Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NR96 (TLR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Toll-like receptor 9
Alternative name(s):
CD_antigen=CD289
Gene names
Name:TLR9
ORF Names:UNQ5798/PRO19605
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1032 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Ref.10 Ref.11

Subunit structure

Interacts with MYD88 via their respective TIR domains By similarity. Interacts (via transmembrane domain) with UNC93B1 By similarity. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses By similarity. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Ref.11 Ref.12

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Endosome By similarity. Lysosome By similarity. Cytoplasmic vesiclephagosome By similarity. Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist By similarity.

Tissue specificity

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 26 LRR (leucine-rich) repeats.

Contains 1 TIR domain.

Ontologies

Keywords
   Biological processImmunity
Inflammatory response
Innate immunity
   Cellular componentCytoplasmic vesicle
Endoplasmic reticulum
Endosome
Lysosome
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainLeucine-rich repeat
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processI-kappaB phosphorylation

Inferred from direct assay PubMed 19740627. Source: BHF-UCL

MyD88-dependent toll-like receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

defense response to Gram-negative bacterium

Inferred from mutant phenotype PubMed 22427638. Source: UniProt

defense response to bacterium

Non-traceable author statement Ref.3. Source: UniProtKB

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Traceable author statement PubMed 15356140. Source: BHF-UCL

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

maintenance of gastrointestinal epithelium

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of NF-kappaB transcription factor activity

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

negative regulation of interleukin-6 production

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of interleukin-8 production

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

negative regulation of toll-like receptor signaling pathway

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

positive regulation of JNK cascade

Inferred by curator PubMed 17128265. Source: BHF-UCL

positive regulation of JUN kinase activity

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

positive regulation of NF-kappaB import into nucleus

Inferred from direct assay PubMed 19740627. Source: BHF-UCL

positive regulation of NF-kappaB transcription factor activity

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

positive regulation of chemokine production

Inferred from direct assay PubMed 19740627. Source: BHF-UCL

positive regulation of inflammatory response

Inferred by curator PubMed 19740627. Source: BHF-UCL

positive regulation of interferon-alpha biosynthetic process

Inferred from direct assay PubMed 16286015. Source: UniProtKB

positive regulation of interferon-beta biosynthetic process

Inferred from direct assay PubMed 16286015. Source: UniProtKB

positive regulation of interferon-beta production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interferon-gamma biosynthetic process

Inferred from direct assay PubMed 16286015. Source: UniProtKB

positive regulation of interleukin-10 production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interleukin-12 production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interleukin-18 production

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of interleukin-6 production

Inferred from direct assay PubMed 19740627. Source: BHF-UCL

positive regulation of interleukin-8 production

Inferred from direct assay PubMed 17128265PubMed 19740627. Source: BHF-UCL

positive regulation of nitric-oxide synthase biosynthetic process

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of toll-like receptor signaling pathway

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of tumor necrosis factor production

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of cytokine secretion

Inferred from electronic annotation. Source: InterPro

response to molecule of bacterial origin

Traceable author statement PubMed 15356140. Source: BHF-UCL

toll-like receptor 9 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentGolgi membrane

Traceable author statement. Source: Reactome

apical plasma membrane

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

basolateral plasma membrane

Inferred from direct assay PubMed 17128265. Source: BHF-UCL

cytoplasm

Inferred from direct assay PubMed 19740627. Source: BHF-UCL

early phagosome

Inferred from sequence or structural similarity. Source: UniProtKB

endolysosome membrane

Traceable author statement. Source: Reactome

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

endosome

Inferred from sequence or structural similarity. Source: UniProtKB

endosome membrane

Traceable author statement. Source: Reactome

extracellular region

Non-traceable author statement Ref.3. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosome

Inferred from sequence or structural similarity. Source: UniProtKB

plasma membrane

Inferred from direct assay PubMed 19740627. Source: BHF-UCL

   Molecular_functioninterleukin-1 receptor binding

Inferred from physical interaction PubMed 12925853. Source: UniProtKB

siRNA binding

Inferred from mutant phenotype PubMed 15723075. Source: UniProtKB

transmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9NR96-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NR96-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
Isoform 3 (identifier: Q9NR96-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPMKWSGWRWSWGPATHTALPPPQ
Isoform 4 (identifier: Q9NR96-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLYSSCKSRLLDSVEQDFHLEIAKK
Isoform 5 (identifier: Q9NR96-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGFCRSALHPLSLLVQ → M

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 10321007Toll-like receptor 9
PRO_0000034737

Regions

Topological domain26 – 818793Extracellular Potential
Transmembrane819 – 83921Helical; Potential
Topological domain840 – 1032193Cytoplasmic Potential
Repeat62 – 8524LRR 1
Repeat87 – 11024LRR 2
Repeat122 – 14726LRR 3
Repeat150 – 16617LRR 4
Repeat167 – 19024LRR 5
Repeat198 – 22124LRR 6
Repeat223 – 24220LRR 7
Repeat243 – 26826LRR 8
Repeat283 – 30624LRR 9
Repeat308 – 33225LRR 10
Repeat333 – 35624LRR 11
Repeat363 – 38624LRR 12
Repeat390 – 41324LRR 13
Repeat415 – 44026LRR 14
Repeat470 – 49425LRR 15
Repeat496 – 51924LRR 16
Repeat520 – 54324LRR 17
Repeat545 – 57228LRR 18
Repeat574 – 59825LRR 19
Repeat600 – 62223LRR 20
Repeat627 – 65024LRR 21
Repeat652 – 67524LRR 22
Repeat676 – 69924LRR 23
Repeat701 – 72323LRR 24
Repeat724 – 74724LRR 25
Repeat749 – 77224LRR 26
Domain868 – 1016149TIR

Amino acid modifications

Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential
Glycosylation5131N-linked (GlcNAc...) Potential
Glycosylation5671N-linked (GlcNAc...) Potential
Glycosylation6941N-linked (GlcNAc...) Potential
Glycosylation7311N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 5757Missing in isoform 2.
VSP_006520
Alternative sequence1 – 1616MGFCR…SLLVQ → M in isoform 5.
VSP_006523
Alternative sequence11M → MPMKWSGWRWSWGPATHTAL PPPQ in isoform 3.
VSP_006521
Alternative sequence11M → MLYSSCKSRLLDSVEQDFHL EIAKK in isoform 4.
VSP_006522
Natural variant51R → C.
Corresponds to variant rs5743842 [ dbSNP | Ensembl ].
VAR_024668
Natural variant791H → Q.
Corresponds to variant rs5743843 [ dbSNP | Ensembl ].
VAR_052364
Natural variant8631R → Q.
Corresponds to variant rs5743845 [ dbSNP | Ensembl ].
VAR_034555
Natural variant8821A → T.
Corresponds to variant rs5743846 [ dbSNP | Ensembl ].
VAR_052365
Natural variant9011R → H in a colorectal cancer sample; somatic mutation. Ref.14
VAR_036077
Natural variant9331T → M in a colorectal cancer sample; somatic mutation. Ref.14
VAR_036078

Experimental info

Sequence conflict2001N → S in AAQ89443. Ref.7
Sequence conflict3301F → L in AAQ89443. Ref.7
Sequence conflict5301H → R in AAF78037. Ref.2
Sequence conflict6881Q → R in AAF78037. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified January 31, 2002. Version 2.
Checksum: 71280AA9680EDCE2

FASTA1,032115,860
        10         20         30         40         50         60 
MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL KSVPHFSMAA 

        70         80         90        100        110        120 
PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP VGLSPMHFPC HMTIEPSTFL 

       130        140        150        160        170        180 
AVPTLEELNL SYNNIMTVPA LPKSLISLSL SHTNILMLDS ASLAGLHALR FLFMDGNCYY 

       190        200        210        220        230        240 
KNPCRQALEV APGALLGLGN LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL 

       250        260        270        280        290        300 
ANLTALRVLD VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN 

       310        320        330        340        350        360 
ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS FAHLSLAPSF 

       370        380        390        400        410        420 
GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM NFINQAQLGI FRAFPGLRYV 

       430        440        450        460        470        480 
DLSDNRISGA SELTATMGEA DGGEKVWLQP GDLAPAPVDT PSSEDFRPNC STLNFTLDLS 

       490        500        510        520        530        540 
RNNLVTVQPE MFAQLSHLQC LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS 

       550        560        570        580        590        600 
FTELPRLEAL DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL 

       610        620        630        640        650        660 
RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN LPKSLQVLRL 

       670        680        690        700        710        720 
RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG TRLRRLDVSC NSISFVAPGF 

       730        740        750        760        770        780 
FSKAKELREL NLSANALKTV DHSWFGPLAS ALQILDVSAN PLHCACGAAF MDFLLEVQAA 

       790        800        810        820        830        840 
VPGLPSRVKC GSPGQLQGLS IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG 

       850        860        870        880        890        900 
WDLWYCFHLC LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG 

       910        920        930        940        950        960 
RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS FLLAQQRLLE 

       970        980        990       1000       1010       1020 
DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS GQRSFWAQLG MALTRDNHHF 

      1030 
YNRNFCQGPT AE 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 61D105163587A75F
Show »

FASTA975109,628
Isoform 3 [UniParc].

Checksum: 4072A104D14022F6
Show »

FASTA1,055118,517
Isoform 4 [UniParc].

Checksum: 9159C051473E88FC
Show »

FASTA1,056118,652
Isoform 5 [UniParc].

Checksum: 7EF80765E4675C9C
Show »

FASTA1,017114,237

References

« Hide 'large scale' references
[1]"Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."
Du X., Poltorak A., Wei Y., Beutler B.
Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Monocytic leukemia.
[2]"Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."
Chuang T.-H., Ulevitch R.J.
Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5).
Tissue: Placenta.
[3]"A Toll-like receptor recognizes bacterial DNA."
Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., Akira S.
Nature 408:740-745(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]Liu Z., Wang J., Xiao W.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Natural selection in the TLR-related genes in the course of primate evolution."
Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
Georgel P., Macquin C., Bahram S.
PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[7]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph.
[10]"Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells."
Takeshita F., Leifer C.A., Gursel I., Ishii K.J., Takeshita S., Gursel M., Klinman D.M.
J. Immunol. 167:3555-3558(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase."
Doyle S.L., Jefferies C.A., Feighery C., O'Neill L.A.
J. Biol. Chem. 282:36953-36960(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH BTK.
[12]"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CNPY3 AND HSP90B1.
[13]Erratum
Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
Nat. Commun. 3:653-653(2012)
[14]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-901 AND MET-933.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF259262 mRNA. Translation: AAF72189.1.
AF259263 mRNA. Translation: AAF72190.1.
AF245704 mRNA. Translation: AAF78037.1.
AF246972 mRNA. Translation: AAG01734.1.
AF246973 mRNA. Translation: AAG01735.1.
AF246974 mRNA. Translation: AAG01736.1.
AB045180 mRNA. Translation: BAB19259.1.
EU170540 Genomic DNA. Translation: ABW37075.1.
EU170541 Genomic DNA. Translation: ABW37076.1.
EU170542 Genomic DNA. Translation: ABW37077.1.
EU170543 Genomic DNA. Translation: ABW37078.1.
AB445673 mRNA. Translation: BAG55070.1.
DQ019992 Genomic DNA. Translation: AAZ95513.1.
DQ019993 Genomic DNA. Translation: AAZ95514.1.
DQ019994 Genomic DNA. Translation: AAZ95515.1.
DQ019995 Genomic DNA. Translation: AAZ95516.1.
DQ019996 Genomic DNA. Translation: AAZ95517.1.
DQ019999 Genomic DNA. Translation: AAZ95520.1.
AY359085 mRNA. Translation: AAQ89443.1.
CH471055 Genomic DNA. Translation: EAW65191.1.
BC032713 mRNA. Translation: AAH32713.1.
CCDSCCDS2848.1. [Q9NR96-1]
RefSeqNP_059138.1. NM_017442.3. [Q9NR96-1]
UniGeneHs.87968.

3D structure databases

ProteinModelPortalQ9NR96.
SMRQ9NR96. Positions 65-809, 868-1013.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119902. 19 interactions.
IntActQ9NR96. 8 interactions.
STRING9606.ENSP00000353874.

Chemistry

BindingDBQ9NR96.
ChEMBLCHEMBL2111471.
DrugBankDB00608. Chloroquine.

PTM databases

PhosphoSiteQ9NR96.

Polymorphism databases

DMDM20140872.

Proteomic databases

MaxQBQ9NR96.
PaxDbQ9NR96.
PRIDEQ9NR96.

Protocols and materials databases

DNASU54106.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360658; ENSP00000353874; ENSG00000239732. [Q9NR96-1]
ENST00000597542; ENSP00000471046; ENSG00000239732. [Q9NR96-4]
GeneID54106.
KEGGhsa:54106.
UCSCuc003dda.2. human. [Q9NR96-1]

Organism-specific databases

CTD54106.
GeneCardsGC03M052255.
H-InvDBHIX0163454.
HGNCHGNC:15633. TLR9.
HPAHPA004731.
MIM605474. gene.
neXtProtNX_Q9NR96.
PharmGKBPA38010.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOVERGENHBG018601.
InParanoidQ9NR96.
KOK10161.
OrthoDBEOG7C8GGD.
PhylomeDBQ9NR96.
TreeFamTF325595.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_6900. Immune System.

Gene expression databases

BgeeQ9NR96.
CleanExHS_TLR9.
GenevestigatorQ9NR96.

Family and domain databases

Gene3D3.40.50.10140. 1 hit.
InterProIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamPF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 6 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTSM00369. LRR_TYP. 2 hits.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS51450. LRR. 17 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTLR9.
GenomeRNAi54106.
NextBio56466.
PROQ9NR96.
SOURCESearch...

Entry information

Entry nameTLR9_HUMAN
AccessionPrimary (citable) accession number: Q9NR96
Secondary accession number(s): B3Y661 expand/collapse secondary AC list , D1CS56, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: July 9, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries