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Q9NR82

- KCNQ5_HUMAN

UniProt

Q9NR82 - KCNQ5_HUMAN

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Protein
Potassium voltage-gated channel subfamily KQT member 5
Gene
KCNQ5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M1 muscarinic receptors.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. inward rectifier potassium channel activity Source: ProtInc

GO - Biological processi

  1. protein complex assembly Source: ProtInc
  2. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 5
Alternative name(s):
KQT-like 5
Potassium channel subunit alpha KvLQT5
Voltage-gated potassium channel subunit Kv7.5
Gene namesi
Name:KCNQ5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6299. KCNQ5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei126 – 14621Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei157 – 17721Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei230 – 25223Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Transmembranei267 – 28721Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Intramembranei299 – 31921Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Transmembranei326 – 34621Helical; Name=Segment S6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. plasma membrane Source: Reactome
  2. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30077.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 932932Potassium voltage-gated channel subfamily KQT member 5
PRO_0000054040Add
BLAST

Proteomic databases

PaxDbiQ9NR82.
PRIDEiQ9NR82.

PTM databases

PhosphoSiteiQ9NR82.

Expressioni

Tissue specificityi

Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.

Gene expression databases

ArrayExpressiQ9NR82.
BgeeiQ9NR82.
CleanExiHS_KCNQ5.
GenevestigatoriQ9NR82.

Organism-specific databases

HPAiHPA016655.

Interactioni

Subunit structurei

Heteromultimer with KCNQ3.

Protein-protein interaction databases

BioGridi121149. 2 interactions.
STRINGi9606.ENSP00000359425.

Structurei

3D structure databases

ProteinModelPortaliQ9NR82.
SMRiQ9NR82. Positions 128-377, 598-627.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi311 – 3166Selectivity filter By similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOVERGENiHBG059014.
KOiK04930.
PhylomeDBiQ9NR82.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01459. KCNQCHANNEL.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NR82-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS    50
AAARGDGLLL LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ 100
SCRRNVKYRR VQNYLYNVLE RPRGWAFIYH AFVFLLVFGC LILSVFSTIP 150
EHTKLASSCL LILEFVMIVV FGLEFIIRIW SAGCCCRYRG WQGRLRFARK 200
PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL RMVRMDRRGG 250
TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD 300
ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF 350
ALKVQEQHRQ KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL 400
HTCSPTKKEQ GEASSSQKLS FKERVRMASP RGQSIKSRQA SVGDRRSPST 450
DITAEGSPTK VQKSWSFNDR TRFRPSLRLK SSQPKPVIDA DTALGTDDVY 500
DEKGCQCDVS VEDLTPPLKT VIRAIRIMKF HVAKRKFKET LRPYDVKDVI 550
EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI TAEHETTDDL 600
SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA LASFQIPPFE 650
CEQTSDYQSP VDSKDLSGSA QNSGCLSRST SANISRGLQF ILTPNEFSAQ 700
TFYALSPTMH SQATQVPISQ SDGSAVAATN TIANQINTAP KPAAPTTLQI 750
PPPLPAIKHL PRPETLHPNP AGLQESISDV TTCLVASKEN VQVAQSNLTK 800
DRSMRKSFDM GGETLLSVCP MVPKDLGKSL SVQNLIRSTE ELNIQLSGSE 850
SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP QPAREAAFAS 900
DSLRTGRSRS SQSICKAGES TDALSLPHVK LK 932
Length:932
Mass (Da):102,179
Last modified:January 9, 2007 - v3
Checksum:iCB41C243FD2B00FC
GO
Isoform 2 (identifier: Q9NR82-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-416: KKEQGEASSS → N

Show »
Length:923
Mass (Da):101,261
Checksum:i3471634490A35B18
GO
Isoform 3 (identifier: Q9NR82-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-416: KKEQGEASSS → NKFCSNKQKLFRMYTSRKQS

Show »
Length:942
Mass (Da):103,624
Checksum:iF7580704F95D1CC3
GO
Isoform 4 (identifier: Q9NR82-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-427: SQKLSFKERVRM → RFVISLLLHVCL
     428-932: Missing.

Note: No experimental confirmation available.

Show »
Length:427
Mass (Da):46,943
Checksum:i175F91B7BB48836B
GO
Isoform 5 (identifier: Q9NR82-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-525: Missing.

Note: No experimental confirmation available.

Show »
Length:822
Mass (Da):89,987
Checksum:iEC339886F1755506
GO

Sequence cautioni

The sequence BAG61495.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911W → G in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035772
Natural varianti244 – 2441R → C in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035773

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei407 – 41610KKEQGEASSS → N in isoform 2.
VSP_001014
Alternative sequencei407 – 41610KKEQGEASSS → NKFCSNKQKLFRMYTSRKQS in isoform 3.
VSP_001015
Alternative sequencei416 – 525110Missing in isoform 5.
VSP_045487Add
BLAST
Alternative sequencei416 – 42712SQKLS…ERVRM → RFVISLLLHVCL in isoform 4.
VSP_022318Add
BLAST
Alternative sequencei428 – 932505Missing in isoform 4.
VSP_022319Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 932KP → SR in AAF91335. 1 Publication
Sequence conflicti109 – 1091R → Q in BAG61495. 1 Publication
Sequence conflicti129 – 1291Y → H in AAF73446. 1 Publication
Sequence conflicti727 – 7271A → V in AAF73446. 1 Publication
Sequence conflicti799 – 7991T → P in AAF73446. 1 Publication
Sequence conflicti857 – 8571S → R in AAF73446. 1 Publication
Sequence conflicti909 – 9091R → Q in AAF73446. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF249278 mRNA. Translation: AAF91335.1.
AL049845 Genomic DNA. No translation available.
AL360232 Genomic DNA. No translation available.
AL360236 Genomic DNA. No translation available.
AL365232 Genomic DNA. No translation available.
FO393414 Genomic DNA. No translation available.
AL513522 Genomic DNA. No translation available.
AL671823 Genomic DNA. No translation available.
BC050689 mRNA. Translation: AAH50689.1.
BC117359 mRNA. Translation: AAI17360.1.
BC143554 mRNA. Translation: AAI43555.1.
AK299550 mRNA. Translation: BAG61495.1. Different initiation.
AF202977 mRNA. Translation: AAF69797.1.
AJ272506
, AJ272507, AJ272508, AJ272509, AJ272510, AJ272511, AJ272512, AJ272513, AJ272514, AJ272515, AJ272516, AJ272517, AJ272518, AJ272519 Genomic DNA. Translation: CAC88112.1.
AF263835 mRNA. Translation: AAF73446.1.
CCDSiCCDS4976.1. [Q9NR82-1]
CCDS55035.1. [Q9NR82-5]
CCDS55036.1. [Q9NR82-3]
CCDS55037.1. [Q9NR82-2]
RefSeqiNP_001153602.1. NM_001160130.1. [Q9NR82-2]
NP_001153604.1. NM_001160132.1. [Q9NR82-3]
NP_001153606.1. NM_001160134.1. [Q9NR82-5]
NP_062816.2. NM_019842.3. [Q9NR82-1]
UniGeneiHs.445324.

Genome annotation databases

EnsembliENST00000370392; ENSP00000359419; ENSG00000185760. [Q9NR82-4]
ENST00000370398; ENSP00000359425; ENSG00000185760. [Q9NR82-1]
ENST00000402622; ENSP00000385501; ENSG00000185760. [Q9NR82-3]
ENST00000403813; ENSP00000384453; ENSG00000185760. [Q9NR82-2]
ENST00000414165; ENSP00000409861; ENSG00000185760. [Q9NR82-5]
GeneIDi56479.
KEGGihsa:56479.
UCSCiuc003pgj.4. human. [Q9NR82-4]
uc003pgk.3. human. [Q9NR82-1]
uc010kat.3. human. [Q9NR82-2]
uc011dyi.2. human. [Q9NR82-3]

Polymorphism databases

DMDMi122065285.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF249278 mRNA. Translation: AAF91335.1 .
AL049845 Genomic DNA. No translation available.
AL360232 Genomic DNA. No translation available.
AL360236 Genomic DNA. No translation available.
AL365232 Genomic DNA. No translation available.
FO393414 Genomic DNA. No translation available.
AL513522 Genomic DNA. No translation available.
AL671823 Genomic DNA. No translation available.
BC050689 mRNA. Translation: AAH50689.1 .
BC117359 mRNA. Translation: AAI17360.1 .
BC143554 mRNA. Translation: AAI43555.1 .
AK299550 mRNA. Translation: BAG61495.1 . Different initiation.
AF202977 mRNA. Translation: AAF69797.1 .
AJ272506
, AJ272507 , AJ272508 , AJ272509 , AJ272510 , AJ272511 , AJ272512 , AJ272513 , AJ272514 , AJ272515 , AJ272516 , AJ272517 , AJ272518 , AJ272519 Genomic DNA. Translation: CAC88112.1 .
AF263835 mRNA. Translation: AAF73446.1 .
CCDSi CCDS4976.1. [Q9NR82-1 ]
CCDS55035.1. [Q9NR82-5 ]
CCDS55036.1. [Q9NR82-3 ]
CCDS55037.1. [Q9NR82-2 ]
RefSeqi NP_001153602.1. NM_001160130.1. [Q9NR82-2 ]
NP_001153604.1. NM_001160132.1. [Q9NR82-3 ]
NP_001153606.1. NM_001160134.1. [Q9NR82-5 ]
NP_062816.2. NM_019842.3. [Q9NR82-1 ]
UniGenei Hs.445324.

3D structure databases

ProteinModelPortali Q9NR82.
SMRi Q9NR82. Positions 128-377, 598-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121149. 2 interactions.
STRINGi 9606.ENSP00000359425.

Chemistry

BindingDBi Q9NR82.
ChEMBLi CHEMBL2925.
GuidetoPHARMACOLOGYi 564.

PTM databases

PhosphoSitei Q9NR82.

Polymorphism databases

DMDMi 122065285.

Proteomic databases

PaxDbi Q9NR82.
PRIDEi Q9NR82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370392 ; ENSP00000359419 ; ENSG00000185760 . [Q9NR82-4 ]
ENST00000370398 ; ENSP00000359425 ; ENSG00000185760 . [Q9NR82-1 ]
ENST00000402622 ; ENSP00000385501 ; ENSG00000185760 . [Q9NR82-3 ]
ENST00000403813 ; ENSP00000384453 ; ENSG00000185760 . [Q9NR82-2 ]
ENST00000414165 ; ENSP00000409861 ; ENSG00000185760 . [Q9NR82-5 ]
GeneIDi 56479.
KEGGi hsa:56479.
UCSCi uc003pgj.4. human. [Q9NR82-4 ]
uc003pgk.3. human. [Q9NR82-1 ]
uc010kat.3. human. [Q9NR82-2 ]
uc011dyi.2. human. [Q9NR82-3 ]

Organism-specific databases

CTDi 56479.
GeneCardsi GC06P073331.
HGNCi HGNC:6299. KCNQ5.
HPAi HPA016655.
MIMi 607357. gene.
neXtProti NX_Q9NR82.
PharmGKBi PA30077.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOVERGENi HBG059014.
KOi K04930.
PhylomeDBi Q9NR82.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNQ5.
GenomeRNAii 56479.
NextBioi 62021.
PROi Q9NR82.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NR82.
Bgeei Q9NR82.
CleanExi HS_KCNQ5.
Genevestigatori Q9NR82.

Family and domain databases

InterProi IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01459. KCNQCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity."
    Lerche C., Scherer C.R., Seebohm G., Derst C., Wei A.D., Busch A.E., Steinmeyer K.
    J. Biol. Chem. 275:22395-22400(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-822 (ISOFORM 5).
    Tissue: Brain.
  5. "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents."
    Schroeder B.C., Hechenberger M., Weinreich F., Kubisch C., Jentsch T.J.
    J. Biol. Chem. 275:24089-24095(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-932 (ISOFORMS 1; 2 AND 3).
    Tissue: Brain.
  6. "The new voltage gated potassium channel KCNQ5 and early infantile convulsions."
    Kananura C., Biervert B., Hechenberger M., Engels H., Steinlein O.K.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-932.
  7. "A new gene of the voltage-gated potassium channel KCNQ family, KCNQ5, is a candidate gene for retinal disorders."
    Kniazeva M., Han M.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-932 (ISOFORM 1).
    Tissue: Brain and Retina.
  8. "Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells."
    Wickenden A.D., Zou A., Wagoner P.K., Jegla T.
    Br. J. Pharmacol. 132:381-384(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, ACTIVATION BY RETICABINE.
  9. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-191 AND CYS-244.

Entry informationi

Entry nameiKCNQ5_HUMAN
AccessioniPrimary (citable) accession number: Q9NR82
Secondary accession number(s): B4DS33
, B5MC83, B7ZL37, F5GZV0, Q17RE1, Q5VVP3, Q86W40, Q9NRN0, Q9NYA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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