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Protein

Scavenger receptor cysteine-rich type 1 protein M160

Gene

CD163L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177675-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor cysteine-rich type 1 protein M160
Alternative name(s):
CD163 antigen-like 1
CD_antigen: CD163b
Gene namesi
Name:CD163L1
Synonyms:CD163B, M160
ORF Names:UNQ6434/PRO23202
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30375. CD163L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 1359ExtracellularSequence analysisAdd BLAST1319
Transmembranei1360 – 1380HelicalSequence analysisAdd BLAST21
Topological domaini1381 – 1453CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi283316.
OpenTargetsiENSG00000177675.
PharmGKBiPA142672145.

Polymorphism and mutation databases

BioMutaiCD163L1.
DMDMi296434413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 401 PublicationAdd BLAST40
ChainiPRO_000004539241 – 1453Scavenger receptor cysteine-rich type 1 protein M160Add BLAST1413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi73 ↔ 137PROSITE-ProRule annotation
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi86 ↔ 147PROSITE-ProRule annotation
Disulfide bondi117 ↔ 127PROSITE-ProRule annotation
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi180 ↔ 244PROSITE-ProRule annotation
Disulfide bondi193 ↔ 254PROSITE-ProRule annotation
Disulfide bondi224 ↔ 234PROSITE-ProRule annotation
Disulfide bondi287 ↔ 351PROSITE-ProRule annotation
Disulfide bondi300 ↔ 361PROSITE-ProRule annotation
Disulfide bondi331 ↔ 341PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...)Sequence analysis1
Glycosylationi377N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi394 ↔ 458PROSITE-ProRule annotation
Disulfide bondi407 ↔ 468PROSITE-ProRule annotation
Disulfide bondi438 ↔ 448PROSITE-ProRule annotation
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi501 ↔ 565PROSITE-ProRule annotation
Disulfide bondi514 ↔ 575PROSITE-ProRule annotation
Disulfide bondi545 ↔ 555PROSITE-ProRule annotation
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi608 ↔ 672PROSITE-ProRule annotation
Disulfide bondi621 ↔ 682PROSITE-ProRule annotation
Glycosylationi637N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi652 ↔ 662PROSITE-ProRule annotation
Disulfide bondi715 ↔ 779PROSITE-ProRule annotation
Disulfide bondi728 ↔ 789PROSITE-ProRule annotation
Disulfide bondi759 ↔ 769PROSITE-ProRule annotation
Disulfide bondi820 ↔ 884PROSITE-ProRule annotation
Disulfide bondi833 ↔ 894PROSITE-ProRule annotation
Disulfide bondi864 ↔ 874PROSITE-ProRule annotation
Disulfide bondi925 ↔ 989PROSITE-ProRule annotation
Disulfide bondi938 ↔ 999PROSITE-ProRule annotation
Disulfide bondi969 ↔ 979PROSITE-ProRule annotation
Glycosylationi972N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1013N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1061 ↔ 1125PROSITE-ProRule annotation
Disulfide bondi1074 ↔ 1135PROSITE-ProRule annotation
Glycosylationi1084N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1104N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1105 ↔ 1115PROSITE-ProRule annotation
Glycosylationi1161N-linked (GlcNAc...)1 Publication1
Glycosylationi1171N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1181 ↔ 1242PROSITE-ProRule annotation
Disulfide bondi1212 ↔ 1222PROSITE-ProRule annotation
Disulfide bondi1271 ↔ 1335PROSITE-ProRule annotation
Disulfide bondi1284 ↔ 1345PROSITE-ProRule annotation
Disulfide bondi1315 ↔ 1325PROSITE-ProRule annotation
Glycosylationi1318N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1354N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NR16.
PeptideAtlasiQ9NR16.
PRIDEiQ9NR16.

PTM databases

iPTMnetiQ9NR16.
PhosphoSitePlusiQ9NR16.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen.1 Publication

Gene expression databases

BgeeiENSG00000177675.
CleanExiHS_CD163L1.
ExpressionAtlasiQ9NR16. baseline and differential.
GenevisibleiQ9NR16. HS.

Organism-specific databases

HPAiHPA015663.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000315945.

Structurei

3D structure databases

ProteinModelPortaliQ9NR16.
SMRiQ9NR16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 148SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini155 – 255SRCR 2PROSITE-ProRule annotationAdd BLAST101
Domaini262 – 362SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini369 – 469SRCR 4PROSITE-ProRule annotationAdd BLAST101
Domaini476 – 576SRCR 5PROSITE-ProRule annotationAdd BLAST101
Domaini583 – 683SRCR 6PROSITE-ProRule annotationAdd BLAST101
Domaini690 – 790SRCR 7PROSITE-ProRule annotationAdd BLAST101
Domaini795 – 895SRCR 8PROSITE-ProRule annotationAdd BLAST101
Domaini900 – 1000SRCR 9PROSITE-ProRule annotationAdd BLAST101
Domaini1036 – 1136SRCR 10PROSITE-ProRule annotationAdd BLAST101
Domaini1141 – 1243SRCR 11PROSITE-ProRule annotationAdd BLAST103
Domaini1246 – 1346SRCR 12PROSITE-ProRule annotationAdd BLAST101

Sequence similaritiesi

Contains 12 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00840000129699.
HOGENOMiHOG000290652.
HOVERGENiHBG080943.
InParanoidiQ9NR16.
KOiK06545.
OMAiWINSISC.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9NR16.
TreeFamiTF329295.

Family and domain databases

Gene3Di3.10.250.10. 12 hits.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF00530. SRCR. 12 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 12 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 12 hits.
PROSITEiPS00420. SRCR_1. 5 hits.
PS50287. SRCR_2. 12 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NR16-1) [UniParc]FASTAAdd to basket
Also known as: M160-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL
60 70 80 90 100
VNGDGPCSGT VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF
110 120 130 140 150
GQAVTRHGKI WLDDVSCYGN ESALWECQHR EWGSHNCYHG EDVGVNCYGE
160 170 180 190 200
ANLGLRLVDG NNSCSGRVEV KFQERWGTIC DDGWNLNTAA VVCRQLGCPS
210 220 230 240 250
SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG NHDCSHNEDV
260 270 280 290 300
TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC
310 320 330 340 350
KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD
360 370 380 390 400
CLHQNDVSVI CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN
410 420 430 440 450
EQALVVCKQL GCPFSVFGSR RAKPSNEARD IWINSISCTG NESALWDCTY
460 470 480 490 500
DGKAKRTCFR RSDAGVICSD KADLDLRLVG AHSPCYGRLE VKYQGEWGTV
510 520 530 540 550
CHDRWSTRNA AVVCKQLGCG KPLHVFGMTY FKEASGPIWL DDVSCIGNES
560 570 580 590 600
NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF
610 620 630 640 650
QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV
660 670 680 690 700
SCDGDESDLW SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA
710 720 730 740 750
GKVEVNVQGA VGILCANGWG MNIAEVVCRQ LECGSAIRVS REPHFTERTL
760 770 780 790 800
HILMSNSGCT GGEASLWDCI RWEWKQTACH LNMEASLICS AHRQPRLVGA
810 820 830 840 850
DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD AISLSVGDHF
860 870 880 890 900
GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV
910 920 930 940 950
RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT
960 970 980 990 1000
GGKYIGERSV RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT
1010 1020 1030 1040 1050
GSLTQPLFPC LANVSDPYLS AVPEGSALIC LEDKRLRLVD GDSRCAGRVE
1060 1070 1080 1090 1100
IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG VAFNATVSAH FGEGSGPIWL
1110 1120 1130 1140 1150
DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA LRLYSETETE
1160 1170 1180 1190 1200
SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT
1210 1220 1230 1240 1250
GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSPAEETWI TCEDRIRVRG
1260 1270 1280 1290 1300
GDTECSGRVE IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS
1310 1320 1330 1340 1350
FGQGTGTIWL DDMRCKGNES FLWDCHAKPW GQSDCGHKED AGVRCSGQSL
1360 1370 1380 1390 1400
KSLNASSGHL ALILSSIFGL LLLVLFILFL TWCRVQKQKH LPLRVSTRRR
1410 1420 1430 1440 1450
GSLEENLFHE METCLKREDP HGTRTSDDTP NHGCEDASDT SLLGVLPASE

ATK
Length:1,453
Mass (Da):159,239
Last modified:May 18, 2010 - v2
Checksum:iEBF90FBEE4FDF4CE
GO
Isoform 2 (identifier: Q9NR16-2) [UniParc]FASTAAdd to basket
Also known as: M160-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1395-1426: Missing.

Show »
Length:1,421
Mass (Da):155,484
Checksum:iE070F676F8099DBA
GO
Isoform 3 (identifier: Q9NR16-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     718-727: GWGMNIAEVV → SFLMTSSKPR
     728-1453: Missing.

Note: No experimental confirmation available.
Show »
Length:727
Mass (Da):79,769
Checksum:iF03D2BC09B1BD919
GO
Isoform 4 (identifier: Q9NR16-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-148: Y → YGKSLTRVGRQ

Note: No experimental confirmation available.
Show »
Length:1,463
Mass (Da):160,322
Checksum:iFAAF9E5EB74C9C40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105T → S in BAG64429 (PubMed:14702039).Curated1
Sequence conflicti333G → V in BAG64429 (PubMed:14702039).Curated1
Sequence conflicti1234P → T in AAF91396 (PubMed:11086079).Curated1
Sequence conflicti1234P → T in AAQ89215 (PubMed:12975309).Curated1
Sequence conflicti1359H → R in AAF91396 (PubMed:11086079).Curated1
Sequence conflicti1359H → R in AAQ89215 (PubMed:12975309).Curated1
Sequence conflicti1373L → P in AAF91396 (PubMed:11086079).Curated1
Sequence conflicti1373L → P in AAQ89215 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059810523L → M.5 PublicationsCorresponds to variant rs6488268dbSNPEnsembl.1
Natural variantiVAR_057206578D → N.Corresponds to variant rs4072797dbSNPEnsembl.1
Natural variantiVAR_057207582G → A.Corresponds to variant rs4072796dbSNPEnsembl.1
Natural variantiVAR_0572081055G → S.Corresponds to variant rs36206713dbSNPEnsembl.1
Natural variantiVAR_0572091108M → T.Corresponds to variant rs35480970dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047557148Y → YGKSLTRVGRQ in isoform 4. 1 Publication1
Alternative sequenceiVSP_016875718 – 727GWGMNIAEVV → SFLMTSSKPR in isoform 3. 1 Publication10
Alternative sequenceiVSP_016876728 – 1453Missing in isoform 3. 1 PublicationAdd BLAST726
Alternative sequenceiVSP_0168771395 – 1426Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264014 mRNA. Translation: AAF91396.1.
GQ397482 mRNA. Translation: ADB45259.1.
AY358856 mRNA. Translation: AAQ89215.1.
AK303372 mRNA. Translation: BAG64429.1.
AC131205 Genomic DNA. No translation available.
AC131206 Genomic DNA. No translation available.
AC131207 Genomic DNA. No translation available.
BC104962 mRNA. Translation: AAI04963.1.
BC104964 mRNA. Translation: AAI04965.1.
CCDSiCCDS73434.1. [Q9NR16-4]
CCDS8577.1. [Q9NR16-1]
RefSeqiNP_001284579.1. NM_001297650.1.
NP_777601.2. NM_174941.5.
XP_011518918.1. XM_011520616.1. [Q9NR16-2]
UniGeneiHs.631727.

Genome annotation databases

EnsembliENST00000313599; ENSP00000315945; ENSG00000177675. [Q9NR16-1]
ENST00000416109; ENSP00000393474; ENSG00000177675. [Q9NR16-4]
GeneIDi283316.
KEGGihsa:283316.
UCSCiuc001qsy.4. human. [Q9NR16-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264014 mRNA. Translation: AAF91396.1.
GQ397482 mRNA. Translation: ADB45259.1.
AY358856 mRNA. Translation: AAQ89215.1.
AK303372 mRNA. Translation: BAG64429.1.
AC131205 Genomic DNA. No translation available.
AC131206 Genomic DNA. No translation available.
AC131207 Genomic DNA. No translation available.
BC104962 mRNA. Translation: AAI04963.1.
BC104964 mRNA. Translation: AAI04965.1.
CCDSiCCDS73434.1. [Q9NR16-4]
CCDS8577.1. [Q9NR16-1]
RefSeqiNP_001284579.1. NM_001297650.1.
NP_777601.2. NM_174941.5.
XP_011518918.1. XM_011520616.1. [Q9NR16-2]
UniGeneiHs.631727.

3D structure databases

ProteinModelPortaliQ9NR16.
SMRiQ9NR16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000315945.

PTM databases

iPTMnetiQ9NR16.
PhosphoSitePlusiQ9NR16.

Polymorphism and mutation databases

BioMutaiCD163L1.
DMDMi296434413.

Proteomic databases

PaxDbiQ9NR16.
PeptideAtlasiQ9NR16.
PRIDEiQ9NR16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313599; ENSP00000315945; ENSG00000177675. [Q9NR16-1]
ENST00000416109; ENSP00000393474; ENSG00000177675. [Q9NR16-4]
GeneIDi283316.
KEGGihsa:283316.
UCSCiuc001qsy.4. human. [Q9NR16-1]

Organism-specific databases

CTDi283316.
DisGeNETi283316.
GeneCardsiCD163L1.
HGNCiHGNC:30375. CD163L1.
HPAiHPA015663.
MIMi606079. gene.
neXtProtiNX_Q9NR16.
OpenTargetsiENSG00000177675.
PharmGKBiPA142672145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00840000129699.
HOGENOMiHOG000290652.
HOVERGENiHBG080943.
InParanoidiQ9NR16.
KOiK06545.
OMAiWINSISC.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9NR16.
TreeFamiTF329295.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177675-MONOMER.

Miscellaneous databases

ChiTaRSiCD163L1. human.
GenomeRNAii283316.
PROiQ9NR16.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177675.
CleanExiHS_CD163L1.
ExpressionAtlasiQ9NR16. baseline and differential.
GenevisibleiQ9NR16. HS.

Family and domain databases

Gene3Di3.10.250.10. 12 hits.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF00530. SRCR. 12 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 12 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 12 hits.
PROSITEiPS00420. SRCR_1. 5 hits.
PS50287. SRCR_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC163B_HUMAN
AccessioniPrimary (citable) accession number: Q9NR16
Secondary accession number(s): B4E0G7
, C9JHR7, E7EVK4, Q2M3B7, Q6UWC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.