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Q9NR20

- DYRK4_HUMAN

UniProt

Q9NR20 - DYRK4_HUMAN

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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Gene
DYRK4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possible non-essential role in spermiogenesis By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331ATP
Active sitei230 – 2301Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1189ATP By similarity
Nucleotide bindingi183 – 1864ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
  5. protein serine/threonine kinase activity Source: UniProtKB-KW
  6. protein tyrosine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9NR20.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC:2.7.12.1)
Gene namesi
Name:DYRK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:3095. DYRK4.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi133 – 1331K → R: Loss of kinase activity. 1 Publication

Organism-specific databases

PharmGKBiPA27552.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Dual specificity tyrosine-phosphorylation-regulated kinase 4PRO_0000085940Add
BLAST

Post-translational modificationi

Autophosphorylated on tyrosine residues By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NR20.
PRIDEiQ9NR20.

PTM databases

PhosphoSiteiQ9NR20.

Expressioni

Gene expression databases

ArrayExpressiQ9NR20.
BgeeiQ9NR20.
CleanExiHS_DYRK4.
GenevestigatoriQ9NR20.

Organism-specific databases

HPAiHPA028065.
HPA056073.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DYRK2Q926303EBI-3914009,EBI-749432

Protein-protein interaction databases

BioGridi114326. 15 interactions.
IntActiQ9NR20. 11 interactions.
STRINGi9606.ENSP00000010132.

Structurei

3D structure databases

ProteinModelPortaliQ9NR20.
SMRiQ9NR20. Positions 30-400.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 400297Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000220863.
HOVERGENiHBG051426.
InParanoidiQ9NR20.
KOiK08825.
OMAiQHSGDQQ.
PhylomeDBiQ9NR20.
TreeFamiTF314624.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NR20-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS    50
PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 100
AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 150
ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 200
GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 250
FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 300
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 350
RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI 400
HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE 450
KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT 500
SPGQSKNFSL KNTNVLPPIV 520

Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Length:520
Mass (Da):59,608
Last modified:May 10, 2005 - v2
Checksum:i33FECD8249DDB223
GO
Isoform 2 (identifier: Q9NR20-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-441: Missing.

Show »
Length:519
Mass (Da):59,537
Checksum:i2ACD1BC87AA1591B
GO

Sequence cautioni

The sequence AAF91393.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611A → T.
Corresponds to variant rs12306130 [ dbSNP | Ensembl ].
VAR_033900
Natural varianti70 – 701A → S.1 Publication
VAR_040465
Natural varianti95 – 951V → I.1 Publication
VAR_010721
Natural varianti189 – 1891N → S.1 Publication
Corresponds to variant rs3741927 [ dbSNP | Ensembl ].
VAR_010722
Natural varianti454 – 4541D → V.
Corresponds to variant rs1801016 [ dbSNP | Ensembl ].
VAR_014948

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei441 – 4411Missing in isoform 2. VSP_013745

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF263541 mRNA. Translation: AAF91393.1. Different initiation.
BC031244 mRNA. Translation: AAH31244.1.
Y09305 mRNA. Translation: CAA70488.1.
CCDSiCCDS8530.1. [Q9NR20-1]
RefSeqiNP_003836.1. NM_003845.2. [Q9NR20-1]
UniGeneiHs.439530.

Genome annotation databases

EnsembliENST00000010132; ENSP00000010132; ENSG00000010219. [Q9NR20-1]
ENST00000540757; ENSP00000441755; ENSG00000010219. [Q9NR20-1]
ENST00000543431; ENSP00000439697; ENSG00000010219. [Q9NR20-2]
GeneIDi8798.
KEGGihsa:8798.
UCSCiuc001qmx.3. human. [Q9NR20-1]
uc001qmy.2. human. [Q9NR20-2]

Polymorphism databases

DMDMi68566308.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF263541 mRNA. Translation: AAF91393.1 . Different initiation.
BC031244 mRNA. Translation: AAH31244.1 .
Y09305 mRNA. Translation: CAA70488.1 .
CCDSi CCDS8530.1. [Q9NR20-1 ]
RefSeqi NP_003836.1. NM_003845.2. [Q9NR20-1 ]
UniGenei Hs.439530.

3D structure databases

ProteinModelPortali Q9NR20.
SMRi Q9NR20. Positions 30-400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114326. 15 interactions.
IntActi Q9NR20. 11 interactions.
STRINGi 9606.ENSP00000010132.

Chemistry

ChEMBLi CHEMBL1075115.
GuidetoPHARMACOLOGYi 2013.

PTM databases

PhosphoSitei Q9NR20.

Polymorphism databases

DMDMi 68566308.

Proteomic databases

PaxDbi Q9NR20.
PRIDEi Q9NR20.

Protocols and materials databases

DNASUi 8798.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000010132 ; ENSP00000010132 ; ENSG00000010219 . [Q9NR20-1 ]
ENST00000540757 ; ENSP00000441755 ; ENSG00000010219 . [Q9NR20-1 ]
ENST00000543431 ; ENSP00000439697 ; ENSG00000010219 . [Q9NR20-2 ]
GeneIDi 8798.
KEGGi hsa:8798.
UCSCi uc001qmx.3. human. [Q9NR20-1 ]
uc001qmy.2. human. [Q9NR20-2 ]

Organism-specific databases

CTDi 8798.
GeneCardsi GC12P004699.
HGNCi HGNC:3095. DYRK4.
HPAi HPA028065.
HPA056073.
MIMi 609181. gene.
neXtProti NX_Q9NR20.
PharmGKBi PA27552.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000220863.
HOVERGENi HBG051426.
InParanoidi Q9NR20.
KOi K08825.
OMAi QHSGDQQ.
PhylomeDBi Q9NR20.
TreeFami TF314624.

Enzyme and pathway databases

SignaLinki Q9NR20.

Miscellaneous databases

GenomeRNAii 8798.
NextBioi 33000.
PROi Q9NR20.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NR20.
Bgeei Q9NR20.
CleanExi HS_DYRK4.
Genevestigatori Q9NR20.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
    White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.
    Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS ILE-95 AND SER-189.
    Tissue: Brain and Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases."
    Becker W., Weber Y., Wetzel K., Eirmbter K., Tejedor F.J., Joost H.-G.
    J. Biol. Chem. 273:25893-25902(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 280-520 (ISOFORM 2).
    Tissue: Lung.
  4. "The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice."
    Sacher F., Moeller C., Bone W., Gottwald U., Fritsch M.
    Mol. Cell. Endocrinol. 267:80-88(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-133.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-70.

Entry informationi

Entry nameiDYRK4_HUMAN
AccessioniPrimary (citable) accession number: Q9NR20
Secondary accession number(s): Q8NEF2, Q92631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 10, 2005
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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