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Protein

GTP-binding protein SAR1a

Gene

SAR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi75 – 78GTPBy similarity4
Nucleotide bindingi134 – 137GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079332-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein SAR1a
Alternative name(s):
COPII-associated small GTPase
Gene namesi
Name:SAR1A
Synonyms:SAR1, SARA, SARA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:10534. SAR1A.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56681.
OpenTargetsiENSG00000079332.
PharmGKBiPA34942.

Polymorphism and mutation databases

BioMutaiSAR1A.
DMDMi14548013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062581 – 198GTP-binding protein SAR1aAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei139PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NR31.
MaxQBiQ9NR31.
PaxDbiQ9NR31.
PeptideAtlasiQ9NR31.
PRIDEiQ9NR31.
TopDownProteomicsiQ9NR31-1. [Q9NR31-1]

2D gel databases

OGPiQ9NR31.

PTM databases

iPTMnetiQ9NR31.
PhosphoSitePlusiQ9NR31.
SwissPalmiQ9NR31.

Expressioni

Gene expression databases

BgeeiENSG00000079332.
CleanExiHS_SAR1A.
ExpressionAtlasiQ9NR31. baseline and differential.
GenevisibleiQ9NR31. HS.

Organism-specific databases

HPAiCAB022545.
HPA006923.
HPA048368.

Interactioni

Subunit structurei

Interacts with B3GAT1.1 Publication

Protein-protein interaction databases

BioGridi121186. 20 interactors.
DIPiDIP-59790N.
IntActiQ9NR31. 5 interactors.
STRINGi9606.ENSP00000362335.

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 19Combined sources6
Beta strandi26 – 31Combined sources6
Helixi38 – 44Combined sources7
Beta strandi61 – 66Combined sources6
Beta strandi69 – 73Combined sources5
Helixi86 – 89Combined sources4
Helixi90 – 92Combined sources3
Beta strandi95 – 101Combined sources7
Helixi105 – 107Combined sources3
Helixi108 – 120Combined sources13
Helixi122 – 124Combined sources3
Beta strandi129 – 134Combined sources6
Helixi144 – 150Combined sources7
Turni154 – 156Combined sources3
Turni165 – 167Combined sources3
Beta strandi173 – 177Combined sources5
Turni180 – 183Combined sources4
Helixi186 – 194Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GAOX-ray2.00A/B10-198[»]
ProteinModelPortaliQ9NR31.
SMRiQ9NR31.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NR31.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. SAR1 family.Curated

Phylogenomic databases

eggNOGiKOG0077. Eukaryota.
ENOG410YIKI. LUCA.
GeneTreeiENSGT00550000074696.
HOGENOMiHOG000163690.
HOVERGENiHBG104997.
InParanoidiQ9NR31.
KOiK07953.
OMAiNAVSEDQ.
OrthoDBiEOG091G0KFV.
PhylomeDBiQ9NR31.
TreeFamiTF312890.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR006689. Small_GTPase_ARF/SAR.
IPR006687. Small_GTPase_SAR1.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51422. SAR1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL
60 70 80 90 100
GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV
110 120 130 140 150
DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI
160 170 180 190
FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID
Length:198
Mass (Da):22,367
Last modified:October 1, 2000 - v1
Checksum:i38A869175CBA54F3
GO
Isoform 2 (identifier: Q9NR31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,500
Checksum:i5255243DB5CF522C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562201 – 43Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261717 mRNA. Translation: AAF81741.1.
AL136724 mRNA. Translation: CAB66658.1.
AY008268 mRNA. Translation: AAG16638.1.
AK298591 mRNA. Translation: BAG60781.1.
AL731540 Genomic DNA. No translation available.
BC003658 mRNA. Translation: AAH03658.1.
CCDSiCCDS7298.1. [Q9NR31-1]
RefSeqiNP_001136120.1. NM_001142648.1. [Q9NR31-1]
NP_064535.1. NM_020150.4. [Q9NR31-1]
UniGeneiHs.499960.

Genome annotation databases

EnsembliENST00000373238; ENSP00000362335; ENSG00000079332. [Q9NR31-1]
ENST00000373241; ENSP00000362338; ENSG00000079332. [Q9NR31-1]
ENST00000373242; ENSP00000362339; ENSG00000079332. [Q9NR31-1]
ENST00000431664; ENSP00000399698; ENSG00000079332. [Q9NR31-1]
GeneIDi56681.
KEGGihsa:56681.
UCSCiuc010qjh.3. human. [Q9NR31-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261717 mRNA. Translation: AAF81741.1.
AL136724 mRNA. Translation: CAB66658.1.
AY008268 mRNA. Translation: AAG16638.1.
AK298591 mRNA. Translation: BAG60781.1.
AL731540 Genomic DNA. No translation available.
BC003658 mRNA. Translation: AAH03658.1.
CCDSiCCDS7298.1. [Q9NR31-1]
RefSeqiNP_001136120.1. NM_001142648.1. [Q9NR31-1]
NP_064535.1. NM_020150.4. [Q9NR31-1]
UniGeneiHs.499960.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GAOX-ray2.00A/B10-198[»]
ProteinModelPortaliQ9NR31.
SMRiQ9NR31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121186. 20 interactors.
DIPiDIP-59790N.
IntActiQ9NR31. 5 interactors.
STRINGi9606.ENSP00000362335.

PTM databases

iPTMnetiQ9NR31.
PhosphoSitePlusiQ9NR31.
SwissPalmiQ9NR31.

Polymorphism and mutation databases

BioMutaiSAR1A.
DMDMi14548013.

2D gel databases

OGPiQ9NR31.

Proteomic databases

EPDiQ9NR31.
MaxQBiQ9NR31.
PaxDbiQ9NR31.
PeptideAtlasiQ9NR31.
PRIDEiQ9NR31.
TopDownProteomicsiQ9NR31-1. [Q9NR31-1]

Protocols and materials databases

DNASUi56681.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373238; ENSP00000362335; ENSG00000079332. [Q9NR31-1]
ENST00000373241; ENSP00000362338; ENSG00000079332. [Q9NR31-1]
ENST00000373242; ENSP00000362339; ENSG00000079332. [Q9NR31-1]
ENST00000431664; ENSP00000399698; ENSG00000079332. [Q9NR31-1]
GeneIDi56681.
KEGGihsa:56681.
UCSCiuc010qjh.3. human. [Q9NR31-1]

Organism-specific databases

CTDi56681.
DisGeNETi56681.
GeneCardsiSAR1A.
HGNCiHGNC:10534. SAR1A.
HPAiCAB022545.
HPA006923.
HPA048368.
MIMi607691. gene.
neXtProtiNX_Q9NR31.
OpenTargetsiENSG00000079332.
PharmGKBiPA34942.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0077. Eukaryota.
ENOG410YIKI. LUCA.
GeneTreeiENSGT00550000074696.
HOGENOMiHOG000163690.
HOVERGENiHBG104997.
InParanoidiQ9NR31.
KOiK07953.
OMAiNAVSEDQ.
OrthoDBiEOG091G0KFV.
PhylomeDBiQ9NR31.
TreeFamiTF312890.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000079332-MONOMER.

Miscellaneous databases

ChiTaRSiSAR1A. human.
EvolutionaryTraceiQ9NR31.
GenomeRNAii56681.
PROiQ9NR31.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079332.
CleanExiHS_SAR1A.
ExpressionAtlasiQ9NR31. baseline and differential.
GenevisibleiQ9NR31. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR006689. Small_GTPase_ARF/SAR.
IPR006687. Small_GTPase_SAR1.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51422. SAR1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAR1A_HUMAN
AccessioniPrimary (citable) accession number: Q9NR31
Secondary accession number(s): B4DQ19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.