##gff-version 3 Q9NR48 UniProtKB Chain 1 2969 . . . ID=PRO_0000259516;Note=Histone-lysine N-methyltransferase ASH1L Q9NR48 UniProtKB Domain 2091 2142 . . . Note=AWS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00562 Q9NR48 UniProtKB Domain 2145 2261 . . . Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190 Q9NR48 UniProtKB Domain 2269 2285 . . . Note=Post-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00155 Q9NR48 UniProtKB Domain 2463 2533 . . . Note=Bromo;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00035 Q9NR48 UniProtKB Domain 2661 2798 . . . Note=BAH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00370 Q9NR48 UniProtKB DNA binding 887 899 . . . Note=A.T hook 1 Q9NR48 UniProtKB DNA binding 1347 1359 . . . Note=A.T hook 2 Q9NR48 UniProtKB DNA binding 1847 1859 . . . Note=A.T hook 3 Q9NR48 UniProtKB Zinc finger 2585 2631 . . . Note=PHD-type Q9NR48 UniProtKB Region 1 70 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 118 143 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 501 525 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 537 583 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 824 845 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 878 966 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 1100 1128 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 1151 1231 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 1243 1281 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 1489 1508 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 1580 1711 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 1741 1761 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 1911 1991 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 2069 2288 . . . Note=Catalytic domain Q9NR48 UniProtKB Region 2288 2346 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 2825 2856 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Region 2876 2919 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 17 31 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 34 63 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 123 143 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 541 583 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 824 841 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 922 937 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 946 966 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 1100 1126 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 1165 1214 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 1215 1230 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 1580 1640 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 1653 1702 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 1911 1943 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 2289 2306 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 2309 2326 . . . Note=Basic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 2838 2856 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Compositional bias 2879 2904 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9NR48 UniProtKB Modified residue 22 22 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9NR48 UniProtKB Modified residue 375 375 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Q9NR48 UniProtKB Modified residue 1162 1162 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99MY8 Q9NR48 UniProtKB Modified residue 1170 1170 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99MY8 Q9NR48 UniProtKB Modified residue 1220 1220 . . . Note=N5-methylglutamine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26797129;Dbxref=PMID:26797129 Q9NR48 UniProtKB Modified residue 2317 2317 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99MY8 Q9NR48 UniProtKB Modified residue 2319 2319 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99MY8 Q9NR48 UniProtKB Modified residue 2323 2323 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99MY8 Q9NR48 UniProtKB Cross-link 34 34 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9NR48 UniProtKB Cross-link 425 425 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9NR48 UniProtKB Alternative sequence 2035 2039 . . . ID=VSP_039421;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9NR48 UniProtKB Natural variant 277 277 . . . ID=VAR_069405;Note=S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs186255422,PMID:23033978 Q9NR48 UniProtKB Natural variant 724 724 . . . ID=VAR_069406;Note=In MRD52%3B uncertain significance. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs1293246328,PMID:23033978 Q9NR48 UniProtKB Natural variant 972 972 . . . ID=VAR_069407;Note=In MRD52%3B uncertain significance. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=PMID:23033978 Q9NR48 UniProtKB Natural variant 1276 1276 . . . ID=VAR_069408;Note=In MRD52%3B uncertain significance. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs539982914,PMID:23033978 Q9NR48 UniProtKB Natural variant 1416 1416 . . . ID=VAR_055905;Note=S->P;Dbxref=dbSNP:rs13373934 Q9NR48 UniProtKB Natural variant 1771 1771 . . . ID=VAR_028949;Note=T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10860993;Dbxref=dbSNP:rs4971053,PMID:10860993 Q9NR48 UniProtKB Natural variant 1775 1775 . . . ID=VAR_069409;Note=In MRD52%3B uncertain significance. C->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=dbSNP:rs753734834,PMID:23033978 Q9NR48 UniProtKB Natural variant 2085 2085 . . . ID=VAR_080559;Note=In MRD52%3B uncertain significance. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27824329;Dbxref=dbSNP:rs749494995,PMID:27824329 Q9NR48 UniProtKB Natural variant 2148 2969 . . . ID=VAR_080560;Note=In MRD52. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=PMID:28191889 Q9NR48 UniProtKB Natural variant 2396 2396 . . . ID=VAR_080561;Note=In MRD52%3B uncertain significance. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28191889;Dbxref=dbSNP:rs753029013,PMID:28191889 Q9NR48 UniProtKB Natural variant 2791 2791 . . . ID=VAR_080562;Note=In MRD52. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28394464;Dbxref=dbSNP:rs1553241570,PMID:28394464 Q9NR48 UniProtKB Natural variant 2853 2853 . . . ID=VAR_069410;Note=In MRD52%3B uncertain significance. D->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23033978;Dbxref=PMID:23033978 Q9NR48 UniProtKB Mutagenesis 1220 1220 . . . Note=Abolishes methylation by N6AMT1. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26797129;Dbxref=PMID:26797129 Q9NR48 UniProtKB Sequence conflict 2594 2594 . . . Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NR48 UniProtKB Sequence conflict 2697 2697 . . . Note=D->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9NR48 UniProtKB Helix 2040 2044 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6INE Q9NR48 UniProtKB Helix 2054 2065 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6INE Q9NR48 UniProtKB Beta strand 2081 2084 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2104 2106 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3OPE Q9NR48 UniProtKB Beta strand 2108 2111 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6AGO Q9NR48 UniProtKB Helix 2116 2118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Turn 2124 2126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Helix 2130 2132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2133 2135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Turn 2137 2141 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2147 2151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2155 2163 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2170 2173 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2177 2180 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Helix 2181 2190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Helix 2192 2194 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Helix 2195 2197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6AGO Q9NR48 UniProtKB Beta strand 2200 2204 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2207 2210 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2212 2215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Helix 2217 2220 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2228 2236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2239 2248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Helix 2260 2263 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WZW Q9NR48 UniProtKB Beta strand 2282 2284 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4YNM Q9NR48 UniProtKB Helix 2438 2458 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MQM Q9NR48 UniProtKB Helix 2469 2471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MQM Q9NR48 UniProtKB Helix 2477 2479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MQM Q9NR48 UniProtKB Helix 2483 2486 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MQM Q9NR48 UniProtKB Helix 2493 2501 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MQM Q9NR48 UniProtKB Helix 2508 2526 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MQM Q9NR48 UniProtKB Helix 2531 2558 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3MQM