Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Poly [ADP-ribose] polymerase 11

Gene

PARP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562).By similarity1 Publication

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

GO - Molecular functioni

  • NAD+ ADP-ribosyltransferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processDifferentiation, mRNA transport, Protein transport, Spermatogenesis, Translocation, Transport
LigandNAD

Enzyme and pathway databases

BRENDAi2.4.2.30. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 11 (EC:2.4.2.30)
Short name:
PARP-11
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 11
Short name:
ARTD11
Gene namesi
Name:PARP11
Synonyms:C12orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111224.13.
HGNCiHGNC:1186. PARP11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31Y → A: No effect on subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi41F → A: No effect on subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi77Y → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi86Q → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi95R → A: Loss of subcellular location at the nuclear envelope. 1 Publication1
Mutagenesisi198G → W: No effect on subcellular location at the nuclear envelope. 1 Publication1

Organism-specific databases

DisGeNETi57097.
OpenTargetsiENSG00000111224.
PharmGKBiPA25507.

Chemistry databases

ChEMBLiCHEMBL2380189.

Polymorphism and mutation databases

DMDMi74734315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734191 – 331Poly [ADP-ribose] polymerase 11Add BLAST331

Post-translational modificationi

In vitro, can undergo mono-ADP-ribosylation.1 Publication

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDbiQ9NR21.
PRIDEiQ9NR21.

PTM databases

iPTMnetiQ9NR21.
PhosphoSitePlusiQ9NR21.

Expressioni

Gene expression databases

BgeeiENSG00000111224.
CleanExiHS_PARP11.
ExpressionAtlasiQ9NR21. baseline and differential.
GenevisibleiQ9NR21. HS.

Organism-specific databases

HPAiHPA026895.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121365. 11 interactors.
IntActiQ9NR21. 9 interactors.
MINTiMINT-1446506.
STRINGi9606.ENSP00000228820.

Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 31Combined sources5
Beta strandi34 – 36Combined sources3
Beta strandi44 – 46Combined sources3
Helixi53 – 62Combined sources10
Beta strandi66 – 72Combined sources7
Beta strandi75 – 80Combined sources6
Turni81 – 84Combined sources4
Beta strandi85 – 91Combined sources7
Beta strandi94 – 102Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK6NMR-A15-103[»]
ProteinModelPortaliQ9NR21.
SMRiQ9NR21.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NR21.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 99WWEAdd BLAST85
Domaini116 – 331PARP catalyticAdd BLAST216

Phylogenomic databases

eggNOGiENOG410IJ12. Eukaryota.
ENOG4110TY6. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000237349.
HOVERGENiHBG056772.
InParanoidiQ9NR21.
KOiK15259.
OMAiDTNIQCS.
OrthoDBiEOG091G14UY.
PhylomeDBiQ9NR21.
TreeFamiTF338389.

Family and domain databases

InterProiView protein in InterPro
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR037197. WWE_dom_sf.
PfamiView protein in Pfam
PF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
SUPFAMiSSF117839. SSF117839. 1 hit.
PROSITEiView protein in PROSITE
PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFHKAEELFS KTTNNEVDDM DTSDTQWGWF YLAECGKWHM FQPDTNSQCS
60 70 80 90 100
VSSEDIEKSF KTNPCGSISF TTSKFSYKID FAEMKQMNLT TGKQRLIKRA
110 120 130 140 150
PFSISAFSYI CENEAIPMPP HWENVNTQVP YQLIPLHNQT HEYNEVANLF
160 170 180 190 200
GKTMDRNRIK RIQRIQNLDL WEFFCRKKAQ LKKKRGVPQI NEQMLFHGTS
210 220 230 240 250
SEFVEAICIH NFDWRINGIH GAVFGKGTYF ARDAAYSSRF CKDDIKHGNT
260 270 280 290 300
FQIHGVSLQQ RHLFRTYKSM FLARVLIGDY INGDSKYMRP PSKDGSYVNL
310 320 330
YDSCVDDTWN PKIFVVFDAN QIYPEYLIDF H
Length:331
Mass (Da):38,739
Last modified:October 1, 2000 - v1
Checksum:i732A46ABC0456E7E
GO
Isoform 2 (identifier: Q9NR21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-82: FSYKIDFA → MWEVAHVS

Show »
Length:257
Mass (Da):30,212
Checksum:iC31718D5A6CDD6D9
GO
Isoform 3 (identifier: Q9NR21-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWEANPEM

Show »
Length:338
Mass (Da):39,597
Checksum:i2019EB49823BB08F
GO

Sequence cautioni

The sequence AAH17569 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH31073 differs from that shown. Probable cloning artifact.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225531 – 74Missing in isoform 2. 2 PublicationsAdd BLAST74
Alternative sequenceiVSP_0403781M → MWEANPEM in isoform 3. 1 Publication1
Alternative sequenceiVSP_02255475 – 82FSYKIDFA → MWEVAHVS in isoform 2. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263540 mRNA. Translation: AAF91391.1.
AK299372 mRNA. Translation: BAG61362.1.
CR749294 mRNA. Translation: CAH18149.1.
AC005842 Genomic DNA. No translation available.
AC006207 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88853.1.
BC017569 mRNA. Translation: AAH17569.1. Different initiation.
BC031073 mRNA. Translation: AAH31073.1. Sequence problems.
CCDSiCCDS66281.1. [Q9NR21-2]
CCDS8523.2. [Q9NR21-4]
RefSeqiNP_001273450.1. NM_001286521.1. [Q9NR21-2]
NP_001273451.1. NM_001286522.1. [Q9NR21-2]
NP_065100.2. NM_020367.5. [Q9NR21-4]
XP_005253768.1. XM_005253711.4. [Q9NR21-1]
XP_011519272.1. XM_011520970.1. [Q9NR21-1]
XP_011519273.1. XM_011520971.2. [Q9NR21-1]
XP_011519275.1. XM_011520973.2. [Q9NR21-1]
XP_016875159.1. XM_017019670.1. [Q9NR21-1]
XP_016875160.1. XM_017019671.1. [Q9NR21-2]
UniGeneiHs.657268.

Genome annotation databases

EnsembliENST00000228820; ENSP00000228820; ENSG00000111224. [Q9NR21-4]
ENST00000427057; ENSP00000397058; ENSG00000111224. [Q9NR21-2]
ENST00000447133; ENSP00000405385; ENSG00000111224. [Q9NR21-2]
GeneIDi57097.
KEGGihsa:57097.
UCSCiuc001qml.4. human. [Q9NR21-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAR11_HUMAN
AccessioniPrimary (citable) accession number: Q9NR21
Secondary accession number(s): B4DRQ0, Q68DS1, Q8N5Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references