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Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

BATF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.By similarity3 Publications

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc
  4. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. dendritic cell differentiation Source: UniProtKB
  2. myeloid dendritic cell differentiation Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  4. response to virus Source: UniProtKB
  5. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Alternative name(s):
21 kDa small nuclear factor isolated from T-cells
Jun dimerization protein p21SNFT
Gene namesi
Name:BATF3
Synonyms:SNFT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28915. BATF3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Basic leucine zipper transcriptional factor ATF-like 3PRO_0000326106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NR55.
PaxDbiQ9NR55.
PRIDEiQ9NR55.

PTM databases

PhosphoSiteiQ9NR55.

Expressioni

Gene expression databases

BgeeiQ9NR55.
CleanExiHS_BATF3.
GenevestigatoriQ9NR55.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.1 Publication

Protein-protein interaction databases

BioGridi120689. 18 interactions.
STRINGi9606.ENSP00000243440.

Structurei

3D structure databases

ProteinModelPortaliQ9NR55.
SMRiQ9NR55. Positions 40-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 9864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 6226Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni63 – 9129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG283780.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiQ9NR55.
KOiK09034.
OMAiCPLLHCT.
OrthoDBiEOG7H794S.
PhylomeDBiQ9NR55.
TreeFamiTF332340.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF13. PTHR23351:SF13. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NR55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ
60 70 80 90 100
RSRKKQTQKA DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK
110 120
MCPLLLCPMN FVPVPPRPDP VAGCLPR
Length:127
Mass (Da):14,468
Last modified:October 1, 2000 - v1
Checksum:i3C595D708D5D4F5F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111V → I.
Corresponds to variant rs2202683 [ dbSNP | Ensembl ].
VAR_039988

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255346 mRNA. Translation: AAF73966.1.
AL591647 Genomic DNA. Translation: CAI17048.1.
CH471100 Genomic DNA. Translation: EAW93381.1.
BC117489 mRNA. Translation: AAI17490.1.
BC117491 mRNA. Translation: AAI17492.1.
CCDSiCCDS1508.1.
RefSeqiNP_061134.1. NM_018664.2.
UniGeneiHs.62919.

Genome annotation databases

EnsembliENST00000243440; ENSP00000243440; ENSG00000123685.
GeneIDi55509.
KEGGihsa:55509.
UCSCiuc001hjl.2. human.

Polymorphism databases

DMDMi74752916.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255346 mRNA. Translation: AAF73966.1.
AL591647 Genomic DNA. Translation: CAI17048.1.
CH471100 Genomic DNA. Translation: EAW93381.1.
BC117489 mRNA. Translation: AAI17490.1.
BC117491 mRNA. Translation: AAI17492.1.
CCDSiCCDS1508.1.
RefSeqiNP_061134.1. NM_018664.2.
UniGeneiHs.62919.

3D structure databases

ProteinModelPortaliQ9NR55.
SMRiQ9NR55. Positions 40-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120689. 18 interactions.
STRINGi9606.ENSP00000243440.

PTM databases

PhosphoSiteiQ9NR55.

Polymorphism databases

DMDMi74752916.

Proteomic databases

MaxQBiQ9NR55.
PaxDbiQ9NR55.
PRIDEiQ9NR55.

Protocols and materials databases

DNASUi55509.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243440; ENSP00000243440; ENSG00000123685.
GeneIDi55509.
KEGGihsa:55509.
UCSCiuc001hjl.2. human.

Organism-specific databases

CTDi55509.
GeneCardsiGC01M212859.
HGNCiHGNC:28915. BATF3.
MIMi612470. gene.
neXtProtiNX_Q9NR55.
PharmGKBiPA162377349.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG283780.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiQ9NR55.
KOiK09034.
OMAiCPLLHCT.
OrthoDBiEOG7H794S.
PhylomeDBiQ9NR55.
TreeFamiTF332340.

Miscellaneous databases

ChiTaRSiBATF3. human.
GenomeRNAii55509.
NextBioi59915.
PROiQ9NR55.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NR55.
CleanExiHS_BATF3.
GenevestigatoriQ9NR55.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF13. PTHR23351:SF13. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein."
    Iacobelli M., Wachsman W., McGuire K.L.
    J. Immunol. 165:860-868(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."
    Bower K.E., Zeller R.W., Wachsman W., Martinez T., McGuire K.L.
    J. Biol. Chem. 277:34967-34977(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH JUN.
  6. "Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells."
    Bower K.E., Fritz J.M., McGuire K.L.
    Oncogene 23:8805-8814(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiBATF3_HUMAN
AccessioniPrimary (citable) accession number: Q9NR55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.