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Protein

Peroxisomal membrane protein 2

Gene

PXMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

Protein family/group databases

TCDBi9.B.192.1.3. the mpv17/pmp22 4 tms putative porin (mpv17) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 2
Alternative name(s):
22 kDa peroxisomal membrane protein
Gene namesi
Name:PXMP2
Synonyms:PMP22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9716. PXMP2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3029CytoplasmicSequence analysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence analysisAdd
BLAST
Topological domaini52 – 7524PeroxisomalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Topological domaini97 – 11418CytoplasmicSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Topological domaini136 – 17338PeroxisomalSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • peroxisomal membrane Source: UniProtKB
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34059.

Polymorphism and mutation databases

DMDMi27923831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 195194Peroxisomal membrane protein 2PRO_0000218929Add
BLAST

Proteomic databases

EPDiQ9NR77.
MaxQBiQ9NR77.
PaxDbiQ9NR77.
PRIDEiQ9NR77.
TopDownProteomicsiQ9NR77.

Expressioni

Gene expression databases

BgeeiQ9NR77.
CleanExiHS_PMP22.
HS_PXMP2.
ExpressionAtlasiQ9NR77. baseline and differential.
GenevisibleiQ9NR77. HS.

Interactioni

Subunit structurei

Interacts with PEX19 and SIVA1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX19P408552EBI-1392944,EBI-594747
SIVA1O153043EBI-1392944,EBI-520756

Protein-protein interaction databases

BioGridi111785. 18 interactions.
IntActiQ9NR77. 2 interactions.
MINTiMINT-3072799.
STRINGi9606.ENSP00000321271.

Structurei

3D structure databases

ProteinModelPortaliQ9NR77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1944. Eukaryota.
ENOG4111SYH. LUCA.
GeneTreeiENSGT00530000063005.
HOGENOMiHOG000008014.
HOVERGENiHBG052506.
InParanoidiQ9NR77.
KOiK13347.
OMAiSHYFYLL.
OrthoDBiEOG7D59PW.
PhylomeDBiQ9NR77.
TreeFamiTF105311.

Family and domain databases

InterProiIPR007248. Mpv17_PMP22.
[Graphical view]
PANTHERiPTHR11266. PTHR11266. 1 hit.
PfamiPF04117. Mpv17_PMP22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NR77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAASRLRA EAGLGALPRR ALAQYLLFLR LYPVLTKAAT SGILSALGNF
60 70 80 90 100
LAQMIEKKRK KENSRSLDVG GPLRYAVYGF FFTGPLSHFF YFFMEHWIPP
110 120 130 140 150
EVPLAGLRRL LLDRLVFAPA FLMLFFLIMN FLEGKDASAF AAKMRGGFWP
160 170 180 190
ALRMNWRVWT PLQFININYV PLKFRVLFAN LAALFWYAYL ASLGK
Length:195
Mass (Da):22,253
Last modified:January 23, 2007 - v3
Checksum:i9CA7FD67F8391E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250136 mRNA. Translation: AAF73963.1.
AY044439 mRNA. Translation: AAK95858.1.
BC073997 mRNA. Translation: AAH73997.1.
CCDSiCCDS9279.1.
RefSeqiNP_061133.1. NM_018663.2.
UniGeneiHs.430299.

Genome annotation databases

EnsembliENST00000317479; ENSP00000321271; ENSG00000176894.
GeneIDi5827.
KEGGihsa:5827.
UCSCiuc001ukt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250136 mRNA. Translation: AAF73963.1.
AY044439 mRNA. Translation: AAK95858.1.
BC073997 mRNA. Translation: AAH73997.1.
CCDSiCCDS9279.1.
RefSeqiNP_061133.1. NM_018663.2.
UniGeneiHs.430299.

3D structure databases

ProteinModelPortaliQ9NR77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111785. 18 interactions.
IntActiQ9NR77. 2 interactions.
MINTiMINT-3072799.
STRINGi9606.ENSP00000321271.

Protein family/group databases

TCDBi9.B.192.1.3. the mpv17/pmp22 4 tms putative porin (mpv17) family.

Polymorphism and mutation databases

DMDMi27923831.

Proteomic databases

EPDiQ9NR77.
MaxQBiQ9NR77.
PaxDbiQ9NR77.
PRIDEiQ9NR77.
TopDownProteomicsiQ9NR77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317479; ENSP00000321271; ENSG00000176894.
GeneIDi5827.
KEGGihsa:5827.
UCSCiuc001ukt.3. human.

Organism-specific databases

CTDi5827.
GeneCardsiPXMP2.
HGNCiHGNC:9716. PXMP2.
neXtProtiNX_Q9NR77.
PharmGKBiPA34059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1944. Eukaryota.
ENOG4111SYH. LUCA.
GeneTreeiENSGT00530000063005.
HOGENOMiHOG000008014.
HOVERGENiHBG052506.
InParanoidiQ9NR77.
KOiK13347.
OMAiSHYFYLL.
OrthoDBiEOG7D59PW.
PhylomeDBiQ9NR77.
TreeFamiTF105311.

Miscellaneous databases

GenomeRNAii5827.
PROiQ9NR77.

Gene expression databases

BgeeiQ9NR77.
CleanExiHS_PMP22.
HS_PXMP2.
ExpressionAtlasiQ9NR77. baseline and differential.
GenevisibleiQ9NR77. HS.

Family and domain databases

InterProiIPR007248. Mpv17_PMP22.
[Graphical view]
PANTHERiPTHR11266. PTHR11266. 1 hit.
PfamiPF04117. Mpv17_PMP22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Modulation of endothelium by tumor environment."
    Bani M.R., Giavazzi R.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes."
    Brosius U., Dehmel T., Gaertner J.
    J. Biol. Chem. 277:774-784(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retinoblastoma.
  4. "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis."
    Sacksteder K.A., Jones J.M., South S.T., Li X., Liu Y., Gould S.J.
    J. Cell Biol. 148:931-944(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PEX19.
  5. "The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22."
    Nestler M., Martin U., Hortschansky P., Saluz H.-P., Henke A., Munder T.
    Mol. Cell. Biochem. 287:147-155(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SIVA1.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPXMP2_HUMAN
AccessioniPrimary (citable) accession number: Q9NR77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.