Q9NR82 (KCNQ5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily KQT member 5

Alternative name(s):
KQT-like 5
Potassium channel subunit alpha KvLQT5
Voltage-gated potassium channel subunit Kv7.5

Gene names

Name:

KCNQ5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	932 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M1 muscarinic receptors.
Subunit structure	Heteromultimer with KCNQ3.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.
Sequence similarities	Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. [View classification]
Sequence caution	The sequence BAG61495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein complex assembly Non-traceable author statement Ref.1. Source: ProtInc synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome inward rectifier potassium channel activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NR82-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NR82-2)

The sequence of this isoform differs from the canonical sequence as follows:
     407-416: KKEQGEASSS → N

Isoform 3 (identifier: Q9NR82-3)

The sequence of this isoform differs from the canonical sequence as follows:
     407-416: KKEQGEASSS → NKFCSNKQKLFRMYTSRKQS

Isoform 4 (identifier: Q9NR82-4)

The sequence of this isoform differs from the canonical sequence as follows:
     416-427: SQKLSFKERVRM → RFVISLLLHVCL
     428-932: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9NR82-5)

The sequence of this isoform differs from the canonical sequence as follows:
     416-525: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 932	932	Potassium voltage-gated channel subfamily KQT member 5		PRO_0000054040
Regions
	Transmembrane	126 – 146	21	Helical; Name=Segment S1; Potential
	Transmembrane	157 – 177	21	Helical; Name=Segment S2; Potential
	Transmembrane	201 – 221	21	Helical; Name=Segment S3; Potential
	Transmembrane	230 – 252	23	Helical; Voltage-sensor; Name=Segment S4; Potential
	Transmembrane	267 – 287	21	Helical; Name=Segment S5; Potential
	Intramembrane	299 – 319	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	326 – 346	21	Helical; Name=Segment S6; Potential
	Motif	311 – 316	6	Selectivity filter By similarity
Natural variations
	Alternative sequence	407 – 416	10	KKEQGEASSS → N in isoform 2.		VSP_001014
	Alternative sequence	407 – 416	10	KKEQGEASSS → NKFCSNKQKLFRMYTSRKQS in isoform 3.		VSP_001015
	Alternative sequence	416 – 525	110	Missing in isoform 5.		VSP_045487
	Alternative sequence	416 – 427	12	SQKLS…ERVRM → RFVISLLLHVCL in isoform 4.		VSP_022318
	Alternative sequence	428 – 932	505	Missing in isoform 4.		VSP_022319
	Natural variant	191	1	W → G in a colorectal cancer sample; somatic mutation. Ref.9		VAR_035772
	Natural variant	244	1	R → C in a colorectal cancer sample; somatic mutation. Ref.9		VAR_035773
Experimental info
	Sequence conflict	92 – 93	2	KP → SR in AAF91335. Ref.1
	Sequence conflict	109	1	R → Q in BAG61495. Ref.4
	Sequence conflict	129	1	Y → H in AAF73446. Ref.7
	Sequence conflict	727	1	A → V in AAF73446. Ref.7
	Sequence conflict	799	1	T → P in AAF73446. Ref.7
	Sequence conflict	857	1	S → R in AAF73446. Ref.7
	Sequence conflict	909	1	R → Q in AAF73446. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 3. Checksum: CB41C243FD2B00FC	FASTA	932	102,179
	10 20 30 40 50 60 MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS AAARGDGLLL 70 80 90 100 110 120 LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ SCRRNVKYRR VQNYLYNVLE 130 140 150 160 170 180 RPRGWAFIYH AFVFLLVFGC LILSVFSTIP EHTKLASSCL LILEFVMIVV FGLEFIIRIW 190 200 210 220 230 240 SAGCCCRYRG WQGRLRFARK PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL 250 260 270 280 290 300 RMVRMDRRGG TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD 310 320 330 340 350 360 ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF ALKVQEQHRQ 370 380 390 400 410 420 KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL HTCSPTKKEQ GEASSSQKLS 430 440 450 460 470 480 FKERVRMASP RGQSIKSRQA SVGDRRSPST DITAEGSPTK VQKSWSFNDR TRFRPSLRLK 490 500 510 520 530 540 SSQPKPVIDA DTALGTDDVY DEKGCQCDVS VEDLTPPLKT VIRAIRIMKF HVAKRKFKET 550 560 570 580 590 600 LRPYDVKDVI EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI TAEHETTDDL 610 620 630 640 650 660 SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA LASFQIPPFE CEQTSDYQSP 670 680 690 700 710 720 VDSKDLSGSA QNSGCLSRST SANISRGLQF ILTPNEFSAQ TFYALSPTMH SQATQVPISQ 730 740 750 760 770 780 SDGSAVAATN TIANQINTAP KPAAPTTLQI PPPLPAIKHL PRPETLHPNP AGLQESISDV 790 800 810 820 830 840 TTCLVASKEN VQVAQSNLTK DRSMRKSFDM GGETLLSVCP MVPKDLGKSL SVQNLIRSTE 850 860 870 880 890 900 ELNIQLSGSE SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP QPAREAAFAS 910 920 930 DSLRTGRSRS SQSICKAGES TDALSLPHVK LK
	Isoform 2 [UniParc]. Checksum: 3471634490A35B18	FASTA	923	101,261
	10 20 30 40 50 60 MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS AAARGDGLLL 70 80 90 100 110 120 LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ SCRRNVKYRR VQNYLYNVLE 130 140 150 160 170 180 RPRGWAFIYH AFVFLLVFGC LILSVFSTIP EHTKLASSCL LILEFVMIVV FGLEFIIRIW 190 200 210 220 230 240 SAGCCCRYRG WQGRLRFARK PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL 250 260 270 280 290 300 RMVRMDRRGG TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD 310 320 330 340 350 360 ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF ALKVQEQHRQ 370 380 390 400 410 420 KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL HTCSPTNQKL SFKERVRMAS 430 440 450 460 470 480 PRGQSIKSRQ ASVGDRRSPS TDITAEGSPT KVQKSWSFND RTRFRPSLRL KSSQPKPVID 490 500 510 520 530 540 ADTALGTDDV YDEKGCQCDV SVEDLTPPLK TVIRAIRIMK FHVAKRKFKE TLRPYDVKDV 550 560 570 580 590 600 IEQYSAGHLD MLCRIKSLQT RVDQILGKGQ ITSDKKSREK ITAEHETTDD LSMLGRVVKV 610 620 630 640 650 660 EKQVQSIESK LDCLLDIYQQ VLRKGSASAL ALASFQIPPF ECEQTSDYQS PVDSKDLSGS 670 680 690 700 710 720 AQNSGCLSRS TSANISRGLQ FILTPNEFSA QTFYALSPTM HSQATQVPIS QSDGSAVAAT 730 740 750 760 770 780 NTIANQINTA PKPAAPTTLQ IPPPLPAIKH LPRPETLHPN PAGLQESISD VTTCLVASKE 790 800 810 820 830 840 NVQVAQSNLT KDRSMRKSFD MGGETLLSVC PMVPKDLGKS LSVQNLIRST EELNIQLSGS 850 860 870 880 890 900 ESSGSRGSQD FYPKWRESKL FITDEEVGPE ETETDTFDAA PQPAREAAFA SDSLRTGRSR 910 920 SSQSICKAGE STDALSLPHV KLK
	Isoform 3 [UniParc]. Checksum: F7580704F95D1CC3	FASTA	942	103,624
	10 20 30 40 50 60 MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS AAARGDGLLL 70 80 90 100 110 120 LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ SCRRNVKYRR VQNYLYNVLE 130 140 150 160 170 180 RPRGWAFIYH AFVFLLVFGC LILSVFSTIP EHTKLASSCL LILEFVMIVV FGLEFIIRIW 190 200 210 220 230 240 SAGCCCRYRG WQGRLRFARK PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL 250 260 270 280 290 300 RMVRMDRRGG TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD 310 320 330 340 350 360 ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF ALKVQEQHRQ 370 380 390 400 410 420 KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL HTCSPTNKFC SNKQKLFRMY 430 440 450 460 470 480 TSRKQSQKLS FKERVRMASP RGQSIKSRQA SVGDRRSPST DITAEGSPTK VQKSWSFNDR 490 500 510 520 530 540 TRFRPSLRLK SSQPKPVIDA DTALGTDDVY DEKGCQCDVS VEDLTPPLKT VIRAIRIMKF 550 560 570 580 590 600 HVAKRKFKET LRPYDVKDVI EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI 610 620 630 640 650 660 TAEHETTDDL SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA LASFQIPPFE 670 680 690 700 710 720 CEQTSDYQSP VDSKDLSGSA QNSGCLSRST SANISRGLQF ILTPNEFSAQ TFYALSPTMH 730 740 750 760 770 780 SQATQVPISQ SDGSAVAATN TIANQINTAP KPAAPTTLQI PPPLPAIKHL PRPETLHPNP 790 800 810 820 830 840 AGLQESISDV TTCLVASKEN VQVAQSNLTK DRSMRKSFDM GGETLLSVCP MVPKDLGKSL 850 860 870 880 890 900 SVQNLIRSTE ELNIQLSGSE SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP 910 920 930 940 QPAREAAFAS DSLRTGRSRS SQSICKAGES TDALSLPHVK LK
	Isoform 4 [UniParc]. Checksum: 175F91B7BB48836B	FASTA	427	46,943
	10 20 30 40 50 60 MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS AAARGDGLLL 70 80 90 100 110 120 LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ SCRRNVKYRR VQNYLYNVLE 130 140 150 160 170 180 RPRGWAFIYH AFVFLLVFGC LILSVFSTIP EHTKLASSCL LILEFVMIVV FGLEFIIRIW 190 200 210 220 230 240 SAGCCCRYRG WQGRLRFARK PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL 250 260 270 280 290 300 RMVRMDRRGG TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD 310 320 330 340 350 360 ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF ALKVQEQHRQ 370 380 390 400 410 420 KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL HTCSPTKKEQ GEASSRFVIS LLLHVCL
	Isoform 5 [UniParc]. Checksum: EC339886F1755506	FASTA	822	89,987
	10 20 30 40 50 60 MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS AAARGDGLLL 70 80 90 100 110 120 LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ SCRRNVKYRR VQNYLYNVLE 130 140 150 160 170 180 RPRGWAFIYH AFVFLLVFGC LILSVFSTIP EHTKLASSCL LILEFVMIVV FGLEFIIRIW 190 200 210 220 230 240 SAGCCCRYRG WQGRLRFARK PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL 250 260 270 280 290 300 RMVRMDRRGG TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD 310 320 330 340 350 360 ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF ALKVQEQHRQ 370 380 390 400 410 420 KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL HTCSPTKKEQ GEASSRIMKF 430 440 450 460 470 480 HVAKRKFKET LRPYDVKDVI EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI 490 500 510 520 530 540 TAEHETTDDL SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA LASFQIPPFE 550 560 570 580 590 600 CEQTSDYQSP VDSKDLSGSA QNSGCLSRST SANISRGLQF ILTPNEFSAQ TFYALSPTMH 610 620 630 640 650 660 SQATQVPISQ SDGSAVAATN TIANQINTAP KPAAPTTLQI PPPLPAIKHL PRPETLHPNP 670 680 690 700 710 720 AGLQESISDV TTCLVASKEN VQVAQSNLTK DRSMRKSFDM GGETLLSVCP MVPKDLGKSL 730 740 750 760 770 780 SVQNLIRSTE ELNIQLSGSE SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP 790 800 810 820 QPAREAAFAS DSLRTGRSRS SQSICKAGES TDALSLPHVK LK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity." Lerche C., Scherer C.R., Seebohm G., Derst C., Wei A.D., Busch A.E., Steinmeyer K. J. Biol. Chem. 275:22395-22400(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Placenta.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-822 (ISOFORM 5). Tissue: Brain.
[5]	"KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents." Schroeder B.C., Hechenberger M., Weinreich F., Kubisch C., Jentsch T.J. J. Biol. Chem. 275:24089-24095(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-932 (ISOFORMS 1; 2 AND 3). Tissue: Brain.
[6]	"The new voltage gated potassium channel KCNQ5 and early infantile convulsions." Kananura C., Biervert B., Hechenberger M., Engels H., Steinlein O.K. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-932.
[7]	"A new gene of the voltage-gated potassium channel KCNQ family, KCNQ5, is a candidate gene for retinal disorders." Kniazeva M., Han M. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-932 (ISOFORM 1). Tissue: Brain and Retina.
[8]	"Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells." Wickenden A.D., Zou A., Wagoner P.K., Jegla T. Br. J. Pharmacol. 132:381-384(2001) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, ACTIVATION BY RETICABINE.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-191 AND CYS-244.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF249278 mRNA. Translation: AAF91335.1. AL445569, AL360236, AL365232 Genomic DNA. Translation: CAH70463.1. AL445569, AL360236 Genomic DNA. Translation: CAH70464.1. AL360236, AL365232, AL445569 Genomic DNA. Translation: CAH73176.1. AL360236, AL445569 Genomic DNA. Translation: CAH73177.1. AL365232, AL360236, AL445569 Genomic DNA. Translation: CAI39828.1. AL513522 Genomic DNA. No translation available. AL671823 Genomic DNA. No translation available. BC050689 mRNA. Translation: AAH50689.1. BC117359 mRNA. Translation: AAI17360.1. BC143554 mRNA. Translation: AAI43555.1. AK299550 mRNA. Translation: BAG61495.1. Different initiation. AF202977 mRNA. Translation: AAF69797.1. AJ272506 , AJ272507, AJ272508, AJ272509, AJ272510, AJ272511, AJ272512, AJ272513, AJ272514, AJ272515, AJ272516, AJ272517, AJ272518, AJ272519 Genomic DNA. Translation: CAC88112.1. AF263835 mRNA. Translation: AAF73446.1.
IPI	IPI00473029. IPI00478577. IPI00854572. IPI00930175.
RefSeq	NP_001153602.1. NM_001160130.1. NP_001153604.1. NM_001160132.1. NP_001153606.1. NM_001160134.1. NP_062816.2. NM_019842.3.
UniGene	Hs.445324.
3D structure databases
ProteinModelPortal	Q9NR82.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000359425.
PTM databases
PhosphoSite	Q9NR82.
Polymorphism databases
DMDM	122065285.
Proteomic databases
PaxDb	Q9NR82.
PRIDE	Q9NR82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370392; ENSP00000359419; ENSG00000185760. ENST00000370398; ENSP00000359425; ENSG00000185760. ENST00000402622; ENSP00000385501; ENSG00000185760. ENST00000403813; ENSP00000384453; ENSG00000185760. ENST00000414165; ENSP00000409861; ENSG00000185760.
GeneID	56479.
KEGG	hsa:56479.
UCSC	uc003pgj.4. human. uc003pgk.3. human. uc010kat.3. human. uc011dyi.2. human.
Organism-specific databases
CTD	56479.
GeneCards	GC06P073331.
HGNC	HGNC:6299. KCNQ5.
HPA	HPA016655.
MIM	607357. gene.
neXtProt	NX_Q9NR82.
PharmGKB	PA30077.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOVERGEN	HBG059014.
KO	K04930.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q9NR82.
Bgee	Q9NR82.
CleanEx	HS_KCNQ5.
Genevestigator	Q9NR82.
GermOnline	ENSG00000185760. Homo sapiens.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003937. K_chnl_volt-dep_KCNQ. IPR013821. K_chnl_volt-dep_KCNQ_C. [Graphical view]
Pfam	PF00520. Ion_trans. 1 hit. PF03520. KCNQ_channel. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01459. KCNQCHANNEL.
ProtoNet	Search...
Other
BindingDB	Q9NR82.
ChEMBL	CHEMBL2925.
GenomeRNAi	56479.
NextBio	62021.
SOURCE	Search...

Entry information

Entry name

KCNQ5_HUMAN

Accession

Primary (citable) accession number: Q9NR82
Secondary accession number(s): B4DS33 , B5MC83, B7ZL37, F5GZV0, Q17RE1, Q5VVP3, Q86W40, Q9NRN0, Q9NYA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.