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Q9NR34

- MA1C1_HUMAN

UniProt

Q9NR34 - MA1C1_HUMAN

Protein

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Gene

MAN1C1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce first Man8GlcNAc2 then Man6GlcNAc and a small amount of Man5GlcNAc.

    Catalytic activityi

    Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

    Cofactori

    Calcium.

    Enzyme regulationi

    Inhibited by both 1-deoxymannojirimycin and kifunensine.

    Pathwayi

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. post-translational protein modification Source: Reactome
    3. protein N-linked glycosylation Source: UniProtKB
    4. protein N-linked glycosylation via asparagine Source: Reactome

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_25396. Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGH47. Glycoside Hydrolase Family 47.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC:3.2.1.113)
    Alternative name(s):
    HMIC
    Mannosidase alpha class 1C member 1
    Processing alpha-1,2-mannosidase IC
    Short name:
    Alpha-1,2-mannosidase IC
    Gene namesi
    Name:MAN1C1
    Synonyms:MAN1A3, MAN1C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19080. MAN1C1.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: Reactome
    2. integral component of Golgi membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38788.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 630630Mannosyl-oligosaccharide 1,2-alpha-mannosidase ICPRO_0000210315Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi618 – 6181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9NR34.
    PaxDbiQ9NR34.
    PRIDEiQ9NR34.

    PTM databases

    PhosphoSiteiQ9NR34.

    Expressioni

    Tissue specificityi

    Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.

    Gene expression databases

    ArrayExpressiQ9NR34.
    BgeeiQ9NR34.
    CleanExiHS_MAN1C1.
    GenevestigatoriQ9NR34.

    Organism-specific databases

    HPAiHPA048352.

    Interactioni

    Protein-protein interaction databases

    BioGridi121395. 1 interaction.
    IntActiQ9NR34. 1 interaction.
    MINTiMINT-1187619.
    STRINGi9606.ENSP00000363452.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NR34.
    SMRiQ9NR34. Positions 163-617.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini44 – 630587LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 47 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300315.
    HOGENOMiHOG000181988.
    HOVERGENiHBG052389.
    InParanoidiQ9NR34.
    KOiK01230.
    OMAiRSWGWAM.
    OrthoDBiEOG7X0VH1.
    PhylomeDBiQ9NR34.
    TreeFamiTF313420.

    Family and domain databases

    Gene3Di1.50.10.50. 1 hit.
    InterProiIPR001382. Glyco_hydro_47.
    [Graphical view]
    PANTHERiPTHR11742. PTHR11742. 1 hit.
    PfamiPF01532. Glyco_hydro_47. 1 hit.
    [Graphical view]
    PRINTSiPR00747. GLYHDRLASE47.
    SUPFAMiSSF48225. SSF48225. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NR34-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLMRKVPGFV PASPWGLRLP QKFLFLLFLS GLVTLCFGAL FLLPHSSRLK    50
    RLFLAPRTQQ PGLEVVAEIA GHAPAREQEP PPNPAPAAPA PGEDDPSSWA 100
    SPRRRKGGLR RTRPTGPREE ATAARGNSIP ASRPGDEGVP FRFDFNAFRS 150
    RLRHPVLGTR ADESQEPQSQ VRAQREKIKE MMQFAWQSYK RYAMGKNELR 200
    PLTKDGYEGN MFGGLSGATV IDSLDTLYLM ELKEEFQEAK AWVGESFHLN 250
    VSGEASLFEV NIRYIGGLLS AFYLTGEEVF RIKAIRLGEK LLPAFNTPTG 300
    IPKGVVSFKS GNWGWATAGS SSILAEFGSL HLEFLHLTEL SGNQVFAEKV 350
    RNIRKVLRKI EKPFGLYPNF LSPVSGNWVQ HHVSVGGLGD SFYEYLIKSW 400
    LMSGKTDMEA KNMYYEALEA IETYLLNVSP GGLTYIAEWR GGILDHKMGH 450
    LACFSGGMIA LGAEDAKEEK RAHYRELAAQ ITKTCHESYA RSDTKLGPEA 500
    FWFNSGREAV ATQLSESYYI LRPEVVESYM YLWRQTHNPI YREWGWEVVL 550
    ALEKYCRTEA GFSGIQDVYS STPNHDNKQQ SFFLAETLKY LYLLFSEDDL 600
    LSLEDWVFNT EAHPLPVNHS DSSGRAWGRH 630
    Length:630
    Mass (Da):70,911
    Last modified:October 1, 2000 - v1
    Checksum:i80FFC71EFB36552A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261655 mRNA. Translation: AAF97058.1.
    AL031280, AL020996 Genomic DNA. Translation: CAI19714.1.
    BC137017 mRNA. Translation: AAI37018.1.
    CCDSiCCDS265.1.
    RefSeqiNP_001275939.1. NM_001289010.1.
    NP_065112.1. NM_020379.3.
    UniGeneiHs.197043.

    Genome annotation databases

    EnsembliENST00000374332; ENSP00000363452; ENSG00000117643.
    GeneIDi57134.
    KEGGihsa:57134.
    UCSCiuc001bkm.2. human.

    Polymorphism databases

    DMDMi17369308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261655 mRNA. Translation: AAF97058.1 .
    AL031280 , AL020996 Genomic DNA. Translation: CAI19714.1 .
    BC137017 mRNA. Translation: AAI37018.1 .
    CCDSi CCDS265.1.
    RefSeqi NP_001275939.1. NM_001289010.1.
    NP_065112.1. NM_020379.3.
    UniGenei Hs.197043.

    3D structure databases

    ProteinModelPortali Q9NR34.
    SMRi Q9NR34. Positions 163-617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121395. 1 interaction.
    IntActi Q9NR34. 1 interaction.
    MINTi MINT-1187619.
    STRINGi 9606.ENSP00000363452.

    Protein family/group databases

    CAZyi GH47. Glycoside Hydrolase Family 47.

    PTM databases

    PhosphoSitei Q9NR34.

    Polymorphism databases

    DMDMi 17369308.

    Proteomic databases

    MaxQBi Q9NR34.
    PaxDbi Q9NR34.
    PRIDEi Q9NR34.

    Protocols and materials databases

    DNASUi 57134.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374332 ; ENSP00000363452 ; ENSG00000117643 .
    GeneIDi 57134.
    KEGGi hsa:57134.
    UCSCi uc001bkm.2. human.

    Organism-specific databases

    CTDi 57134.
    GeneCardsi GC01P025943.
    HGNCi HGNC:19080. MAN1C1.
    HPAi HPA048352.
    neXtProti NX_Q9NR34.
    PharmGKBi PA38788.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300315.
    HOGENOMi HOG000181988.
    HOVERGENi HBG052389.
    InParanoidi Q9NR34.
    KOi K01230.
    OMAi RSWGWAM.
    OrthoDBi EOG7X0VH1.
    PhylomeDBi Q9NR34.
    TreeFami TF313420.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_25396. Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2.

    Miscellaneous databases

    GenomeRNAii 57134.
    NextBioi 63051.
    PROi Q9NR34.

    Gene expression databases

    ArrayExpressi Q9NR34.
    Bgeei Q9NR34.
    CleanExi HS_MAN1C1.
    Genevestigatori Q9NR34.

    Family and domain databases

    Gene3Di 1.50.10.50. 1 hit.
    InterProi IPR001382. Glyco_hydro_47.
    [Graphical view ]
    PANTHERi PTHR11742. PTHR11742. 1 hit.
    Pfami PF01532. Glyco_hydro_47. 1 hit.
    [Graphical view ]
    PRINTSi PR00747. GLYHDRLASE47.
    SUPFAMi SSF48225. SSF48225. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a cDNA encoding a novel human Golgi alpha 1,2-mannosidase involved in N-glycan biosynthesis."
      Tremblay L.O., Herscovics A.
      J. Biol. Chem. 275:31655-31660(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Eye.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiMA1C1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR34
    Secondary accession number(s): A6NNE2, B2RNP2, Q9Y545
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3