Q9NR28 (DBLOH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diablo homolog, mitochondrial

Alternative name(s):
Direct IAP-binding protein with low pI
Second mitochondria-derived activator of caspase
Short name=Smac

Gene names

Name:	DIABLO
Synonyms:	SMAC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. Ref.1 Ref.3 Ref.7
Subunit structure	Homodimer. Interacts with NGFRAP1/BEX3 By similarity. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Interacts with the monomeric and dimeric form of BIRC5/survivin. Ref.7 Ref.8 Ref.10
Subcellular location	Mitochondrion. Note: Released into the cytosol when cells undergo apoptosis. Ref.3
Tissue specificity	Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. Ref.1 Ref.3
Domain	The mature N-terminus mediates interaction with XIAP/BIRC4.
Post-translational modification	Ubiquitinated by BIRC7/livin. Ref.8
Involvement in disease	Deafness, autosomal dominant, 64 (DFNA64) [MIM:614152]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Disease	Deafness Disease mutation Non-syndromic deafness
Domain	Transit peptide
PTM	Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Traceable author statement Ref.1. Source: ProtInc extrinsic apoptotic signaling pathway via death domain receptors Traceable author statement Ref.2. Source: ProtInc induction of apoptosis Traceable author statement PubMed 10929712. Source: ProtInc intrinsic apoptotic signaling pathway Traceable author statement PubMed 18309324. Source: UniProtKB intrinsic apoptotic signaling pathway in response to oxidative stress Inferred from electronic annotation. Source: Compara
Cellular_component	CD40 receptor complex Inferred from sequence or structural similarity. Source: BHF-UCL cytosol Traceable author statement. Source: Reactome internal side of plasma membrane Inferred from sequence or structural similarity. Source: BHF-UCL mitochondrial intermembrane space Traceable author statement. Source: Reactome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BIRC2	Q13490	4	EBI-517508,EBI-514538
BIRC3	Q13489	2	EBI-517508,EBI-517709
BIRC7	Q96CA5	6	EBI-517508,EBI-517623
XIAP	P98170	7	EBI-517508,EBI-517127
Xiap	Q60989	3	EBI-517508,EBI-517478	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NR28-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NR28-2)

Also known as: Diablo-S;

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MAALKSWLSRSVTSFFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTIGFGVTLCAVPIA → MKSDFYF

Isoform 3 (identifier: Q9NR28-3)

Also known as: SMAC3;

The sequence of this isoform differs from the canonical sequence as follows:
     62-105: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 55

55

Mitochondrion

Chain

56 – 239

184

Diablo homolog, mitochondrial

PRO_0000021072

Regions

Motif

56 – 60

5

IAP-binding

Natural variations

Alternative sequence

1 – 60

60

MAALK…AVPIA → MKSDFYF in isoform 2.

VSP_004397

Alternative sequence

62 – 105

44

Missing in isoform 3.

VSP_042785

Natural variant

126

1

S → L in DFNA64; does not increase apoptotic activity compared to wild-type; enhances the degradation of mutant and wild-type protein via heterodimerization; cells expressing the mutant protein show increased susceptibility to calcium-induced loss of mitochondrial potential compared to wild-type, indicating increased sensitivity to mitochondrial stress and suggestive of mitochondrial dysfunction. Ref.13

VAR_066487

Experimental info

Sequence conflict

32

1

K → E in BAB71568. Ref.4

Sequence conflict

44

1

K → R in BAB14994. Ref.4

Sequence conflict

165

1

E → K in BAB71568. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

239

Helix Strand Turn

Details...

Beta strand

57 – 59

3

Helix

69 – 119

51

Turn

120 – 123

4

Helix

127 – 173

47

Helix

177 – 211

35

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 70C2AE0DC654D031	FASTA	239	27,131
	10 20 30 40 50 60 MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA 70 80 90 100 110 120 QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL 130 140 150 160 170 180 LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS 190 200 210 220 230 ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED
	Isoform 2 (Diablo-S) [UniParc]. Checksum: FF567F7827AB6108	FASTA	186	21,233
	10 20 30 40 50 60 MKSDFYFQKS EPHSLSSEAL MRRAVSLVTD STSTFLSQTT YALIEAITEY TKAVYTLTSL 70 80 90 100 110 120 YRQYTSLLGK MNSEEEDEVW QVIIGARAEM TSKHQEYLKL ETTWMTAVGL SEMAAEAAYQ 130 140 150 160 170 180 TGADQASITA RNHIQLVKLQ VEEVHQLSRK AETKLAEAQI EELRQKTQEE GEERAESEQE AYLRED
	Isoform 3 (SMAC3) [UniParc]. Checksum: B344087CF2A87C05	FASTA	195	22,284
	10 20 30 40 50 60 MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA 70 80 90 100 110 120 QAVYTLTSLY RQYTSLLGKM NSEEEDEVWQ VIIGARAEMT SKHQEYLKLE TTWMTAVGLS 130 140 150 160 170 180 EMAAEAAYQT GADQASITAR NHIQLVKLQV EEVHQLSRKA ETKLAEAQIE ELRQKTQEEG 190 EERAESEQEA YLRED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition." Du C., Fang M., Li Y., Li L., Wang X. Cell 102:33-42(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY.
[2]	"Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway." Srinivasula S.M., Datta P., Fan X.J., Fernandes-Alnemri T., Huang Z., Alnemri E.S. J. Biol. Chem. 275:36152-36157(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHARACTERIZATION.
[3]	"Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein." Fu J., Jin Y., Arend L.J. J. Biol. Chem. 278:52660-52672(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Stomach.
[5]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle and Uterus.
[7]	"Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase." Bartke T., Pohl C., Pyrowolakis G., Jentsch S. Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH BIRC6/BRUCE.
[8]	"Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway." Ma L., Huang Y., Song Z., Feng S., Tian X., Du W., Qiu X., Heese K., Wu M. Cell Death Differ. 13:2079-2088(2006) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION BY BIRC7/LIVIN, INTERACTION WITH BIRC7/LIVIN.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"Survivin monomer plays an essential role in apoptosis regulation." Pavlyukov M.S., Antipova N.V., Balashova M.V., Vinogradova T.V., Kopantzev E.P., Shakhparonov M.I. J. Biol. Chem. 286:23296-23307(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BIRC5/SURVIVIN.
[11]	"Structural and biochemical basis of apoptotic activation by Smac/DIABLO." Chai J., Du C., Wu J.W., Kyin S., Wang X., Shi Y. Nature 406:855-862(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 56-239.
[12]	"Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain." Liu Z., Sun C., Olejniczak E.T., Meadows R.P., Betz S.F., Oost T., Herrmann J., Wu J.C., Fesik S.W. Nature 408:1004-1008(2000) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 56-64 IN COMPLEX WITH XIAP.
[13]	"Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64." Cheng J., Zhu Y., He S., Lu Y., Chen J., Han B., Petrillo M., Wrzeszczynski K.O., Yang S., Dai P., Zhai S., Han D., Zhang M.Q., Li W., Liu X., Li H., Chen Z.Y., Yuan H. Am. J. Hum. Genet. 89:56-66(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT DFNA64 LEU-126, CHARACTERIZATION OF DFNA64 LEU-126.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF262240 mRNA. Translation: AAF87716.1.
AY313210 mRNA. Translation: AAQ86939.1.
AK024768 mRNA. Translation: BAB14994.1.
AK057778 mRNA. Translation: BAB71568.1.
AK315629 mRNA. Translation: BAG37997.1.
AF298770 mRNA. Translation: AAG22077.1.
AC048338 Genomic DNA. No translation available.
BC004417 mRNA. Translation: AAH04417.1.
BC011909 mRNA. Translation: AAH11909.1.

IPI

IPI00008418.
IPI00219865.

RefSeq

NP_063940.1. NM_019887.4.
NP_620307.1. NM_138929.3.

UniGene

Hs.169611.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FEW	X-ray	2.20	A	56-239	[»]
1G3F	NMR	-	B	56-64	[»]
1G73	X-ray	2.00	A/B	56-217	[»]
1TW6	X-ray	1.71	C/D	56-64	[»]
1XB0	X-ray	2.20	G/H/I/J/K/L	56-62	[»]
1XB1	X-ray	2.70	G/H/I/J/K/L	56-62	[»]
3D9U	X-ray	2.30	B	56-61	[»]
3UIH	X-ray	2.40	P/Q	56-70	[»]
3UIJ	X-ray	2.70	P/Q	56-70	[»]

ProteinModelPortal

Q9NR28.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-27627N.

IntAct

Q9NR28. 15 interactions.

MINT

MINT-141675.

STRING

9606.ENSP00000267169.

PTM databases

PhosphoSite

Q9NR28.

Polymorphism databases

DMDM

18203316.

Proteomic databases

PaxDb

Q9NR28.

PRIDE

Q9NR28.

Protocols and materials databases

DNASU

56616.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000267169; ENSP00000267169; ENSG00000184047.
ENST00000353548; ENSP00000320343; ENSG00000184047.
ENST00000413918; ENSP00000411638; ENSG00000184047.
ENST00000443649; ENSP00000398495; ENSG00000184047.
ENST00000464942; ENSP00000442360; ENSG00000184047.

GeneID

56616.

KEGG

hsa:56616.

UCSC

uc010tab.2. human.

Organism-specific databases

CTD

56616.

GeneCards

GC12M122692.

HGNC

HGNC:21528. DIABLO.

HPA

CAB003857.
CAB016688.
HPA001825.

MIM

605219. gene.
614152. phenotype.

neXtProt

NX_Q9NR28.

Orphanet

90635. Autosomal dominant nonsyndromic sensorineural deafness type DFNA.

PharmGKB

PA134945044.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42122.

HOGENOM

HOG000217916.

HOVERGEN

HBG051315.

InParanoid

Q9NR28.

KO

K10522.

OMA

AQKPEPH.

PhylomeDB

Q9NR28.

Enzyme and pathway databases

Pathway_Interaction_DB

caspase_pathway. Caspase cascade in apoptosis.
p75ntrpathway. p75(NTR)-mediated signaling.

Reactome

REACT_578. Apoptosis.

Gene expression databases

ArrayExpress

Q9NR28.

Bgee

Q9NR28.

CleanEx

HS_DIABLO.

Genevestigator

Q9NR28.

GermOnline

ENSG00000184047. Homo sapiens.

Family and domain databases

InterPro

IPR015142. Smac_DIABLO.
IPR009062. Smac_DIABLO-like.
[Graphical view]

Pfam

PF09057. Smac_DIABLO. 1 hit.
[Graphical view]

SUPFAM

SSF46984. Smac_Diablo. 1 hit.

ProtoNet

Search...

Other

ChiTaRS

DIABLO. human.

EvolutionaryTrace

Q9NR28.

GenomeRNAi

56616.

NextBio

62059.

PMAP-CutDB

Q9NR28.

SOURCE

Search...

Entry information

Entry name

DBLOH_HUMAN

Accession

Primary (citable) accession number: Q9NR28
Secondary accession number(s): B2RDQ0 , Q6W3F3, Q96LV0, Q9BT11, Q9HAV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.