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Q9NR55

- BATF3_HUMAN

UniProt

Q9NR55 - BATF3_HUMAN

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Protein
Basic leucine zipper transcriptional factor ATF-like 3
Gene
BATF3, SNFT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens By similarity. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.3 Publications

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. dendritic cell differentiation Source: UniProtKB
  2. myeloid dendritic cell differentiation Source: UniProtKB
  3. response to virus Source: UniProtKB
  4. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Alternative name(s):
21 kDa small nuclear factor isolated from T-cells
Jun dimerization protein p21SNFT
Gene namesi
Name:BATF3
Synonyms:SNFT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28915. BATF3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Basic leucine zipper transcriptional factor ATF-like 3
PRO_0000326106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NR55.
PaxDbiQ9NR55.
PRIDEiQ9NR55.

PTM databases

PhosphoSiteiQ9NR55.

Expressioni

Gene expression databases

BgeeiQ9NR55.
CleanExiHS_BATF3.
GenevestigatoriQ9NR55.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.1 Publication

Protein-protein interaction databases

BioGridi120689. 18 interactions.
STRINGi9606.ENSP00000243440.

Structurei

3D structure databases

ProteinModelPortaliQ9NR55.
SMRiQ9NR55. Positions 40-86.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 9864bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 6226Basic motif By similarity
Add
BLAST
Regioni63 – 9129Leucine-zipper By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family.

Phylogenomic databases

eggNOGiNOG283780.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiQ9NR55.
KOiK09034.
OMAiCPLLHCT.
OrthoDBiEOG7H794S.
PhylomeDBiQ9NR55.
TreeFamiTF332340.

Family and domain databases

InterProiIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NR55-1 [UniParc]FASTAAdd to Basket

« Hide

MSQGLPAAGS VLQRSVAAPG NQPQPQPQQQ SPEDDDRKVR RREKNRVAAQ    50
RSRKKQTQKA DKLHEEYESL EQENTMLRRE IGKLTEELKH LTEALKEHEK 100
MCPLLLCPMN FVPVPPRPDP VAGCLPR 127
Length:127
Mass (Da):14,468
Last modified:October 1, 2000 - v1
Checksum:i3C595D708D5D4F5F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111V → I.
Corresponds to variant rs2202683 [ dbSNP | Ensembl ].
VAR_039988

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255346 mRNA. Translation: AAF73966.1.
AL591647 Genomic DNA. Translation: CAI17048.1.
CH471100 Genomic DNA. Translation: EAW93381.1.
BC117489 mRNA. Translation: AAI17490.1.
BC117491 mRNA. Translation: AAI17492.1.
CCDSiCCDS1508.1.
RefSeqiNP_061134.1. NM_018664.2.
UniGeneiHs.62919.

Genome annotation databases

EnsembliENST00000243440; ENSP00000243440; ENSG00000123685.
GeneIDi55509.
KEGGihsa:55509.
UCSCiuc001hjl.2. human.

Polymorphism databases

DMDMi74752916.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255346 mRNA. Translation: AAF73966.1 .
AL591647 Genomic DNA. Translation: CAI17048.1 .
CH471100 Genomic DNA. Translation: EAW93381.1 .
BC117489 mRNA. Translation: AAI17490.1 .
BC117491 mRNA. Translation: AAI17492.1 .
CCDSi CCDS1508.1.
RefSeqi NP_061134.1. NM_018664.2.
UniGenei Hs.62919.

3D structure databases

ProteinModelPortali Q9NR55.
SMRi Q9NR55. Positions 40-86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120689. 18 interactions.
STRINGi 9606.ENSP00000243440.

PTM databases

PhosphoSitei Q9NR55.

Polymorphism databases

DMDMi 74752916.

Proteomic databases

MaxQBi Q9NR55.
PaxDbi Q9NR55.
PRIDEi Q9NR55.

Protocols and materials databases

DNASUi 55509.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243440 ; ENSP00000243440 ; ENSG00000123685 .
GeneIDi 55509.
KEGGi hsa:55509.
UCSCi uc001hjl.2. human.

Organism-specific databases

CTDi 55509.
GeneCardsi GC01M212859.
HGNCi HGNC:28915. BATF3.
MIMi 612470. gene.
neXtProti NX_Q9NR55.
PharmGKBi PA162377349.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283780.
HOGENOMi HOG000236325.
HOVERGENi HBG096186.
InParanoidi Q9NR55.
KOi K09034.
OMAi CPLLHCT.
OrthoDBi EOG7H794S.
PhylomeDBi Q9NR55.
TreeFami TF332340.

Miscellaneous databases

GenomeRNAii 55509.
NextBioi 59915.
PROi Q9NR55.
SOURCEi Search...

Gene expression databases

Bgeei Q9NR55.
CleanExi HS_BATF3.
Genevestigatori Q9NR55.

Family and domain databases

InterProi IPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
PRINTSi PR00042. LEUZIPPRFOS.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein."
    Iacobelli M., Wachsman W., McGuire K.L.
    J. Immunol. 165:860-868(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."
    Bower K.E., Zeller R.W., Wachsman W., Martinez T., McGuire K.L.
    J. Biol. Chem. 277:34967-34977(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH JUN.
  6. "Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells."
    Bower K.E., Fritz J.M., McGuire K.L.
    Oncogene 23:8805-8814(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiBATF3_HUMAN
AccessioniPrimary (citable) accession number: Q9NR55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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