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Q9NR20

- DYRK4_HUMAN

UniProt

Q9NR20 - DYRK4_HUMAN

Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 4

Gene

DYRK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (10 May 2005)
      Previous versions | rss
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    Functioni

    Possible non-essential role in spermiogenesis.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331ATP
    Active sitei230 – 2301Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi110 – 1189ATPPROSITE-ProRule annotation
    Nucleotide bindingi183 – 1864ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
    5. protein serine/threonine kinase activity Source: UniProtKB-KW
    6. protein tyrosine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9NR20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC:2.7.12.1)
    Gene namesi
    Name:DYRK4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:3095. DYRK4.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: HPA

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi133 – 1331K → R: Loss of kinase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA27552.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Dual specificity tyrosine-phosphorylation-regulated kinase 4PRO_0000085940Add
    BLAST

    Post-translational modificationi

    Autophosphorylated on tyrosine residues.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9NR20.
    PRIDEiQ9NR20.

    PTM databases

    PhosphoSiteiQ9NR20.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NR20.
    BgeeiQ9NR20.
    CleanExiHS_DYRK4.
    GenevestigatoriQ9NR20.

    Organism-specific databases

    HPAiHPA028065.
    HPA056073.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DYRK2Q926303EBI-3914009,EBI-749432

    Protein-protein interaction databases

    BioGridi114326. 15 interactions.
    IntActiQ9NR20. 12 interactions.
    STRINGi9606.ENSP00000010132.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NR20.
    SMRiQ9NR20. Positions 30-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 400297Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000220863.
    HOVERGENiHBG051426.
    InParanoidiQ9NR20.
    KOiK08825.
    OMAiQHSGDQQ.
    PhylomeDBiQ9NR20.
    TreeFamiTF314624.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NR20-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS    50
    PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI 100
    AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK 150
    ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ 200
    GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID 250
    FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 300
    YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN 350
    RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI 400
    HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE 450
    KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT 500
    SPGQSKNFSL KNTNVLPPIV 520

    Note: May be due to a competing acceptor splice site. No experimental confirmation available.

    Length:520
    Mass (Da):59,608
    Last modified:May 10, 2005 - v2
    Checksum:i33FECD8249DDB223
    GO
    Isoform 2 (identifier: Q9NR20-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         441-441: Missing.

    Show »
    Length:519
    Mass (Da):59,537
    Checksum:i2ACD1BC87AA1591B
    GO

    Sequence cautioni

    The sequence AAF91393.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611A → T.
    Corresponds to variant rs12306130 [ dbSNP | Ensembl ].
    VAR_033900
    Natural varianti70 – 701A → S.1 Publication
    VAR_040465
    Natural varianti95 – 951V → I.1 Publication
    VAR_010721
    Natural varianti189 – 1891N → S.1 Publication
    Corresponds to variant rs3741927 [ dbSNP | Ensembl ].
    VAR_010722
    Natural varianti454 – 4541D → V.
    Corresponds to variant rs1801016 [ dbSNP | Ensembl ].
    VAR_014948

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei441 – 4411Missing in isoform 2. 2 PublicationsVSP_013745

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF263541 mRNA. Translation: AAF91393.1. Different initiation.
    BC031244 mRNA. Translation: AAH31244.1.
    Y09305 mRNA. Translation: CAA70488.1.
    CCDSiCCDS8530.1. [Q9NR20-1]
    RefSeqiNP_003836.1. NM_003845.2. [Q9NR20-1]
    UniGeneiHs.439530.

    Genome annotation databases

    EnsembliENST00000010132; ENSP00000010132; ENSG00000010219. [Q9NR20-1]
    ENST00000540757; ENSP00000441755; ENSG00000010219. [Q9NR20-1]
    ENST00000543431; ENSP00000439697; ENSG00000010219. [Q9NR20-2]
    GeneIDi8798.
    KEGGihsa:8798.
    UCSCiuc001qmx.3. human. [Q9NR20-1]
    uc001qmy.2. human. [Q9NR20-2]

    Polymorphism databases

    DMDMi68566308.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF263541 mRNA. Translation: AAF91393.1 . Different initiation.
    BC031244 mRNA. Translation: AAH31244.1 .
    Y09305 mRNA. Translation: CAA70488.1 .
    CCDSi CCDS8530.1. [Q9NR20-1 ]
    RefSeqi NP_003836.1. NM_003845.2. [Q9NR20-1 ]
    UniGenei Hs.439530.

    3D structure databases

    ProteinModelPortali Q9NR20.
    SMRi Q9NR20. Positions 30-400.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114326. 15 interactions.
    IntActi Q9NR20. 12 interactions.
    STRINGi 9606.ENSP00000010132.

    Chemistry

    ChEMBLi CHEMBL1075115.
    GuidetoPHARMACOLOGYi 2013.

    PTM databases

    PhosphoSitei Q9NR20.

    Polymorphism databases

    DMDMi 68566308.

    Proteomic databases

    PaxDbi Q9NR20.
    PRIDEi Q9NR20.

    Protocols and materials databases

    DNASUi 8798.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000010132 ; ENSP00000010132 ; ENSG00000010219 . [Q9NR20-1 ]
    ENST00000540757 ; ENSP00000441755 ; ENSG00000010219 . [Q9NR20-1 ]
    ENST00000543431 ; ENSP00000439697 ; ENSG00000010219 . [Q9NR20-2 ]
    GeneIDi 8798.
    KEGGi hsa:8798.
    UCSCi uc001qmx.3. human. [Q9NR20-1 ]
    uc001qmy.2. human. [Q9NR20-2 ]

    Organism-specific databases

    CTDi 8798.
    GeneCardsi GC12P004699.
    HGNCi HGNC:3095. DYRK4.
    HPAi HPA028065.
    HPA056073.
    MIMi 609181. gene.
    neXtProti NX_Q9NR20.
    PharmGKBi PA27552.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000220863.
    HOVERGENi HBG051426.
    InParanoidi Q9NR20.
    KOi K08825.
    OMAi QHSGDQQ.
    PhylomeDBi Q9NR20.
    TreeFami TF314624.

    Enzyme and pathway databases

    SignaLinki Q9NR20.

    Miscellaneous databases

    GenomeRNAii 8798.
    NextBioi 33000.
    PROi Q9NR20.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NR20.
    Bgeei Q9NR20.
    CleanExi HS_DYRK4.
    Genevestigatori Q9NR20.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
      White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.
      Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS ILE-95 AND SER-189.
      Tissue: Brain and Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases."
      Becker W., Weber Y., Wetzel K., Eirmbter K., Tejedor F.J., Joost H.-G.
      J. Biol. Chem. 273:25893-25902(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 280-520 (ISOFORM 2).
      Tissue: Lung.
    4. "The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice."
      Sacher F., Moeller C., Bone W., Gottwald U., Fritsch M.
      Mol. Cell. Endocrinol. 267:80-88(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-133.
    5. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-70.

    Entry informationi

    Entry nameiDYRK4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR20
    Secondary accession number(s): Q8NEF2, Q92631
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3