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Protein

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Gene

MAN1C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce first Man8GlcNAc2 then Man6GlcNAc and a small amount of Man5GlcNAc.

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.By similarity

Cofactori

Ca2+By similarity

Enzyme regulationi

Inhibited by both 1-deoxymannojirimycin and kifunensine.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei499Proton donorBy similarity1
Metal bindingi610CalciumBy similarity1

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB

GO - Biological processi

  • Golgi apparatus mannose trimming Source: Reactome
  • N-glycan processing Source: GO_Central
  • protein N-linked glycosylation Source: UniProtKB

Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS04162-MONOMER
BRENDAi3.2.1.113 2681
ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
UniPathwayiUPA00378

Protein family/group databases

CAZyiGH47 Glycoside Hydrolase Family 47

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC:3.2.1.113By similarity)
Alternative name(s):
HMIC
Mannosidase alpha class 1C member 1
Processing alpha-1,2-mannosidase IC
Short name:
Alpha-1,2-mannosidase IC
Gene namesi
Name:MAN1C1
Synonyms:MAN1A3, MAN1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117643.14
HGNCiHGNC:19080 MAN1C1
neXtProtiNX_Q9NR34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini44 – 630LumenalSequence analysisAdd BLAST587

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57134
OpenTargetsiENSG00000117643
PharmGKBiPA38788

Polymorphism and mutation databases

BioMutaiMAN1C1
DMDMi17369308

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002103151 – 630Mannosyl-oligosaccharide 1,2-alpha-mannosidase ICAdd BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei164PhosphoserineCombined sources1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi453 ↔ 485By similarity
Glycosylationi618N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NR34
MaxQBiQ9NR34
PaxDbiQ9NR34
PeptideAtlasiQ9NR34
PRIDEiQ9NR34

PTM databases

iPTMnetiQ9NR34
PhosphoSitePlusiQ9NR34

Expressioni

Tissue specificityi

Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.

Gene expression databases

BgeeiENSG00000117643
CleanExiHS_MAN1C1
ExpressionAtlasiQ9NR34 baseline and differential
GenevisibleiQ9NR34 HS

Organism-specific databases

HPAiHPA048352

Interactioni

Protein-protein interaction databases

BioGridi1213952 interactors.
IntActiQ9NR34 3 interactors.
MINTiQ9NR34
STRINGi9606.ENSP00000363452

Structurei

3D structure databases

ProteinModelPortaliQ9NR34
SMRiQ9NR34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2431 Eukaryota
ENOG410XP04 LUCA
GeneTreeiENSGT00390000016529
HOGENOMiHOG000181988
HOVERGENiHBG052389
InParanoidiQ9NR34
KOiK01230
OMAiGHIGNMF
OrthoDBiEOG091G04C8
PhylomeDBiQ9NR34
TreeFamiTF313420

Family and domain databases

Gene3Di1.50.10.101 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR001382 Glyco_hydro_47
IPR036026 Seven-hairpin_glycosidases
PfamiView protein in Pfam
PF01532 Glyco_hydro_47, 1 hit
PRINTSiPR00747 GLYHDRLASE47
SUPFAMiSSF48225 SSF48225, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NR34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMRKVPGFV PASPWGLRLP QKFLFLLFLS GLVTLCFGAL FLLPHSSRLK
60 70 80 90 100
RLFLAPRTQQ PGLEVVAEIA GHAPAREQEP PPNPAPAAPA PGEDDPSSWA
110 120 130 140 150
SPRRRKGGLR RTRPTGPREE ATAARGNSIP ASRPGDEGVP FRFDFNAFRS
160 170 180 190 200
RLRHPVLGTR ADESQEPQSQ VRAQREKIKE MMQFAWQSYK RYAMGKNELR
210 220 230 240 250
PLTKDGYEGN MFGGLSGATV IDSLDTLYLM ELKEEFQEAK AWVGESFHLN
260 270 280 290 300
VSGEASLFEV NIRYIGGLLS AFYLTGEEVF RIKAIRLGEK LLPAFNTPTG
310 320 330 340 350
IPKGVVSFKS GNWGWATAGS SSILAEFGSL HLEFLHLTEL SGNQVFAEKV
360 370 380 390 400
RNIRKVLRKI EKPFGLYPNF LSPVSGNWVQ HHVSVGGLGD SFYEYLIKSW
410 420 430 440 450
LMSGKTDMEA KNMYYEALEA IETYLLNVSP GGLTYIAEWR GGILDHKMGH
460 470 480 490 500
LACFSGGMIA LGAEDAKEEK RAHYRELAAQ ITKTCHESYA RSDTKLGPEA
510 520 530 540 550
FWFNSGREAV ATQLSESYYI LRPEVVESYM YLWRQTHNPI YREWGWEVVL
560 570 580 590 600
ALEKYCRTEA GFSGIQDVYS STPNHDNKQQ SFFLAETLKY LYLLFSEDDL
610 620 630
LSLEDWVFNT EAHPLPVNHS DSSGRAWGRH
Length:630
Mass (Da):70,911
Last modified:October 1, 2000 - v1
Checksum:i80FFC71EFB36552A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261655 mRNA Translation: AAF97058.1
AL031280, AL020996 Genomic DNA Translation: CAI19714.1
BC137017 mRNA Translation: AAI37018.1
CCDSiCCDS265.1
RefSeqiNP_001275939.1, NM_001289010.1
NP_065112.1, NM_020379.3
UniGeneiHs.197043

Genome annotation databases

EnsembliENST00000374332; ENSP00000363452; ENSG00000117643
GeneIDi57134
KEGGihsa:57134
UCSCiuc001bkm.3 human

Similar proteinsi

Entry informationi

Entry nameiMA1C1_HUMAN
AccessioniPrimary (citable) accession number: Q9NR34
Secondary accession number(s): A6NNE2, B2RNP2, Q9Y545
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome