Reviewed,
UniProtKB/Swiss-Prot Q9NR19 (ACSA_HUMAN)
Last modified
June 16, 2009.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acetyl-coenzyme A synthetase, cytoplasmic EC=6.2.1.1 Alternative name(s): Acetate--CoA ligase Acyl-activating enzyme Acetyl-CoA synthetase Short name=AceCS Short name=ACS Acyl-CoA synthetase short-chain family member 2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 701 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Activates acetate so that it can be used for lipid synthesis or for energy generation. |
| Catalytic activity | ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. |
| Subunit structure | Monomer. |
| Subcellular location | |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | lipid biosynthetic process Ref.1 Inferred from mutant phenotype. Source: UniProtKB |
| Cellular component | cytosol Ref.1 Inferred from Experiment. Source: Reactome nucleusInferred from direct assay. Source: HPA |
| Molecular function | AMP binding Ref.1 Inferred by curator. Source: UniProtKB ATP bindingInferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Ref.1Inferred from direct assay. Source: UniProtKB protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 701 | 701 | Acetyl-coenzyme A synthetase, cytoplasmic | PRO_0000208423 | |||||
Amino acid modifications | |||||||||
| Modified residue | 30 | 1 | Phosphoserine Ref.4 Ref.5 | ||||||
| Modified residue | 263 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 267 | 1 | Phosphoserine Ref.5 | ||||||
Experimental info | |||||||||
| Sequence conflict | 615 | 1 | V → F in AAH12172. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins." Luong A., Hannah V.C., Brown M.S., Goldstein J.L. J. Biol. Chem. 275:26458-26466(2000) [PubMed: 10843999] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. |
| [2] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| [4] | "Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, MASS SPECTROMETRY. Tissue: Platelet. |
| [5] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 AND SER-267, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF263614 mRNA. Translation: AAF75064.1. AL049709, AL133324 Genomic DNA. Translation: CAI19726.1. AL133324, AL049709 Genomic DNA. Translation: CAI19312.1. BC012172 mRNA. Translation: AAH12172.1. | |
| IPI | IPI00413730. |
| RefSeq | NP_061147.1. |
| UniGene | Hs.517034 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1PG4 based on UniProtKB Q8ZKF6. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NR19. 2 interactions. |
PTM databases | |
| PhosphoSite | Q9NR19. |
Proteomic databases | |
| PRIDE | Q9NR19. |
Genome annotation databases | |
| Ensembl | ENSG00000131069. Homo sapiens. [Contig view] |
| GeneID | 55902. |
Organism-specific databases | |
| GeneCards | GC20P032927. |
| H-InvDB | HIX0015754. |
| HGNC | HGNC:15814. ACSS2. |
| HPA | HPA004141. |
| MIM | 605832. gene. |
| PharmGKB | PA24429. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9NR19. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:ENSG00000131069-MON. |
| BRENDA | 6.2.1.1. 247. |
| Pathway_Interaction_DB | hdac_classiii_pathway. Signaling events mediated by HDAC Class III. |
| Reactome | REACT_13433. Biological oxidations. |
Gene expression databases | |
| ArrayExpress | Q9NR19. |
| Bgee | Q9NR19. |
| CleanEx | HS_ACSS2. |
| GermOnline | ENSG00000131069. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011904. Ac_CoA_lig_AcsA. IPR000873. AMP-dep_Synth/Lig. [Graphical view] |
| Pfam | PF00501. AMP-binding. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02188. Ac_CoA_lig_AcsA. 1 hit. |
| PROSITE | PS00455. AMP_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00131. Adenosine monophosphate. DB00171. Adenosine triphosphate. |
| NextBio | 61271. |
| SOURCE | Search... |
Entry information
| Entry name | ACSA_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NR19 Secondary accession number(s): Q5QPH2 Q9UJ15 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


