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Q9NR55

- BATF3_HUMAN

UniProt

Q9NR55 - BATF3_HUMAN

Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

BATF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens By similarity. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.By similarity3 Publications

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc
    4. transcription corepressor activity Source: ProtInc

    GO - Biological processi

    1. dendritic cell differentiation Source: UniProtKB
    2. myeloid dendritic cell differentiation Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    4. response to virus Source: UniProtKB
    5. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like 3
    Short name:
    B-ATF-3
    Alternative name(s):
    21 kDa small nuclear factor isolated from T-cells
    Jun dimerization protein p21SNFT
    Gene namesi
    Name:BATF3
    Synonyms:SNFT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28915. BATF3.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162377349.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Basic leucine zipper transcriptional factor ATF-like 3PRO_0000326106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NR55.
    PaxDbiQ9NR55.
    PRIDEiQ9NR55.

    PTM databases

    PhosphoSiteiQ9NR55.

    Expressioni

    Gene expression databases

    BgeeiQ9NR55.
    CleanExiHS_BATF3.
    GenevestigatoriQ9NR55.

    Interactioni

    Subunit structurei

    Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.1 Publication

    Protein-protein interaction databases

    BioGridi120689. 18 interactions.
    STRINGi9606.ENSP00000243440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NR55.
    SMRiQ9NR55. Positions 40-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 9864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 6226Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni63 – 9129Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG283780.
    HOGENOMiHOG000236325.
    HOVERGENiHBG096186.
    InParanoidiQ9NR55.
    KOiK09034.
    OMAiCPLLHCT.
    OrthoDBiEOG7H794S.
    PhylomeDBiQ9NR55.
    TreeFamiTF332340.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00042. LEUZIPPRFOS.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NR55-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ    50
    RSRKKQTQKA DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK 100
    MCPLLLCPMN FVPVPPRPDP VAGCLPR 127
    Length:127
    Mass (Da):14,468
    Last modified:October 1, 2000 - v1
    Checksum:i3C595D708D5D4F5F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111V → I.
    Corresponds to variant rs2202683 [ dbSNP | Ensembl ].
    VAR_039988

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255346 mRNA. Translation: AAF73966.1.
    AL591647 Genomic DNA. Translation: CAI17048.1.
    CH471100 Genomic DNA. Translation: EAW93381.1.
    BC117489 mRNA. Translation: AAI17490.1.
    BC117491 mRNA. Translation: AAI17492.1.
    CCDSiCCDS1508.1.
    RefSeqiNP_061134.1. NM_018664.2.
    UniGeneiHs.62919.

    Genome annotation databases

    EnsembliENST00000243440; ENSP00000243440; ENSG00000123685.
    GeneIDi55509.
    KEGGihsa:55509.
    UCSCiuc001hjl.2. human.

    Polymorphism databases

    DMDMi74752916.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255346 mRNA. Translation: AAF73966.1 .
    AL591647 Genomic DNA. Translation: CAI17048.1 .
    CH471100 Genomic DNA. Translation: EAW93381.1 .
    BC117489 mRNA. Translation: AAI17490.1 .
    BC117491 mRNA. Translation: AAI17492.1 .
    CCDSi CCDS1508.1.
    RefSeqi NP_061134.1. NM_018664.2.
    UniGenei Hs.62919.

    3D structure databases

    ProteinModelPortali Q9NR55.
    SMRi Q9NR55. Positions 40-86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120689. 18 interactions.
    STRINGi 9606.ENSP00000243440.

    PTM databases

    PhosphoSitei Q9NR55.

    Polymorphism databases

    DMDMi 74752916.

    Proteomic databases

    MaxQBi Q9NR55.
    PaxDbi Q9NR55.
    PRIDEi Q9NR55.

    Protocols and materials databases

    DNASUi 55509.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243440 ; ENSP00000243440 ; ENSG00000123685 .
    GeneIDi 55509.
    KEGGi hsa:55509.
    UCSCi uc001hjl.2. human.

    Organism-specific databases

    CTDi 55509.
    GeneCardsi GC01M212859.
    HGNCi HGNC:28915. BATF3.
    MIMi 612470. gene.
    neXtProti NX_Q9NR55.
    PharmGKBi PA162377349.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283780.
    HOGENOMi HOG000236325.
    HOVERGENi HBG096186.
    InParanoidi Q9NR55.
    KOi K09034.
    OMAi CPLLHCT.
    OrthoDBi EOG7H794S.
    PhylomeDBi Q9NR55.
    TreeFami TF332340.

    Miscellaneous databases

    GenomeRNAii 55509.
    NextBioi 59915.
    PROi Q9NR55.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NR55.
    CleanExi HS_BATF3.
    Genevestigatori Q9NR55.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00042. LEUZIPPRFOS.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein."
      Iacobelli M., Wachsman W., McGuire K.L.
      J. Immunol. 165:860-868(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."
      Bower K.E., Zeller R.W., Wachsman W., Martinez T., McGuire K.L.
      J. Biol. Chem. 277:34967-34977(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH JUN.
    6. "Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells."
      Bower K.E., Fritz J.M., McGuire K.L.
      Oncogene 23:8805-8814(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiBATF3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3