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Q9NR63

- CP26B_HUMAN

UniProt

Q9NR63 - CP26B_HUMAN

Protein

Cytochrome P450 26B1

Gene

CYP26B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.2 Publications

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi441 – 4411Iron (heme axial ligand)Sequence Analysis

    GO - Molecular functioni

    1. heme binding Source: BHF-UCL
    2. iron ion binding Source: InterPro
    3. retinoic acid 4-hydroxylase activity Source: BHF-UCL
    4. retinoic acid binding Source: BHF-UCL

    GO - Biological processi

    1. bone morphogenesis Source: UniProtKB
    2. cell fate determination Source: BHF-UCL
    3. cellular response to retinoic acid Source: Ensembl
    4. embryonic limb morphogenesis Source: BHF-UCL
    5. male meiosis Source: BHF-UCL
    6. negative regulation of retinoic acid receptor signaling pathway Source: BHF-UCL
    7. oxidation-reduction process Source: BHF-UCL
    8. positive regulation of gene expression Source: Ensembl
    9. positive regulation of tongue muscle cell differentiation Source: Ensembl
    10. proximal/distal pattern formation Source: BHF-UCL
    11. retinoic acid catabolic process Source: BHF-UCL
    12. retinoic acid receptor signaling pathway Source: Ensembl
    13. small molecule metabolic process Source: Reactome
    14. spermatogenesis Source: BHF-UCL
    15. tongue morphogenesis Source: Ensembl
    16. vitamin metabolic process Source: Reactome
    17. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13450. Vitamins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 26B1 (EC:1.14.-.-)
    Alternative name(s):
    Cytochrome P450 26A2
    Cytochrome P450 retinoic acid-inactivating 2
    Short name:
    Cytochrome P450RAI-2
    Retinoic acid-metabolizing cytochrome
    Gene namesi
    Name:CYP26B1
    Synonyms:CYP26A2, P450RAI2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20581. CYP26B1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum membrane Source: Reactome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Involvement in diseasei

    Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) [MIM:614416]: A disease characterized by craniofacial malformations, occipital encephalocele, radiohumeral fusions, oligodactyly, advanced osseous maturation, and calvarial mineralization defects.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti146 – 1461S → P in RHFCA. 1 Publication
    Corresponds to variant rs281875232 [ dbSNP | Ensembl ].
    VAR_067923
    Natural varianti363 – 3631R → L in RHFCA. 1 Publication
    Corresponds to variant rs281875231 [ dbSNP | Ensembl ].
    VAR_067924

    Keywords - Diseasei

    Craniosynostosis, Disease mutation

    Organism-specific databases

    MIMi614416. phenotype.
    Orphaneti293925. Lethal occipital encephalocele-skeletal dysplasia syndrome.
    PharmGKBiPA134879191.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Cytochrome P450 26B1PRO_0000051985Add
    BLAST

    Proteomic databases

    MaxQBiQ9NR63.
    PaxDbiQ9NR63.
    PRIDEiQ9NR63.

    PTM databases

    PhosphoSiteiQ9NR63.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, particularly in the cerebellum and pons.1 Publication

    Inductioni

    By retinoic acid.

    Gene expression databases

    ArrayExpressiQ9NR63.
    BgeeiQ9NR63.
    CleanExiHS_CYP26B1.
    GenevestigatoriQ9NR63.

    Organism-specific databases

    HPAiHPA012567.

    Interactioni

    Protein-protein interaction databases

    BioGridi121153. 2 interactions.
    STRINGi9606.ENSP00000001146.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NR63.
    SMRiQ9NR63. Positions 32-493.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000220829.
    HOVERGENiHBG051099.
    InParanoidiQ9NR63.
    KOiK12664.
    OMAiWSSQPEA.
    OrthoDBiEOG7F24SP.
    PhylomeDBiQ9NR63.
    TreeFamiTF105093.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00465. EP450IV.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NR63-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLFEGLDLVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP    50
    KGSMGFPLIG ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE 100
    NVRKILMGEH HLVSTEWPRS TRMLLGPNTV SNSIGDIHRN KRKVFSKIFS 150
    HEALESYLPK IQLVIQDTLR AWSSHPEAIN VYQEAQKLTF RMAIRVLLGF 200
    SIPEEDLGHL FEVYQQFVDN VFSLPVDLPF SGYRRGIQAR QILQKGLEKA 250
    IREKLQCTQG KDYLDALDLL IESSKEHGKE MTMQELKDGT LELIFAAYAT 300
    TASASTSLIM QLLKHPTVLE KLRDELRAHG ILHSGGCPCE GTLRLDTLSG 350
    LRYLDCVIKE VMRLFTPISG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH 400
    DTAPVFKDVN VFDPDRFSQA RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF 450
    LKVLAVELAS TSRFELATRT FPRITLVPVL HPVDGLSVKF FGLDSNQNEI 500
    LPETEAMLSA TV 512
    Length:512
    Mass (Da):57,513
    Last modified:October 1, 2000 - v1
    Checksum:iA06D1D9944E6726F
    GO
    Isoform 2 (identifier: Q9NR63-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         69-143: Missing.

    Show »
    Length:437
    Mass (Da):49,007
    Checksum:i85CA080EB0045520
    GO
    Isoform 3 (identifier: Q9NR63-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-67: MLFEGLDLVS...LIGETGHWLL → MKNKTCVLVC...TLRETRVWLP

    Note: No experimental confirmation available.

    Show »
    Length:495
    Mass (Da):55,756
    Checksum:iF5BBD7200E20573B
    GO

    Sequence cautioni

    The sequence BAH12154.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti265 – 2651D → G in BAH11930. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti146 – 1461S → P in RHFCA. 1 Publication
    Corresponds to variant rs281875232 [ dbSNP | Ensembl ].
    VAR_067923
    Natural varianti181 – 1811V → M.1 Publication
    VAR_038722
    Natural varianti185 – 1851A → V.1 Publication
    VAR_038723
    Natural varianti191 – 1911R → H.1 Publication
    Corresponds to variant rs76025186 [ dbSNP | Ensembl ].
    VAR_038724
    Natural varianti227 – 2271D → N.1 Publication
    VAR_038725
    Natural varianti264 – 2641L → S.3 Publications
    Corresponds to variant rs2241057 [ dbSNP | Ensembl ].
    VAR_024383
    Natural varianti363 – 3631R → L in RHFCA. 1 Publication
    Corresponds to variant rs281875231 [ dbSNP | Ensembl ].
    VAR_067924
    Natural varianti380 – 3801E → K.1 Publication
    Corresponds to variant rs2286965 [ dbSNP | Ensembl ].
    VAR_038726
    Natural varianti420 – 4201A → G.1 Publication
    Corresponds to variant rs7568553 [ dbSNP | Ensembl ].
    VAR_038727
    Natural varianti473 – 4731R → C.1 Publication
    Corresponds to variant rs61751056 [ dbSNP | Ensembl ].
    VAR_038728
    Natural varianti479 – 4791V → I.1 Publication
    Corresponds to variant rs148075682 [ dbSNP | Ensembl ].
    VAR_038729

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6767MLFEG…GHWLL → MKNKTCVLVCVSVFGGERGQ VTVPRVGVRRPSLAGPLQKC TLRETRVWLP in isoform 3. 1 PublicationVSP_042967Add
    BLAST
    Alternative sequencei69 – 14375Missing in isoform 2. 2 PublicationsVSP_042968Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF252297 mRNA. Translation: AAF76003.1.
    FJ467289 mRNA. Translation: ACR19332.1.
    AK294814 mRNA. Translation: BAH11892.1.
    AK294933 mRNA. Translation: BAH11930.1.
    AK295683 mRNA. Translation: BAH12154.1. Different initiation.
    AK313433 mRNA. Translation: BAG36224.1.
    AC007002 Genomic DNA. Translation: AAY14690.1.
    BC069443 mRNA. Translation: AAH69443.1.
    BC109205 mRNA. Translation: AAI09206.1.
    CCDSiCCDS1919.1. [Q9NR63-1]
    CCDS62934.1. [Q9NR63-2]
    RefSeqiNP_001264671.1. NM_001277742.1. [Q9NR63-2]
    NP_063938.1. NM_019885.3. [Q9NR63-1]
    UniGeneiHs.91546.

    Genome annotation databases

    EnsembliENST00000001146; ENSP00000001146; ENSG00000003137. [Q9NR63-1]
    ENST00000546307; ENSP00000443304; ENSG00000003137. [Q9NR63-2]
    GeneIDi56603.
    KEGGihsa:56603.
    UCSCiuc002sih.2. human. [Q9NR63-1]
    uc010yra.1. human. [Q9NR63-3]
    uc010yrb.2. human. [Q9NR63-2]

    Polymorphism databases

    DMDMi20137526.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF252297 mRNA. Translation: AAF76003.1 .
    FJ467289 mRNA. Translation: ACR19332.1 .
    AK294814 mRNA. Translation: BAH11892.1 .
    AK294933 mRNA. Translation: BAH11930.1 .
    AK295683 mRNA. Translation: BAH12154.1 . Different initiation.
    AK313433 mRNA. Translation: BAG36224.1 .
    AC007002 Genomic DNA. Translation: AAY14690.1 .
    BC069443 mRNA. Translation: AAH69443.1 .
    BC109205 mRNA. Translation: AAI09206.1 .
    CCDSi CCDS1919.1. [Q9NR63-1 ]
    CCDS62934.1. [Q9NR63-2 ]
    RefSeqi NP_001264671.1. NM_001277742.1. [Q9NR63-2 ]
    NP_063938.1. NM_019885.3. [Q9NR63-1 ]
    UniGenei Hs.91546.

    3D structure databases

    ProteinModelPortali Q9NR63.
    SMRi Q9NR63. Positions 32-493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121153. 2 interactions.
    STRINGi 9606.ENSP00000001146.

    PTM databases

    PhosphoSitei Q9NR63.

    Polymorphism databases

    DMDMi 20137526.

    Proteomic databases

    MaxQBi Q9NR63.
    PaxDbi Q9NR63.
    PRIDEi Q9NR63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000001146 ; ENSP00000001146 ; ENSG00000003137 . [Q9NR63-1 ]
    ENST00000546307 ; ENSP00000443304 ; ENSG00000003137 . [Q9NR63-2 ]
    GeneIDi 56603.
    KEGGi hsa:56603.
    UCSCi uc002sih.2. human. [Q9NR63-1 ]
    uc010yra.1. human. [Q9NR63-3 ]
    uc010yrb.2. human. [Q9NR63-2 ]

    Organism-specific databases

    CTDi 56603.
    GeneCardsi GC02M072268.
    HGNCi HGNC:20581. CYP26B1.
    HPAi HPA012567.
    MIMi 605207. gene.
    614416. phenotype.
    neXtProti NX_Q9NR63.
    Orphaneti 293925. Lethal occipital encephalocele-skeletal dysplasia syndrome.
    PharmGKBi PA134879191.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000220829.
    HOVERGENi HBG051099.
    InParanoidi Q9NR63.
    KOi K12664.
    OMAi WSSQPEA.
    OrthoDBi EOG7F24SP.
    PhylomeDBi Q9NR63.
    TreeFami TF105093.

    Enzyme and pathway databases

    Reactomei REACT_13450. Vitamins.

    Miscellaneous databases

    GeneWikii CYP26B1.
    GenomeRNAii 56603.
    NextBioi 62039.
    PROi Q9NR63.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NR63.
    Bgeei Q9NR63.
    CleanExi HS_CYP26B1.
    Genevestigatori Q9NR63.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00465. EP450IV.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism."
      White J.A., Ramshaw H., Taimi M., Stangle W., Zhang A., Everingham S., Creighton S., Tam S.-P., Jones G., Petkovich M.
      Proc. Natl. Acad. Sci. U.S.A. 97:6403-6408(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Retina.
    2. "A spliced version of the human cytochrome P450 26B1 has an alternative function in retinoic acid metabolism."
      Savenstrand H., Kumawat A., Karlsson M., Eriksson L.A., Sirsjo A., Strid A.
      Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT SER-264.
      Tissue: Vascular smooth muscle.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT SER-264.
      Tissue: Brain, Cerebellum and Hippocampus.
    4. SeattleSNPs variation discovery resource
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-181; VAL-185; HIS-191; ASN-227; SER-264; LYS-380; GLY-420; CYS-473 AND ILE-479.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid."
      Laue K., Pogoda H.M., Daniel P.B., van Haeringen A., Alanay Y., von Ameln S., Rachwalski M., Morgan T., Gray M.J., Breuning M.H., Sawyer G.M., Sutherland-Smith A.J., Nikkels P.G., Kubisch C., Bloch W., Wollnik B., Hammerschmidt M., Robertson S.P.
      Am. J. Hum. Genet. 89:595-606(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, VARIANTS RHFCA PRO-146 AND LEU-363.

    Entry informationi

    Entry nameiCP26B_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR63
    Secondary accession number(s): B2R8M7
    , B7Z2K6, B7Z2P4, B7Z3B8, E4W5W7, Q32MC0, Q53TW1, Q9NP41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3