Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal membrane protein 2

Gene

PXMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.

Enzyme and pathway databases

ReactomeiR-HSA-389661. Glyoxylate metabolism and glycine degradation.

Protein family/group databases

TCDBi9.B.192.1.3. the mpv17/pmp22 4 tms putative porin (mpv17) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 2
Alternative name(s):
22 kDa peroxisomal membrane protein
Gene namesi
Name:PXMP2
Synonyms:PMP22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9716. PXMP2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 75PeroxisomalSequence analysisAdd BLAST24
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 114CytoplasmicSequence analysisAdd BLAST18
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 173PeroxisomalSequence analysisAdd BLAST38
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • integral component of peroxisomal membrane Source: GO_Central
  • membrane Source: UniProtKB
  • peroxisomal membrane Source: UniProtKB
  • protein complex Source: UniProtKB

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi5827.
OpenTargetsiENSG00000176894.
PharmGKBiPA34059.

Polymorphism and mutation databases

DMDMi27923831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189291 – 195Peroxisomal membrane protein 2Add BLAST195

Proteomic databases

EPDiQ9NR77.
MaxQBiQ9NR77.
PaxDbiQ9NR77.
PeptideAtlasiQ9NR77.
PRIDEiQ9NR77.
TopDownProteomicsiQ9NR77.

PTM databases

PhosphoSitePlusiQ9NR77.

Expressioni

Gene expression databases

BgeeiENSG00000176894.
CleanExiHS_PMP22.
HS_PXMP2.
ExpressionAtlasiQ9NR77. baseline and differential.
GenevisibleiQ9NR77. HS.

Interactioni

Subunit structurei

Interacts with PEX19 and SIVA1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111785. 23 interactors.
IntActiQ9NR77. 3 interactors.
MINTiMINT-3072799.
STRINGi9606.ENSP00000321271.

Structurei

3D structure databases

ProteinModelPortaliQ9NR77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1944. Eukaryota.
ENOG4111SYH. LUCA.
GeneTreeiENSGT00530000063005.
HOGENOMiHOG000008014.
HOVERGENiHBG052506.
InParanoidiQ9NR77.
KOiK13347.
OMAiNWKVWTP.
PhylomeDBiQ9NR77.
TreeFamiTF105311.

Family and domain databases

InterProiView protein in InterPro
IPR007248. Mpv17_PMP22.
PANTHERiPTHR11266. PTHR11266. 1 hit.
PfamiView protein in Pfam
PF04117. Mpv17_PMP22. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NR77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAASRLRA EAGLGALPRR ALAQYLLFLR LYPVLTKAAT SGILSALGNF
60 70 80 90 100
LAQMIEKKRK KENSRSLDVG GPLRYAVYGF FFTGPLSHFF YFFMEHWIPP
110 120 130 140 150
EVPLAGLRRL LLDRLVFAPA FLMLFFLIMN FLEGKDASAF AAKMRGGFWP
160 170 180 190
ALRMNWRVWT PLQFININYV PLKFRVLFAN LAALFWYAYL ASLGK
Length:195
Mass (Da):22,253
Last modified:January 23, 2007 - v3
Checksum:i9CA7FD67F8391E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250136 mRNA. Translation: AAF73963.1.
AY044439 mRNA. Translation: AAK95858.1.
BC073997 mRNA. Translation: AAH73997.1.
CCDSiCCDS9279.1.
RefSeqiNP_061133.1. NM_018663.2.
UniGeneiHs.430299.

Genome annotation databases

EnsembliENST00000317479; ENSP00000321271; ENSG00000176894.
GeneIDi5827.
KEGGihsa:5827.
UCSCiuc001ukt.3. human.

Similar proteinsi

Entry informationi

Entry nameiPXMP2_HUMAN
AccessioniPrimary (citable) accession number: Q9NR77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families