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Q9NR80

- ARHG4_HUMAN

UniProt

Q9NR80 - ARHG4_HUMAN

Protein

Rho guanine nucleotide exchange factor 4

Gene

ARHGEF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.5 Publications

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein domain specific binding Source: UniProtKB
    4. Rac guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic signaling pathway Source: Reactome
    2. filopodium assembly Source: UniProtKB
    3. lamellipodium assembly Source: UniProtKB
    4. neurotrophin TRK receptor signaling pathway Source: Reactome
    5. positive regulation of apoptotic process Source: Reactome
    6. positive regulation of GTPase activity Source: GOC
    7. positive regulation of Rac GTPase activity Source: GOC
    8. regulation of small GTPase mediated signal transduction Source: Reactome
    9. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 4
    Alternative name(s):
    APC-stimulated guanine nucleotide exchange factor 1
    Short name:
    Asef
    Short name:
    Asef1
    Gene namesi
    Name:ARHGEF4
    Synonyms:KIAA1112
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:684. ARHGEF4.

    Subcellular locationi

    Isoform 3 : Cytoplasm. Cell projectionruffle membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
    Note: Associated with membrane ruffles.Curated

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. ruffle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24974.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 690690Rho guanine nucleotide exchange factor 4PRO_0000080914Add
    BLAST

    Proteomic databases

    PaxDbiQ9NR80.
    PRIDEiQ9NR80.

    PTM databases

    PhosphoSiteiQ9NR80.

    Expressioni

    Tissue specificityi

    Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors.3 Publications

    Gene expression databases

    ArrayExpressiQ9NR80.
    BgeeiQ9NR80.
    CleanExiHS_ARHGEF4.
    GenevestigatoriQ9NR80.

    Organism-specific databases

    HPAiHPA018267.

    Interactioni

    Subunit structurei

    Isoform 3 interacts with RHOA and RAC1, and (via ABR domain) with APC. Found in a complex consisting of ARHGEF4, APC and CTNNB1.1 Publication

    Protein-protein interaction databases

    BioGridi119114. 5 interactions.
    DIPiDIP-40814N.
    IntActiQ9NR80. 3 interactions.
    MINTiMINT-142950.
    STRINGi9606.ENSP00000316845.

    Structurei

    Secondary structure

    1
    690
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi187 – 1915
    Turni192 – 1943
    Beta strandi197 – 2037
    Beta strandi220 – 2256
    Beta strandi228 – 2369
    Beta strandi239 – 2446
    Helixi245 – 2473
    Beta strandi248 – 2503
    Helixi281 – 30929
    Helixi311 – 3166
    Turni318 – 3203
    Helixi323 – 3308
    Helixi333 – 35018
    Beta strandi353 – 3553
    Helixi356 – 3583
    Helixi362 – 3676
    Helixi369 – 3724
    Helixi375 – 39319
    Helixi396 – 40914
    Helixi416 – 43924
    Helixi448 – 48437
    Beta strandi485 – 4873
    Helixi493 – 4964
    Beta strandi500 – 50910
    Turni511 – 5133
    Beta strandi516 – 5249
    Beta strandi527 – 5337
    Beta strandi541 – 5488
    Turni549 – 5513
    Beta strandi553 – 5564
    Beta strandi559 – 5613
    Beta strandi571 – 5766
    Beta strandi578 – 5803
    Beta strandi583 – 5908
    Helixi591 – 60919

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DX1X-ray2.36A143-611[»]
    2PZ1X-ray2.25A170-632[»]
    3NMXX-ray2.30D/E/F170-194[»]
    3NMZX-ray3.01C/D170-276[»]
    ProteinModelPortaliQ9NR80.
    SMRiQ9NR80. Positions 171-611.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NR80.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini194 – 25360SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini284 – 468185DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini499 – 606108PHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni73 – 12654ABR (APC-binding region) domainAdd
    BLAST

    Domaini

    In an autoinhibited form the SH3 domain binds intramolecularly to the DH domain, thus blocking the Rac-binding site.1 Publication

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG5422.
    HOGENOMiHOG000237363.
    HOVERGENiHBG050568.
    KOiK05769.
    OMAiINILIRP.
    PhylomeDBiQ9NR80.
    TreeFamiTF316832.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NR80-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPWEEPAGEK PSCSHSQKAF HMEPAQKPCF TTDMVTWALL CISAETVRGE    50
    APSQPRGIPH RSPVSVDDLW LEKTQRKKLQ KQAHVERRLH IGAVHKDGVK 100
    CWRKTIITSP ESLNLPRRSH PLSQSAPTGL NHMGWPEHTP GTAMPDGALD 150
    TAVCADEVGS EEDLYDDLHS SSHHYSHPGG GGEQLAINEL ISDGSVVCAE 200
    ALWDHVTMDD QELGFKAGDV IEVMDATNRE WWWGRVADGE GWFPASFVRL 250
    RVNQDEPADD DAPLAGNSGA EDGGAEAQSS KDQMRTNVIN EILSTERDYI 300
    KHLRDICEGY VRQCRKRADM FSEEQLRTIF GNIEDIYRCQ KAFVKALEQR 350
    FNRERPHLSE LGACFLEHQA DFQIYSEYCN NHPNACVELS RLTKLSKYVY 400
    FFEACRLLQK MIDISLDGFL LTPVQKICKY PLQLAELLKY THPQHRDFKD 450
    VEAALHAMKN VAQLINERKR RLENIDKIAQ WQSSIEDWEG EDLLVRSSEL 500
    IYSGELTRVT QPQAKSQQRM FFLFDHQLIY CKKDLLRRDV LYYKGRLDMD 550
    GLEVVDLEDG KDRDLHVSIK NAFRLHRGAT GDSHLLCTRK PEQKQRWLKA 600
    FAREREQVQL DQETGFSITE LQRKQAMLNA SKQQVTGKPK AVGRPCYLTR 650
    QKHPALPSNR PQQQVLVLAE PRRKPSTFWH SISRLAPFRK 690
    Length:690
    Mass (Da):79,067
    Last modified:May 5, 2009 - v3
    Checksum:i47E5B61C91950CD2
    GO
    Isoform 3 (identifier: Q9NR80-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-71: Missing.
         72-142: EKTQRKKLQK...MGWPEHTPGT → MRPDGQQALD...RRGRDGTCTG

    Show »
    Length:619
    Mass (Da):71,130
    Checksum:i2FEAB258AB1687C5
    GO
    Isoform 4 (identifier: Q9NR80-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         641-690: AVGRPCYLTR...SISRLAPFRK → GRRTAAPPPRLPGPYPADIIPFSEPQSQAS

    Show »
    Length:670
    Mass (Da):76,420
    Checksum:i90161166120CE37C
    GO

    Sequence cautioni

    The sequence AAF79955.1 differs from that shown. Reason: Frameshift at positions 638 and 643.
    The sequence AAF79955.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA83064.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331D → H.
    Corresponds to variant rs10188052 [ dbSNP | Ensembl ].
    VAR_057187
    Natural varianti100 – 1001K → R in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035970
    Natural varianti441 – 4411T → R in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035971

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7171Missing in isoform 3. 1 PublicationVSP_011617Add
    BLAST
    Alternative sequencei72 – 14271EKTQR…HTPGT → MRPDGQQALDAVVRSFDCHS EAALRQRNDVIYCSLPRTAQ GIVQREDQLEVLVSLREVWG RRRGRDGTCTG in isoform 3. 1 PublicationVSP_011618Add
    BLAST
    Alternative sequencei641 – 69050AVGRP…APFRK → GRRTAAPPPRLPGPYPADII PFSEPQSQAS in isoform 4. 1 PublicationVSP_037119Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF249745 mRNA. Translation: AAF79955.1. Sequence problems.
    AB042199 mRNA. Translation: BAB11941.1.
    AB029035 mRNA. Translation: BAA83064.1. Different initiation.
    CCDSiCCDS2165.1. [Q9NR80-1]
    CCDS42754.1. [Q9NR80-4]
    RefSeqiNP_056135.2. NM_015320.3. [Q9NR80-1]
    NP_127462.1. NM_032995.2. [Q9NR80-4]
    XP_005263743.1. XM_005263686.1. [Q9NR80-3]
    XP_005275988.2. XM_005275931.2. [Q9NR80-3]
    UniGeneiHs.469935.

    Genome annotation databases

    EnsembliENST00000326016; ENSP00000316845; ENSG00000136002. [Q9NR80-1]
    ENST00000355771; ENSP00000348017; ENSG00000136002. [Q9NR80-3]
    ENST00000392953; ENSP00000376680; ENSG00000136002. [Q9NR80-4]
    ENST00000525839; ENSP00000432267; ENSG00000136002. [Q9NR80-4]
    GeneIDi101930241.
    50649.
    KEGGihsa:101930241.
    hsa:50649.
    UCSCiuc002tsa.1. human. [Q9NR80-1]
    uc002tsb.1. human. [Q9NR80-4]

    Polymorphism databases

    DMDMi229463003.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF249745 mRNA. Translation: AAF79955.1 . Sequence problems.
    AB042199 mRNA. Translation: BAB11941.1 .
    AB029035 mRNA. Translation: BAA83064.1 . Different initiation.
    CCDSi CCDS2165.1. [Q9NR80-1 ]
    CCDS42754.1. [Q9NR80-4 ]
    RefSeqi NP_056135.2. NM_015320.3. [Q9NR80-1 ]
    NP_127462.1. NM_032995.2. [Q9NR80-4 ]
    XP_005263743.1. XM_005263686.1. [Q9NR80-3 ]
    XP_005275988.2. XM_005275931.2. [Q9NR80-3 ]
    UniGenei Hs.469935.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DX1 X-ray 2.36 A 143-611 [» ]
    2PZ1 X-ray 2.25 A 170-632 [» ]
    3NMX X-ray 2.30 D/E/F 170-194 [» ]
    3NMZ X-ray 3.01 C/D 170-276 [» ]
    ProteinModelPortali Q9NR80.
    SMRi Q9NR80. Positions 171-611.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119114. 5 interactions.
    DIPi DIP-40814N.
    IntActi Q9NR80. 3 interactions.
    MINTi MINT-142950.
    STRINGi 9606.ENSP00000316845.

    PTM databases

    PhosphoSitei Q9NR80.

    Polymorphism databases

    DMDMi 229463003.

    Proteomic databases

    PaxDbi Q9NR80.
    PRIDEi Q9NR80.

    Protocols and materials databases

    DNASUi 50649.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326016 ; ENSP00000316845 ; ENSG00000136002 . [Q9NR80-1 ]
    ENST00000355771 ; ENSP00000348017 ; ENSG00000136002 . [Q9NR80-3 ]
    ENST00000392953 ; ENSP00000376680 ; ENSG00000136002 . [Q9NR80-4 ]
    ENST00000525839 ; ENSP00000432267 ; ENSG00000136002 . [Q9NR80-4 ]
    GeneIDi 101930241.
    50649.
    KEGGi hsa:101930241.
    hsa:50649.
    UCSCi uc002tsa.1. human. [Q9NR80-1 ]
    uc002tsb.1. human. [Q9NR80-4 ]

    Organism-specific databases

    CTDi 50649.
    GeneCardsi GC02P131595.
    HGNCi HGNC:684. ARHGEF4.
    HPAi HPA018267.
    MIMi 605216. gene.
    neXtProti NX_Q9NR80.
    PharmGKBi PA24974.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5422.
    HOGENOMi HOG000237363.
    HOVERGENi HBG050568.
    KOi K05769.
    OMAi INILIRP.
    PhylomeDBi Q9NR80.
    TreeFami TF316832.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Miscellaneous databases

    EvolutionaryTracei Q9NR80.
    GeneWikii ARHGEF4.
    GenomeRNAii 50649.
    NextBioi 53194.
    PROi Q9NR80.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NR80.
    Bgeei Q9NR80.
    CleanExi HS_ARHGEF4.
    Genevestigatori Q9NR80.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001331. GDS_CDC24_CS.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS00741. DH_1. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22."
      Thiesen S., Kuebart S., Ropers H.-H., Nothwang H.G.
      Biochem. Biophys. Res. Commun. 273:364-369(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Asef, a link between the tumor suppressor APC and G-protein signaling."
      Kawasaki Y., Senda T., Ishidate T., Koyama R., Morishita T., Iwayama Y., Higuchi O., Akiyama T.
      Science 289:1194-1197(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH APC; RHOA AND RAC1, IDENTIFICATION IN A COMPLEX WITH APC AND CTNNB1.
      Tissue: Fetal brain.
    3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. "Mutated APC and Asef are involved in the migration of colorectal tumour cells."
      Kawasaki Y., Sato R., Akiyama T.
      Nat. Cell Biol. 5:211-215(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element."
      Hamann M.J., Lubking C.M., Luchini D.N., Billadeau D.D.
      Mol. Cell. Biol. 27:1380-1393(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    7. "Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42."
      Kawasaki Y., Sagara M., Shibata Y., Shirouzu M., Yokoyama S., Akiyama T.
      Oncogene 26:7620-7627(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."
      Kawasaki Y., Tsuji S., Muroya K., Furukawa S., Shibata Y., Okuno M., Ohwada S., Akiyama T.
      EMBO Rep. 10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    9. Cited for: X-RAY CRYSTALLOGRAPHY (2.36 ANGSTROMS) OF 143-611, SH3 DOMAIN.
    10. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-100 AND ARG-441.

    Entry informationi

    Entry nameiARHG4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR80
    Secondary accession number(s): Q9HDC6, Q9UPP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3