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Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

BATF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Alternative name(s):
21 kDa small nuclear factor isolated from T-cells
Jun dimerization protein p21SNFT
Gene namesi
Name:BATF3
Synonyms:SNFT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000123685.8
HGNCiHGNC:28915 BATF3
MIMi612470 gene
neXtProtiNX_Q9NR55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55509
OpenTargetsiENSG00000123685
PharmGKBiPA162377349

Polymorphism and mutation databases

BioMutaiBATF3
DMDMi74752916

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261061 – 127Basic leucine zipper transcriptional factor ATF-like 3Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NR55
PaxDbiQ9NR55
PeptideAtlasiQ9NR55
PRIDEiQ9NR55
ProteomicsDBi82278

PTM databases

iPTMnetiQ9NR55
PhosphoSitePlusiQ9NR55

Expressioni

Gene expression databases

BgeeiENSG00000123685
CleanExiHS_BATF3
GenevisibleiQ9NR55 HS

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120689, 46 interactors
IntActiQ9NR55, 19 interactors
MINTiQ9NR55
STRINGi9606.ENSP00000243440

Structurei

3D structure databases

ProteinModelPortaliQ9NR55
SMRiQ9NR55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 98bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 62Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni63 – 91Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00390000016869
HOGENOMiHOG000236325
HOVERGENiHBG096186
InParanoidiQ9NR55
KOiK09034
OMAiLTDEMKH
OrthoDBiEOG091G0YSM
PhylomeDBiQ9NR55
TreeFamiTF332340

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029818 p21SNFT
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF13 PTHR23351:SF13, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NR55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ
60 70 80 90 100
RSRKKQTQKA DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK
110 120
MCPLLLCPMN FVPVPPRPDP VAGCLPR
Length:127
Mass (Da):14,468
Last modified:October 1, 2000 - v1
Checksum:i3C595D708D5D4F5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03998811V → I. Corresponds to variant dbSNP:rs2202683Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255346 mRNA Translation: AAF73966.1
AL591647 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93381.1
BC117489 mRNA Translation: AAI17490.1
BC117491 mRNA Translation: AAI17492.1
CCDSiCCDS1508.1
RefSeqiNP_061134.1, NM_018664.2
UniGeneiHs.62919

Genome annotation databases

EnsembliENST00000243440; ENSP00000243440; ENSG00000123685
GeneIDi55509
KEGGihsa:55509
UCSCiuc001hjl.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBATF3_HUMAN
AccessioniPrimary (citable) accession number: Q9NR55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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