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Protein

Kelch-like protein 1

Gene

KLHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in organizing the actin cytoskeleton of the brain cells.

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 1
Gene namesi
Name:KLHL1
Synonyms:KIAA1490
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6352. KLHL1.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: GO_Central
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • dendrite Source: GO_Central
  • neuronal cell body Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi57626.
OpenTargetsiENSG00000150361.
PharmGKBiPA30142.

Polymorphism and mutation databases

BioMutaiKLHL1.
DMDMi13431647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190991 – 748Kelch-like protein 1Add BLAST748

Proteomic databases

MaxQBiQ9NR64.
PaxDbiQ9NR64.
PeptideAtlasiQ9NR64.
PRIDEiQ9NR64.

PTM databases

iPTMnetiQ9NR64.
PhosphoSitePlusiQ9NR64.

Expressioni

Tissue specificityi

Highly expressed in brain.

Gene expression databases

BgeeiENSG00000150361.
CleanExiHS_KLHL1.
ExpressionAtlasiQ9NR64. baseline and differential.
GenevisibleiQ9NR64. HS.

Organism-specific databases

HPAiHPA021196.

Interactioni

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121671. 6 interactors.
IntActiQ9NR64. 9 interactors.
STRINGi9606.ENSP00000367075.

Structurei

3D structure databases

ProteinModelPortaliQ9NR64.
SMRiQ9NR64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 279BTBPROSITE-ProRule annotationAdd BLAST68
Repeati460 – 506Kelch 1Add BLAST47
Repeati507 – 553Kelch 2Add BLAST47
Repeati555 – 600Kelch 3Add BLAST46
Repeati601 – 647Kelch 4Add BLAST47
Repeati649 – 700Kelch 5Add BLAST52
Repeati701 – 747Kelch 6Add BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 88Ser-richAdd BLAST46

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiQ9NR64.
KOiK10442.
OMAiDVCCHFL.
OrthoDBiEOG091G04QJ.
PhylomeDBiQ9NR64.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NR64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSGRKDFD VKHILRLRWK LFSHPSPSTG GPAGGGCLQQ DGSGSFEHWG
60 70 80 90 100
PSQSRLLKSQ ERSGVSTFWK KPSSSSSSSS SPSSSSSSFN PLNGTLLPVA
110 120 130 140 150
TRLQQGAPGQ GTQQPARTLF YVESLEEEVV PGMDFPGPHE KGLVLQELKV
160 170 180 190 200
EPDNSSQATG EGCGHRLSST GHSMTPQSDL DSSSSEEFYQ AVHHAEQTFR
210 220 230 240 250
KMESYLKQQQ LCDVILIVGN RKIPAHRLVL SSVSDYFAAM FTSDVCEAKQ
260 270 280 290 300
EEIKMEGIDP NALWDLVQFA YTGCLELKED TIENLLAAAC LLQLPQVVEV
310 320 330 340 350
CCHFLMKLLH PSNCLGIRAF ADAQGCIELM KVAHSYTMEN IMEVIRNQEF
360 370 380 390 400
LLLPAEELHK LLASDDVNVP DEETIFHALM MWVKYDMQSR CNDLSMLLAF
410 420 430 440 450
IRLPLLPPQI LADLENHALF KNDLECQKLI LEAMKYHLLP ERRTLMQSPR
460 470 480 490 500
TKPRKSTVGT LYAVGGMDNN KGATTIEKYD LRTNLWIQAG MMNGRRLQFG
510 520 530 540 550
VAVIDDKLFV IGGRDGLKTL NTVECYNPKT KTWTVLPPMS THRHGLGVTV
560 570 580 590 600
LEGPIYAVGG HDGWSYLNTV ERWDPQSQQW TFVASMSIAR STVGVAALNG
610 620 630 640 650
KLYSVGGRDG SSCLSSMEYY DPHTNKWNMC APMCKRRGGV GVATCDGFLY
660 670 680 690 700
AVGGHDAPAS NHCSRLLDYV ERYDPKTDTW TMVAPLSMPR DAVGVCLLGD
710 720 730 740
RLYAVGGYDG QTYLNTMESY DPQTNEWTQM ASLNIGRAGA CVVVIKQP
Length:748
Mass (Da):82,680
Last modified:October 1, 2000 - v1
Checksum:iC11C43D8282F9FF9
GO

Sequence cautioni

The sequence BAA96014 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252283 mRNA. Translation: AAF81719.1.
AF252279 Genomic DNA. Translation: AAF81716.1.
AB040923 mRNA. Translation: BAA96014.1. Different initiation.
AK291435 mRNA. Translation: BAF84124.1.
AL160391
, AL162378, AL353738, AL356384 Genomic DNA. Translation: CAH70258.2.
AL162378
, AL160391, AL353738, AL356384 Genomic DNA. Translation: CAH73330.2.
AL353738
, AL160391, AL162378, AL356384 Genomic DNA. Translation: CAH71287.2.
AL356384
, AL160391, AL162378, AL353738 Genomic DNA. Translation: CAH73834.2.
CH471093 Genomic DNA. Translation: EAW80503.1.
CCDSiCCDS9445.1.
RefSeqiNP_001273654.1. NM_001286725.1.
NP_065917.1. NM_020866.2.
UniGeneiHs.508201.

Genome annotation databases

EnsembliENST00000377844; ENSP00000367075; ENSG00000150361.
GeneIDi57626.
KEGGihsa:57626.
UCSCiuc001vip.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252283 mRNA. Translation: AAF81719.1.
AF252279 Genomic DNA. Translation: AAF81716.1.
AB040923 mRNA. Translation: BAA96014.1. Different initiation.
AK291435 mRNA. Translation: BAF84124.1.
AL160391
, AL162378, AL353738, AL356384 Genomic DNA. Translation: CAH70258.2.
AL162378
, AL160391, AL353738, AL356384 Genomic DNA. Translation: CAH73330.2.
AL353738
, AL160391, AL162378, AL356384 Genomic DNA. Translation: CAH71287.2.
AL356384
, AL160391, AL162378, AL353738 Genomic DNA. Translation: CAH73834.2.
CH471093 Genomic DNA. Translation: EAW80503.1.
CCDSiCCDS9445.1.
RefSeqiNP_001273654.1. NM_001286725.1.
NP_065917.1. NM_020866.2.
UniGeneiHs.508201.

3D structure databases

ProteinModelPortaliQ9NR64.
SMRiQ9NR64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121671. 6 interactors.
IntActiQ9NR64. 9 interactors.
STRINGi9606.ENSP00000367075.

PTM databases

iPTMnetiQ9NR64.
PhosphoSitePlusiQ9NR64.

Polymorphism and mutation databases

BioMutaiKLHL1.
DMDMi13431647.

Proteomic databases

MaxQBiQ9NR64.
PaxDbiQ9NR64.
PeptideAtlasiQ9NR64.
PRIDEiQ9NR64.

Protocols and materials databases

DNASUi57626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377844; ENSP00000367075; ENSG00000150361.
GeneIDi57626.
KEGGihsa:57626.
UCSCiuc001vip.4. human.

Organism-specific databases

CTDi57626.
DisGeNETi57626.
GeneCardsiKLHL1.
HGNCiHGNC:6352. KLHL1.
HPAiHPA021196.
MIMi605332. gene.
neXtProtiNX_Q9NR64.
OpenTargetsiENSG00000150361.
PharmGKBiPA30142.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOGENOMiHOG000230814.
HOVERGENiHBG014286.
InParanoidiQ9NR64.
KOiK10442.
OMAiDVCCHFL.
OrthoDBiEOG091G04QJ.
PhylomeDBiQ9NR64.
TreeFamiTF329218.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150361-MONOMER.

Miscellaneous databases

ChiTaRSiKLHL1. human.
GeneWikiiKLHL1.
GenomeRNAii57626.
PROiQ9NR64.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150361.
CleanExiHS_KLHL1.
ExpressionAtlasiQ9NR64. baseline and differential.
GenevisibleiQ9NR64. HS.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLHL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NR64
Secondary accession number(s): A8K5X0
, Q5VZ64, Q9H4X4, Q9NR65, Q9P238
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.