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Q9NR16

- C163B_HUMAN

UniProt

Q9NR16 - C163B_HUMAN

Protein

Scavenger receptor cysteine-rich type 1 protein M160

Gene

CD163L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. scavenger receptor activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Scavenger receptor cysteine-rich type 1 protein M160
    Alternative name(s):
    CD163 antigen-like 1
    CD_antigen: CD163b
    Gene namesi
    Name:CD163L1
    Synonyms:CD163B, M160
    ORF Names:UNQ6434/PRO23202
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:30375. CD163L1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672145.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 40401 PublicationAdd
    BLAST
    Chaini41 – 14531413Scavenger receptor cysteine-rich type 1 protein M160PRO_0000045392Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi73 ↔ 137PROSITE-ProRule annotation
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi86 ↔ 147PROSITE-ProRule annotation
    Disulfide bondi117 ↔ 127PROSITE-ProRule annotation
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi180 ↔ 244PROSITE-ProRule annotation
    Disulfide bondi193 ↔ 254PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 234PROSITE-ProRule annotation
    Disulfide bondi287 ↔ 351PROSITE-ProRule annotation
    Disulfide bondi300 ↔ 361PROSITE-ProRule annotation
    Disulfide bondi331 ↔ 341PROSITE-ProRule annotation
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi394 ↔ 458PROSITE-ProRule annotation
    Disulfide bondi407 ↔ 468PROSITE-ProRule annotation
    Disulfide bondi438 ↔ 448PROSITE-ProRule annotation
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi501 ↔ 565PROSITE-ProRule annotation
    Disulfide bondi514 ↔ 575PROSITE-ProRule annotation
    Disulfide bondi545 ↔ 555PROSITE-ProRule annotation
    Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi608 ↔ 672PROSITE-ProRule annotation
    Disulfide bondi621 ↔ 682PROSITE-ProRule annotation
    Glycosylationi637 – 6371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi652 ↔ 662PROSITE-ProRule annotation
    Disulfide bondi715 ↔ 779PROSITE-ProRule annotation
    Disulfide bondi728 ↔ 789PROSITE-ProRule annotation
    Disulfide bondi759 ↔ 769PROSITE-ProRule annotation
    Disulfide bondi820 ↔ 884PROSITE-ProRule annotation
    Disulfide bondi833 ↔ 894PROSITE-ProRule annotation
    Disulfide bondi864 ↔ 874PROSITE-ProRule annotation
    Disulfide bondi925 ↔ 989PROSITE-ProRule annotation
    Disulfide bondi938 ↔ 999PROSITE-ProRule annotation
    Disulfide bondi969 ↔ 979PROSITE-ProRule annotation
    Glycosylationi972 – 9721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1013 – 10131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1061 ↔ 1125PROSITE-ProRule annotation
    Disulfide bondi1074 ↔ 1135PROSITE-ProRule annotation
    Glycosylationi1084 – 10841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1104 – 11041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1105 ↔ 1115PROSITE-ProRule annotation
    Glycosylationi1161 – 11611N-linked (GlcNAc...)1 Publication
    Glycosylationi1171 – 11711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1181 ↔ 1242PROSITE-ProRule annotation
    Disulfide bondi1212 ↔ 1222PROSITE-ProRule annotation
    Disulfide bondi1271 ↔ 1335PROSITE-ProRule annotation
    Disulfide bondi1284 ↔ 1345PROSITE-ProRule annotation
    Disulfide bondi1315 ↔ 1325PROSITE-ProRule annotation
    Glycosylationi1318 – 13181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1354 – 13541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9NR16.
    PRIDEiQ9NR16.

    PTM databases

    PhosphoSiteiQ9NR16.

    Expressioni

    Tissue specificityi

    Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ9NR16.
    BgeeiQ9NR16.
    CleanExiHS_CD163L1.
    GenevestigatoriQ9NR16.

    Organism-specific databases

    HPAiHPA015663.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000315945.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NR16.
    SMRiQ9NR16. Positions 45-153, 155-260, 262-362, 366-474, 487-576, 583-683, 686-790, 796-898, 900-1000, 1031-1141, 1246-1349.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini41 – 13591319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1381 – 145373CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1360 – 138021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 148101SRCR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini155 – 255101SRCR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini262 – 362101SRCR 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini369 – 469101SRCR 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini476 – 576101SRCR 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini583 – 683101SRCR 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini690 – 790101SRCR 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini795 – 895101SRCR 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini900 – 1000101SRCR 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1036 – 1136101SRCR 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1141 – 1243103SRCR 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1246 – 1346101SRCR 12PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 SRCR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG83796.
    HOGENOMiHOG000290652.
    HOVERGENiHBG080943.
    InParanoidiQ9NR16.
    KOiK06545.
    OMAiQLGCPFS.
    OrthoDBiEOG7RNK07.
    PhylomeDBiQ9NR16.
    TreeFamiTF329295.

    Family and domain databases

    Gene3Di3.10.250.10. 12 hits.
    InterProiIPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view]
    PfamiPF00530. SRCR. 12 hits.
    [Graphical view]
    PRINTSiPR00258. SPERACTRCPTR.
    SMARTiSM00202. SR. 12 hits.
    [Graphical view]
    SUPFAMiSSF56487. SSF56487. 12 hits.
    PROSITEiPS00420. SRCR_1. 5 hits.
    PS50287. SRCR_2. 12 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NR16-1) [UniParc]FASTAAdd to Basket

    Also known as: M160-alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL     50
    VNGDGPCSGT VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF 100
    GQAVTRHGKI WLDDVSCYGN ESALWECQHR EWGSHNCYHG EDVGVNCYGE 150
    ANLGLRLVDG NNSCSGRVEV KFQERWGTIC DDGWNLNTAA VVCRQLGCPS 200
    SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG NHDCSHNEDV 250
    TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC 300
    KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD 350
    CLHQNDVSVI CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN 400
    EQALVVCKQL GCPFSVFGSR RAKPSNEARD IWINSISCTG NESALWDCTY 450
    DGKAKRTCFR RSDAGVICSD KADLDLRLVG AHSPCYGRLE VKYQGEWGTV 500
    CHDRWSTRNA AVVCKQLGCG KPLHVFGMTY FKEASGPIWL DDVSCIGNES 550
    NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF 600
    QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV 650
    SCDGDESDLW SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA 700
    GKVEVNVQGA VGILCANGWG MNIAEVVCRQ LECGSAIRVS REPHFTERTL 750
    HILMSNSGCT GGEASLWDCI RWEWKQTACH LNMEASLICS AHRQPRLVGA 800
    DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD AISLSVGDHF 850
    GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV 900
    RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT 950
    GGKYIGERSV RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT 1000
    GSLTQPLFPC LANVSDPYLS AVPEGSALIC LEDKRLRLVD GDSRCAGRVE 1050
    IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG VAFNATVSAH FGEGSGPIWL 1100
    DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA LRLYSETETE 1150
    SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT 1200
    GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSPAEETWI TCEDRIRVRG 1250
    GDTECSGRVE IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS 1300
    FGQGTGTIWL DDMRCKGNES FLWDCHAKPW GQSDCGHKED AGVRCSGQSL 1350
    KSLNASSGHL ALILSSIFGL LLLVLFILFL TWCRVQKQKH LPLRVSTRRR 1400
    GSLEENLFHE METCLKREDP HGTRTSDDTP NHGCEDASDT SLLGVLPASE 1450
    ATK 1453
    Length:1,453
    Mass (Da):159,239
    Last modified:May 18, 2010 - v2
    Checksum:iEBF90FBEE4FDF4CE
    GO
    Isoform 2 (identifier: Q9NR16-2) [UniParc]FASTAAdd to Basket

    Also known as: M160-beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1395-1426: Missing.

    Show »
    Length:1,421
    Mass (Da):155,484
    Checksum:iE070F676F8099DBA
    GO
    Isoform 3 (identifier: Q9NR16-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         718-727: GWGMNIAEVV → SFLMTSSKPR
         728-1453: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:727
    Mass (Da):79,769
    Checksum:iF03D2BC09B1BD919
    GO
    Isoform 4 (identifier: Q9NR16-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         148-148: Y → YGKSLTRVGRQ

    Note: No experimental confirmation available.

    Show »
    Length:1,463
    Mass (Da):160,322
    Checksum:iFAAF9E5EB74C9C40
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051T → S in BAG64429. (PubMed:14702039)Curated
    Sequence conflicti333 – 3331G → V in BAG64429. (PubMed:14702039)Curated
    Sequence conflicti1234 – 12341P → T in AAF91396. (PubMed:11086079)Curated
    Sequence conflicti1234 – 12341P → T in AAQ89215. (PubMed:12975309)Curated
    Sequence conflicti1359 – 13591H → R in AAF91396. (PubMed:11086079)Curated
    Sequence conflicti1359 – 13591H → R in AAQ89215. (PubMed:12975309)Curated
    Sequence conflicti1373 – 13731L → P in AAF91396. (PubMed:11086079)Curated
    Sequence conflicti1373 – 13731L → P in AAQ89215. (PubMed:12975309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti523 – 5231L → M.5 Publications
    Corresponds to variant rs6488268 [ dbSNP | Ensembl ].
    VAR_059810
    Natural varianti578 – 5781D → N.
    Corresponds to variant rs4072797 [ dbSNP | Ensembl ].
    VAR_057206
    Natural varianti582 – 5821G → A.
    Corresponds to variant rs4072796 [ dbSNP | Ensembl ].
    VAR_057207
    Natural varianti1055 – 10551G → S.
    Corresponds to variant rs36206713 [ dbSNP | Ensembl ].
    VAR_057208
    Natural varianti1108 – 11081M → T.
    Corresponds to variant rs35480970 [ dbSNP | Ensembl ].
    VAR_057209

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei148 – 1481Y → YGKSLTRVGRQ in isoform 4. 1 PublicationVSP_047557
    Alternative sequencei718 – 72710GWGMNIAEVV → SFLMTSSKPR in isoform 3. 1 PublicationVSP_016875
    Alternative sequencei728 – 1453726Missing in isoform 3. 1 PublicationVSP_016876Add
    BLAST
    Alternative sequencei1395 – 142632Missing in isoform 2. 1 PublicationVSP_016877Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF264014 mRNA. Translation: AAF91396.1.
    GQ397482 mRNA. Translation: ADB45259.1.
    AY358856 mRNA. Translation: AAQ89215.1.
    AK303372 mRNA. Translation: BAG64429.1.
    AC131205 Genomic DNA. No translation available.
    AC131206 Genomic DNA. No translation available.
    AC131207 Genomic DNA. No translation available.
    BC104962 mRNA. Translation: AAI04963.1.
    BC104964 mRNA. Translation: AAI04965.1.
    CCDSiCCDS8577.1. [Q9NR16-1]
    RefSeqiNP_777601.2. NM_174941.4.
    XP_005253405.1. XM_005253348.2. [Q9NR16-4]
    UniGeneiHs.631727.

    Genome annotation databases

    EnsembliENST00000313599; ENSP00000315945; ENSG00000177675. [Q9NR16-1]
    ENST00000416109; ENSP00000393474; ENSG00000177675. [Q9NR16-4]
    GeneIDi283316.
    KEGGihsa:283316.
    UCSCiuc001qsy.3. human.

    Polymorphism databases

    DMDMi296434413.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF264014 mRNA. Translation: AAF91396.1 .
    GQ397482 mRNA. Translation: ADB45259.1 .
    AY358856 mRNA. Translation: AAQ89215.1 .
    AK303372 mRNA. Translation: BAG64429.1 .
    AC131205 Genomic DNA. No translation available.
    AC131206 Genomic DNA. No translation available.
    AC131207 Genomic DNA. No translation available.
    BC104962 mRNA. Translation: AAI04963.1 .
    BC104964 mRNA. Translation: AAI04965.1 .
    CCDSi CCDS8577.1. [Q9NR16-1 ]
    RefSeqi NP_777601.2. NM_174941.4.
    XP_005253405.1. XM_005253348.2. [Q9NR16-4 ]
    UniGenei Hs.631727.

    3D structure databases

    ProteinModelPortali Q9NR16.
    SMRi Q9NR16. Positions 45-153, 155-260, 262-362, 366-474, 487-576, 583-683, 686-790, 796-898, 900-1000, 1031-1141, 1246-1349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000315945.

    PTM databases

    PhosphoSitei Q9NR16.

    Polymorphism databases

    DMDMi 296434413.

    Proteomic databases

    PaxDbi Q9NR16.
    PRIDEi Q9NR16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313599 ; ENSP00000315945 ; ENSG00000177675 . [Q9NR16-1 ]
    ENST00000416109 ; ENSP00000393474 ; ENSG00000177675 . [Q9NR16-4 ]
    GeneIDi 283316.
    KEGGi hsa:283316.
    UCSCi uc001qsy.3. human.

    Organism-specific databases

    CTDi 283316.
    GeneCardsi GC12M007507.
    HGNCi HGNC:30375. CD163L1.
    HPAi HPA015663.
    MIMi 606079. gene.
    neXtProti NX_Q9NR16.
    PharmGKBi PA142672145.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83796.
    HOGENOMi HOG000290652.
    HOVERGENi HBG080943.
    InParanoidi Q9NR16.
    KOi K06545.
    OMAi QLGCPFS.
    OrthoDBi EOG7RNK07.
    PhylomeDBi Q9NR16.
    TreeFami TF329295.

    Miscellaneous databases

    ChiTaRSi CD163L1. human.
    GenomeRNAii 283316.
    NextBioi 35476751.
    PROi Q9NR16.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NR16.
    Bgeei Q9NR16.
    CleanExi HS_CD163L1.
    Genevestigatori Q9NR16.

    Family and domain databases

    Gene3Di 3.10.250.10. 12 hits.
    InterProi IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    [Graphical view ]
    Pfami PF00530. SRCR. 12 hits.
    [Graphical view ]
    PRINTSi PR00258. SPERACTRCPTR.
    SMARTi SM00202. SR. 12 hits.
    [Graphical view ]
    SUPFAMi SSF56487. SSF56487. 12 hits.
    PROSITEi PS00420. SRCR_1. 5 hits.
    PS50287. SRCR_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages."
      Groenlund J., Vitved L., Lausen M., Skjoedt K., Holmskov U.
      J. Immunol. 165:6406-6415(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANT MET-523.
    2. "Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus."
      Van Gorp H., Van Breedam W., Van Doorsselaere J., Delputte P.L., Nauwynck H.J.
      J. Virol. 84:3101-3105(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-523.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-523.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT MET-523.
      Tissue: Thymus.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-523.
      Tissue: Heart and Lung.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 41-55.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1161.
      Tissue: Liver.

    Entry informationi

    Entry nameiC163B_HUMAN
    AccessioniPrimary (citable) accession number: Q9NR16
    Secondary accession number(s): B4E0G7
    , C9JHR7, E7EVK4, Q2M3B7, Q6UWC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3