Reviewed,
UniProtKB/Swiss-Prot Q9NR61 (DLL4_HUMAN)
Last modified
February 9, 2010.
Version 89.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Delta-like protein 4 Alternative name(s): Drosophila Delta homolog 4 Short name=Delta4 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 685 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 By similarity. |
| Subunit structure | Binds to Notch-1 and Notch-4 By similarity. |
| Subcellular location | Membrane; Single-pass type I membrane protein Probable. |
| Tissue specificity | Expressed in vascular endothelium. |
| Domain | The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor. |
| Post-translational modification | Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation By similarity. |
| Sequence similarities | Contains 1 DSL domain. Contains 8 EGF-like domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Differentiation Notch signaling pathway |
| Cellular component | Membrane |
| Domain | EGF-like domain Repeat Signal Transmembrane |
| Molecular function | Developmental protein |
| PTM | Disulfide bond Glycoprotein Ubl conjugation |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | Notch signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW blood circulation Ref.1Traceable author statement. Source: ProtInc cell differentiationInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | Notch binding Ref.1 Traceable author statement. Source: ProtInc calcium ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 26 | 26 | Ref.6 | ||||||||
| Chain | 27 – 685 | 659 | Delta-like protein 4 | PRO_0000007512 | |||||||
Regions | |||||||||||
| Topological domain | 27 – 529 | 503 | Extracellular Potential | ||||||||
| Transmembrane | 530 – 550 | 21 | Potential | ||||||||
| Topological domain | 551 – 685 | 135 | Cytoplasmic Potential | ||||||||
| Domain | 173 – 217 | 45 | DSL | ||||||||
| Domain | 218 – 251 | 34 | EGF-like 1 | ||||||||
| Domain | 252 – 282 | 31 | EGF-like 2 | ||||||||
| Domain | 284 – 322 | 39 | EGF-like 3 | ||||||||
| Domain | 324 – 360 | 37 | EGF-like 4 | ||||||||
| Domain | 362 – 400 | 39 | EGF-like 5 | ||||||||
| Domain | 402 – 438 | 37 | EGF-like 6 | ||||||||
| Domain | 440 – 476 | 37 | EGF-like 7 | ||||||||
| Domain | 480 – 518 | 39 | EGF-like 8 | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 108 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 183 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 205 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 393 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 175 ↔ 184 | By similarity | |||||||||
| Disulfide bond | 188 ↔ 200 | By similarity | |||||||||
| Disulfide bond | 208 ↔ 217 | By similarity | |||||||||
| Disulfide bond | 222 ↔ 233 | By similarity | |||||||||
| Disulfide bond | 226 ↔ 239 | By similarity | |||||||||
| Disulfide bond | 241 ↔ 250 | By similarity | |||||||||
| Disulfide bond | 253 ↔ 264 | By similarity | |||||||||
| Disulfide bond | 259 ↔ 270 | By similarity | |||||||||
| Disulfide bond | 272 ↔ 281 | By similarity | |||||||||
| Disulfide bond | 288 ↔ 300 | By similarity | |||||||||
| Disulfide bond | 294 ↔ 310 | By similarity | |||||||||
| Disulfide bond | 312 ↔ 321 | By similarity | |||||||||
| Disulfide bond | 328 ↔ 339 | By similarity | |||||||||
| Disulfide bond | 333 ↔ 348 | By similarity | |||||||||
| Disulfide bond | 350 ↔ 359 | By similarity | |||||||||
| Disulfide bond | 366 ↔ 377 | By similarity | |||||||||
| Disulfide bond | 371 ↔ 388 | By similarity | |||||||||
| Disulfide bond | 390 ↔ 399 | By similarity | |||||||||
| Disulfide bond | 406 ↔ 417 | By similarity | |||||||||
| Disulfide bond | 411 ↔ 426 | By similarity | |||||||||
| Disulfide bond | 428 ↔ 437 | By similarity | |||||||||
| Disulfide bond | 444 ↔ 455 | By similarity | |||||||||
| Disulfide bond | 449 ↔ 464 | By similarity | |||||||||
| Disulfide bond | 466 ↔ 475 | By similarity | |||||||||
| Disulfide bond | 484 ↔ 495 | By similarity | |||||||||
| Disulfide bond | 489 ↔ 506 | By similarity | |||||||||
| Disulfide bond | 508 ↔ 517 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Dll4, a novel Notch ligand expressed in arterial endothelium." Shutter J.R., Scully S., Fan W., Richards W.G., Kitajewski J., Deblandre G.A., Kintner C.R., Stark K.L. Genes Dev. 14:1313-1318(2000) [PubMed: 10837024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Human Delta-2, Notch ligand gene." Sakano S. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Molecular cloning of Delta-4, a new mouse and human Notch ligand." Yoneya T., Tahara T., Nagao K., Yamada Y., Yamamoto T., Miyatani S., Nishikawa M. J. Biochem. 129:27-34(2001) [PubMed: 11134954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 27-41. |
| [7] | "A novel Delta gene expressed in embryonic and tumour vasculature." Mailhos C., Modlich U., Lewis J., Harris A., Bicknell R., Ish-Horowicz D. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-685. Tissue: Placenta. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF253468 mRNA. Translation: AAF76427.1. AB036931 mRNA. Translation: BAB16085.1. AB043894 mRNA. Translation: BAB18581.1. AY358894 mRNA. Translation: AAQ89253.1. BC106950 mRNA. Translation: AAI06951.1. AF279305 mRNA. Translation: AAF81912.1. |
| IPI | IPI00015994. |
| PIR | JC7570. |
| RefSeq | NP_061947.1. |
| UniGene | Hs.511076 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9NR61. |
Proteomic databases | |
| PRIDE | Q9NR61. |
Genome annotation databases | |
| Ensembl | ENST00000249749; ENSP00000249749; ENSG00000128917; Homo sapiens. [Genome view] |
| GeneID | 54567. |
| KEGG | hsa:54567. |
| UCSC | uc001zng.1. human. |
Organism-specific databases | |
| CTD | 54567. |
| GeneCards | GC15P039008. |
| H-InvDB | HIX0038067. |
| HGNC | HGNC:2910. DLL4. |
| MIM | 605185. gene. |
| PharmGKB | PA27366. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG11597. |
| HOGENOM | HBG403082. |
| HOVERGEN | Q9NR61. |
| InParanoid | Q9NR61. |
| OMA | IIEAWHA. |
| OrthoDB | EOG9R52N0. |
| PhylomeDB | Q9NR61. |
Enzyme and pathway databases | |
| Reactome | REACT_299. Signaling by Notch. |
Gene expression databases | |
| ArrayExpress | Q9NR61. |
| Bgee | Q9NR61. |
| CleanEx | HS_DLL4. |
| Genevestigator | Q9NR61. |
| GermOnline | ENSG00000128917. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001774. DSL. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR001438. EGF_2. IPR000742. EGF_3. IPR001881. EGF_Ca_bd. IPR011651. Notch_ligand_N. [Graphical view] |
| Pfam | PF01414. DSL. 1 hit. PF07657. MNNL. 1 hit. [Graphical view] |
| PRINTS | PR00010. EGFBLOOD. |
| SMART | SM00051. DSL. 1 hit. SM00181. EGF. 6 hits. SM00179. EGF_CA. 2 hits. [Graphical view] |
| PROSITE | PS00010. ASX_HYDROXYL. 1 hit. PS51051. DSL. 1 hit. PS00022. EGF_1. 8 hits. PS01186. EGF_2. 7 hits. PS50026. EGF_3. 8 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 57056. |
| SOURCE | Search... |
Entry information
| Entry name | DLL4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NR61 Secondary accession number(s): Q3KP23, Q9NQT9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


