ID DDX21_HUMAN Reviewed; 783 AA. AC Q9NR30-1; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 27-SEP-2005, sequence version 5. DT 27-MAR-2024, entry version 233. DE RecName: Full=Isoform 1 of Nucleolar RNA helicase 2 {ECO:0000305}; DE EC=3.6.4.13 {ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:9461305}; DE AltName: Full=DEAD box protein 21; DE AltName: Full=Gu-alpha; DE AltName: Full=Nucleolar RNA helicase Gu; DE AltName: Full=Nucleolar RNA helicase II; DE AltName: Full=RH II/Gu; GN Name=DDX21; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND VARIANT RP ILE-27. RX PubMed=8614622; DOI=10.1093/nar/24.7.1220; RA Valdez B.C., Henning D., Busch R.K., Woods K., Flores-Rozas H., Hurwitz J., RA Perlaky L., Busch H.; RT "A nucleolar RNA helicase recognized by autoimmune antibodies from a RT patient with watermelon stomach disease."; RL Nucleic Acids Res. 24:1220-1224(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-27. RC TISSUE=Cervix adenocarcinoma; RX PubMed=11237763; DOI=10.1006/bbrc.2001.4446; RA Zhu K., Henning D., Valdez B.C., Busch H.; RT "Human RNA helicase II/Gu gene: genomic organization and promoter RT analysis."; RL Biochem. Biophys. Res. Commun. 281:1006-1011(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Uterine endothelium; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Colon, and Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP PROTEIN SEQUENCE OF 7-18; 117-131; 185-199; 205-215; 237-247; 258-270; RP 287-304; 307-318; 364-387; 392-402; 407-417; 424-432; 450-474; 485-499; RP 545-555; 606-627; 659-668; 679-696 AND 703-718, PHOSPHORYLATION AT SER-121, RP AND IDENTIFICATION BY MASS SPECTROMETRY. RC TISSUE=Cervix carcinoma; RA Bienvenut W.V., Waridel P., Quadroni M.; RL Submitted (MAR-2009) to UniProtKB. RN [9] RP PROTEIN SEQUENCE OF 185-199; 260-270 AND 563-573, FUNCTION, SUBCELLULAR RP LOCATION, AND INTERACTION WITH JUN. RX PubMed=11823437; DOI=10.1093/emboj/21.3.451; RA Westermarck J., Weiss C., Saffrich R., Kast J., Musti A.M., Wessely M., RA Ansorge W., Seraphin B., Wilm M., Valdez B.C., Bohmann D.; RT "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated RT transcription."; RL EMBO J. 21:451-460(2002). RN [10] RP FUNCTION, CATALYTIC ACTIVITY, AND MUTAGENESIS OF 339-ASP-GLU-340 AND RP 375-SER-ALA-376. RX PubMed=9461305; DOI=10.1111/j.1432-1033.1997.00800.x; RA Valdez B.C., Henning D., Perumal K., Busch H.; RT "RNA-unwinding and RNA-folding activities of RNA helicase II/Gu--two RT activities in separate domains of the same protein."; RL Eur. J. Biochem. 250:800-807(1997). RN [11] RP FUNCTION. RX PubMed=14559904; DOI=10.1074/jbc.m310846200; RA Henning D., So R.B., Jin R., Lau L.F., Valdez B.C.; RT "Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA RT production."; RL J. Biol. Chem. 278:52307-52314(2003). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY. RC TISSUE=Lymphoblast; RX PubMed=14654843; DOI=10.1038/nature02166; RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.; RT "Proteomic characterization of the human centrosome by protein correlation RT profiling."; RL Nature 426:570-574(2003). RN [13] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89 AND SER-121, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling RT networks."; RL Cell 127:635-648(2006). RN [14] RP IDENTIFICATION IN THE B-WICH COMPLEX. RX PubMed=16603771; DOI=10.1074/jbc.m600233200; RA Cavellan E., Asp P., Percipalle P., Oestlund Farrants A.-K.; RT "The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear RT proteins in transcription."; RL J. Biol. Chem. 281:16264-16271(2006). RN [15] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=17924679; DOI=10.1021/pr070152u; RA Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; RT "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells RT and high confident phosphopeptide identification by cross-validation of RT MS/MS and MS/MS/MS spectra."; RL J. Proteome Res. 6:4150-4162(2007). RN [16] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=18180292; DOI=10.1074/jbc.m709613200; RA Holmstrom T.H., Mialon A., Kallio M., Nymalm Y., Mannermaa L., Holm T., RA Johansson H., Black E., Gillespie D., Salminen T.A., Langel U., RA Valdez B.C., Westermarck J.; RT "c-Jun supports ribosomal RNA processing and nucleolar localization of RNA RT helicase DDX21."; RL J. Biol. Chem. 283:7046-7053(2008). RN [17] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-71 AND SER-89, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [18] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [19] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200; RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., RA Mann M., Daub H.; RT "Large-scale proteomics analysis of the human kinome."; RL Mol. Cell. Proteomics 8:1751-1764(2009). RN [20] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-121, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [21] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-779, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). RN [22] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-71; SER-89; SER-121; RP THR-296 AND SER-567, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE RP ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [23] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [24] RP INTERACTION WITH C1QBP. RX PubMed=21536856; DOI=10.1074/mcp.m110.006148; RA Yoshikawa H., Komatsu W., Hayano T., Miura Y., Homma K., Izumikawa K., RA Ishikawa H., Miyazawa N., Tachikawa H., Yamauchi Y., Isobe T., RA Takahashi N.; RT "Splicing factor 2-associated protein p32 participates in ribosome RT biogenesis by regulating the binding of Nop52 and fibrillarin to RT preribosome particles."; RL Mol. Cell. Proteomics 10:0-0(2011). RN [25] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-71; SER-89 AND RP SER-121, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [26] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORM 2), AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [27] RP SUBCELLULAR LOCATION, AND INTERACTION WITH WDR46. RX PubMed=23848194; DOI=10.1111/gtc.12077; RA Hirai Y., Louvet E., Oda T., Kumeta M., Watanabe Y., Horigome T., RA Takeyasu K.; RT "Nucleolar scaffold protein, WDR46, determines the granular compartmental RT localization of nucleolin and DDX21."; RL Genes Cells 18:780-797(2013). RN [28] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-13; SER-71; SER-89; RP SER-121; THR-296 AND SER-567, AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [29] RP INTERACTION WITH MCM3AP. RX PubMed=23652018; DOI=10.1038/ncomms2823; RA Singh S.K., Maeda K., Eid M.M., Almofty S.A., Ono M., Pham P., RA Goodman M.F., Sakaguchi N.; RT "GANP regulates recruitment of AID to immunoglobulin variable regions by RT modulating transcription and nucleosome occupancy."; RL Nat. Commun. 4:1830-1830(2013). RN [30] RP FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=25260534; DOI=10.1186/s13058-014-0449-z; RA Zhang Y., Baysac K.C., Yee L.F., Saporita A.J., Weber J.D.; RT "Elevated DDX21 regulates c-Jun activity and rRNA processing in human RT breast cancers."; RL Breast Cancer Res. 16:449-449(2014). RN [31] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [32] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-116, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25114211; DOI=10.1073/pnas.1413825111; RA Impens F., Radoshevich L., Cossart P., Ribet D.; RT "Mapping of SUMO sites and analysis of SUMOylation changes induced by RT external stimuli."; RL Proc. Natl. Acad. Sci. U.S.A. 111:12432-12437(2014). RN [33] RP FUNCTION, RNA-BINDING, SUBCELLULAR LOCATION, AND MUTAGENESIS OF RP 339-ASP-GLU-340 AND 375-SER-ALA-376. RX PubMed=25470060; DOI=10.1038/nature13923; RA Calo E., Flynn R.A., Martin L., Spitale R.C., Chang H.Y., Wysocka J.; RT "RNA helicase DDX21 coordinates transcription and ribosomal RNA RT processing."; RL Nature 518:249-253(2015). RN [34] RP FUNCTION, AND RNA-BINDING. RX PubMed=25477391; DOI=10.1093/nar/gku1291; RA Sloan K.E., Leisegang M.S., Doebele C., Ramirez A.S., Simm S., RA Safferthal C., Kretschmer J., Schorge T., Markoutsa S., Haag S., Karas M., RA Ebersberger I., Schleiff E., Watkins N.J., Bohnsack M.T.; RT "The association of late-acting snoRNPs with human pre-ribosomal complexes RT requires the RNA helicase DDX21."; RL Nucleic Acids Res. 43:553-564(2015). RN [35] RP FUNCTION, CATALYTIC ACTIVITY, ACETYLATION AT LYS-18; LYS-137 AND LYS-600, RP AND MUTAGENESIS OF LYS-18; LYS-137; 339-ASP-GLU-340; 375-SER-ALA-376 AND RP LYS-600. RX PubMed=28790157; DOI=10.1101/gad.300624.117; RA Song C., Hotz-Wagenblatt A., Voit R., Grummt I.; RT "SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops RT and safeguard genome stability."; RL Genes Dev. 31:1370-1381(2017). RN [36] RP FUNCTION, AND MIRNA-BINDING. RX PubMed=28431233; DOI=10.1016/j.molcel.2017.03.014; RA Treiber T., Treiber N., Plessmann U., Harlander S., Daiss J.L., Eichner N., RA Lehmann G., Schall K., Urlaub H., Meister G.; RT "A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis."; RL Mol. Cell 66:270-284(2017). RN [37] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-116, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). RN [38] RP INTERACTION WITH KPNA3. RX PubMed=34564892; DOI=10.1002/ana.26228; RA Schob C., Hempel M., Safka Brozkova D., Jiang H., Kim S.Y., Batzir N.A., RA Orenstein N., Bierhals T., Johannsen J., Uhrova Meszarosova A., Chae J.H., RA Seeman P., Woidy M., Fang F., Kubisch C., Kindler S., Denecke J.; RT "Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic RT Paraplegia."; RL Ann. Neurol. 90:738-750(2021). RN [39] RP STRUCTURE BY NMR OF 617-710. RA Dutta S.K., Serrano P., Geralt M., Wuthrich K.; RT "NMR structure of the GUCT domain from human DEAD box polypeptide 21 RT (DDX21)."; RL Submitted (JAN-2013) to the PDB data bank. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9NR30-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9NR30-2; Sequence=VSP_015716; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR CCDS; CCDS31211.1; -. DR RefSeq; NP_004719.2; NM_004728.3. DR ProteomicsDB; 82265; -. DR TopDownProteomics; Q9NR30-1; -. DR Ensembl; ENST00000354185.9; ENSP00000346120.4; ENSG00000165732.14. DR UCSC; uc001jov.3; human. DR Proteomes; UP000005640; Chromosome 10. PE 1: Evidence at protein level; SQ SEQUENCE 783 AA; 87344 MW; 4F6673E38686644F CRC64; MPGKLRSDAG LESDTAMKKG ETLRKQTEEK EKKEKPKSDK TEEIAEEEET VFPKAKQVKK KAEPSEVDMN SPKSKKAKKK EEPSQNDISP KTKSLRKKKE PIEKKVVSSK TKKVTKNEEP SEEEIDAPKP KKMKKEKEMN GETREKSPKL KNGFPHPEPD CNPSEAASEE SNSEIEQEIP VEQKEGAFSN FPISEETIKL LKGRGVTFLF PIQAKTFHHV YSGKDLIAQA RTGTGKTFSF AIPLIEKLHG ELQDRKRGRA PQVLVLAPTR ELANQVSKDF SDITKKLSVA CFYGGTPYGG QFERMRNGID ILVGTPGRIK DHIQNGKLDL TKLKHVVLDE VDQMLDMGFA DQVEEILSVA YKKDSEDNPQ TLLFSATCPH WVFNVAKKYM KSTYEQVDLI GKKTQKTAIT VEHLAIKCHW TQRAAVIGDV IRVYSGHQGR TIIFCETKKE AQELSQNSAI KQDAQSLHGD IPQKQREITL KGFRNGSFGV LVATNVAARG LDIPEVDLVI QSSPPKDVES YIHRSGRTGR AGRTGVCICF YQHKEEYQLV QVEQKAGIKF KRIGVPSATE IIKASSKDAI RLLDSVPPTA ISHFKQSAEK LIEEKGAVEA LAAALAHISG ATSVDQRSLI NSNVGFVTMI LQCSIEMPNI SYAWKELKEQ LGEEIDSKVK GMVFLKGKLG VCFDVPTASV TEIQEKWHDS RRWQLSVATE QPELEGPREG YGGFRGQREG SRGFRGQRDG NRRFRGQREG SRGPRGQRSG GGNKSNRSQN KGQKRSFSKA FGQ //