Q9NR16 (C163B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Scavenger receptor cysteine-rich type 1 protein M160

Alternative name(s):
CD163 antigen-like 1
CD_antigen=CD163b

Gene names

Name:	CD163L1
Synonyms:	CD163B, M160
ORF Names:	UNQ6434/PRO23202

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein Probable. Isoform 2: Cell membrane; Single-pass type I membrane protein Probable. Isoform 3: Secreted Probable.
Tissue specificity	Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen. Ref.1
Sequence similarities	Contains 12 SRCR domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	scavenger receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NR16-1)

Also known as: M160-alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NR16-2)

Also known as: M160-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1395-1426: Missing.

Isoform 3 (identifier: Q9NR16-3)

The sequence of this isoform differs from the canonical sequence as follows:
     718-727: GWGMNIAEVV → SFLMTSSKPR
     728-1453: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 40	40	Ref.4
	Chain	41 – 1453	1413	Scavenger receptor cysteine-rich type 1 protein M160		PRO_0000045392
Regions
	Topological domain	41 – 1359	1319	Extracellular Potential
	Transmembrane	1360 – 1380	21	Helical; Potential
	Topological domain	1381 – 1453	73	Cytoplasmic Potential
	Domain	48 – 148	101	SRCR 1
	Domain	155 – 255	101	SRCR 2
	Domain	262 – 362	101	SRCR 3
	Domain	369 – 469	101	SRCR 4
	Domain	476 – 576	101	SRCR 5
	Domain	583 – 683	101	SRCR 6
	Domain	690 – 790	101	SRCR 7
	Domain	795 – 895	101	SRCR 8
	Domain	900 – 1000	101	SRCR 9
	Domain	1036 – 1136	101	SRCR 10
	Domain	1141 – 1243	103	SRCR 11
	Domain	1246 – 1346	101	SRCR 12
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	334	1	N-linked (GlcNAc...) Potential
	Glycosylation	377	1	N-linked (GlcNAc...) Potential
	Glycosylation	441	1	N-linked (GlcNAc...) Potential
	Glycosylation	548	1	N-linked (GlcNAc...) Potential
	Glycosylation	637	1	N-linked (GlcNAc...) Potential
	Glycosylation	972	1	N-linked (GlcNAc...) Potential
	Glycosylation	1013	1	N-linked (GlcNAc...) Potential
	Glycosylation	1084	1	N-linked (GlcNAc...) Potential
	Glycosylation	1104	1	N-linked (GlcNAc...) Potential
	Glycosylation	1161	1	N-linked (GlcNAc...) Ref.5
	Glycosylation	1171	1	N-linked (GlcNAc...) Potential
	Glycosylation	1318	1	N-linked (GlcNAc...) Potential
	Glycosylation	1354	1	N-linked (GlcNAc...) Potential
	Disulfide bond	73 ↔ 137		By similarity
	Disulfide bond	86 ↔ 147		By similarity
	Disulfide bond	117 ↔ 127		By similarity
	Disulfide bond	180 ↔ 244		By similarity
	Disulfide bond	193 ↔ 254		By similarity
	Disulfide bond	224 ↔ 234		By similarity
	Disulfide bond	287 ↔ 351		By similarity
	Disulfide bond	300 ↔ 361		By similarity
	Disulfide bond	331 ↔ 341		By similarity
	Disulfide bond	394 ↔ 458		By similarity
	Disulfide bond	407 ↔ 468		By similarity
	Disulfide bond	438 ↔ 448		By similarity
	Disulfide bond	501 ↔ 565		By similarity
	Disulfide bond	514 ↔ 575		By similarity
	Disulfide bond	545 ↔ 555		By similarity
	Disulfide bond	608 ↔ 672		By similarity
	Disulfide bond	621 ↔ 682		By similarity
	Disulfide bond	652 ↔ 662		By similarity
	Disulfide bond	715 ↔ 779		By similarity
	Disulfide bond	728 ↔ 789		By similarity
	Disulfide bond	759 ↔ 769		By similarity
	Disulfide bond	820 ↔ 884		By similarity
	Disulfide bond	833 ↔ 894		By similarity
	Disulfide bond	864 ↔ 874		By similarity
	Disulfide bond	925 ↔ 989		By similarity
	Disulfide bond	938 ↔ 999		By similarity
	Disulfide bond	969 ↔ 979		By similarity
	Disulfide bond	1061 ↔ 1125		By similarity
	Disulfide bond	1074 ↔ 1135		By similarity
	Disulfide bond	1105 ↔ 1115		By similarity
	Disulfide bond	1181 ↔ 1242		By similarity
	Disulfide bond	1212 ↔ 1222		By similarity
	Disulfide bond	1271 ↔ 1335		By similarity
	Disulfide bond	1284 ↔ 1345		By similarity
	Disulfide bond	1315 ↔ 1325		By similarity
Natural variations
	Alternative sequence	718 – 727	10	GWGMNIAEVV → SFLMTSSKPR in isoform 3.		VSP_016875
	Alternative sequence	728 – 1453	726	Missing in isoform 3.		VSP_016876
	Alternative sequence	1395 – 1426	32	Missing in isoform 2.		VSP_016877
	Natural variant	523	1	L → M. Ref.1 Ref.2 Corresponds to variant rs6488268 [ dbSNP | Ensembl ].		VAR_059810
	Natural variant	578	1	D → N. Corresponds to variant rs4072797 [ dbSNP | Ensembl ].		VAR_057206
	Natural variant	582	1	G → A. Corresponds to variant rs4072796 [ dbSNP | Ensembl ].		VAR_057207
	Natural variant	1055	1	G → S. Corresponds to variant rs36206713 [ dbSNP | Ensembl ].		VAR_057208
	Natural variant	1108	1	M → T. Corresponds to variant rs35480970 [ dbSNP | Ensembl ].		VAR_057209
Experimental info
	Sequence conflict	1234	1	P → T in AAF91396. Ref.1
	Sequence conflict	1234	1	P → T in AAQ89215. Ref.2
	Sequence conflict	1359	1	H → R in AAF91396. Ref.1
	Sequence conflict	1359	1	H → R in AAQ89215. Ref.2
	Sequence conflict	1373	1	L → P in AAF91396. Ref.1
	Sequence conflict	1373	1	L → P in AAQ89215. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (M160-alpha) [UniParc]. Last modified May 18, 2010. Version 2. Checksum: EBF90FBEE4FDF4CE	FASTA	1,453	159,239
	10 20 30 40 50 60 MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL VNGDGPCSGT 70 80 90 100 110 120 VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF GQAVTRHGKI WLDDVSCYGN 130 140 150 160 170 180 ESALWECQHR EWGSHNCYHG EDVGVNCYGE ANLGLRLVDG NNSCSGRVEV KFQERWGTIC 190 200 210 220 230 240 DDGWNLNTAA VVCRQLGCPS SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG 250 260 270 280 290 300 NHDCSHNEDV TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC 310 320 330 340 350 360 KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD CLHQNDVSVI 370 380 390 400 410 420 CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN EQALVVCKQL GCPFSVFGSR 430 440 450 460 470 480 RAKPSNEARD IWINSISCTG NESALWDCTY DGKAKRTCFR RSDAGVICSD KADLDLRLVG 490 500 510 520 530 540 AHSPCYGRLE VKYQGEWGTV CHDRWSTRNA AVVCKQLGCG KPLHVFGMTY FKEASGPIWL 550 560 570 580 590 600 DDVSCIGNES NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF 610 620 630 640 650 660 QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV SCDGDESDLW 670 680 690 700 710 720 SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA GKVEVNVQGA VGILCANGWG 730 740 750 760 770 780 MNIAEVVCRQ LECGSAIRVS REPHFTERTL HILMSNSGCT GGEASLWDCI RWEWKQTACH 790 800 810 820 830 840 LNMEASLICS AHRQPRLVGA DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD 850 860 870 880 890 900 AISLSVGDHF GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV 910 920 930 940 950 960 RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT GGKYIGERSV 970 980 990 1000 1010 1020 RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT GSLTQPLFPC LANVSDPYLS 1030 1040 1050 1060 1070 1080 AVPEGSALIC LEDKRLRLVD GDSRCAGRVE IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG 1090 1100 1110 1120 1130 1140 VAFNATVSAH FGEGSGPIWL DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA 1150 1160 1170 1180 1190 1200 LRLYSETETE SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT 1210 1220 1230 1240 1250 1260 GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSPAEETWI TCEDRIRVRG GDTECSGRVE 1270 1280 1290 1300 1310 1320 IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS FGQGTGTIWL DDMRCKGNES 1330 1340 1350 1360 1370 1380 FLWDCHAKPW GQSDCGHKED AGVRCSGQSL KSLNASSGHL ALILSSIFGL LLLVLFILFL 1390 1400 1410 1420 1430 1440 TWCRVQKQKH LPLRVSTRRR GSLEENLFHE METCLKREDP HGTRTSDDTP NHGCEDASDT 1450 SLLGVLPASE ATK
	Isoform 2 (M160-beta) [UniParc]. Checksum: E070F676F8099DBA	FASTA	1,421	155,484
	10 20 30 40 50 60 MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL VNGDGPCSGT 70 80 90 100 110 120 VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF GQAVTRHGKI WLDDVSCYGN 130 140 150 160 170 180 ESALWECQHR EWGSHNCYHG EDVGVNCYGE ANLGLRLVDG NNSCSGRVEV KFQERWGTIC 190 200 210 220 230 240 DDGWNLNTAA VVCRQLGCPS SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG 250 260 270 280 290 300 NHDCSHNEDV TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC 310 320 330 340 350 360 KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD CLHQNDVSVI 370 380 390 400 410 420 CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN EQALVVCKQL GCPFSVFGSR 430 440 450 460 470 480 RAKPSNEARD IWINSISCTG NESALWDCTY DGKAKRTCFR RSDAGVICSD KADLDLRLVG 490 500 510 520 530 540 AHSPCYGRLE VKYQGEWGTV CHDRWSTRNA AVVCKQLGCG KPLHVFGMTY FKEASGPIWL 550 560 570 580 590 600 DDVSCIGNES NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF 610 620 630 640 650 660 QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV SCDGDESDLW 670 680 690 700 710 720 SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA GKVEVNVQGA VGILCANGWG 730 740 750 760 770 780 MNIAEVVCRQ LECGSAIRVS REPHFTERTL HILMSNSGCT GGEASLWDCI RWEWKQTACH 790 800 810 820 830 840 LNMEASLICS AHRQPRLVGA DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD 850 860 870 880 890 900 AISLSVGDHF GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV 910 920 930 940 950 960 RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT GGKYIGERSV 970 980 990 1000 1010 1020 RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT GSLTQPLFPC LANVSDPYLS 1030 1040 1050 1060 1070 1080 AVPEGSALIC LEDKRLRLVD GDSRCAGRVE IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG 1090 1100 1110 1120 1130 1140 VAFNATVSAH FGEGSGPIWL DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA 1150 1160 1170 1180 1190 1200 LRLYSETETE SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT 1210 1220 1230 1240 1250 1260 GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSPAEETWI TCEDRIRVRG GDTECSGRVE 1270 1280 1290 1300 1310 1320 IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS FGQGTGTIWL DDMRCKGNES 1330 1340 1350 1360 1370 1380 FLWDCHAKPW GQSDCGHKED AGVRCSGQSL KSLNASSGHL ALILSSIFGL LLLVLFILFL 1390 1400 1410 1420 TWCRVQKQKH LPLRDDTPNH GCEDASDTSL LGVLPASEAT K
	Isoform 3 [UniParc]. Checksum: F03D2BC09B1BD919	FASTA	727	79,769
	10 20 30 40 50 60 MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL VNGDGPCSGT 70 80 90 100 110 120 VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF GQAVTRHGKI WLDDVSCYGN 130 140 150 160 170 180 ESALWECQHR EWGSHNCYHG EDVGVNCYGE ANLGLRLVDG NNSCSGRVEV KFQERWGTIC 190 200 210 220 230 240 DDGWNLNTAA VVCRQLGCPS SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG 250 260 270 280 290 300 NHDCSHNEDV TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC 310 320 330 340 350 360 KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD CLHQNDVSVI 370 380 390 400 410 420 CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN EQALVVCKQL GCPFSVFGSR 430 440 450 460 470 480 RAKPSNEARD IWINSISCTG NESALWDCTY DGKAKRTCFR RSDAGVICSD KADLDLRLVG 490 500 510 520 530 540 AHSPCYGRLE VKYQGEWGTV CHDRWSTRNA AVVCKQLGCG KPLHVFGMTY FKEASGPIWL 550 560 570 580 590 600 DDVSCIGNES NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF 610 620 630 640 650 660 QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV SCDGDESDLW 670 680 690 700 710 720 SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA GKVEVNVQGA VGILCANSFL MTSSKPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages." Groenlund J., Vitved L., Lausen M., Skjoedt K., Holmskov U. J. Immunol. 165:6406-6415(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANT MET-523.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-523.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 41-55.
[5]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1161, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF264014 mRNA. Translation: AAF91396.1. AY358856 mRNA. Translation: AAQ89215.1. AC131205 Genomic DNA. No translation available. AC131206 Genomic DNA. No translation available. AC131207 Genomic DNA. No translation available.
IPI	IPI00657946. IPI00658056. IPI00942499.
RefSeq	NP_777601.2. NM_174941.4.
UniGene	Hs.631727.
3D structure databases
ProteinModelPortal	Q9NR16.
SMR	Q9NR16. Positions 45-153, 155-260, 262-362, 366-474, 487-576, 583-683, 686-790, 796-898, 900-1000, 1031-1141, 1246-1349.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000315945.
PTM databases
PhosphoSite	Q9NR16.
Polymorphism databases
DMDM	296434413.
Proteomic databases
PaxDb	Q9NR16.
PRIDE	Q9NR16.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313599; ENSP00000315945; ENSG00000177675. ENST00000396630; ENSP00000379871; ENSG00000177675.
GeneID	283316.
KEGG	hsa:283316.
Organism-specific databases
CTD	283316.
GeneCards	GC12M007507.
HGNC	HGNC:30375. CD163L1.
HPA	HPA015663.
MIM	606079. gene.
neXtProt	NX_Q9NR16.
PharmGKB	PA142672145.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG83796.
HOGENOM	HOG000290652.
HOVERGEN	HBG080943.
InParanoid	Q9NR16.
KO	K06545.
OrthoDB	EOG4RR6GF.
PhylomeDB	Q9NR16.
Gene expression databases
ArrayExpress	Q9NR16.
Bgee	Q9NR16.
CleanEx	HS_CD163L1.
Genevestigator	Q9NR16.
GermOnline	ENSG00000177675. Homo sapiens.
Family and domain databases
InterPro	IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. [Graphical view]
Pfam	PF00530. SRCR. 12 hits. [Graphical view]
PRINTS	PR00258. SPERACTRCPTR.
SMART	SM00202. SR. 12 hits. [Graphical view]
SUPFAM	SSF56487. Srcr_receptor. 12 hits.
PROSITE	PS00420. SRCR_1. 5 hits. PS50287. SRCR_2. 12 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CD163L1. human.
GenomeRNAi	283316.
NextBio	93813.
SOURCE	Search...

Entry information

Entry name

C163B_HUMAN

Accession

Primary (citable) accession number: Q9NR16
Secondary accession number(s): C9JHR7, Q6UWC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.