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Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

BATF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.By similarity3 Publications

GO - Molecular functioni

  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Alternative name(s):
21 kDa small nuclear factor isolated from T-cells
Jun dimerization protein p21SNFT
Gene namesi
Name:BATF3
Synonyms:SNFT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28915. BATF3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: ProtInc

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55509.
OpenTargetsiENSG00000123685.
PharmGKBiPA162377349.

Polymorphism and mutation databases

BioMutaiBATF3.
DMDMi74752916.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261061 – 127Basic leucine zipper transcriptional factor ATF-like 3Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NR55.
PaxDbiQ9NR55.
PeptideAtlasiQ9NR55.
PRIDEiQ9NR55.

PTM databases

iPTMnetiQ9NR55.
PhosphoSitePlusiQ9NR55.

Expressioni

Gene expression databases

BgeeiENSG00000123685.
CleanExiHS_BATF3.
GenevisibleiQ9NR55. HS.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120689. 44 interactors.
IntActiQ9NR55. 19 interactors.
STRINGi9606.ENSP00000243440.

Structurei

3D structure databases

ProteinModelPortaliQ9NR55.
SMRiQ9NR55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 98bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 62Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni63 – 91Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiQ9NR55.
KOiK09034.
OMAiCPLLHCT.
OrthoDBiEOG091G0YSM.
PhylomeDBiQ9NR55.
TreeFamiTF332340.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF33. PTHR23351:SF33. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NR55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ
60 70 80 90 100
RSRKKQTQKA DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK
110 120
MCPLLLCPMN FVPVPPRPDP VAGCLPR
Length:127
Mass (Da):14,468
Last modified:October 1, 2000 - v1
Checksum:i3C595D708D5D4F5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03998811V → I. Corresponds to variant dbSNP:rs2202683Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255346 mRNA. Translation: AAF73966.1.
AL591647 Genomic DNA. Translation: CAI17048.1.
CH471100 Genomic DNA. Translation: EAW93381.1.
BC117489 mRNA. Translation: AAI17490.1.
BC117491 mRNA. Translation: AAI17492.1.
CCDSiCCDS1508.1.
RefSeqiNP_061134.1. NM_018664.2.
UniGeneiHs.62919.

Genome annotation databases

EnsembliENST00000243440; ENSP00000243440; ENSG00000123685.
GeneIDi55509.
KEGGihsa:55509.
UCSCiuc001hjl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255346 mRNA. Translation: AAF73966.1.
AL591647 Genomic DNA. Translation: CAI17048.1.
CH471100 Genomic DNA. Translation: EAW93381.1.
BC117489 mRNA. Translation: AAI17490.1.
BC117491 mRNA. Translation: AAI17492.1.
CCDSiCCDS1508.1.
RefSeqiNP_061134.1. NM_018664.2.
UniGeneiHs.62919.

3D structure databases

ProteinModelPortaliQ9NR55.
SMRiQ9NR55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120689. 44 interactors.
IntActiQ9NR55. 19 interactors.
STRINGi9606.ENSP00000243440.

PTM databases

iPTMnetiQ9NR55.
PhosphoSitePlusiQ9NR55.

Polymorphism and mutation databases

BioMutaiBATF3.
DMDMi74752916.

Proteomic databases

MaxQBiQ9NR55.
PaxDbiQ9NR55.
PeptideAtlasiQ9NR55.
PRIDEiQ9NR55.

Protocols and materials databases

DNASUi55509.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243440; ENSP00000243440; ENSG00000123685.
GeneIDi55509.
KEGGihsa:55509.
UCSCiuc001hjl.3. human.

Organism-specific databases

CTDi55509.
DisGeNETi55509.
GeneCardsiBATF3.
HGNCiHGNC:28915. BATF3.
MIMi612470. gene.
neXtProtiNX_Q9NR55.
OpenTargetsiENSG00000123685.
PharmGKBiPA162377349.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000016869.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiQ9NR55.
KOiK09034.
OMAiCPLLHCT.
OrthoDBiEOG091G0YSM.
PhylomeDBiQ9NR55.
TreeFamiTF332340.

Miscellaneous databases

ChiTaRSiBATF3. human.
GenomeRNAii55509.
PROiPR:Q9NR55.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123685.
CleanExiHS_BATF3.
GenevisibleiQ9NR55. HS.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF33. PTHR23351:SF33. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBATF3_HUMAN
AccessioniPrimary (citable) accession number: Q9NR55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: March 15, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.