Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endophilin-B2

Gene

SH3GLB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-B2
Alternative name(s):
SH3 domain-containing GRB2-like protein B2
Gene namesi
Name:SH3GLB2
Synonyms:KIAA1848
ORF Names:PP578
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148341.17.
HGNCiHGNC:10834. SH3GLB2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi56904.
OpenTargetsiENSG00000148341.
PharmGKBiPA35740.

Polymorphism and mutation databases

DMDMi41018150.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467551 – 395Endophilin-B2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei395PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NR46.
MaxQBiQ9NR46.
PaxDbiQ9NR46.
PeptideAtlasiQ9NR46.
PRIDEiQ9NR46.
TopDownProteomicsiQ9NR46-1. [Q9NR46-1]

PTM databases

iPTMnetiQ9NR46.
PhosphoSitePlusiQ9NR46.

Expressioni

Tissue specificityi

Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland.1 Publication

Gene expression databases

BgeeiENSG00000148341.
CleanExiHS_SH3GLB2.
ExpressionAtlasiQ9NR46. baseline and differential.
GenevisibleiQ9NR46. HS.

Organism-specific databases

HPAiHPA021438.
HPA024734.

Interactioni

Subunit structurei

Homodimer, and heterodimer with SH3GLB1.

Binary interactionsi

Show more details

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi121234. 30 interactors.
IntActiQ9NR46. 31 interactors.
MINTiMINT-1458485.
STRINGi9606.ENSP00000361640.

Structurei

3D structure databases

ProteinModelPortaliQ9NR46.
SMRiQ9NR46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 287BARPROSITE-ProRule annotationAdd BLAST264
Domaini335 – 395SH3PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 27Membrane-binding amphipathic helixBy similarityAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 132Sequence analysisAdd BLAST17
Coiled coili206 – 240Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the endophilin family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3725. Eukaryota.
ENOG410XPA6. LUCA.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000232056.
HOVERGENiHBG054448.
InParanoidiQ9NR46.
KOiK21269.
OMAiQYMAEAA.
OrthoDBiEOG091G09WR.
PhylomeDBiQ9NR46.
TreeFamiTF313281.

Family and domain databases

CDDicd11944. SH3_Endophilin_B2. 1 hit.
Gene3Di1.20.1270.60. 2 hits.
InterProiView protein in InterPro
IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR035640. Endophilin_B2_SH3.
IPR036028. SH3-like_dom.
IPR001452. SH3_domain.
IPR028500. SH3GLB2.
PANTHERiPTHR44071:SF2. PTHR44071:SF2. 1 hit.
PfamiView protein in Pfam
PF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF103657. SSF103657. 2 hits.
SSF50044. SSF50044. 2 hits.
PROSITEiView protein in PROSITE
PS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK
60 70 80 90 100
NWTEKILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAD
110 120 130 140 150
AASELGPTTP YGKTLIKVAE AEKQLGAAER DFIHTASISF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATTVP DFQETRPRNY
210 220 230 240 250
ILSASASALW NDEVDKAEQE LRVAQTEFDR QAEVTRLLLE GISSTHVNHL
260 270 280 290 300
RCLHEFVKSQ TTYYAQCYRH MLDLQKQLGR FPGTFVGTTE PASPPLSSTS
310 320 330 340 350
PTTAAATMPV VPSVASLAPP GEASLCLEEV APPASGTRKA RVLYDYEAAD
360 370 380 390
SSELALLADE LITVYSLPGM DPDWLIGERG NKKGKVPVTY LELLS
Length:395
Mass (Da):43,974
Last modified:October 1, 2000 - v1
Checksum:i5549631DB2EB7CAA
GO
Isoform 2 (identifier: Q9NR46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-187: T → TCEGD
     280-280: R → SSQGAI

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):44,766
Checksum:i830D75563D5896D3
GO

Sequence cautioni

Q9NR46: The sequence AAG23792 differs from that shown. Reason: Frameshift at positions 122 and 128.Curated
Q9NR46: The sequence BAB47477 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053078305A → V. Corresponds to variant dbSNP:rs17455482Ensembl.1
Natural variantiVAR_053079319P → L. Corresponds to variant dbSNP:rs17455475Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009278187T → TCEGD in isoform 2. 1 Publication1
Alternative sequenceiVSP_009279280R → SSQGAI in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257319 mRNA. Translation: AAF81226.1.
AB058751 mRNA. Translation: BAB47477.2. Different initiation.
AF258589 mRNA. Translation: AAG23792.1. Frameshift.
AL592211 Genomic DNA. Translation: CAI12365.1.
AL592211 Genomic DNA. Translation: CAI12366.1.
BC014635 mRNA. Translation: AAH14635.1.
CCDSiCCDS6916.1. [Q9NR46-1]
CCDS69680.1. [Q9NR46-2]
RefSeqiNP_001273974.1. NM_001287045.1. [Q9NR46-2]
NP_001273975.1. NM_001287046.1. [Q9NR46-1]
NP_064530.1. NM_020145.3. [Q9NR46-1]
XP_005252158.1. XM_005252101.3.
UniGeneiHs.460238.

Genome annotation databases

EnsembliENST00000372554; ENSP00000361634; ENSG00000148341. [Q9NR46-2]
ENST00000372559; ENSP00000361640; ENSG00000148341. [Q9NR46-1]
ENST00000372564; ENSP00000361645; ENSG00000148341. [Q9NR46-1]
GeneIDi56904.
KEGGihsa:56904.
UCSCiuc004bwv.5. human. [Q9NR46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSHLB2_HUMAN
AccessioniPrimary (citable) accession number: Q9NR46
Secondary accession number(s): A6NC47
, A8MPS4, Q8WY61, Q96JH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families