GTP-binding protein SAR1a - Homo sapiens (Human)

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Q9NR31 (SAR1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
GTP-binding protein SAR1a

Alternative name(s):
COPII-associated small GTPase

Gene names

Name:	SAR1A
Synonyms:	SAR1, SARA, SARA1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in transport from the endoplasmic reticulum to the Golgi apparatus By similarity. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). Ref.5
Subcellular location	Endoplasmic reticulum By similarity. Golgi apparatus By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. SAR1 family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ER to Golgi vesicle-mediated transport Non-traceable author statement. Source: UniProtKB intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from direct assay. Source: HPA
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 198

198

GTP-binding protein SAR1a

PRO_0000206258

Regions

Nucleotide binding

32 – 39

GTP By similarity

Nucleotide binding

75 – 78

GTP By similarity

Nucleotide binding

134 – 137

GTP By similarity

Amino acid modifications

Modified residue

139

Phosphothreonine Ref.6

Secondary structure

198

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9NR31 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 38A869175CBA54F3
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FASTA

198

22,367

        10         20         30         40         50         60 
MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT 

        70         80         90        100        110        120 
SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT 

       130        140        150        160        170        180 
DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV 

       190 
LKRQGYGEGF RWLSQYID

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis." South S.T., Sacksteder K.A., Li X., Liu Y., Gould S.J. J. Cell Biol. 149:1345-1360(2000) [PubMed: 10871277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"Identification of putative target genes involved in lung carcinogenesis." Pietas A., Petersen I., Schluens K., Petersen S. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[5]	"Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells." Watson P., Townley A.K., Koka P., Palmer K.J., Stephens D.J. Traffic 7:1678-1687(2006) [PubMed: 17005010] [Abstract] Cited for: FUNCTION.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-139, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF261717 mRNA. Translation: AAF81741.1.
AL136724 mRNA. Translation: CAB66658.1.
AY008268 mRNA. Translation: AAG16638.1.
BC003658 mRNA. Translation: AAH03658.1.

IPI

IPI00015954.

RefSeq

NP_001136120.1. NM_001142648.1.
NP_064535.1. NM_020150.4.

UniGene

Hs.499960.
Hs.594910.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GAO	X-ray	2.00	A/B	10-198	[»]

ProteinModelPortal

Q9NR31.

SMR

Q9NR31. Positions 14-198.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NR31. 1 interaction.

STRING

Q9NR31.

PTM databases

PhosphoSite

Q9NR31.

Polymorphism databases

DMDM

14548013.

2D gel databases

OGP

Q9NR31.

Proteomic databases

PeptideAtlas

Q9NR31.

PRIDE

Q9NR31.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000373238; ENSP00000362335; ENSG00000079332.
ENST00000373239; ENSP00000362336; ENSG00000079332.
ENST00000373241; ENSP00000362338; ENSG00000079332.
ENST00000373242; ENSP00000362339; ENSG00000079332.
ENST00000431664; ENSP00000399698; ENSG00000079332.

GeneID

56681.

KEGG

hsa:56681.

UCSC

uc001jqu.1. human.

Organism-specific databases

CTD

56681.

GeneCards

GC10M071909.

H-InvDB

HIX0201480.

HGNC

HGNC:10534. SAR1A.

HPA

CAB022545.
HPA006923.

MIM

607691. gene.

neXtProt

NX_Q9NR31.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00550000074696.

HOGENOM

HBG745225.

HOVERGEN

HBG104997.

InParanoid

Q9NR31.

OMA

DDRLAQH.

OrthoDB

EOG4SJ5FT.

PhylomeDB

Q9NR31.

Gene expression databases

ArrayExpress

Q9NR31.

Bgee

Q9NR31.

CleanEx

HS_SAR1A.

Genevestigator

Q9NR31.

GermOnline

ENSG00000079332. Homo sapiens.

Family and domain databases

InterPro

IPR005225. Small_GTP-bd_dom.
IPR006689. Small_GTPase_ARF/SAR.
IPR006687. Small_GTPase_SAR1.
[Graphical view]

K07953.

PANTHER

PTHR11711. ARF/SAR. 1 hit.
PTHR11711:SF12. SAR1_GTP_bd. 1 hit.

Pfam

PF00025. Arf. 1 hit.
[Graphical view]

PRINTS

PR00328. SAR1GTPBP.

SMART

SM00178. SAR. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. Small_GTP. 1 hit.

PROSITE

PS51422. SAR1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

62187.

SOURCE

Search...

Entry information

Entry name

SAR1A_HUMAN

Accession

Primary (citable) accession number: Q9NR31

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents