
Add
BLAST
Repeati363 – 38624LRR 12
Add
BLAST
Repeati390 – 41324LRR 13
Add
BLAST
Repeati415 – 44026LRR 14
Add
BLAST
Repeati470 – 49425LRR 15
Add
BLAST
Repeati496 – 51924LRR 16
Add
BLAST
Repeati520 – 54324LRR 17
Add
BLAST
Repeati545 – 57228LRR 18
Add
BLAST
Repeati574 – 59825LRR 19
Add
BLAST
Repeati600 – 62223LRR 20
Add
BLAST
Repeati627 – 65024LRR 21
Add
BLAST
Repeati652 – 67524LRR 22
Add
BLAST
Repeati676 – 69924LRR 23
Add
BLAST
Repeati701 – 72323LRR 24
Add
BLAST
Repeati724 – 74724LRR 25
Add
BLAST
Repeati749 – 77224LRR 26
Add
BLAST
Domaini868 – 1016149TIR
Add
BLAST

Sequence similaritiesi

Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOVERGENiHBG018601.
InParanoidiQ9NR96.
KOiK10161.
OrthoDBiEOG7C8GGD.
PhylomeDBiQ9NR96.
TreeFamiTF325595.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 6 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9NR96-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL     50
KSVPHFSMAA PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP 100
VGLSPMHFPC HMTIEPSTFL AVPTLEELNL SYNNIMTVPA LPKSLISLSL 150
SHTNILMLDS ASLAGLHALR FLFMDGNCYY KNPCRQALEV APGALLGLGN 200
LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL ANLTALRVLD 250
VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN 300
ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS 350
FAHLSLAPSF GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM 400
NFINQAQLGI FRAFPGLRYV DLSDNRISGA SELTATMGEA DGGEKVWLQP 450
GDLAPAPVDT PSSEDFRPNC STLNFTLDLS RNNLVTVQPE MFAQLSHLQC 500
LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS FTELPRLEAL 550
DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL 600
RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN 650
LPKSLQVLRL RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG 700
TRLRRLDVSC NSISFVAPGF FSKAKELREL NLSANALKTV DHSWFGPLAS 750
ALQILDVSAN PLHCACGAAF MDFLLEVQAA VPGLPSRVKC GSPGQLQGLS 800
IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG WDLWYCFHLC 850
LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG 900
RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS 950
FLLAQQRLLE DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS 1000
GQRSFWAQLG MALTRDNHHF YNRNFCQGPT AE 1032
Length:1,032
Mass (Da):115,860
Last modified:January 31, 2002 - v2
Checksum:i71280AA9680EDCE2
GO
Isoform 2 (identifier: Q9NR96-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:975
Mass (Da):109,628
Checksum:i61D105163587A75F
GO
Isoform 3 (identifier: Q9NR96-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPMKWSGWRWSWGPATHTALPPPQ

Show »
Length:1,055
Mass (Da):118,517
Checksum:i4072A104D14022F6
GO
Isoform 4 (identifier: Q9NR96-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLYSSCKSRLLDSVEQDFHLEIAKK

Show »
Length:1,056
Mass (Da):118,652
Checksum:i9159C051473E88FC
GO
Isoform 5 (identifier: Q9NR96-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGFCRSALHPLSLLVQ → M

Show »
Length:1,017
Mass (Da):114,237
Checksum:i7EF80765E4675C9C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51R → C.
Corresponds to variant rs5743842 [ dbSNP | Ensembl ].
VAR_024668
Natural varianti79 – 791H → Q.
Corresponds to variant rs5743843 [ dbSNP | Ensembl ].
VAR_052364
Natural varianti863 – 8631R → Q.
Corresponds to variant rs5743845 [ dbSNP | Ensembl ].
VAR_034555
Natural varianti882 – 8821A → T.
Corresponds to variant rs5743846 [ dbSNP | Ensembl ].
VAR_052365
Natural varianti901 – 9011R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036077
Natural varianti933 – 9331T → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036078

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5757Missing in isoform 2.
VSP_006520Add
BLAST
Alternative sequencei1 – 1616MGFCR…SLLVQ → M in isoform 5.
VSP_006523Add
BLAST
Alternative sequencei1 – 11M → MPMKWSGWRWSWGPATHTAL PPPQ in isoform 3.
VSP_006521
Alternative sequencei1 – 11M → MLYSSCKSRLLDSVEQDFHL EIAKK in isoform 4.
VSP_006522

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001N → S in AAQ89443. 1 Publication
Sequence conflicti330 – 3301F → L in AAQ89443. 1 Publication
Sequence conflicti530 – 5301H → R in AAF78037. 1 Publication
Sequence conflicti688 – 6881Q → R in AAF78037. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF259262 mRNA. Translation: AAF72189.1.
AF259263 mRNA. Translation: AAF72190.1.
AF245704 mRNA. Translation: AAF78037.1.
AF246972 mRNA. Translation: AAG01734.1.
AF246973 mRNA. Translation: AAG01735.1.
AF246974 mRNA. Translation: AAG01736.1.
AB045180 mRNA. Translation: BAB19259.1.
EU170540 Genomic DNA. Translation: ABW37075.1.
EU170541 Genomic DNA. Translation: ABW37076.1.
EU170542 Genomic DNA. Translation: ABW37077.1.
EU170543 Genomic DNA. Translation: ABW37078.1.
AB445673 mRNA. Translation: BAG55070.1.
DQ019992 Genomic DNA. Translation: AAZ95513.1.
DQ019993 Genomic DNA. Translation: AAZ95514.1.
DQ019994 Genomic DNA. Translation: AAZ95515.1.
DQ019995 Genomic DNA. Translation: AAZ95516.1.
DQ019996 Genomic DNA. Translation: AAZ95517.1.
DQ019999 Genomic DNA. Translation: AAZ95520.1.
AY359085 mRNA. Translation: AAQ89443.1.
CH471055 Genomic DNA. Translation: EAW65191.1.
BC032713 mRNA. Translation: AAH32713.1.
CCDSiCCDS2848.1. [Q9NR96-1]
RefSeqiNP_059138.1. NM_017442.3. [Q9NR96-1]
UniGeneiHs.87968.

Genome annotation databases

EnsembliENST00000360658; ENSP00000353874; ENSG00000239732. [Q9NR96-1]
ENST00000597542; ENSP00000471046; ENSG00000239732. [Q9NR96-4]
GeneIDi54106.
KEGGihsa:54106.
UCSCiuc003dda.2. human. [Q9NR96-1]

Polymorphism databases

DMDMi20140872.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF259262 mRNA. Translation: AAF72189.1 .
AF259263 mRNA. Translation: AAF72190.1 .
AF245704 mRNA. Translation: AAF78037.1 .
AF246972 mRNA. Translation: AAG01734.1 .
AF246973 mRNA. Translation: AAG01735.1 .
AF246974 mRNA. Translation: AAG01736.1 .
AB045180 mRNA. Translation: BAB19259.1 .
EU170540 Genomic DNA. Translation: ABW37075.1 .
EU170541 Genomic DNA. Translation: ABW37076.1 .
EU170542 Genomic DNA. Translation: ABW37077.1 .
EU170543 Genomic DNA. Translation: ABW37078.1 .
AB445673 mRNA. Translation: BAG55070.1 .
DQ019992 Genomic DNA. Translation: AAZ95513.1 .
DQ019993 Genomic DNA. Translation: AAZ95514.1 .
DQ019994 Genomic DNA. Translation: AAZ95515.1 .
DQ019995 Genomic DNA. Translation: AAZ95516.1 .
DQ019996 Genomic DNA. Translation: AAZ95517.1 .
DQ019999 Genomic DNA. Translation: AAZ95520.1 .
AY359085 mRNA. Translation: AAQ89443.1 .
CH471055 Genomic DNA. Translation: EAW65191.1 .
BC032713 mRNA. Translation: AAH32713.1 .
CCDSi CCDS2848.1. [Q9NR96-1 ]
RefSeqi NP_059138.1. NM_017442.3. [Q9NR96-1 ]
UniGenei Hs.87968.

3D structure databases

ProteinModelPortali Q9NR96.
SMRi Q9NR96. Positions 65-809, 868-1013.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119902. 19 interactions.
IntActi Q9NR96. 8 interactions.
STRINGi 9606.ENSP00000353874.

Chemistry

BindingDBi Q9NR96.
ChEMBLi CHEMBL2111471.
DrugBanki DB00608. Chloroquine.
GuidetoPHARMACOLOGYi 1759.

PTM databases

PhosphoSitei Q9NR96.

Polymorphism databases

DMDMi 20140872.

Proteomic databases

MaxQBi Q9NR96.
PaxDbi Q9NR96.
PRIDEi Q9NR96.

Protocols and materials databases

DNASUi 54106.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360658 ; ENSP00000353874 ; ENSG00000239732 . [Q9NR96-1 ]
ENST00000597542 ; ENSP00000471046 ; ENSG00000239732 . [Q9NR96-4 ]
GeneIDi 54106.
KEGGi hsa:54106.
UCSCi uc003dda.2. human. [Q9NR96-1 ]

Organism-specific databases

CTDi 54106.
GeneCardsi GC03M052255.
H-InvDB HIX0163454.
HGNCi HGNC:15633. TLR9.
HPAi HPA004731.
MIMi 605474. gene.
neXtProti NX_Q9NR96.
PharmGKBi PA38010.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOVERGENi HBG018601.
InParanoidi Q9NR96.
KOi K10161.
OrthoDBi EOG7C8GGD.
PhylomeDBi Q9NR96.
TreeFami TF325595.

Enzyme and pathway databases

Reactomei REACT_118632. Trafficking and processing of endosomal TLR.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_25222. MyD88 dependent cascade initiated on endosome.
REACT_9047. Toll Like Receptor 9 (TLR9) Cascade.
REACT_976. PI3K Cascade.

Miscellaneous databases

GeneWikii TLR9.
GenomeRNAii 54106.
NextBioi 56466.
PROi Q9NR96.
SOURCEi Search...

Gene expression databases

Bgeei Q9NR96.
CleanExi HS_TLR9.
Genevestigatori Q9NR96.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view ]
PANTHERi PTHR24373:SF37. PTHR24373:SF37. 1 hit.
Pfami PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 6 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."
    Du X., Poltorak A., Wei Y., Beutler B.
    Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Monocytic leukemia.
  2. "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."
    Chuang T.-H., Ulevitch R.J.
    Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5).
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Liu Z., Wang J., Xiao W.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Natural selection in the TLR-related genes in the course of primate evolution."
    Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
    Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
    Georgel P., Macquin C., Bahram S.
    PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph.
  10. "Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells."
    Takeshita F., Leifer C.A., Gursel I., Ishii K.J., Takeshita S., Gursel M., Klinman D.M.
    J. Immunol. 167:3555-3558(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase."
    Doyle S.L., Jefferies C.A., Feighery C., O'Neill L.A.
    J. Biol. Chem. 282:36953-36960(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BTK.
  12. "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
    Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
    Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNPY3 AND HSP90B1.
  13. Erratum
    Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
    Nat. Commun. 3:653-653(2012)
  14. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-901 AND MET-933.

Entry informationi

Entry nameiTLR9_HUMAN
AccessioniPrimary (citable) accession number: Q9NR96
Secondary accession number(s): B3Y661
, D1CS56, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: September 3, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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