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Protein

Potassium voltage-gated channel subfamily KQT member 5

Gene

KCNQ5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M1 muscarinic receptors.

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: GO_Central
  • inward rectifier potassium channel activity Source: ProtInc
  • voltage-gated potassium channel activity Source: UniProtKB

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • protein complex assembly Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:G66-31038-MONOMER.
ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 5
Alternative name(s):
KQT-like 5
Potassium channel subunit alpha KvLQT5
Voltage-gated potassium channel subunit Kv7.5
Gene namesi
Name:KCNQ5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6299. KCNQ5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei126 – 146Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei157 – 177Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei201 – 221Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei230 – 252Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST23
Transmembranei267 – 287Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei299 – 319Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei326 – 346Helical; Name=Segment S6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • clathrin coat Source: UniProtKB
  • plasma membrane Source: Reactome
  • voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56479.
OpenTargetsiENSG00000185760.
PharmGKBiPA30077.

Chemistry databases

ChEMBLiCHEMBL2925.
DrugBankiDB04953. Ezogabine.
GuidetoPHARMACOLOGYi564.

Polymorphism and mutation databases

BioMutaiKCNQ5.
DMDMi122065285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540401 – 932Potassium voltage-gated channel subfamily KQT member 5Add BLAST932

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineBy similarity1
Modified residuei447PhosphoserineBy similarity1
Modified residuei831PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NR82.
PeptideAtlasiQ9NR82.
PRIDEiQ9NR82.

PTM databases

iPTMnetiQ9NR82.
PhosphoSitePlusiQ9NR82.

Expressioni

Tissue specificityi

Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.

Gene expression databases

BgeeiENSG00000185760.
CleanExiHS_KCNQ5.
ExpressionAtlasiQ9NR82. baseline and differential.
GenevisibleiQ9NR82. HS.

Organism-specific databases

HPAiHPA016655.

Interactioni

Subunit structurei

Heteromultimer with KCNQ3 (PubMed:11159685). Heterotetramer with KCNQ1; has a voltage-gated potassium channel activity (PubMed:24855057).2 Publications

Protein-protein interaction databases

BioGridi121149. 6 interactors.
STRINGi9606.ENSP00000345055.

Chemistry databases

BindingDBiQ9NR82.

Structurei

3D structure databases

ProteinModelPortaliQ9NR82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi311 – 316Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1419. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiQ9NR82.
KOiK04930.
OMAiRMYTSRK.
PhylomeDBiQ9NR82.
TreeFamiTF315186.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01459. KCNQCHANNEL.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRHHAGGEE GGAAGLWVKS GAAAAAAGGG RLGSGMKDVE SGRGRVLLNS
60 70 80 90 100
AAARGDGLLL LGTRAATLGG GGGGLRESRR GKQGARMSLL GKPLSYTSSQ
110 120 130 140 150
SCRRNVKYRR VQNYLYNVLE RPRGWAFIYH AFVFLLVFGC LILSVFSTIP
160 170 180 190 200
EHTKLASSCL LILEFVMIVV FGLEFIIRIW SAGCCCRYRG WQGRLRFARK
210 220 230 240 250
PFCVIDTIVL IASIAVVSAK TQGNIFATSA LRSLRFLQIL RMVRMDRRGG
260 270 280 290 300
TWKLLGSVVY AHSKELITAW YIGFLVLIFS SFLVYLVEKD ANKEFSTYAD
310 320 330 340 350
ALWWGTITLT TIGYGDKTPL TWLGRLLSAG FALLGISFFA LPAGILGSGF
360 370 380 390 400
ALKVQEQHRQ KHFEKRRNPA ANLIQCVWRS YAADEKSVSI ATWKPHLKAL
410 420 430 440 450
HTCSPTKKEQ GEASSSQKLS FKERVRMASP RGQSIKSRQA SVGDRRSPST
460 470 480 490 500
DITAEGSPTK VQKSWSFNDR TRFRPSLRLK SSQPKPVIDA DTALGTDDVY
510 520 530 540 550
DEKGCQCDVS VEDLTPPLKT VIRAIRIMKF HVAKRKFKET LRPYDVKDVI
560 570 580 590 600
EQYSAGHLDM LCRIKSLQTR VDQILGKGQI TSDKKSREKI TAEHETTDDL
610 620 630 640 650
SMLGRVVKVE KQVQSIESKL DCLLDIYQQV LRKGSASALA LASFQIPPFE
660 670 680 690 700
CEQTSDYQSP VDSKDLSGSA QNSGCLSRST SANISRGLQF ILTPNEFSAQ
710 720 730 740 750
TFYALSPTMH SQATQVPISQ SDGSAVAATN TIANQINTAP KPAAPTTLQI
760 770 780 790 800
PPPLPAIKHL PRPETLHPNP AGLQESISDV TTCLVASKEN VQVAQSNLTK
810 820 830 840 850
DRSMRKSFDM GGETLLSVCP MVPKDLGKSL SVQNLIRSTE ELNIQLSGSE
860 870 880 890 900
SSGSRGSQDF YPKWRESKLF ITDEEVGPEE TETDTFDAAP QPAREAAFAS
910 920 930
DSLRTGRSRS SQSICKAGES TDALSLPHVK LK
Length:932
Mass (Da):102,179
Last modified:January 9, 2007 - v3
Checksum:iCB41C243FD2B00FC
GO
Isoform 2 (identifier: Q9NR82-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-416: KKEQGEASSS → N

Show »
Length:923
Mass (Da):101,261
Checksum:i3471634490A35B18
GO
Isoform 3 (identifier: Q9NR82-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-416: KKEQGEASSS → NKFCSNKQKLFRMYTSRKQS

Show »
Length:942
Mass (Da):103,624
Checksum:iF7580704F95D1CC3
GO
Isoform 4 (identifier: Q9NR82-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-427: SQKLSFKERVRM → RFVISLLLHVCL
     428-932: Missing.

Note: No experimental confirmation available.
Show »
Length:427
Mass (Da):46,943
Checksum:i175F91B7BB48836B
GO
Isoform 5 (identifier: Q9NR82-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-525: Missing.

Note: No experimental confirmation available.
Show »
Length:822
Mass (Da):89,987
Checksum:iEC339886F1755506
GO
Isoform 6 (identifier: Q9NR82-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-416: S → SKFCSNKQKLFRMYTSRKQS

Note: No experimental confirmation available.
Show »
Length:951
Mass (Da):104,542
Checksum:iDB6CFDB0C6267F6F
GO
Isoform 7 (identifier: Q9NR82-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-416: KEQGEASSS → QNQQGESQSC

Note: No experimental confirmation available.
Show »
Length:933
Mass (Da):102,365
Checksum:i6B39865CBDB05D2E
GO

Sequence cautioni

The sequence BAG61495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92 – 93KP → SR in AAF91335 (PubMed:10787416).Curated2
Sequence conflicti109R → Q in BAG61495 (PubMed:14702039).Curated1
Sequence conflicti129Y → H in AAF73446 (Ref. 7) Curated1
Sequence conflicti727A → V in AAF73446 (Ref. 7) Curated1
Sequence conflicti799T → P in AAF73446 (Ref. 7) Curated1
Sequence conflicti857S → R in AAF73446 (Ref. 7) Curated1
Sequence conflicti909R → Q in AAF73446 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035772191W → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035773244R → C in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001014407 – 416KKEQGEASSS → N in isoform 2. 2 Publications10
Alternative sequenceiVSP_001015407 – 416KKEQGEASSS → NKFCSNKQKLFRMYTSRKQS in isoform 3. 1 Publication10
Alternative sequenceiVSP_056730408 – 416KEQGEASSS → QNQQGESQSC in isoform 7. Curated9
Alternative sequenceiVSP_045487416 – 525Missing in isoform 5. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_022318416 – 427SQKLS…ERVRM → RFVISLLLHVCL in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_056731416S → SKFCSNKQKLFRMYTSRKQS in isoform 6. Curated1
Alternative sequenceiVSP_022319428 – 932Missing in isoform 4. 1 PublicationAdd BLAST505

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249278 mRNA. Translation: AAF91335.1.
AL445569 Genomic DNA. No translation available.
AL049845 Genomic DNA. No translation available.
AL360232 Genomic DNA. No translation available.
AL360236 Genomic DNA. No translation available.
AL365232 Genomic DNA. No translation available.
FO393414 Genomic DNA. No translation available.
AL513522 Genomic DNA. No translation available.
AL671823 Genomic DNA. No translation available.
BC050689 mRNA. Translation: AAH50689.1.
BC117359 mRNA. Translation: AAI17360.1.
BC143554 mRNA. Translation: AAI43555.1.
AK299550 mRNA. Translation: BAG61495.1. Different initiation.
AF202977 mRNA. Translation: AAF69797.1.
AJ272506
, AJ272507, AJ272508, AJ272509, AJ272510, AJ272511, AJ272512, AJ272513, AJ272514, AJ272515, AJ272516, AJ272517, AJ272518, AJ272519 Genomic DNA. Translation: CAC88112.1.
AF263835 mRNA. Translation: AAF73446.1.
CCDSiCCDS4976.1. [Q9NR82-1]
CCDS55034.1. [Q9NR82-6]
CCDS55035.1. [Q9NR82-5]
CCDS55037.1. [Q9NR82-2]
RefSeqiNP_001153602.1. NM_001160130.1. [Q9NR82-2]
NP_001153604.1. NM_001160132.1. [Q9NR82-3]
NP_001153605.1. NM_001160133.1. [Q9NR82-6]
NP_001153606.1. NM_001160134.1. [Q9NR82-5]
NP_062816.2. NM_019842.3. [Q9NR82-1]
UniGeneiHs.445324.

Genome annotation databases

EnsembliENST00000342056; ENSP00000345055; ENSG00000185760. [Q9NR82-6]
ENST00000370392; ENSP00000359419; ENSG00000185760. [Q9NR82-4]
ENST00000370398; ENSP00000359425; ENSG00000185760. [Q9NR82-1]
ENST00000628967; ENSP00000486187; ENSG00000185760. [Q9NR82-5]
ENST00000629977; ENSP00000485743; ENSG00000185760. [Q9NR82-2]
GeneIDi56479.
KEGGihsa:56479.
UCSCiuc003pgj.5. human. [Q9NR82-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249278 mRNA. Translation: AAF91335.1.
AL445569 Genomic DNA. No translation available.
AL049845 Genomic DNA. No translation available.
AL360232 Genomic DNA. No translation available.
AL360236 Genomic DNA. No translation available.
AL365232 Genomic DNA. No translation available.
FO393414 Genomic DNA. No translation available.
AL513522 Genomic DNA. No translation available.
AL671823 Genomic DNA. No translation available.
BC050689 mRNA. Translation: AAH50689.1.
BC117359 mRNA. Translation: AAI17360.1.
BC143554 mRNA. Translation: AAI43555.1.
AK299550 mRNA. Translation: BAG61495.1. Different initiation.
AF202977 mRNA. Translation: AAF69797.1.
AJ272506
, AJ272507, AJ272508, AJ272509, AJ272510, AJ272511, AJ272512, AJ272513, AJ272514, AJ272515, AJ272516, AJ272517, AJ272518, AJ272519 Genomic DNA. Translation: CAC88112.1.
AF263835 mRNA. Translation: AAF73446.1.
CCDSiCCDS4976.1. [Q9NR82-1]
CCDS55034.1. [Q9NR82-6]
CCDS55035.1. [Q9NR82-5]
CCDS55037.1. [Q9NR82-2]
RefSeqiNP_001153602.1. NM_001160130.1. [Q9NR82-2]
NP_001153604.1. NM_001160132.1. [Q9NR82-3]
NP_001153605.1. NM_001160133.1. [Q9NR82-6]
NP_001153606.1. NM_001160134.1. [Q9NR82-5]
NP_062816.2. NM_019842.3. [Q9NR82-1]
UniGeneiHs.445324.

3D structure databases

ProteinModelPortaliQ9NR82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121149. 6 interactors.
STRINGi9606.ENSP00000345055.

Chemistry databases

BindingDBiQ9NR82.
ChEMBLiCHEMBL2925.
DrugBankiDB04953. Ezogabine.
GuidetoPHARMACOLOGYi564.

PTM databases

iPTMnetiQ9NR82.
PhosphoSitePlusiQ9NR82.

Polymorphism and mutation databases

BioMutaiKCNQ5.
DMDMi122065285.

Proteomic databases

PaxDbiQ9NR82.
PeptideAtlasiQ9NR82.
PRIDEiQ9NR82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342056; ENSP00000345055; ENSG00000185760. [Q9NR82-6]
ENST00000370392; ENSP00000359419; ENSG00000185760. [Q9NR82-4]
ENST00000370398; ENSP00000359425; ENSG00000185760. [Q9NR82-1]
ENST00000628967; ENSP00000486187; ENSG00000185760. [Q9NR82-5]
ENST00000629977; ENSP00000485743; ENSG00000185760. [Q9NR82-2]
GeneIDi56479.
KEGGihsa:56479.
UCSCiuc003pgj.5. human. [Q9NR82-1]

Organism-specific databases

CTDi56479.
DisGeNETi56479.
GeneCardsiKCNQ5.
HGNCiHGNC:6299. KCNQ5.
HPAiHPA016655.
MIMi607357. gene.
neXtProtiNX_Q9NR82.
OpenTargetsiENSG00000185760.
PharmGKBiPA30077.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1419. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiQ9NR82.
KOiK04930.
OMAiRMYTSRK.
PhylomeDBiQ9NR82.
TreeFamiTF315186.

Enzyme and pathway databases

BioCyciZFISH:G66-31038-MONOMER.
ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSiKCNQ5. human.
GeneWikiiKCNQ5.
GenomeRNAii56479.
PROiQ9NR82.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185760.
CleanExiHS_KCNQ5.
ExpressionAtlasiQ9NR82. baseline and differential.
GenevisibleiQ9NR82. HS.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 3 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNQ5_HUMAN
AccessioniPrimary (citable) accession number: Q9NR82
Secondary accession number(s): A6NKT6
, A6PVT6, A8MSQ5, B4DS33, B5MC83, B7ZL37, F5GZV0, Q17RE1, Q5VVP3, Q86W40, Q9NRN0, Q9NYA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.