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Q9NR20 (DYRK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 4

EC=2.7.12.1
Gene names
Name:DYRK4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possible non-essential role in spermiogenesis By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Subcellular location

Cytoplasm Ref.4.

Post-translational modification

Autophosphorylated on tyrosine residues By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAF91393.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DYRK2Q926303EBI-3914009,EBI-749432

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NR20-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Isoform 2 (identifier: Q9NR20-2)

The sequence of this isoform differs from the canonical sequence as follows:
     441-441: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Dual specificity tyrosine-phosphorylation-regulated kinase 4
PRO_0000085940

Regions

Domain104 – 400297Protein kinase
Nucleotide binding110 – 1189ATP By similarity
Nucleotide binding183 – 1864ATP By similarity

Sites

Active site2301Proton acceptor By similarity
Binding site1331ATP

Natural variations

Alternative sequence4411Missing in isoform 2.
VSP_013745
Natural variant611A → T.
Corresponds to variant rs12306130 [ dbSNP | Ensembl ].
VAR_033900
Natural variant701A → S. Ref.5
VAR_040465
Natural variant951V → I. Ref.1
VAR_010721
Natural variant1891N → S. Ref.1
Corresponds to variant rs3741927 [ dbSNP | Ensembl ].
VAR_010722
Natural variant4541D → V.
Corresponds to variant rs1801016 [ dbSNP | Ensembl ].
VAR_014948

Experimental info

Mutagenesis1331K → R: Loss of kinase activity. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2005. Version 2.
Checksum: 33FECD8249DDB223

FASTA52059,608
        10         20         30         40         50         60 
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY 

        70         80         90        100        110        120 
AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK 

       130        140        150        160        170        180 
CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 

       190        200        210        220        230        240 
ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ 

       250        260        270        280        290        300 
KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 

       310        320        330        340        350        360 
YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK 

       370        380        390        400        410        420 
DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS 

       430        440        450        460        470        480 
FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP 

       490        500        510        520 
QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV 

« Hide

Isoform 2 [UniParc].

Checksum: 2ACD1BC87AA1591B
Show »

FASTA51959,537

References

« Hide 'large scale' references
[1]"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M.
Nat. Genet. 26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS ILE-95 AND SER-189.
Tissue: Brain and Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[3]"Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases."
Becker W., Weber Y., Wetzel K., Eirmbter K., Tejedor F.J., Joost H.-G.
J. Biol. Chem. 273:25893-25902(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 280-520 (ISOFORM 2).
Tissue: Lung.
[4]"The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice."
Sacher F., Moeller C., Bone W., Gottwald U., Fritsch M.
Mol. Cell. Endocrinol. 267:80-88(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-133.
[5]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-70.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF263541 mRNA. Translation: AAF91393.1. Different initiation.
BC031244 mRNA. Translation: AAH31244.1.
Y09305 mRNA. Translation: CAA70488.1.
CCDSCCDS8530.1. [Q9NR20-1]
RefSeqNP_003836.1. NM_003845.2. [Q9NR20-1]
UniGeneHs.439530.

3D structure databases

ProteinModelPortalQ9NR20.
SMRQ9NR20. Positions 30-400.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114326. 15 interactions.
IntActQ9NR20. 11 interactions.
STRING9606.ENSP00000010132.

Chemistry

ChEMBLCHEMBL1075115.
GuidetoPHARMACOLOGY2013.

PTM databases

PhosphoSiteQ9NR20.

Polymorphism databases

DMDM68566308.

Proteomic databases

PaxDbQ9NR20.
PRIDEQ9NR20.

Protocols and materials databases

DNASU8798.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000010132; ENSP00000010132; ENSG00000010219. [Q9NR20-1]
ENST00000540757; ENSP00000441755; ENSG00000010219. [Q9NR20-1]
ENST00000543431; ENSP00000439697; ENSG00000010219. [Q9NR20-2]
GeneID8798.
KEGGhsa:8798.
UCSCuc001qmx.3. human. [Q9NR20-1]
uc001qmy.2. human. [Q9NR20-2]

Organism-specific databases

CTD8798.
GeneCardsGC12P004699.
HGNCHGNC:3095. DYRK4.
HPAHPA028065.
HPA056073.
MIM609181. gene.
neXtProtNX_Q9NR20.
PharmGKBPA27552.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000220863.
HOVERGENHBG051426.
InParanoidQ9NR20.
KOK08825.
OMAQHSGDQQ.
PhylomeDBQ9NR20.
TreeFamTF314624.

Enzyme and pathway databases

SignaLinkQ9NR20.

Gene expression databases

ArrayExpressQ9NR20.
BgeeQ9NR20.
CleanExHS_DYRK4.
GenevestigatorQ9NR20.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8798.
NextBio33000.
PROQ9NR20.
SOURCESearch...

Entry information

Entry nameDYRK4_HUMAN
AccessionPrimary (citable) accession number: Q9NR20
Secondary accession number(s): Q8NEF2, Q92631
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 10, 2005
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM