Q9NR55 (BATF3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name=B-ATF-3

Alternative name(s):
21 kDa small nuclear factor isolated from T-cells
Jun dimerization protein p21SNFT

Gene names

Name:	BATF3
Synonyms:	SNFT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens By similarity. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Ref.1 Ref.5 Ref.6
Subunit structure	Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN. Ref.5
Subcellular location	Nucleus Ref.5.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Activator Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dendritic cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB myeloid dendritic cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB response to virus Inferred from sequence or structural similarity. Source: UniProtKB transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc
Cellular_component	nucleus Traceable author statement Ref.1. Source: ProtInc
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc transcription corepressor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Basic leucine zipper transcriptional factor ATF-like 3		PRO_0000326106
Regions
	Domain	35 – 98	64	bZIP
	Region	37 – 62	26	Basic motif By similarity
	Region	63 – 91	29	Leucine-zipper By similarity
Amino acid modifications
	Modified residue	31	1	Phosphoserine Ref.7
Natural variations
	Natural variant	11	1	V → I. Corresponds to variant rs2202683 [ dbSNP | Ensembl ].		VAR_039988

Sequences

	Sequence		Length	Mass (Da)
	Q9NR55 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3C595D708D5D4F5F	FASTA	127	14,468
	10 20 30 40 50 60 MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ RSRKKQTQKA 70 80 90 100 110 120 DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK MCPLLLCPMN FVPVPPRPDP VAGCLPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein." Iacobelli M., Wachsman W., McGuire K.L. J. Immunol. 165:860-868(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions." Bower K.E., Zeller R.W., Wachsman W., Martinez T., McGuire K.L. J. Biol. Chem. 277:34967-34977(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH JUN.
[6]	"Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells." Bower K.E., Fritz J.M., McGuire K.L. Oncogene 23:8805-8814(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF255346 mRNA. Translation: AAF73966.1. AL591647 Genomic DNA. Translation: CAI17048.1. CH471100 Genomic DNA. Translation: EAW93381.1. BC117489 mRNA. Translation: AAI17490.1. BC117491 mRNA. Translation: AAI17492.1.
IPI	IPI00032898.
RefSeq	NP_061134.1. NM_018664.2.
UniGene	Hs.62919.
3D structure databases
HSSP	HSSP built from PDB template 1FOS based on UniProtKB P01100.
ProteinModelPortal	Q9NR55.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000243440.
PTM databases
PhosphoSite	Q9NR55.
Polymorphism databases
DMDM	74752916.
Proteomic databases
PaxDb	Q9NR55.
PRIDE	Q9NR55.
Protocols and materials databases
DNASU	55509.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000243440; ENSP00000243440; ENSG00000123685.
GeneID	55509.
KEGG	hsa:55509.
UCSC	uc001hjl.2. human.
Organism-specific databases
CTD	55509.
GeneCards	GC01M212859.
HGNC	HGNC:28915. BATF3.
MIM	612470. gene.
neXtProt	NX_Q9NR55.
PharmGKB	PA162377349.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283780.
HOGENOM	HOG000236325.
HOVERGEN	HBG096186.
InParanoid	Q9NR55.
KO	K09034.
OMA	EHEKICP.
OrthoDB	EOG4V172C.
PhylomeDB	Q9NR55.
Enzyme and pathway databases
Pathway_Interaction_DB	nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes. tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway.
Gene expression databases
Bgee	Q9NR55.
CleanEx	HS_BATF3.
Genevestigator	Q9NR55.
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55509.
NextBio	59915.
SOURCE	Search...

Entry information

Entry name

BATF3_HUMAN

Accession

Primary (citable) accession number: Q9NR55

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.