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Q9NR31

- SAR1A_HUMAN

UniProt

Q9NR31 - SAR1A_HUMAN

Protein

GTP-binding protein SAR1a

Gene

SAR1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in transport from the endoplasmic reticulum to the Golgi apparatus By similarity. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi32 – 398GTPBy similarity
    Nucleotide bindingi75 – 784GTPBy similarity
    Nucleotide bindingi134 – 1374GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein SAR1a
    Alternative name(s):
    COPII-associated small GTPase
    Gene namesi
    Name:SAR1A
    Synonyms:SAR1, SARA, SARA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:10534. SAR1A.

    Subcellular locationi

    Endoplasmic reticulum By similarity. Golgi apparatus By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. sarcoplasmic reticulum Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34942.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198GTP-binding protein SAR1aPRO_0000206258Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei139 – 1391Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NR31.
    PaxDbiQ9NR31.
    PeptideAtlasiQ9NR31.
    PRIDEiQ9NR31.

    2D gel databases

    OGPiQ9NR31.

    PTM databases

    PhosphoSiteiQ9NR31.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NR31.
    BgeeiQ9NR31.
    CleanExiHS_SAR1A.
    GenevestigatoriQ9NR31.

    Organism-specific databases

    HPAiCAB022545.
    HPA006923.
    HPA048368.

    Interactioni

    Protein-protein interaction databases

    BioGridi121186. 8 interactions.
    DIPiDIP-59790N.
    IntActiQ9NR31. 2 interactions.
    STRINGi9606.ENSP00000362335.

    Structurei

    Secondary structure

    1
    198
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi14 – 196
    Beta strandi26 – 316
    Helixi38 – 447
    Beta strandi61 – 666
    Beta strandi69 – 735
    Helixi86 – 894
    Helixi90 – 923
    Beta strandi95 – 1017
    Helixi105 – 1073
    Helixi108 – 12013
    Helixi122 – 1243
    Beta strandi129 – 1346
    Helixi144 – 1507
    Turni154 – 1563
    Turni165 – 1673
    Beta strandi173 – 1775
    Turni180 – 1834
    Helixi186 – 1949

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GAOX-ray2.00A/B10-198[»]
    ProteinModelPortaliQ9NR31.
    SMRiQ9NR31. Positions 14-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NR31.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. SAR1 family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000163690.
    HOVERGENiHBG104997.
    InParanoidiQ9NR31.
    KOiK07953.
    OMAiQQARRIW.
    OrthoDBiEOG7W1550.
    PhylomeDBiQ9NR31.
    TreeFamiTF312890.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR006689. Small_GTPase_ARF/SAR.
    IPR006687. Small_GTPase_SAR1.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SMARTiSM00178. SAR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51422. SAR1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NR31-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL    50
    GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV 100
    DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI 150
    FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID 198
    Length:198
    Mass (Da):22,367
    Last modified:October 1, 2000 - v1
    Checksum:i38A869175CBA54F3
    GO
    Isoform 2 (identifier: Q9NR31-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-43: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:155
    Mass (Da):17,500
    Checksum:i5255243DB5CF522C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4343Missing in isoform 2. 1 PublicationVSP_056220Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261717 mRNA. Translation: AAF81741.1.
    AL136724 mRNA. Translation: CAB66658.1.
    AY008268 mRNA. Translation: AAG16638.1.
    AK298591 mRNA. Translation: BAG60781.1.
    AL731540 Genomic DNA. No translation available.
    BC003658 mRNA. Translation: AAH03658.1.
    CCDSiCCDS7298.1.
    RefSeqiNP_001136120.1. NM_001142648.1.
    NP_064535.1. NM_020150.4.
    UniGeneiHs.499960.

    Genome annotation databases

    EnsembliENST00000373238; ENSP00000362335; ENSG00000079332.
    ENST00000373241; ENSP00000362338; ENSG00000079332.
    ENST00000373242; ENSP00000362339; ENSG00000079332.
    ENST00000431664; ENSP00000399698; ENSG00000079332.
    ENST00000458634; ENSP00000437979; ENSG00000079332.
    GeneIDi56681.
    KEGGihsa:56681.
    UCSCiuc010qjh.2. human.

    Polymorphism databases

    DMDMi14548013.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261717 mRNA. Translation: AAF81741.1 .
    AL136724 mRNA. Translation: CAB66658.1 .
    AY008268 mRNA. Translation: AAG16638.1 .
    AK298591 mRNA. Translation: BAG60781.1 .
    AL731540 Genomic DNA. No translation available.
    BC003658 mRNA. Translation: AAH03658.1 .
    CCDSi CCDS7298.1.
    RefSeqi NP_001136120.1. NM_001142648.1.
    NP_064535.1. NM_020150.4.
    UniGenei Hs.499960.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GAO X-ray 2.00 A/B 10-198 [» ]
    ProteinModelPortali Q9NR31.
    SMRi Q9NR31. Positions 14-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121186. 8 interactions.
    DIPi DIP-59790N.
    IntActi Q9NR31. 2 interactions.
    STRINGi 9606.ENSP00000362335.

    PTM databases

    PhosphoSitei Q9NR31.

    Polymorphism databases

    DMDMi 14548013.

    2D gel databases

    OGPi Q9NR31.

    Proteomic databases

    MaxQBi Q9NR31.
    PaxDbi Q9NR31.
    PeptideAtlasi Q9NR31.
    PRIDEi Q9NR31.

    Protocols and materials databases

    DNASUi 56681.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373238 ; ENSP00000362335 ; ENSG00000079332 .
    ENST00000373241 ; ENSP00000362338 ; ENSG00000079332 .
    ENST00000373242 ; ENSP00000362339 ; ENSG00000079332 .
    ENST00000431664 ; ENSP00000399698 ; ENSG00000079332 .
    ENST00000458634 ; ENSP00000437979 ; ENSG00000079332 .
    GeneIDi 56681.
    KEGGi hsa:56681.
    UCSCi uc010qjh.2. human.

    Organism-specific databases

    CTDi 56681.
    GeneCardsi GC10M071909.
    HGNCi HGNC:10534. SAR1A.
    HPAi CAB022545.
    HPA006923.
    HPA048368.
    MIMi 607691. gene.
    neXtProti NX_Q9NR31.
    PharmGKBi PA34942.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000163690.
    HOVERGENi HBG104997.
    InParanoidi Q9NR31.
    KOi K07953.
    OMAi QQARRIW.
    OrthoDBi EOG7W1550.
    PhylomeDBi Q9NR31.
    TreeFami TF312890.

    Miscellaneous databases

    ChiTaRSi SAR1A. human.
    EvolutionaryTracei Q9NR31.
    GenomeRNAii 56681.
    NextBioi 62187.
    PROi Q9NR31.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NR31.
    Bgeei Q9NR31.
    CleanExi HS_SAR1A.
    Genevestigatori Q9NR31.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR006689. Small_GTPase_ARF/SAR.
    IPR006687. Small_GTPase_SAR1.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SMARTi SM00178. SAR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51422. SAR1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis."
      South S.T., Sacksteder K.A., Li X., Liu Y., Gould S.J.
      J. Cell Biol. 149:1345-1360(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. "Identification of putative target genes involved in lung carcinogenesis."
      Pietas A., Petersen I., Schluens K., Petersen S.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lung.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    7. "Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells."
      Watson P., Townley A.K., Koka P., Palmer K.J., Stephens D.J.
      Traffic 7:1678-1687(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSAR1A_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR31
    Secondary accession number(s): B4DQ19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3