Reviewed,
UniProtKB/Swiss-Prot Q9NR20 (DYRK4_HUMAN)
Last modified
June 16, 2009.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dual specificity tyrosine-phosphorylation-regulated kinase 4 EC=2.7.12.1 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 520 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Possible non-essential role in spermiogenesis By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Cofactor | Magnesium By similarity. |
| Subcellular location | |
| Post-translational modification | Autophosphorylated on tyrosine residues By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Non-traceable author statement. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Non-traceable author statement. Source: UniProtKB magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activityNon-traceable author statement. Source: UniProtKB protein tyrosine kinase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9NR20-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: May be due to a competing acceptor splice site. No experimental confirmation available. | ||||||
| Isoform 2 (identifier: Q9NR20-2) The sequence of this isoform differs from the canonical sequence as follows: 441-441: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 520 | 520 | Dual specificity tyrosine-phosphorylation-regulated kinase 4 | PRO_0000085940 | |||||
Regions | |||||||||
| Domain | 104 – 400 | 297 | Protein kinase | ||||||
| Nucleotide binding | 110 – 118 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 230 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 133 | 1 | ATP | ||||||
Amino acid modifications | |||||||||
| Modified residue | 264 | 1 | Phosphotyrosine Ref.4 | ||||||
Natural variations | |||||||||
| Alternative sequence | 441 | 1 | Missing in isoform 2. | VSP_013745 | |||||
| Natural variant | 61 | 1 | A → T: dbSNP rs12306130. | VAR_033900 | |||||
| Natural variant | 70 | 1 | A → S Ref.6 | VAR_040465 | |||||
| Natural variant | 95 | 1 | V → I Ref.1 | VAR_010721 | |||||
| Natural variant | 189 | 1 | N → S: dbSNP rs3741927. Ref.1 | VAR_010722 | |||||
| Natural variant | 454 | 1 | D → V: dbSNP rs1801016. | VAR_014948 | |||||
Experimental info | |||||||||
| Mutagenesis | 133 | 1 | K → R: Loss of kinase activity. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23." White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M. Nat. Genet. 26:345-348(2000) [PubMed: 11062477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS ILE-95 AND SER-189. Tissue: Brain and Kidney. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis. |
| [3] | "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases." Becker W., Weber Y., Wetzel K., Eirmbter K., Tejedor F.J., Joost H.-G. J. Biol. Chem. 273:25893-25902(1998) [PubMed: 9748265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 280-520 (ISOFORM 2). Tissue: Lung. |
| [4] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-264, MASS SPECTROMETRY. |
| [5] | "The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice." Sacher F., Moeller C., Bone W., Gottwald U., Fritsch M. Mol. Cell. Endocrinol. 267:80-88(2007) [PubMed: 17292540] [Abstract] Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-133. |
| [6] | "Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-70. |
Cross-references
Sequence databases | |
|---|---|
| AF263541 mRNA. Translation: AAF91393.1. Different initiation. BC031244 mRNA. Translation: AAH31244.1. Y09305 mRNA. Translation: CAA70488.1. | |
| IPI | IPI00396286. IPI00555676. |
| RefSeq | NP_003836.1. |
| UniGene | Hs.439530 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BI8 based on UniProtKB Q00534. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9NR20. |
Proteomic databases | |
| PRIDE | Q9NR20. |
Genome annotation databases | |
| Ensembl | ENSG00000010219. Homo sapiens. [Contig view] |
| GeneID | 8798. |
| KEGG | hsa:8798. |
Organism-specific databases | |
| GeneCards | GC12P004569. |
| H-InvDB | HIX0010350. |
| HGNC | HGNC:3095. DYRK4. |
| MIM | 609181. gene. |
| PharmGKB | PA27552. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NR20. |
| HOVERGEN | Q9NR20. |
| OMA | Q9NR20. LYEQSEI. |
Enzyme and pathway databases | |
| BRENDA | 2.7.12.1. 247. |
Gene expression databases | |
| Bgee | Q9NR20. |
| CleanEx | HS_DYRK4. |
| GermOnline | ENSG00000010219. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 33000. |
| SOURCE | Search... |
Entry information
| Entry name | DYRK4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NR20 Secondary accession number(s): Q8NEF2, Q92631 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


