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Reviewed, UniProtKB/Swiss-Prot Q9NR16 (C163B_HUMAN)

Last modified January 19, 2010. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Scavenger receptor cysteine-rich type 1 protein M160
Alternative name(s):
    CD163 antigen-like 1
    CD_antigen=CD163b
Gene names
Name: CD163L1
Synonyms: CD163B, M160
ORF Names: UNQ6434/PRO23202
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1453 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein Probable.

Isoform 2: Cell membrane; Single-pass type I membrane protein Probable.

Isoform 3: Secreted Probable.

Tissue specificity

Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen. Ref.1

Sequence similarities

Contains 12 SRCR domains.

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Ontologies

Keywords
   Cellular componentCell membrane
Membrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionscavenger receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NR16-1)

Also known as: M160-alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NR16-2)

Also known as: M160-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1395-1426: Missing.
Isoform 3 (identifier: Q9NR16-3)

The sequence of this isoform differs from the canonical sequence as follows:
     718-727: GWGMNIAEVV → SFLMTSSKPR
     728-1453: Missing.
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040 Ref.3
Chain41 – 14531413Scavenger receptor cysteine-rich type 1 protein M160
PRO_0000045392

Regions

Topological domain41 – 13591319Extracellular Potential
Transmembrane1360 – 138021 Potential
Topological domain1381 – 145373Cytoplasmic Potential
Domain48 – 148101SRCR 1
Domain155 – 255101SRCR 2
Domain262 – 362101SRCR 3
Domain369 – 469101SRCR 4
Domain476 – 576101SRCR 5
Domain583 – 683101SRCR 6
Domain690 – 790101SRCR 7
Domain795 – 895101SRCR 8
Domain900 – 1000101SRCR 9
Domain1036 – 1136101SRCR 10
Domain1141 – 1243103SRCR 11
Domain1246 – 1346101SRCR 12

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation3341N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation5481N-linked (GlcNAc...) Potential
Glycosylation6371N-linked (GlcNAc...) Potential
Glycosylation9721N-linked (GlcNAc...) Potential
Glycosylation10131N-linked (GlcNAc...) Potential
Glycosylation10841N-linked (GlcNAc...) Potential
Glycosylation11041N-linked (GlcNAc...) Potential
Glycosylation11611N-linked (GlcNAc...) Ref.4
Glycosylation11711N-linked (GlcNAc...) Potential
Glycosylation13181N-linked (GlcNAc...) Potential
Glycosylation13541N-linked (GlcNAc...) Potential
Disulfide bond73 ↔ 137 By similarity
Disulfide bond86 ↔ 147 By similarity
Disulfide bond117 ↔ 127 By similarity
Disulfide bond180 ↔ 244 By similarity
Disulfide bond193 ↔ 254 By similarity
Disulfide bond224 ↔ 234 By similarity
Disulfide bond287 ↔ 351 By similarity
Disulfide bond300 ↔ 361 By similarity
Disulfide bond331 ↔ 341 By similarity
Disulfide bond394 ↔ 458 By similarity
Disulfide bond407 ↔ 468 By similarity
Disulfide bond438 ↔ 448 By similarity
Disulfide bond501 ↔ 565 By similarity
Disulfide bond514 ↔ 575 By similarity
Disulfide bond545 ↔ 555 By similarity
Disulfide bond608 ↔ 672 By similarity
Disulfide bond621 ↔ 682 By similarity
Disulfide bond652 ↔ 662 By similarity
Disulfide bond715 ↔ 779 By similarity
Disulfide bond728 ↔ 789 By similarity
Disulfide bond759 ↔ 769 By similarity
Disulfide bond820 ↔ 884 By similarity
Disulfide bond833 ↔ 894 By similarity
Disulfide bond864 ↔ 874 By similarity
Disulfide bond925 ↔ 989 By similarity
Disulfide bond938 ↔ 999 By similarity
Disulfide bond969 ↔ 979 By similarity
Disulfide bond1061 ↔ 1125 By similarity
Disulfide bond1074 ↔ 1135 By similarity
Disulfide bond1105 ↔ 1115 By similarity
Disulfide bond1181 ↔ 1242 By similarity
Disulfide bond1212 ↔ 1222 By similarity
Disulfide bond1271 ↔ 1335 By similarity
Disulfide bond1284 ↔ 1345 By similarity
Disulfide bond1315 ↔ 1325 By similarity

Natural variations

Alternative sequence718 – 72710GWGMNIAEVV → SFLMTSSKPR in isoform 3.
VSP_016875
Alternative sequence728 – 1453726Missing in isoform 3.
VSP_016876
Alternative sequence1395 – 142632Missing in isoform 2.
VSP_016877
Natural variant5231M → L: dbSNP rs6488268.
VAR_059810
Natural variant5781D → N: dbSNP rs4072797.
VAR_057206
Natural variant5821G → A: dbSNP rs4072796.
VAR_057207
Natural variant10551G → S: dbSNP rs36206713.
VAR_057208
Natural variant11081M → T: dbSNP rs35480970.
VAR_057209

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (M160-alpha) [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 15445CE9868CF58A

FASTA1,453159,264
        10         20         30         40         50         60 
MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL VNGDGPCSGT 

        70         80         90        100        110        120 
VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF GQAVTRHGKI WLDDVSCYGN 

       130        140        150        160        170        180 
ESALWECQHR EWGSHNCYHG EDVGVNCYGE ANLGLRLVDG NNSCSGRVEV KFQERWGTIC 

       190        200        210        220        230        240 
DDGWNLNTAA VVCRQLGCPS SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG 

       250        260        270        280        290        300 
NHDCSHNEDV TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC 

       310        320        330        340        350        360 
KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD CLHQNDVSVI 

       370        380        390        400        410        420 
CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN EQALVVCKQL GCPFSVFGSR 

       430        440        450        460        470        480 
RAKPSNEARD IWINSISCTG NESALWDCTY DGKAKRTCFR RSDAGVICSD KADLDLRLVG 

       490        500        510        520        530        540 
AHSPCYGRLE VKYQGEWGTV CHDRWSTRNA AVVCKQLGCG KPMHVFGMTY FKEASGPIWL 

       550        560        570        580        590        600 
DDVSCIGNES NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF 

       610        620        630        640        650        660 
QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV SCDGDESDLW 

       670        680        690        700        710        720 
SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA GKVEVNVQGA VGILCANGWG 

       730        740        750        760        770        780 
MNIAEVVCRQ LECGSAIRVS REPHFTERTL HILMSNSGCT GGEASLWDCI RWEWKQTACH 

       790        800        810        820        830        840 
LNMEASLICS AHRQPRLVGA DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD 

       850        860        870        880        890        900 
AISLSVGDHF GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV 

       910        920        930        940        950        960 
RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT GGKYIGERSV 

       970        980        990       1000       1010       1020 
RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT GSLTQPLFPC LANVSDPYLS 

      1030       1040       1050       1060       1070       1080 
AVPEGSALIC LEDKRLRLVD GDSRCAGRVE IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG 

      1090       1100       1110       1120       1130       1140 
VAFNATVSAH FGEGSGPIWL DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA 

      1150       1160       1170       1180       1190       1200 
LRLYSETETE SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT 

      1210       1220       1230       1240       1250       1260 
GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSTAEETWI TCEDRIRVRG GDTECSGRVE 

      1270       1280       1290       1300       1310       1320 
IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS FGQGTGTIWL DDMRCKGNES 

      1330       1340       1350       1360       1370       1380 
FLWDCHAKPW GQSDCGHKED AGVRCSGQSL KSLNASSGRL ALILSSIFGL LLPVLFILFL 

      1390       1400       1410       1420       1430       1440 
TWCRVQKQKH LPLRVSTRRR GSLEENLFHE METCLKREDP HGTRTSDDTP NHGCEDASDT 

      1450 
SLLGVLPASE ATK

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Isoform 2 (M160-beta).

Checksum: D8BD5BEF76906465
Show »

FASTA1,421155,509
Isoform 3.

Checksum: 11E691B140F4EC86
Show »

FASTA72779,788

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References

« Hide 'large scale' references
[1]"Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages."
Groenlund J., Vitved L., Lausen M., Skjoedt K., Holmskov U.
J. Immunol. 165:6406-6415(2000) [PubMed: 11086079] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 41-55.
[4]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1161, MASS SPECTROMETRY.
Tissue: Liver.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF264014 mRNA. Translation: AAF91396.1.
AY358856 mRNA. Translation: AAQ89215.1.
IPIIPI00657946.
IPI00658056.
IPI00942499.
RefSeqNP_777601.2.
UniGeneHs.631727

3D structure databases

SMRQ9NR16. Positions 1031-1141, 1243-1349.
ModBaseSearch...

PTM databases

PhosphoSiteQ9NR16.

Proteomic databases

PRIDEQ9NR16.

Genome annotation databases

EnsemblENST00000313599; ENSP00000315945; ENSG00000177675; Homo sapiens. [Genome view]
GeneID283316.
KEGGhsa:283316.

Organism-specific databases

CTD283316.
GeneCardsGC12M007399.
H-InvDBHIX0018278.
HGNCHGNC:30375. CD163L1.
HPAHPA015663.
MIM606079. gene.
PharmGKBPA142672145.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9NR16.
InParanoidQ9NR16.

Gene expression databases

ArrayExpressQ9NR16.
BgeeQ9NR16.
CleanExHS_CD163L1.
GenevestigatorQ9NR16.
GermOnlineENSG00000177675. Homo sapiens.

Family and domain databases

InterProIPR001190. Srcr_rcpt.
IPR017448. Srcr_rcpt-rel.
[Graphical view]
PfamPF00530. SRCR. 12 hits.
[Graphical view]
PRINTSPR00258. SPERACTRCPTR.
SMARTSM00202. SR. 12 hits.
[Graphical view]
PROSITEPS00420. SRCR_1. 5 hits.
PS50287. SRCR_2. 12 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio93813.
SOURCESearch...

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Entry information

Entry nameC163B_HUMAN
AccessionPrimary (citable) accession number: Q9NR16
Secondary accession number(s): Q6UWC2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: January 19, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents