Q9NR21 (PAR11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly [ADP-ribose] polymerase 11
Short name=PARP-11
EC=2.4.2.30

Gene names

Name:	PARP11
Synonyms:	C12orf6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Sequence similarities	Contains 1 PARP catalytic domain. Contains 1 WWE domain.
Sequence caution	The sequence AAH17569.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH31073.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	NAD
Molecular function	Glycosyltransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NR21-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NR21-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-82: FSYKIDFA → MWEVAHVS

Isoform 3 (identifier: Q9NR21-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWEANPEM

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 331

331

Poly [ADP-ribose] polymerase 11

PRO_0000273419

Regions

Domain

15 – 99

85

WWE

Domain

116 – 331

216

PARP catalytic

Natural variations

Alternative sequence

1 – 74

74

Missing in isoform 2.

VSP_022553

Alternative sequence

1

1

M → MWEANPEM in isoform 3.

VSP_040378

Alternative sequence

75 – 82

8

FSYKIDFA → MWEVAHVS in isoform 2.

VSP_022554

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

331

Helix Strand Turn

Details...

Beta strand

44 – 46

3

Helix

53 – 62

10

Beta strand

68 – 72

5

Beta strand

75 – 80

6

Turn

81 – 84

4

Beta strand

85 – 89

5

Beta strand

94 – 98

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 732A46ABC0456E7E	FASTA	331	38,739
	10 20 30 40 50 60 MFHKAEELFS KTTNNEVDDM DTSDTQWGWF YLAECGKWHM FQPDTNSQCS VSSEDIEKSF 70 80 90 100 110 120 KTNPCGSISF TTSKFSYKID FAEMKQMNLT TGKQRLIKRA PFSISAFSYI CENEAIPMPP 130 140 150 160 170 180 HWENVNTQVP YQLIPLHNQT HEYNEVANLF GKTMDRNRIK RIQRIQNLDL WEFFCRKKAQ 190 200 210 220 230 240 LKKKRGVPQI NEQMLFHGTS SEFVEAICIH NFDWRINGIH GAVFGKGTYF ARDAAYSSRF 250 260 270 280 290 300 CKDDIKHGNT FQIHGVSLQQ RHLFRTYKSM FLARVLIGDY INGDSKYMRP PSKDGSYVNL 310 320 330 YDSCVDDTWN PKIFVVFDAN QIYPEYLIDF H
	Isoform 2 [UniParc]. Checksum: C31718D5A6CDD6D9	FASTA	257	30,212
	10 20 30 40 50 60 MWEVAHVSEM KQMNLTTGKQ RLIKRAPFSI SAFSYICENE AIPMPPHWEN VNTQVPYQLI 70 80 90 100 110 120 PLHNQTHEYN EVANLFGKTM DRNRIKRIQR IQNLDLWEFF CRKKAQLKKK RGVPQINEQM 130 140 150 160 170 180 LFHGTSSEFV EAICIHNFDW RINGIHGAVF GKGTYFARDA AYSSRFCKDD IKHGNTFQIH 190 200 210 220 230 240 GVSLQQRHLF RTYKSMFLAR VLIGDYINGD SKYMRPPSKD GSYVNLYDSC VDDTWNPKIF 250 VVFDANQIYP EYLIDFH
	Isoform 3 [UniParc]. Checksum: 2019EB49823BB08F	FASTA	338	39,597
	10 20 30 40 50 60 MWEANPEMFH KAEELFSKTT NNEVDDMDTS DTQWGWFYLA ECGKWHMFQP DTNSQCSVSS 70 80 90 100 110 120 EDIEKSFKTN PCGSISFTTS KFSYKIDFAE MKQMNLTTGK QRLIKRAPFS ISAFSYICEN 130 140 150 160 170 180 EAIPMPPHWE NVNTQVPYQL IPLHNQTHEY NEVANLFGKT MDRNRIKRIQ RIQNLDLWEF 190 200 210 220 230 240 FCRKKAQLKK KRGVPQINEQ MLFHGTSSEF VEAICIHNFD WRINGIHGAV FGKGTYFARD 250 260 270 280 290 300 AAYSSRFCKD DIKHGNTFQI HGVSLQQRHL FRTYKSMFLA RVLIGDYING DSKYMRPPSK 310 320 330 DGSYVNLYDS CVDDTWNPKI FVVFDANQIY PEYLIDFH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcripts in human map region 12p13.3." Lorenz B., Strom T.M. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Liver.
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Bone marrow and Brain.
[7]	"Solution structure of WWE domain in poly (ADP-ribose) polymerase family, member 11 (PARP11)." RIKEN structural genomics initiative (RSGI) Submitted (FEB-2009) to the PDB data bank Cited for: STRUCTURE BY NMR OF 15-103.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF263540 mRNA. Translation: AAF91391.1.
AK299372 mRNA. Translation: BAG61362.1.
CR749294 mRNA. Translation: CAH18149.1.
AC005842 Genomic DNA. No translation available.
AC006207 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88853.1.
BC017569 mRNA. Translation: AAH17569.1. Different initiation.
BC031073 mRNA. Translation: AAH31073.1. Sequence problems.

IPI

IPI00006899.
IPI00793807.
IPI00925450.

RefSeq

NP_065100.2. NM_020367.4.

UniGene

Hs.657268.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DK6	NMR	-	A	15-103	[»]

ProteinModelPortal

Q9NR21.

SMR

Q9NR21. Positions 10-103, 130-330.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NR21. 5 interactions.

MINT

MINT-1446506.

STRING

Q9NR21.

Polymorphism databases

DMDM

74734315.

Proteomic databases

PRIDE

Q9NR21.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000228820; ENSP00000228820; ENSG00000111224.
ENST00000427057; ENSP00000397058; ENSG00000111224.

GeneID

57097.

KEGG

hsa:57097.

UCSC

uc001qmk.1. human.
uc001qmm.1. human.

Organism-specific databases

CTD

57097.

GeneCards

GC12M003900.

HGNC

HGNC:1186. PARP11.

HPA

HPA026895.

neXtProt

NX_Q9NR21.

PharmGKB

PA25507.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG19682.

GeneTree

ENSGT00600000084343.

HOGENOM

HBG446356.

HOVERGEN

HBG056772.

InParanoid

Q9NR21.

OMA

FCRKKAQ.

PhylomeDB

Q9NR21.

Enzyme and pathway databases

BRENDA

2.4.2.30. 2681.

Gene expression databases

ArrayExpress

Q9NR21.

Bgee

Q9NR21.

CleanEx

HS_PARP11.

Genevestigator

Q9NR21.

Family and domain databases

InterPro

IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
[Graphical view]

KO

K15259.

Pfam

PF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
[Graphical view]

PROSITE

PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

62921.

Entry information

Entry name

PAR11_HUMAN

Accession

Primary (citable) accession number: Q9NR21
Secondary accession number(s): B4DRQ0, Q68DS1, Q8N5Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.