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Q9NR31

- SAR1A_HUMAN

UniProt

Q9NR31 - SAR1A_HUMAN

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Protein

GTP-binding protein SAR1a

Gene

SAR1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398GTPBy similarity
Nucleotide bindingi75 – 784GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. negative regulation of cargo loading into COPII-coated vesicle Source: Ensembl
  3. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein SAR1a
Alternative name(s):
COPII-associated small GTPase
Gene namesi
Name:SAR1A
Synonyms:SAR1, SARA, SARA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:10534. SAR1A.

Subcellular locationi

Endoplasmic reticulum By similarity. Golgi apparatus By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. Golgi apparatus Source: UniProtKB-KW
  3. sarcoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198GTP-binding protein SAR1aPRO_0000206258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei139 – 1391Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NR31.
PaxDbiQ9NR31.
PeptideAtlasiQ9NR31.
PRIDEiQ9NR31.

2D gel databases

OGPiQ9NR31.

PTM databases

PhosphoSiteiQ9NR31.

Expressioni

Gene expression databases

BgeeiQ9NR31.
CleanExiHS_SAR1A.
ExpressionAtlasiQ9NR31. baseline and differential.
GenevestigatoriQ9NR31.

Organism-specific databases

HPAiCAB022545.
HPA006923.
HPA048368.

Interactioni

Protein-protein interaction databases

BioGridi121186. 9 interactions.
DIPiDIP-59790N.
IntActiQ9NR31. 2 interactions.
STRINGi9606.ENSP00000362335.

Structurei

Secondary structure

1
198
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 196
Beta strandi26 – 316
Helixi38 – 447
Beta strandi61 – 666
Beta strandi69 – 735
Helixi86 – 894
Helixi90 – 923
Beta strandi95 – 1017
Helixi105 – 1073
Helixi108 – 12013
Helixi122 – 1243
Beta strandi129 – 1346
Helixi144 – 1507
Turni154 – 1563
Turni165 – 1673
Beta strandi173 – 1775
Turni180 – 1834
Helixi186 – 1949

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GAOX-ray2.00A/B10-198[»]
ProteinModelPortaliQ9NR31.
SMRiQ9NR31. Positions 14-198.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NR31.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. SAR1 family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00550000074696.
HOGENOMiHOG000163690.
HOVERGENiHBG104997.
InParanoidiQ9NR31.
KOiK07953.
OMAiQQARRIW.
OrthoDBiEOG7W1550.
PhylomeDBiQ9NR31.
TreeFamiTF312890.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR006689. Small_GTPase_ARF/SAR.
IPR006687. Small_GTPase_SAR1.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00178. SAR. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51422. SAR1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NR31) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL
60 70 80 90 100
GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV
110 120 130 140 150
DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI
160 170 180 190
FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID
Length:198
Mass (Da):22,367
Last modified:October 1, 2000 - v1
Checksum:i38A869175CBA54F3
GO
Isoform 2 (identifier: Q9NR31-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: No experimental confirmation available.

Show »
Length:155
Mass (Da):17,500
Checksum:i5255243DB5CF522C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform 2. 1 PublicationVSP_056220Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF261717 mRNA. Translation: AAF81741.1.
AL136724 mRNA. Translation: CAB66658.1.
AY008268 mRNA. Translation: AAG16638.1.
AK298591 mRNA. Translation: BAG60781.1.
AL731540 Genomic DNA. No translation available.
BC003658 mRNA. Translation: AAH03658.1.
CCDSiCCDS7298.1. [Q9NR31-1]
RefSeqiNP_001136120.1. NM_001142648.1.
NP_064535.1. NM_020150.4.
UniGeneiHs.499960.

Genome annotation databases

EnsembliENST00000373238; ENSP00000362335; ENSG00000079332. [Q9NR31-1]
ENST00000373241; ENSP00000362338; ENSG00000079332. [Q9NR31-1]
ENST00000373242; ENSP00000362339; ENSG00000079332. [Q9NR31-1]
ENST00000431664; ENSP00000399698; ENSG00000079332. [Q9NR31-1]
GeneIDi56681.
KEGGihsa:56681.
UCSCiuc010qjh.2. human. [Q9NR31-1]

Polymorphism databases

DMDMi14548013.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF261717 mRNA. Translation: AAF81741.1 .
AL136724 mRNA. Translation: CAB66658.1 .
AY008268 mRNA. Translation: AAG16638.1 .
AK298591 mRNA. Translation: BAG60781.1 .
AL731540 Genomic DNA. No translation available.
BC003658 mRNA. Translation: AAH03658.1 .
CCDSi CCDS7298.1. [Q9NR31-1 ]
RefSeqi NP_001136120.1. NM_001142648.1.
NP_064535.1. NM_020150.4.
UniGenei Hs.499960.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GAO X-ray 2.00 A/B 10-198 [» ]
ProteinModelPortali Q9NR31.
SMRi Q9NR31. Positions 14-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121186. 9 interactions.
DIPi DIP-59790N.
IntActi Q9NR31. 2 interactions.
STRINGi 9606.ENSP00000362335.

PTM databases

PhosphoSitei Q9NR31.

Polymorphism databases

DMDMi 14548013.

2D gel databases

OGPi Q9NR31.

Proteomic databases

MaxQBi Q9NR31.
PaxDbi Q9NR31.
PeptideAtlasi Q9NR31.
PRIDEi Q9NR31.

Protocols and materials databases

DNASUi 56681.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373238 ; ENSP00000362335 ; ENSG00000079332 . [Q9NR31-1 ]
ENST00000373241 ; ENSP00000362338 ; ENSG00000079332 . [Q9NR31-1 ]
ENST00000373242 ; ENSP00000362339 ; ENSG00000079332 . [Q9NR31-1 ]
ENST00000431664 ; ENSP00000399698 ; ENSG00000079332 . [Q9NR31-1 ]
GeneIDi 56681.
KEGGi hsa:56681.
UCSCi uc010qjh.2. human. [Q9NR31-1 ]

Organism-specific databases

CTDi 56681.
GeneCardsi GC10M071909.
HGNCi HGNC:10534. SAR1A.
HPAi CAB022545.
HPA006923.
HPA048368.
MIMi 607691. gene.
neXtProti NX_Q9NR31.
PharmGKBi PA34942.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00550000074696.
HOGENOMi HOG000163690.
HOVERGENi HBG104997.
InParanoidi Q9NR31.
KOi K07953.
OMAi QQARRIW.
OrthoDBi EOG7W1550.
PhylomeDBi Q9NR31.
TreeFami TF312890.

Miscellaneous databases

ChiTaRSi SAR1A. human.
EvolutionaryTracei Q9NR31.
GenomeRNAii 56681.
NextBioi 35474023.
PROi Q9NR31.
SOURCEi Search...

Gene expression databases

Bgeei Q9NR31.
CleanExi HS_SAR1A.
ExpressionAtlasi Q9NR31. baseline and differential.
Genevestigatori Q9NR31.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR006689. Small_GTPase_ARF/SAR.
IPR006687. Small_GTPase_SAR1.
[Graphical view ]
Pfami PF00025. Arf. 1 hit.
[Graphical view ]
PRINTSi PR00328. SAR1GTPBP.
SMARTi SM00178. SAR. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51422. SAR1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis."
    South S.T., Sacksteder K.A., Li X., Liu Y., Gould S.J.
    J. Cell Biol. 149:1345-1360(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. "Identification of putative target genes involved in lung carcinogenesis."
    Pietas A., Petersen I., Schluens K., Petersen S.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  7. "Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells."
    Watson P., Townley A.K., Koka P., Palmer K.J., Stephens D.J.
    Traffic 7:1678-1687(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSAR1A_HUMAN
AccessioniPrimary (citable) accession number: Q9NR31
Secondary accession number(s): B4DQ19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3