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Protein

DNA polymerase epsilon subunit 4

Gene

POLE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-directed DNA polymerase activity Source: ProtInc
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: Reactome
  • histone H3 acetylation Source: BHF-UCL

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-174430 Telomere C-strand synthesis initiation
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-68952 DNA replication initiation
R-HSA-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit 4 (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit 4
DNA polymerase epsilon subunit p12
Gene namesi
Name:POLE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115350.11
HGNCiHGNC:18755 POLE4
MIMi607269 gene
neXtProtiNX_Q9NR33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56655
OpenTargetsiENSG00000115350
PharmGKBiPA38677

Chemistry databases

DrugBankiDB00242 Cladribine

Polymorphism and mutation databases

BioMutaiPOLE4
DMDMi116241340

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001917462 – 117DNA polymerase epsilon subunit 4Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei11PhosphothreonineCombined sources1
Modified residuei25PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NR33
MaxQBiQ9NR33
PaxDbiQ9NR33
PeptideAtlasiQ9NR33
PRIDEiQ9NR33
TopDownProteomicsiQ9NR33

PTM databases

iPTMnetiQ9NR33
PhosphoSitePlusiQ9NR33

Expressioni

Gene expression databases

BgeeiENSG00000115350
CleanExiHS_POLE4
GenevisibleiQ9NR33 HS

Organism-specific databases

HPAiHPA054979
HPA071815

Interactioni

Subunit structurei

Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. Interaction with POLE3 is a prerequisite for further binding with POLE and POLE2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121168, 29 interactors
CORUMiQ9NR33
IntActiQ9NR33, 9 interactors
MINTiQ9NR33
STRINGi9606.ENSP00000420176

Structurei

3D structure databases

ProteinModelPortaliQ9NR33
SMRiQ9NR33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1658 Eukaryota
ENOG41122NU LUCA
GeneTreeiENSGT00530000063560
HOGENOMiHOG000007271
HOVERGENiHBG051399
InParanoidiQ9NR33
KOiK03506
OMAiMHVATHE
OrthoDBiEOG091G0HN1
PhylomeDBiQ9NR33
TreeFamiTF103009

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR003958 CBFA_NFYB_domain
IPR009072 Histone-fold
PfamiView protein in Pfam
PF00808 CBFD_NFYB_HMF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NR33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAGSG TPREEEGPAG EAAASQPQAP TSVPGARLSR LPLARVKALV
60 70 80 90 100
KADPDVTLAG QEAIFILARA AELFVETIAK DAYCCAQQGK RKTLQRRDLD
110
NAIEAVDEFA FLEGTLD
Length:117
Mass (Da):12,209
Last modified:October 17, 2006 - v2
Checksum:i1F7273FFEC9D318C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02805017G → VCombined sources2 PublicationsCorresponds to variant dbSNP:rs12366Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261688 Genomic DNA Translation: AAF90132.1
AC007400 Genomic DNA Translation: AAY15030.1
BC031331 mRNA Translation: AAH31331.1
CCDSiCCDS1957.1
RefSeqiNP_063949.2, NM_019896.3
UniGeneiHs.469060

Genome annotation databases

EnsembliENST00000483063; ENSP00000420176; ENSG00000115350
GeneIDi56655
KEGGihsa:56655
UCSCiuc002snf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDPOE4_HUMAN
AccessioniPrimary (citable) accession number: Q9NR33
Secondary accession number(s): Q53TR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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