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Q9NR55 (BATF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Basic leucine zipper transcriptional factor ATF-like 3

Short name=B-ATF-3
Alternative name(s):
21 kDa small nuclear factor isolated from T-cells
Jun dimerization protein p21SNFT
Gene names
Name:BATF3
Synonyms:SNFT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens By similarity. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Ref.1 Ref.5 Ref.6

Subunit structure

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN. Ref.5

Subcellular location

Nucleus Ref.5.

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 127127Basic leucine zipper transcriptional factor ATF-like 3
PRO_0000326106

Regions

Domain35 – 9864bZIP
Region37 – 6226Basic motif By similarity
Region63 – 9129Leucine-zipper By similarity

Amino acid modifications

Modified residue311Phosphoserine Ref.7

Natural variations

Natural variant111V → I.
Corresponds to variant rs2202683 [ dbSNP | Ensembl ].
VAR_039988

Sequences

Sequence LengthMass (Da)Tools
Q9NR55 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3C595D708D5D4F5F

FASTA12714,468
        10         20         30         40         50         60 
MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ RSRKKQTQKA 

        70         80         90        100        110        120 
DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK MCPLLLCPMN FVPVPPRPDP 


VAGCLPR 

« Hide

References

« Hide 'large scale' references
[1]"Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein."
Iacobelli M., Wachsman W., McGuire K.L.
J. Immunol. 165:860-868(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."
Bower K.E., Zeller R.W., Wachsman W., Martinez T., McGuire K.L.
J. Biol. Chem. 277:34967-34977(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH JUN.
[6]"Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells."
Bower K.E., Fritz J.M., McGuire K.L.
Oncogene 23:8805-8814(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF255346 mRNA. Translation: AAF73966.1.
AL591647 Genomic DNA. Translation: CAI17048.1.
CH471100 Genomic DNA. Translation: EAW93381.1.
BC117489 mRNA. Translation: AAI17490.1.
BC117491 mRNA. Translation: AAI17492.1.
RefSeqNP_061134.1. NM_018664.2.
UniGeneHs.62919.

3D structure databases

ProteinModelPortalQ9NR55.
SMRQ9NR55. Positions 39-89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120689. 18 interactions.
STRING9606.ENSP00000243440.

PTM databases

PhosphoSiteQ9NR55.

Polymorphism databases

DMDM74752916.

Proteomic databases

PaxDbQ9NR55.
PRIDEQ9NR55.

Protocols and materials databases

DNASU55509.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243440; ENSP00000243440; ENSG00000123685.
GeneID55509.
KEGGhsa:55509.
UCSCuc001hjl.2. human.

Organism-specific databases

CTD55509.
GeneCardsGC01M212859.
HGNCHGNC:28915. BATF3.
MIM612470. gene.
neXtProtNX_Q9NR55.
PharmGKBPA162377349.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG283780.
HOGENOMHOG000236325.
HOVERGENHBG096186.
InParanoidQ9NR55.
KOK09034.
OMAEHEKICP.
OrthoDBEOG7H794S.
PhylomeDBQ9NR55.
TreeFamTF332340.

Gene expression databases

BgeeQ9NR55.
CleanExHS_BATF3.
GenevestigatorQ9NR55.

Family and domain databases

InterProIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55509.
NextBio59915.
PROQ9NR55.
SOURCESearch...

Entry information

Entry nameBATF3_HUMAN
AccessionPrimary (citable) accession number: Q9NR55
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM