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Q9NR82

- KCNQ5_HUMAN

UniProt

Q9NR82 - KCNQ5_HUMAN

Protein

Potassium voltage-gated channel subfamily KQT member 5

Gene

KCNQ5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M1 muscarinic receptors.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. inward rectifier potassium channel activity Source: ProtInc

    GO - Biological processi

    1. protein complex assembly Source: ProtInc
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily KQT member 5
    Alternative name(s):
    KQT-like 5
    Potassium channel subunit alpha KvLQT5
    Voltage-gated potassium channel subunit Kv7.5
    Gene namesi
    Name:KCNQ5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6299. KCNQ5.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30077.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 932932Potassium voltage-gated channel subfamily KQT member 5PRO_0000054040Add
    BLAST

    Proteomic databases

    PaxDbiQ9NR82.
    PRIDEiQ9NR82.

    PTM databases

    PhosphoSiteiQ9NR82.

    Expressioni

    Tissue specificityi

    Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.

    Gene expression databases

    ArrayExpressiQ9NR82.
    BgeeiQ9NR82.
    CleanExiHS_KCNQ5.
    GenevestigatoriQ9NR82.

    Organism-specific databases

    HPAiHPA016655.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNQ3.

    Protein-protein interaction databases

    BioGridi121149. 2 interactions.
    STRINGi9606.ENSP00000359425.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NR82.
    SMRiQ9NR82. Positions 128-377, 598-627.
    ModBaseiSearch...
    MobiDBiSearch...

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei299 – 31921Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei126 – 14621Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25223Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi311 – 3166Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000220839.
    HOVERGENiHBG059014.
    KOiK04930.
    OMAiYTSSQSC.
    OrthoDBiEOG73804Z.
    PhylomeDBiQ9NR82.
    TreeFamiTF315186.

    Family and domain databases

    InterProiIPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003937. K_chnl_volt-dep_KCNQ.
    IPR013821. K_chnl_volt-dep_KCNQ_C.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    PF03520. KCNQ_channel. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01459. KCNQCHANNEL.

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NR82-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS    50
    AAARGDGLLL LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ 100
    SCRRNVKYRR VQNYLYNVLE RPRGWAFIYH AFVFLLVFGC LILSVFSTIP 150
    EHTKLASSCL LILEFVMIVV FGLEFIIRIW SAGCCCRYRG WQGRLRFARK 200
    PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL RMVRMDRRGG 250
    TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD 300
    ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF 350
    ALKVQEQHRQ KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL 400
    HTCSPTKKEQ GEASSSQKLS FKERVRMASP RGQSIKSRQA SVGDRRSPST 450
    DITAEGSPTK VQKSWSFNDR TRFRPSLRLK SSQPKPVIDA DTALGTDDVY 500
    DEKGCQCDVS VEDLTPPLKT VIRAIRIMKF HVAKRKFKET LRPYDVKDVI 550
    EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI TAEHETTDDL 600
    SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA LASFQIPPFE 650
    CEQTSDYQSP VDSKDLSGSA QNSGCLSRST SANISRGLQF ILTPNEFSAQ 700
    TFYALSPTMH SQATQVPISQ SDGSAVAATN TIANQINTAP KPAAPTTLQI 750
    PPPLPAIKHL PRPETLHPNP AGLQESISDV TTCLVASKEN VQVAQSNLTK 800
    DRSMRKSFDM GGETLLSVCP MVPKDLGKSL SVQNLIRSTE ELNIQLSGSE 850
    SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP QPAREAAFAS 900
    DSLRTGRSRS SQSICKAGES TDALSLPHVK LK 932
    Length:932
    Mass (Da):102,179
    Last modified:January 9, 2007 - v3
    Checksum:iCB41C243FD2B00FC
    GO
    Isoform 2 (identifier: Q9NR82-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         407-416: KKEQGEASSS → N

    Show »
    Length:923
    Mass (Da):101,261
    Checksum:i3471634490A35B18
    GO
    Isoform 3 (identifier: Q9NR82-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         407-416: KKEQGEASSS → NKFCSNKQKLFRMYTSRKQS

    Show »
    Length:942
    Mass (Da):103,624
    Checksum:iF7580704F95D1CC3
    GO
    Isoform 4 (identifier: Q9NR82-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         416-427: SQKLSFKERVRM → RFVISLLLHVCL
         428-932: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:427
    Mass (Da):46,943
    Checksum:i175F91B7BB48836B
    GO
    Isoform 5 (identifier: Q9NR82-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         416-525: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:822
    Mass (Da):89,987
    Checksum:iEC339886F1755506
    GO
    Isoform 6 (identifier: Q9NR82-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         416-416: S → SKFCSNKQKLFRMYTSRKQS

    Note: No experimental confirmation available.

    Show »
    Length:951
    Mass (Da):104,542
    Checksum:iDB6CFDB0C6267F6F
    GO
    Isoform 7 (identifier: Q9NR82-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         408-416: KEQGEASSS → QNQQGESQSC

    Note: No experimental confirmation available.

    Show »
    Length:933
    Mass (Da):102,365
    Checksum:i6B39865CBDB05D2E
    GO

    Sequence cautioni

    The sequence BAG61495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 932KP → SR in AAF91335. (PubMed:10787416)Curated
    Sequence conflicti109 – 1091R → Q in BAG61495. (PubMed:14702039)Curated
    Sequence conflicti129 – 1291Y → H in AAF73446. 1 PublicationCurated
    Sequence conflicti727 – 7271A → V in AAF73446. 1 PublicationCurated
    Sequence conflicti799 – 7991T → P in AAF73446. 1 PublicationCurated
    Sequence conflicti857 – 8571S → R in AAF73446. 1 PublicationCurated
    Sequence conflicti909 – 9091R → Q in AAF73446. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti191 – 1911W → G in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035772
    Natural varianti244 – 2441R → C in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035773

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei407 – 41610KKEQGEASSS → N in isoform 2. 2 PublicationsVSP_001014
    Alternative sequencei407 – 41610KKEQGEASSS → NKFCSNKQKLFRMYTSRKQS in isoform 3. 1 PublicationVSP_001015
    Alternative sequencei408 – 4169KEQGEASSS → QNQQGESQSC in isoform 7. CuratedVSP_056730
    Alternative sequencei416 – 525110Missing in isoform 5. 1 PublicationVSP_045487Add
    BLAST
    Alternative sequencei416 – 42712SQKLS…ERVRM → RFVISLLLHVCL in isoform 4. 1 PublicationVSP_022318Add
    BLAST
    Alternative sequencei416 – 4161S → SKFCSNKQKLFRMYTSRKQS in isoform 6. CuratedVSP_056731
    Alternative sequencei428 – 932505Missing in isoform 4. 1 PublicationVSP_022319Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF249278 mRNA. Translation: AAF91335.1.
    AL445569 Genomic DNA. No translation available.
    AL049845 Genomic DNA. No translation available.
    AL360232 Genomic DNA. No translation available.
    AL360236 Genomic DNA. No translation available.
    AL365232 Genomic DNA. No translation available.
    FO393414 Genomic DNA. No translation available.
    AL513522 Genomic DNA. No translation available.
    AL671823 Genomic DNA. No translation available.
    BC050689 mRNA. Translation: AAH50689.1.
    BC117359 mRNA. Translation: AAI17360.1.
    BC143554 mRNA. Translation: AAI43555.1.
    AK299550 mRNA. Translation: BAG61495.1. Different initiation.
    AF202977 mRNA. Translation: AAF69797.1.
    AJ272506
    , AJ272507, AJ272508, AJ272509, AJ272510, AJ272511, AJ272512, AJ272513, AJ272514, AJ272515, AJ272516, AJ272517, AJ272518, AJ272519 Genomic DNA. Translation: CAC88112.1.
    AF263835 mRNA. Translation: AAF73446.1.
    CCDSiCCDS4976.1. [Q9NR82-1]
    CCDS55035.1. [Q9NR82-5]
    CCDS55036.1. [Q9NR82-3]
    CCDS55037.1. [Q9NR82-2]
    RefSeqiNP_001153602.1. NM_001160130.1. [Q9NR82-2]
    NP_001153604.1. NM_001160132.1. [Q9NR82-3]
    NP_001153605.1. NM_001160133.1.
    NP_001153606.1. NM_001160134.1. [Q9NR82-5]
    NP_062816.2. NM_019842.3. [Q9NR82-1]
    UniGeneiHs.445324.

    Genome annotation databases

    EnsembliENST00000342056; ENSP00000345055; ENSG00000185760.
    ENST00000355194; ENSP00000347326; ENSG00000185760.
    ENST00000355635; ENSP00000347853; ENSG00000185760.
    ENST00000370392; ENSP00000359419; ENSG00000185760. [Q9NR82-4]
    ENST00000370398; ENSP00000359425; ENSG00000185760. [Q9NR82-1]
    ENST00000402622; ENSP00000385501; ENSG00000185760. [Q9NR82-3]
    ENST00000403813; ENSP00000384453; ENSG00000185760. [Q9NR82-2]
    ENST00000414165; ENSP00000409861; ENSG00000185760. [Q9NR82-5]
    GeneIDi56479.
    KEGGihsa:56479.
    UCSCiuc003pgj.4. human. [Q9NR82-4]
    uc003pgk.3. human. [Q9NR82-1]
    uc010kat.3. human. [Q9NR82-2]
    uc011dyh.2. human.
    uc011dyi.2. human. [Q9NR82-3]

    Polymorphism databases

    DMDMi122065285.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF249278 mRNA. Translation: AAF91335.1 .
    AL445569 Genomic DNA. No translation available.
    AL049845 Genomic DNA. No translation available.
    AL360232 Genomic DNA. No translation available.
    AL360236 Genomic DNA. No translation available.
    AL365232 Genomic DNA. No translation available.
    FO393414 Genomic DNA. No translation available.
    AL513522 Genomic DNA. No translation available.
    AL671823 Genomic DNA. No translation available.
    BC050689 mRNA. Translation: AAH50689.1 .
    BC117359 mRNA. Translation: AAI17360.1 .
    BC143554 mRNA. Translation: AAI43555.1 .
    AK299550 mRNA. Translation: BAG61495.1 . Different initiation.
    AF202977 mRNA. Translation: AAF69797.1 .
    AJ272506
    , AJ272507 , AJ272508 , AJ272509 , AJ272510 , AJ272511 , AJ272512 , AJ272513 , AJ272514 , AJ272515 , AJ272516 , AJ272517 , AJ272518 , AJ272519 Genomic DNA. Translation: CAC88112.1 .
    AF263835 mRNA. Translation: AAF73446.1 .
    CCDSi CCDS4976.1. [Q9NR82-1 ]
    CCDS55035.1. [Q9NR82-5 ]
    CCDS55036.1. [Q9NR82-3 ]
    CCDS55037.1. [Q9NR82-2 ]
    RefSeqi NP_001153602.1. NM_001160130.1. [Q9NR82-2 ]
    NP_001153604.1. NM_001160132.1. [Q9NR82-3 ]
    NP_001153605.1. NM_001160133.1.
    NP_001153606.1. NM_001160134.1. [Q9NR82-5 ]
    NP_062816.2. NM_019842.3. [Q9NR82-1 ]
    UniGenei Hs.445324.

    3D structure databases

    ProteinModelPortali Q9NR82.
    SMRi Q9NR82. Positions 128-377, 598-627.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121149. 2 interactions.
    STRINGi 9606.ENSP00000359425.

    Chemistry

    BindingDBi Q9NR82.
    ChEMBLi CHEMBL2925.
    GuidetoPHARMACOLOGYi 564.

    PTM databases

    PhosphoSitei Q9NR82.

    Polymorphism databases

    DMDMi 122065285.

    Proteomic databases

    PaxDbi Q9NR82.
    PRIDEi Q9NR82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342056 ; ENSP00000345055 ; ENSG00000185760 .
    ENST00000355194 ; ENSP00000347326 ; ENSG00000185760 .
    ENST00000355635 ; ENSP00000347853 ; ENSG00000185760 .
    ENST00000370392 ; ENSP00000359419 ; ENSG00000185760 . [Q9NR82-4 ]
    ENST00000370398 ; ENSP00000359425 ; ENSG00000185760 . [Q9NR82-1 ]
    ENST00000402622 ; ENSP00000385501 ; ENSG00000185760 . [Q9NR82-3 ]
    ENST00000403813 ; ENSP00000384453 ; ENSG00000185760 . [Q9NR82-2 ]
    ENST00000414165 ; ENSP00000409861 ; ENSG00000185760 . [Q9NR82-5 ]
    GeneIDi 56479.
    KEGGi hsa:56479.
    UCSCi uc003pgj.4. human. [Q9NR82-4 ]
    uc003pgk.3. human. [Q9NR82-1 ]
    uc010kat.3. human. [Q9NR82-2 ]
    uc011dyh.2. human.
    uc011dyi.2. human. [Q9NR82-3 ]

    Organism-specific databases

    CTDi 56479.
    GeneCardsi GC06P073331.
    HGNCi HGNC:6299. KCNQ5.
    HPAi HPA016655.
    MIMi 607357. gene.
    neXtProti NX_Q9NR82.
    PharmGKBi PA30077.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000220839.
    HOVERGENi HBG059014.
    KOi K04930.
    OMAi YTSSQSC.
    OrthoDBi EOG73804Z.
    PhylomeDBi Q9NR82.
    TreeFami TF315186.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNQ5.
    GenomeRNAii 56479.
    NextBioi 62021.
    PROi Q9NR82.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NR82.
    Bgeei Q9NR82.
    CleanExi HS_KCNQ5.
    Genevestigatori Q9NR82.

    Family and domain databases

    InterProi IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003937. K_chnl_volt-dep_KCNQ.
    IPR013821. K_chnl_volt-dep_KCNQ_C.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    PF03520. KCNQ_channel. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01459. KCNQCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity."
      Lerche C., Scherer C.R., Seebohm G., Derst C., Wei A.D., Busch A.E., Steinmeyer K.
      J. Biol. Chem. 275:22395-22400(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-822 (ISOFORM 5).
      Tissue: Brain.
    5. "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents."
      Schroeder B.C., Hechenberger M., Weinreich F., Kubisch C., Jentsch T.J.
      J. Biol. Chem. 275:24089-24095(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-932 (ISOFORMS 1; 2 AND 3).
      Tissue: Brain.
    6. "The new voltage gated potassium channel KCNQ5 and early infantile convulsions."
      Kananura C., Biervert B., Hechenberger M., Engels H., Steinlein O.K.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-932.
    7. "A new gene of the voltage-gated potassium channel KCNQ family, KCNQ5, is a candidate gene for retinal disorders."
      Kniazeva M., Han M.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-932 (ISOFORM 1).
      Tissue: Brain and Retina.
    8. "Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells."
      Wickenden A.D., Zou A., Wagoner P.K., Jegla T.
      Br. J. Pharmacol. 132:381-384(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, ACTIVATION BY RETICABINE.
    9. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-191 AND CYS-244.

    Entry informationi

    Entry nameiKCNQ5_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR82
    Secondary accession number(s): A6NKT6
    , A6PVT6, A8MSQ5, B4DS33, B5MC83, B7ZL37, F5GZV0, Q17RE1, Q5VVP3, Q86W40, Q9NRN0, Q9NYA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3