Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NR31 (SAR1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP-binding protein SAR1a
Alternative name(s):
COPII-associated small GTPase
Gene names
Name:SAR1A
Synonyms:SAR1, SARA, SARA1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in transport from the endoplasmic reticulum to the Golgi apparatus By similarity. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). Ref.5

Subcellular location

Endoplasmic reticulum By similarity. Golgi apparatus By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. SAR1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198GTP-binding protein SAR1a
PRO_0000206258

Regions

Nucleotide binding32 – 398GTP By similarity
Nucleotide binding75 – 784GTP By similarity
Nucleotide binding134 – 1374GTP By similarity

Amino acid modifications

Modified residue1391Phosphothreonine Ref.6 Ref.7

Secondary structure

................................... 198
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NR31 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 38A869175CBA54F3

FASTA19822,367
        10         20         30         40         50         60 
MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT 

        70         80         90        100        110        120 
SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT 

       130        140        150        160        170        180 
DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV 

       190 
LKRQGYGEGF RWLSQYID 

« Hide

References

« Hide 'large scale' references
[1]"Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis."
South S.T., Sacksteder K.A., Li X., Liu Y., Gould S.J.
J. Cell Biol. 149:1345-1360(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"Identification of putative target genes involved in lung carcinogenesis."
Pietas A., Petersen I., Schluens K., Petersen S.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[5]"Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells."
Watson P., Townley A.K., Koka P., Palmer K.J., Stephens D.J.
Traffic 7:1678-1687(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF261717 mRNA. Translation: AAF81741.1.
AL136724 mRNA. Translation: CAB66658.1.
AY008268 mRNA. Translation: AAG16638.1.
BC003658 mRNA. Translation: AAH03658.1.
RefSeqNP_001136120.1. NM_001142648.1.
NP_064535.1. NM_020150.4.
UniGeneHs.499960.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GAOX-ray2.00A/B10-198[»]
ProteinModelPortalQ9NR31.
SMRQ9NR31. Positions 14-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121186. 8 interactions.
DIPDIP-59790N.
IntActQ9NR31. 2 interactions.
STRING9606.ENSP00000362335.

PTM databases

PhosphoSiteQ9NR31.

Polymorphism databases

DMDM14548013.

2D gel databases

OGPQ9NR31.

Proteomic databases

PaxDbQ9NR31.
PeptideAtlasQ9NR31.
PRIDEQ9NR31.

Protocols and materials databases

DNASU56681.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373238; ENSP00000362335; ENSG00000079332.
ENST00000373241; ENSP00000362338; ENSG00000079332.
ENST00000373242; ENSP00000362339; ENSG00000079332.
ENST00000431664; ENSP00000399698; ENSG00000079332.
GeneID56681.
KEGGhsa:56681.
UCSCuc010qjh.2. human.

Organism-specific databases

CTD56681.
GeneCardsGC10M071909.
HGNCHGNC:10534. SAR1A.
HPACAB022545.
HPA006923.
HPA048368.
MIM607691. gene.
neXtProtNX_Q9NR31.
PharmGKBPA34942.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000163690.
HOVERGENHBG104997.
InParanoidQ9NR31.
KOK07953.
OMADGIRWLS.
OrthoDBEOG7W1550.
PhylomeDBQ9NR31.
TreeFamTF312890.

Gene expression databases

ArrayExpressQ9NR31.
BgeeQ9NR31.
CleanExHS_SAR1A.
GenevestigatorQ9NR31.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR006689. Small_GTPase_ARF/SAR.
IPR006687. Small_GTPase_SAR1.
[Graphical view]
PANTHERPTHR11711:SF12. PTHR11711:SF12. 1 hit.
PfamPF00025. Arf. 1 hit.
[Graphical view]
PRINTSPR00328. SAR1GTPBP.
SMARTSM00178. SAR. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51422. SAR1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSAR1A. human.
EvolutionaryTraceQ9NR31.
GenomeRNAi56681.
NextBio62187.
PROQ9NR31.
SOURCESearch...

Entry information

Entry nameSAR1A_HUMAN
AccessionPrimary (citable) accession number: Q9NR31
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM